Rare case of complete gonadal dysgenesis 46 XY, Swyer syndrome

Swyer syndrome also known as 46XY complete gonadal dysgenesis is a rare cause of primary amenorrhea. These patients are phenotypically females with female type of internal and external genitalia with absence of testicular tissues. They have streak gonads which have increased potential to turn into malignancy.  Bilateral gonadectomy should be done as soon as diagnosis is made. In present case, 20 years unmarried female came with complaints of menstrual bleeding only on taking medication. She never attained menarche, following which she was started on treatment outside, on withdrawal bleeding for the past 3 years. She was now evaluated and diagnosed as Swyer syndrome and bilateral gonadectomy was done laproscopically. Swyer syndrome patients can get married, have normal sexual life and can get pregnant through invitro fertilisation with donor oocyte if desired

Existence of the Schmidt decomposition for tripartite systems

For any bipartite quantum system the Schmidt decomposition allows us to express the state vector in terms of a single sum instead of double sums. We show the existence of the Schmidt decomposition for tripartite system under certain condition. If the partial inner product of a basis (belonging to a Hilbert space of smaller dimension) with the state of the composite system gives a disentangled basis, then the Schmidt decomposition for a tripartite system exists. In this case the reduced density matrix of each of the subsystem has equal spectrum in the Schmidt basis.Comment: Latex prerpint style, 7 page

Review on Transition Metal Oxides and Their Composites for Energy Storage Application

Supercapacitors evolved as a breakthrough to the existing shortages in energy resources because of its enhanced capacitive performance, long-term stability, and high power density. Transition metal oxides (TMOs), a redox active material in energy storage applications, showing high specific capacitance (100–2000 F/g) than the electrical double-layer capacitor (EDLC) material has been reviewed a lot. Among various TMOs, nickel oxide (NiO), tin oxide (SnO2), manganese dioxide (MnO2), tungsten oxide (WO3), vanadium pentoxide (V2O5) are widely used by researchers due to their high theoretical capacitance, low cost, and long cycle life. The limitations of TMO-based electrode material includes low electrical conductivity, ion mobility, and low energy density. It is thus important to develop proper combination of TMO with other transition metals, TMOs, transition metal dichalcogenides (TMDs), conducting polymers (CPs) and carbon-based materials (graphene oxide (GO), activated carbon (AC) and reduced GO (rGO)). This chapter focuses on ongoing development in six TMO-based electrode material (NiO, ZnO, MnO2, SnO2, WO3, V2O5) fabrication for the enhancement of electrochemical performance, their synthesis method and then review about the recent progress in studying the supercapacitor performance of the material. The limitations of each TMOs listed separately, providing new insights for future energy storage applications

Aspergillus spp., a versatile cell factory for enzymes and metabolites: Interventions through genome editing

Aspergillus sp. is widely distributed in nature and plays significant roles in the degradation of lignocellulose biomass and extensively used in bioprocess and fermentation technology and many species are also a generally regarded safe. Many of the Aspergillus species are established cell factories due to their inherent capacity in secreting large number of hydrolytic enzymes. With the advent of next generation genomic technologies and metabolic engineering technologies, the production potential of Aspergillus cell factory has improved over the years. Various genome editing tools has been developed for Aspergillus like engineered nucleases, zinc finger nucleases, TALEN and CRISPR-Cas9 system. Currently, the CRISPR/Cas9-based technique is extensively used to enhance the effectiveness of gene manipulation in model system Aspergillus nidulans and other strains like Aspergillus oryzae, Aspergillus niger and Aspergillus fumigatus. This review describes the recent developments of genome editing technologies in Aspergillus the synthesis of heterologous proteins and secondary metabolites in the Aspergillus species

TRIBUTE TO MAVIS AGBANDJE-MCKENNA A Beautiful Mind and the Heart of an Explorer

Non peer reviewe

Effects of antiplatelet therapy on stroke risk by brain imaging features of intracerebral haemorrhage and cerebral small vessel diseases: subgroup analyses of the RESTART randomised, open-label trial

Background Findings from the RESTART trial suggest that starting antiplatelet therapy might reduce the risk of recurrent symptomatic intracerebral haemorrhage compared with avoiding antiplatelet therapy. Brain imaging features of intracerebral haemorrhage and cerebral small vessel diseases (such as cerebral microbleeds) are associated with greater risks of recurrent intracerebral haemorrhage. We did subgroup analyses of the RESTART trial to explore whether these brain imaging features modify the effects of antiplatelet therapy