Kinetic and Chemical Equilibration in Scalar phi^4 Theory

Approximations based on the 2PI effective action are used to investigate the process of equilibration in phi^4 theory in 3+1 dimensions, both in the symmetric and broken phase. A special emphasis is put on the study of the kinetic and chemical equilibration.Comment: 8 pages, 6 figures, uses axodraw, minor corrections added, based on a talk given at the Workshop on Quark Gluon Plasma Thermalization, Vienna, August 10th-12th, 200

An isoperimetric-type inequality for electrostatic shell interactions for Dirac operators

In this article we investigate spectral properties of the coupling $H+V_\lambda$, where $H=-i\alpha\cdot\nabla +m\beta$ is the free Dirac operator in $\mathbb R^3$, $m>0$ and $V_\lambda$ is an electrostatic shell potential (which depends on a parameter $\lambda\in\mathbb R$) located on the boundary of a smooth domain in $\mathbb R^3$. Our main result is an isoperimetric-type inequality for the admissible range of $\lambda$'s for which the coupling $H+V_\lambda$ generates pure point spectrum in $(-m,m)$. That the ball is the unique optimizer of this inequality is also shown. Regarding some ingredients of the proof, we make use of the Birman-Schwinger principle adapted to our setting in order to prove some monotonicity property of the admissible $\lambda$'s, and we use this to relate the endpoints of the admissible range of $\lambda$'s to the sharp constant of a quadratic form inequality, from which the isoperimetric-type inequality is derived.Comment: 21 page

Identification of Fis1 Interactors in Toxoplasma gondii Reveals a Novel Protein Required for Peripheral Distribution of the Mitochondrion

Toxoplasma gondii’s single mitochondrion is very dynamic and undergoes morphological changes throughout the parasite’s life cycle. During parasite division, the mitochondrion elongates, enters the daughter cells just prior to cytokinesis, and undergoes fission. Extensive morphological changes also occur as the parasite transitions from the intracellular environment to the extracellular environment. We show that treatment with the ionophore monensin causes reversible constriction of the mitochondrial outer membrane and that this effect depends on the function of the fission-related protein Fis1. We also observed that mislocalization of the endogenous Fis1 causes a dominant-negative effect that affects the morphology of the mitochondrion. As this suggests that Fis1 interacts with proteins critical for maintenance of mitochondrial structure, we performed various protein interaction trap screens. In this manner, we identified a novel outer mitochondrial membrane protein, LMF1, which is essential for positioning of the mitochondrion in intracellular parasites. Normally, while inside a host cell, the parasite mitochondrion is maintained in a lasso shape that stretches around the parasite periphery where it has regions of coupling with the parasite pellicle, suggesting the presence of membrane contact sites. In intracellular parasites lacking LMF1, the mitochondrion is retracted away from the pellicle and instead is collapsed, as normally seen only in extracellular parasites. We show that this phenotype is associated with defects in parasite fitness and mitochondrial segregation. Thus, LMF1 is necessary for mitochondrial association with the parasite pellicle during intracellular growth, and proper mitochondrial morphology is a prerequisite for mitochondrial division

Four models and a challenge: past, present, and future of translator training programs in Argentina

Argentina has a long-standing tradition in translation training. This article has two purposes. On the one hand, it seeks to describe four translation training models prevailing in Argentinean universities, especially at Comahue, Córdoba and La Plata universities. The application of such models will be discussed in relation to the foreign-language training of students prior to and throughout undergraduate education. On the other hand, I will present a translation training model with a view to develop research skills in students, which might foster undergraduate education in research. The urgency to build up a research competence in students is backed up by the fact that Translation Studies is at present a vacant research area in the country.Fil: Arrizabalaga, Maria Ines. Universidad Nacional de Córdoba; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentin

The Secreted Acid Phosphatase Domain-Containing GRA44 from Toxoplasma gondii Is Required for c-Myc Induction in Infected Cells.

During host cell invasion, the eukaryotic pathogen Toxoplasma gondii forms a parasitophorous vacuole to safely reside within the cell, while it is partitioned from host cell defense mechanisms. From within this safe niche, parasites sabotage multiple host cell systems, including gene expression, apoptosis, and intracellular immune recognition, by secreting a large arsenal of effector proteins. Many parasite proteins studied for active host cell manipulative interactions have been kinases. The translocation of effectors from the parasitophorous vacuole into the host cell is mediated by a putative translocon complex, which includes the proteins MYR1, MYR2, and MYR3. Whether other proteins are involved in the structure or regulation of this putative translocon is not known. We have discovered that the secreted protein GRA44, which contains a putative acid phosphatase domain, interacts with members of this complex and is required for host cell effects downstream of effector secretion. We have determined that GRA44 is processed in a region with homology to sequences targeted by protozoan proteases of the secretory pathway and that both major cleavage fragments are secreted into the parasitophorous vacuole. Immunoprecipitation experiments showed that GRA44 interacts with a large number of secreted proteins, including MYR1. Importantly, conditional knockdown of GRA44 resulted in a lack of host cell c-Myc upregulation, which mimics the phenotype seen when members of the translocon complex are genetically disrupted. Thus, the putative acid phosphatase GRA44 is crucial for host cell alterations during Toxoplasma infection and is associated with the translocon complex which Toxoplasma relies upon for success as an intracellular pathogen.IMPORTANCE Approximately one-third of humans are infected with the parasite Toxoplasma gondii Toxoplasma infections can lead to severe disease in those with a compromised or suppressed immune system. Additionally, infections during pregnancy present a significant health risk to the developing fetus. Drugs that target this parasite are limited, have significant side effects, and do not target all disease stages. Thus, a thorough understanding of how the parasite propagates within a host is critical in the discovery of novel therapeutic targets. Toxoplasma replication requires that it enter the cells of the infected organism. In order to survive the environment inside a cell, Toxoplasma secretes a large repertoire of proteins, which hijack a number of important cellular functions. How these Toxoplasma proteins move from the parasite into the host cell is not well understood. Our work shows that the putative phosphatase GRA44 is part of a protein complex responsible for this process

Renormalisation of out-of-equilibrium quantum fields

We consider the initial value problem and its renormalisation in the framework of the two-particle-irreducible (2PI) effective action. We argue that in the case of appropriately chosen self-consistent initial conditions, the counterterms needed to renormalise the system in equilibrium are also sufficient to renormalise its time evolution. In this way we improve on Gaussian initial conditions which have the disadvantage of generically not showing a continuum limit. For a more detailed discussion see arXiv:0809.0496.Comment: To appear in the proceedings of SEWM08, Amsterdam, The Netherlands, 26-29 August 200