Oversight and Accountability in Corrections

There are seven underlying principles of our vision of excellence in corrections at Hampden County: the first is balance; second is that we are in the business of not just incarceration but corrections; third is that inmates should be held accountable for being positive and productive; fourth is that whether the prison is a state prison or county facility (urban, rural or in-between) it should be part of the community; fifth is that those in custody should be kept at the lowest level of security that is consistent with public safety; sixth is that corrections should not allow itself to be a scapegoat for the failures of the larger society; and the seventh is respect

Small-Animal PET Imaging of Amyloid-Beta Plaques with [11C]PiB and Its Multi-Modal Validation in an APP/PS1 Mouse Model of Alzheimer's Disease

In vivo imaging and quantification of amyloid-β plaque (Aβ) burden in small-animal models of Alzheimer's disease (AD) is a valuable tool for translational research such as developing specific imaging markers and monitoring new therapy approaches. Methodological constraints such as image resolution of positron emission tomography (PET) and lack of suitable AD models have limited the feasibility of PET in mice. In this study, we evaluated a feasible protocol for PET imaging of Aβ in mouse brain with [11C]PiB and specific activities commonly used in human studies. In vivo mouse brain MRI for anatomical reference was acquired with a clinical 1.5 T system. A recently characterized APP/PS1 mouse was employed to measure Aβ at different disease stages in homozygous and hemizygous animals. We performed multi-modal cross-validations for the PET results with ex vivo and in vitro methodologies, including regional brain biodistribution, multi-label digital autoradiography, protein quantification with ELISA, fluorescence microscopy, semi-automated histological quantification and radioligand binding assays. Specific [11C]PiB uptake in individual brain regions with Aβ deposition was demonstrated and validated in all animals of the study cohort including homozygous AD animals as young as nine months. Corresponding to the extent of Aβ pathology, old homozygous AD animals (21 months) showed the highest uptake followed by old hemizygous (23 months) and young homozygous mice (9 months). In all AD age groups the cerebellum was shown to be suitable as an intracerebral reference region. PET results were cross-validated and consistent with all applied ex vivo and in vitro methodologies. The results confirm that the experimental setup for non-invasive [11C]PiB imaging of Aβ in the APP/PS1 mice provides a feasible, reproducible and robust protocol for small-animal Aβ imaging. It allows longitudinal imaging studies with follow-up periods of approximately one and a half years and provides a foundation for translational Alzheimer neuroimaging in transgenic mice

Erratum to: 36th International Symposium on Intensive Care and Emergency Medicine

[This corrects the article DOI: 10.1186/s13054-016-1208-6.]

Assessment of the Fshery Improvement Opportunities on the Pend Oreille River Annual Report

The purpose of this study was to assess the fishery improvement opportunities on the Box Canyon portion of the Pend Oreilla River. This three year study was initiated as part of the Northwest Power Planning Council's 1987 Columbia River Basin Fish and Wildlife Program. This report contains the findings of the third and final year of the study. The objectives of the third year of the study were to determine the relative abundance of each species in the river and sloughs; the population levels in five selected tributaries and, if possible, for fish in the river and sloughs; each species growth rate, feeding habits abundance preferred prey, and migration patterns; and the seasonal movement patterns and habitat utilization of largemouth bass. 64 refs., 8 figs., 263., tabs