The Relation Between Galaxy ISM and Circumgalactic OVI Gas Kinematics Derived from Observations and Λ\LambdaCDM Simulations

We present the first galaxy-OVI absorption kinematic study for 20 absorption systems (EW>0.1~{\AA}) associated with isolated galaxies (0.15$<z<$0.55) that have accurate redshifts and rotation curves obtained using Keck/ESI. Our sample is split into two azimuthal angle bins: major axis ($\Phi<25^{\circ}$) and minor axis ($\Phi>33^{\circ}$). OVI absorption along the galaxy major axis is not correlated with galaxy rotation kinematics, with only 1/10 systems that could be explained with rotation/accretion models. This is in contrast to co-rotation commonly observed for MgII absorption. OVI along the minor axis could be modeled by accelerating outflows but only for small opening angles, while the majority of the OVI is decelerating. Along both axes, stacked OVI profiles reside at the galaxy systemic velocity with the absorption kinematics spanning the entire dynamical range of their galaxies. The OVI found in AMR cosmological simulations exists within filaments and in halos of ~50 kpc surrounding galaxies. Simulations show that major axis OVI gas inflows along filaments and decelerates as it approaches the galaxy while increasing in its level of co-rotation. Minor axis outflows in the simulations are effective within 50-75 kpc beyond that they decelerate and fall back onto the galaxy. Although the simulations show clear OVI kinematic signatures they are not directly comparable to observations. When we compare kinematic signatures integrated through the entire simulated galaxy halo we find that these signatures are washed out due to full velocity distribution of OVI throughout the halo. We conclude that OVI alone does not serve as a useful kinematic indicator of gas accretion, outflows or star-formation and likely best probes the halo virial temperature.Comment: 24 pages, 21 figures, 4 tables. Accepted to ApJ on November 14, 201

PDS 144: the first confirmed Herbig Ae-Herbig Ae wide binary

PDS 144 is a pair of Herbig Ae stars that are separated by 5.'' 35 on the sky. It has previously been shown to have an A2Ve Herbig Ae star viewed at 83 degrees inclination as its northern member and an A5Ve Herbig Ae star as its southern member. Direct imagery revealed a disk occulting PDS 144 N-the first edge-on disk observed around a Herbig Ae star. The lack of an obvious disk in direct imagery suggested PDS 144 S might be viewed face-on or not physically associated with PDS 144 N. Multi-epoch Hubble Space Telescope imagery of PDS 144 with a 5 year baseline demonstrates PDS 144 N & S are comoving and have a common proper motion with TYC 6782-878-1. TYC 6782-878-1 has previously been identified as a member of Upper Sco sub-association A at d = 145 +/- 2 pc with an age of 5-10 Myr. Ground-based imagery reveals jets and a string of Herbig-Haro knots extending 13' (possibly further) which are aligned to within 7 degrees +/- 6 degrees on the sky. By combining proper motion data and the absence of a dark mid-plane with radial velocity data, we measure the inclination of PDS 144 S to be i = 73 degrees +/- 7 degrees. The radial velocity of the jets from PDS 144 N & S indicates they, and therefore their disks, are misaligned by 25 degrees +/- 9 degrees. This degree of misalignment is similar to that seen in T Tauri wide binaries.Peer reviewe

Polyphenols: A concise overview on the chemistry, occurrence, and human health

This review gives an updated picture of each class of phenolic compounds and their properties. The most common classification implies the subdivision of phenolics in two main groups: flavonoids (e.g., anthocyanins, flavanols, flavanones, flavonols, flavonones, and isoflavones) and non-flavonoids (e.g., phenolic acids, xanthones, stilbens, lignans, and tannins) polyphenols. The great interest in polyphenols is associated with their high potential application for food preservation and for therapeutic beneficial use. The relationship between polyphenol intake and human health has been exploited with special reference to cardiovascular diseases, hypertension, diabetes, metabolic syndrome, obesity, and cancer. The use of current existing databases of bioactive compounds including polyphenols is described as key tools for human health research.info:eu-repo/semantics/publishedVersio

Exploring the Outer Solar System with the ESSENCE Supernova Survey

We report the discovery and orbit determination of 14 trans-Neptunian objects (TNOs) from the ESSENCE Supernova Survey difference imaging dataset. Two additional objects discovered in a similar search of the SDSS-II Supernova Survey database were recovered in this effort. ESSENCE repeatedly observed fields far from the Solar System ecliptic (-21 deg < beta < -5 deg), reaching limiting magnitudes per observation of I~23.1 and R~23.7. We examine several of the newly detected objects in detail, including 2003 UC_414 which orbits entirely between Uranus and Neptune and lies very close to a dynamical region that would make it stable for the lifetime of the Solar System. 2003 SS_422 and 2007 TA_418 have high eccentricities and large perihelia, making them candidate members of an outer class of trans-Neptunian objects. We also report a new member of the ''extended'' or ''detached'' scattered disk, 2004 VN_112, and verify the stability of its orbit using numerical simulations. This object would have been visible to ESSENCE for only ~2% of its orbit, suggesting a vast number of similar objects across the sky. We emphasize that off-ecliptic surveys are optimal for uncovering the diversity of such objects, which in turn will constrain the history of gravitational influences that shaped our early Solar System.Comment: 5 pages, 1 table, accepted for publication in ApJ

Age Related Changes in NAD+ Metabolism Oxidative Stress and Sirt1 Activity in Wistar Rats

The cofactor nicotinamide adenine dinucleotide (NAD+) has emerged as a key regulator of metabolism, stress resistance and longevity. Apart from its role as an important redox carrier, NAD+ also serves as the sole substrate for NAD-dependent enzymes, including poly(ADP-ribose) polymerase (PARP), an important DNA nick sensor, and NAD-dependent histone deacetylases, Sirtuins which play an important role in a wide variety of processes, including senescence, apoptosis, differentiation, and aging. We examined the effect of aging on intracellular NAD+ metabolism in the whole heart, lung, liver and kidney of female wistar rats. Our results are the first to show a significant decline in intracellular NAD+ levels and NAD∶NADH ratio in all organs by middle age (i.e.12 months) compared to young (i.e. 3 month old) rats. These changes in [NAD(H)] occurred in parallel with an increase in lipid peroxidation and protein carbonyls (o- and m- tyrosine) formation and decline in total antioxidant capacity in these organs. An age dependent increase in DNA damage (phosphorylated H2AX) was also observed in these same organs. Decreased Sirt1 activity and increased acetylated p53 were observed in organ tissues in parallel with the drop in NAD+ and moderate over-expression of Sirt1 protein. Reduced mitochondrial activity of complex I–IV was also observed in aging animals, impacting both redox status and ATP production. The strong positive correlation observed between DNA damage associated NAD+ depletion and Sirt1 activity suggests that adequate NAD+ concentrations may be an important longevity assurance factor

J Nat Prod

The inhibition of arginase is of substantial interest for the treatment of various diseases of public health interest including cardiovascular diseases. Using an ex vivo experiment on rat aortic rings and an in vitro assay with liver bovine purified arginase, it was demonstrated that several polyphenolic extracts from Cyperus and Carex species possess vasorelaxant properties and mammalian arginase inhibitory capacities. Phytochemical studies performed on these species led to the identification of eight compounds, including monomers, dimers, trimers, and tetramers of resveratrol. The potential of these stilbenes as inhibitors of mammalian arginase was assessed. Five compounds, scirpusin B (5), ε-viniferin (4), cyperusphenol B (6), carexinol A (7), and the new compound virgatanol (1), showed significant inhibition of arginase, with percentage inhibition ranging from 70% to 95% at 100 μg/mL and IC values between 12.2 and 182.1 μM, confirming that these stilbenes may be useful for the development of new pharmaceutical products

Phytochemical screening and arginase inhibitory activity of extracts from several Tunisian medicinal plants

International audienc

Exploring the Outer Solar System with the ESSENCE Supernova Survey

We report the discovery and orbital determination of 14 trans-Neptunian objects (TNOs) from the ESSENCE Supernova Survey difference imaging data set. Two additional objects discovered in a similar search of the SDSS-II Supernova Survey database were recovered in this effort. ESSENCE repeatedly observed fields far from the solar system ecliptic (-21{sup o} &lt; {beta} &lt; -5{sup o}), reaching limiting magnitudes per observation of I {approx} 23.1 and R {approx} 23.7. We examine several of the newly detected objects in detail, including 2003 UC{sub 414}, which orbits entirely between Uranus and Neptune and lies very close to a dynamical region that would make it stable for the lifetime of the solar system. 2003 SS{sub 422} and 2007 TA{sub 418} have high eccentricities and large perihelia, making them candidate members of an outer class of TNOs. We also report a new member of the 'extended' or 'detached' scattered disk, 2004 VN{sub 112}, and verify the stability of its orbit using numerical simulations. This object would have been visible to ESSENCE for only {approx}2% of its orbit, suggesting a vast number of similar objects across the sky. We emphasize that off-ecliptic surveys are optimal for uncovering the diversity of such objects, which in turn will constrain the history of gravitational influences that shaped our early solar system