2,500 research outputs found
Modeling the dynamics of glacial cycles
This article is concerned with the dynamics of glacial cycles observed in the geological record of the Pleistocene Epoch. It focuses on a conceptual model proposed by Maasch and Saltzman [J. Geophys. Res.,95, D2 (1990), pp. 1955-1963], which is based on physical arguments and emphasizes the role of atmospheric CO2 in the generation and persistence of periodic orbits (limit cycles). The model consists of three ordinary differential equations with four parameters for the anomalies of the total global ice mass, the atmospheric CO2 concentration, and the volume of the North Atlantic Deep Water (NADW). In this article, it is shown that a simplified two-dimensional symmetric version displays many of the essential features of the full model, including equilibrium states, limit cycles, their basic bifurcations, and a Bogdanov-Takens point that serves as an organizing center for the local and global dynamics. Also, symmetry breaking splits the Bogdanov-Takens point into two, with different local dynamics in their neighborhoods
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The stealth episome: suppression of gene expression on the excised genomic island PPHGI-1 from Pseudomonas syringae pv. phaseolicola
Pseudomonas syringae pv. phaseolicola is the causative agent of halo blight in the common bean, Phaseolus vulgaris. P. syringae pv. phaseolicola race 4 strain 1302A contains the avirulence gene avrPphB (syn. hopAR1), which resides on PPHGI-1, a 106 kb genomic island. Loss of PPHGI-1 from P. syringae pv. phaseolicola 1302A following exposure to the hypersensitive resistance response (HR) leads to the evolution of strains with altered virulence. Here we have used fluorescent protein reporter systems to gain insight into the mobility of PPHGI-1. Confocal imaging of dual-labelled P. syringae pv. phaseolicola 1302A strain, F532 (dsRFP in chromosome and eGFP in PPHGI-1), revealed loss of PPHGI-1::eGFP encoded fluorescence during plant infection and when grown in vitro on extracted leaf apoplastic fluids. Fluorescence-activated cell sorting (FACS) of fluorescent and non-fluorescent PPHGI-1::eGFP F532 populations showed that cells lost fluorescence not only when the GI was deleted, but also when it had excised and was present as a circular episome. In addition to reduced expression of eGFP, quantitative PCR on sub-populations separated by FACS showed that transcription of other genes on PPHGI-1 (avrPphB and xerC) was also greatly reduced in F532 cells harbouring the excised PPHGI-1::eGFP episome. Our results show how virulence determinants located on mobile pathogenicity islands may be hidden from detection by host surveillance systems through the suppression of gene expression in the episomal state
On Arnold's 14 `exceptional' N=2 superconformal gauge theories
We study the four-dimensional superconformal N=2 gauge theories engineered by
the Type IIB superstring on Arnold's 14 exceptional unimodal singularities
(a.k.a. Arnold's strange duality list), thus extending the methods of 1006.3435
to singularities which are not the direct sum of minimal ones. In particular,
we compute their BPS spectra in several `strongly coupled' chambers.
From the TBA side, we construct ten new periodic Y-systems, providing
additional evidence for the existence of a periodic Y-system for each isolated
quasi-homogeneous singularity with (more generally, for each N=2
superconformal theory with a finite BPS chamber whose chiral primaries have
dimensions of the form N/l).Comment: 73 pages, 7 figure
Prehistory of Transit Searches
Nowadays the more powerful method to detect extrasolar planets is the transit
method. We review the planet transits which were anticipated, searched, and the
first ones which were observed all through history. Indeed transits of planets
in front of their star were first investigated and studied in the solar system.
The first observations of sunspots were sometimes mistaken for transits of
unknown planets. The first scientific observation and study of a transit in the
solar system was the observation of Mercury transit by Pierre Gassendi in 1631.
Because observations of Venus transits could give a way to determine the
distance Sun-Earth, transits of Venus were overwhelmingly observed. Some
objects which actually do not exist were searched by their hypothetical
transits on the Sun, as some examples a Venus satellite and an infra-mercurial
planet. We evoke the possibly first use of the hypothesis of an exoplanet
transit to explain some periodic variations of the luminosity of a star, namely
the star Algol, during the eighteen century. Then we review the predictions of
detection of exoplanets by their transits, those predictions being sometimes
ancient, and made by astronomers as well as popular science writers. However,
these very interesting predictions were never published in peer-reviewed
journals specialized in astronomical discoveries and results. A possible
transit of the planet beta Pic b was observed in 1981. Shall we see another
transit expected for the same planet during 2018? Today, some studies of
transits which are connected to hypothetical extraterrestrial civilisations are
published in astronomical refereed journals. Some studies which would be
classified not long ago as science fiction are now considered as scientific
ones.Comment: Submiited to Handbook of Exoplanets (Springer
Macrophages orchestrate the expansion of a proangiogenic perivascular niche during cancer progression
Tumor-associated macrophages (TAMs) are a highly plastic stromal cell type that support cancer progression. Using single-cell RNA sequencing of TAMs from a spontaneous murine model of mammary adenocarcinoma (MMTV-PyMT), we characterize a subset of these cells expressing lymphatic vessel endothelial hyaluronic acid receptor 1 (Lyve-1) that spatially reside proximal to blood vasculature. We demonstrate that Lyve-1+ TAMs support tumor growth and identify a pivotal role for these cells in maintaining a population of perivascular mesenchymal cells that express α-smooth muscle actin and phenotypically resemble pericytes. Using photolabeling techniques, we show that mesenchymal cells maintain their prevalence in the growing tumor through proliferation and uncover a role for Lyve-1+ TAMs in orchestrating a selective platelet-derived growth factor–CC–dependent expansion of the perivascular mesenchymal population, creating a proangiogenic niche. This study highlights the inter-reliance of the immune and nonimmune stromal network that supports cancer progression and provides therapeutic opportunities for tackling the disease
Exoplanets and SETI
The discovery of exoplanets has both focused and expanded the search for
extraterrestrial intelligence. The consideration of Earth as an exoplanet, the
knowledge of the orbital parameters of individual exoplanets, and our new
understanding of the prevalence of exoplanets throughout the galaxy have all
altered the search strategies of communication SETI efforts, by inspiring new
"Schelling points" (i.e. optimal search strategies for beacons). Future efforts
to characterize individual planets photometrically and spectroscopically, with
imaging and via transit, will also allow for searches for a variety of
technosignatures on their surfaces, in their atmospheres, and in orbit around
them. In the near-term, searches for new planetary systems might even turn up
free-floating megastructures.Comment: 9 page invited review. v2 adds some references and v3 has other minor
additions and modification
The Genomic Signature of Crop-Wild Introgression in Maize
The evolutionary significance of hybridization and subsequent introgression
has long been appreciated, but evaluation of the genome-wide effects of these
phenomena has only recently become possible. Crop-wild study systems represent
ideal opportunities to examine evolution through hybridization. For example,
maize and the conspecific wild teosinte Zea mays ssp. mexicana, (hereafter,
mexicana) are known to hybridize in the fields of highland Mexico. Despite
widespread evidence of gene flow, maize and mexicana maintain distinct
morphologies and have done so in sympatry for thousands of years. Neither the
genomic extent nor the evolutionary importance of introgression between these
taxa is understood. In this study we assessed patterns of genome-wide
introgression based on 39,029 single nucleotide polymorphisms genotyped in 189
individuals from nine sympatric maize-mexicana populations and reference
allopatric populations. While portions of the maize and mexicana genomes were
particularly resistant to introgression (notably near known
cross-incompatibility and domestication loci), we detected widespread evidence
for introgression in both directions of gene flow. Through further
characterization of these regions and preliminary growth chamber experiments,
we found evidence suggestive of the incorporation of adaptive mexicana alleles
into maize during its expansion to the highlands of central Mexico. In
contrast, very little evidence was found for adaptive introgression from maize
to mexicana. The methods we have applied here can be replicated widely, and
such analyses have the potential to greatly informing our understanding of
evolution through introgressive hybridization. Crop species, due to their
exceptional genomic resources and frequent histories of spread into sympatry
with relatives, should be particularly influential in these studies
Supergoop Dynamics
We initiate a systematic study of the dynamics of multi-particle systems with
supersymmetric Van der Waals and electron-monopole type interactions. The
static interaction allows a complex continuum of ground state configurations,
while the Lorentz interaction tends to counteract this configurational fluidity
by magnetic trapping, thus producing an exotic low temperature phase of matter
aptly named supergoop. Such systems arise naturally in gauge
theories as monopole-dyon mixtures, and in string theory as collections of
particles or black holes obtained by wrapping D-branes on internal space
cycles. After discussing the general system and its relation to quiver quantum
mechanics, we focus on the case of three particles. We give an exhaustive
enumeration of the classical and quantum ground states of a probe in an
arbitrary background with two fixed centers. We uncover a hidden conserved
charge and show that the dynamics of the probe is classically integrable. In
contrast, the dynamics of one heavy and two light particles moving on a line
shows a nontrivial transition to chaos, which we exhibit by studying the
Poincar\'e sections. Finally we explore the complex dynamics of a probe
particle in a background with a large number of centers, observing hints of
ergodicity breaking. We conclude by discussing possible implications in a
holographic context.Comment: 35 pages,11 figures. v2: updated references to include a previous
proof of classical integrability, exchanged a figure for a prettier versio
Hybridization in parasites: consequences for adaptive evolution, pathogenesis and public health in a changing world
[No abstract available
Color & Weak triplet scalars, the dimuon asymmetry in decay, the top forward-backward asymmetry, and the CDF dijet excess
The new physics required to explain the anomalies recently reported by the D0
and CDF collaborations, namely the top forward-backward asymmetry (FBA), the
like-sign dimuon charge asymmetry in semileptonic b decay, and the CDF dijet
excess, has to feature an amount of flavor symmetry in order to satisfy the
severe constrains arising from flavor violation. In this paper we show that,
once baryon number conservation is imposed, color & weak triplet scalars with
hypercharge can feature the required flavor structure as a consequence
of standard model gauge invariance. The color & weak triplet model can
simultaneously explain the top FBA and the dimuon charge asymmetry or the
dimuon charge asymmetry and the CDF dijet excess. However, the CDF dijet excess
appears to be incompatible with the top FBA in the minimal framework. Our model
for the dimuon asymmetry predicts the observed pattern in the
region of parameter space required to explain the top FBA, whereas our model
for the CDF dijet anomaly is characterized by the absence of beyond the SM
b-quark jets in the excess region. Compatibility of the color & weak triplet
with the electroweak constraints is also discussed. We show that a Higgs boson
mass exceeding the LEP bound is typically favored in this scenario, and that
both Higgs production and decay can be significantly altered by the triplet.
The most promising collider signature is found if the splitting among the
components of the triplet is of weak scale magnitude.Comment: references added, published versio
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