1,399 research outputs found
Multiple Sclerosis and Schizophrenia
The psychiatric and neurological aspects of health may present methodological challenges in the diagnosis and treatment of disease. This is especially true for patients whose symptoms indicate the coexistence of multiple sclerosis (MS) and schizophrenia (SCZ). These cases raise critical questions regarding the relationship between the mind and the brain. Studies have noted that patients with MS have an increased risk of developing SCZ or bipolar disorder (BD). It is suggested here that MS and a subgroup of SCZ have similar etiologies. Factors such as gender, ethnicity, geography and season also have an influence on the occurrence of MS and SCZ. This paper aims to examine the differences and similarities between SCZ and MS. For this purpose, scientific papers examining various factors associated with these disorders were reviewed, and similarities and differences in genetic, immunological, seasonal, geographical, and gender-related risk factors and limited similarities in ethnic factors between the two diseases were identified. The findings suggest that subgroups of these two diseases may belong to the same class of disorders
Isoprene emission from Sphagnum species occupying different growth positions above the water table
Isoprene emission from Sphagnum species naturally growing at different positions above the water table were measured in a subarctic peatland and at monoliths from a temperate bog. Our objectives were to investigate (1) whether emission rates were species and/or moisture dependent, and (2) whether short-term temperature history had an influence on emission capacity. We expected greater emission capacities in moist than dry growing conditions, and from species adapted to wet habitats. We also expected that higher emission capacities would be found in response to elevated temperatures. Average peak growing season isoprene emission capacities (standardized to 20 degrees C and PAR 1000 mu mol m(-2) s(-1)) at the subarctic site were 106 and 74 mu g C m(-2) h(-1) from a S. balticum wet lawn and a S. balticum dry hummock/palsa, respectively. Emission capacities correlated strongly with gross primary productivity (GPP) and the average air temperature of the 48 hours prior to measurement (T-48), but the effect of T-48 seemed to be partly masked by the influence of GPP when moisture was not limiting. The laboratory experiments suggested that a typical hummock species, S. rubellum had higher capacity for isoprene emission than a typical lawn species S. magellanicum. Instantaneous emission rates increased with temperature, but no effect of temperature history was discernible. Sphagnum mosses are known to emit substantial amounts of isoprene, but in this study we also showed significant inter-species differences in emission capacity. The results imply that climate change induced alterations of peatland hydrology may change the total ecosystem isoprene source strength, as individual species adapt to new growth conditions or as a consequence of species succession
Determinants and predictability of global wildfire emissions
Biomass burning is one of the largest sources of atmospheric trace gases and aerosols globally. These emissions have a major impact on the radiative balance of the atmosphere and on air quality, and are thus of significant scientific and societal interest. Several datasets have been developed that quantify those emissions on a global grid and offered to the atmospheric modelling community. However, no study has yet attempted to systematically quantify the dependence of the inferred pyrogenic emissions on underlying assumptions and input data. Such a sensitivity study is needed for understanding how well we can currently model those emissions and what the factors are that contribute to uncertainties in those emission estimates. <br><br> Here, we combine various satellite-derived burned area products, a terrestrial ecosystem model to simulate fuel loads and the effect of fire on ecosystem dynamics, a model of fuel combustion, and various emission models that relate combusted biomass to the emission of various trace gases and aerosols. We carry out simulations with varying parameters for combustion completeness and fuel decomposition rates within published estimates, four different emissions models and three different global burned-area products. We find that variations in combustion completeness and simulated fuel loads have the largest impact on simulated global emissions for most species, except for some with highly uncertain emission factors. Variation in burned-area estimates also contribute considerably to emission uncertainties. We conclude that global models urgently need more field-based data for better parameterisation of combustion completeness and validation of simulated fuel loads, and that further validation and improvement of burned area information is necessary for accurately modelling global wildfire emissions. The results are important for chemical transport modelling studies, and for simulations of biomass burning impacts on the atmosphere under future climate change scenarios
Climate, COâ‚‚ and demographic impacts on global wildfire emissions
Abstract. Wildfires are by far the largest contributor to global biomass burning and constitute a large global source of atmospheric traces gases and aerosols. Such emissions have a considerable impact on air quality and constitute a major health hazard. Biomass burning also influences the radiative balance of the atmosphere and is thus not only of societal, but also of significant scientific interest. There is a common perception that climate change will lead to an increase in emissions as hot and dry weather events that promote wildfire will become more common. However, even though a few studies have found that the inclusion of CO2 fertilisation of photosynthesis and changes in human population patterns will tend to somewhat lower predictions of future wildfire emissions, no such study has included full ensemble ranges of both climate predictions and population projections, including the effect of different degrees of urbanisation.
Here, we present a series of 124 simulations with the LPJ–GUESS–SIMFIRE global dynamic vegetation–wildfire model, including a semi-empirical formulation for the prediction of burned area based on fire weather, fuel continuity and human population density. The simulations use Climate Model Intercomparison Project 5 (CMIP5) climate predictions from eight Earth system models. These were combined with two Representative Concentration Pathways (RCPs) and five scenarios of future human population density based on the series of Shared Socioeconomic Pathways (SSPs) to assess the sensitivity of emissions to the effect of climate, CO2 and humans. In addition, two alternative parameterisations of the semi-empirical burned-area model were applied. Contrary to previous work, we find no clear future trend of global wildfire emissions for the moderate emissions and climate change scenario based on the RCP 4.5. Only historical population change introduces a decline by around 15 % since 1900. Future emissions could either increase for low population growth and fast urbanisation, or continue to decline for high population growth and slow urbanisation. Only for high future climate change (RCP8.5), wildfire emissions start to rise again after ca. 2020 but are unlikely to reach the levels of 1900 by the end of the 21st century. We find that climate warming will generally increase the risk of fire, but that this is only one of several equally important factors driving future levels of wildfire emissions, which include population change, CO2 fertilisation causing woody thickening, increased productivity and fuel load and faster litter turnover in a warmer climate
Benefits and trade-offs of optimizing global land use for food, water, and carbon
Current large-scale patterns of land use reflect history, local traditions, and productioncosts, much more so than they reflect biophysical potential or global supply anddemand for food and freshwater, or—more recently—climate change mitigation. Wequantified alternative land-use allocations that consider trade-offs for these demandsby combining a dynamic vegetation model and an optimization algorithm to determinePareto-optimal land-use allocations under changing climate conditions in 2090–2099and alternatively in 2033–2042. These form the outer bounds of the option spacefor global land-use transformation. Results show a potential to increase all threeindicators (+83% in crop production,+8% in available runoff, and+3% in carbonstorage globally) compared to the current land-use configuration, with clear land-use priority areas: Tropical and boreal forests were preserved, crops were produced intemperate regions, and pastures were preferentially allocated in semiarid grasslands andsavannas. Transformations toward optimal land-use patterns would imply extensivereconfigurations and changes in land management, but the required annual land-usechanges were nevertheless of similar magnitude as those suggested by established land-use change scenarios. The optimization results clearly show that large benefits couldbe achieved when land use is reconsidered under a “global supply” perspective with aregional focus that differs across the world’s regions in order to achieve the supply ofkey ecosystem services under the emerging global pressures
Future challenges of representing land-processes in studies on land-atmosphere interactions
Over recent years, it has become increasingly apparent
that climate change and air pollution need to be considered
jointly for improved attribution and projections of
human-caused changes in the Earth system. Exchange processes
at the land surface come into play in this context, because
many compounds that either act as greenhouse gases,
as pollutant precursors, or both, have not only anthropogenic
but also terrestrial sources and sinks. And since the fluxes
of multiple gases and particulate matter between the terrestrial
biota and the atmosphere are directly or indirectly coupled
to vegetation and soil carbon, nutrient and water balances,
quantification of their geographic patterns or changes
over time requires due consideration of the underlying biological
processes. In this review we highlight a number of
critical aspects and recent progress in this respect, identifying
in particular a number of areas where studies have shown
that accounting for ecological process understanding can alter
global model projections of land-atmosphere interactions
substantially. Specifically, this concerns the improved quantification
of uncertainties and dynamic system responses, including
acclimation, and the incorporation of exchange processes
that so far have been missing from global models
even though they are proposed to be of relevance for our understanding
of terrestrial biota-climate feedbacks. Progress
has also been made regarding studies on the impacts of land
use/land cover change on climate change, but the absence of
a mechanistically based representation of human responseprocesses
in ecosystem models that are coupled to climate models limits our ability to analyse how climate change or
air pollution in turn might affect human land use. A more integrated
perspective is necessary and should become an active
area of research that bridges the socio-economic and biophysical
communities
G691S/S904S polymorphism in the RET protooncogene of a 25-year-old medical student with bilateral pheochromocytoma
The case of a 25-year-old medical student with bilateral
pheochromocytoma is described. Following diagnostic testing, tumors
were surgically removed. Genetic analysis revealed that the patient is
a heterozygote with the following mutations on opposite homologs: G691S
(exon 11) and S904S (TCC-TCG, exon 15), suggesting the diagnosis of
multiple endocrine neoplasia 2A (MEN2A). A diagnosis of MEN2 would be
an indication of thyroidectomy in this patient. Although this mutation
is described in the literature, it has no known connection to
pheochromocytomas. Therefore, it is unknown whether there is a causal
connection between the G691S genotype and the pheochromocytomas in this
patient. If so, G691S is to be added to the list of genotypes causing
MEN2A. Here, the procedure of sequencing the RET protooncogene is
described and a possible association between the G691S genotype and
MEN2A is discussed
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