837 research outputs found
Effects of finite arm-length of LISA on analysis of gravitational waves from MBH binaries
Response of an interferometer becomes complicated for gravitational wave
shorter than the arm-length of the detector, as nature of wave appears
strongly. We have studied how parameter estimation for merging massive black
hole binaries are affected by this complicated effect in the case of LISA. It
is shown that three dimensional positions of some binaries might be determined
much better than the past estimations that use the long wave approximation. For
equal mass binaries this improvement is most prominent at \sim 10^5\sol.Comment: 10 pages, 3 figures, to appear in Phys.Rev.
Identifying multiple stressor controls on phytoplankton dynamics in the River Thames (UK) using high-frequency water quality data
River phytoplankton blooms can pose a serious risk to water quality and the structure and function of aquatic
ecosystems. Developing a greater understanding of the physical and chemical controls on the timing, magnitude
and duration of blooms is essential for the effective management of phytoplankton development. Five years of
weekly water quality monitoring data along the River Thames, southern England were combined with hourly
chlorophyll concentration (a proxy for phytoplankton biomass), flow, temperature and daily sunlight data
from the mid-Thames. Weekly chlorophyll data was of insufficient temporal resolution to identify the causes
of short term variations in phytoplankton biomass. However, hourly chlorophyll data enabled identification of
thresholds in water temperature (between 9 and 19 °C) and flow (<30 m3 sâ1) that explained the development
of phytoplankton populations. Analysis showed that periods of high phytoplankton biomass and growth rate
only occurred when these flow and temperature conditions were within these thresholds, and coincided with periods
of long sunshine duration, indicating multiple stressor controls. Nutrient concentrations appeared to have
no impact on the timing or magnitude of phytoplankton bloom development, but severe depletion of dissolved
phosphorus and silicon during periods of high phytoplankton biomass may have contributed to some bloom collapses
through nutrient limitation. This study indicates that for nutrient enriched rivers such as the Thames,manipulating residence time (through removing impoundments) and light/temperature (by increasing riparian
tree shading) may offer more realistic solutions than reducing phosphorus concentrations for controlling excessive
phytoplankton biomass
Pathprinting: An integrative approach to understand the functional basis of disease
New strategies to combat complex human disease require systems approaches to biology that integrate experiments from cell lines, primary tissues and model organisms. We have developed Pathprint, a functional approach that compares gene expression profiles in a set of pathways, networks and transcriptionally regulated targets. It can be applied universally to gene expression profiles across species. Integration of large-scale profiling methods and curation of the public repository overcomes platform, species and batch effects to yield a standard measure of functional distance between experiments. We show that pathprints combine mouse and human blood developmental lineage, and can be used to identify new prognostic indicators in acute myeloid leukemia. The code and resources are available at http://âcompbio.âsph.âharvard.âedu/âhidelab/âpathprin
Higher moments of nucleon spin structure functions in heavy baryon chiral perturbation theory and in a resonance model
The third moment of the twist-3 part of the nucleon spin structure
function is generalized to arbitrary momentum transfer and is
evaluated in heavy baryon chiral perturbation theory (HBChPT) up to order
and in a unitary isobar model (MAID). We show how to link
as well as higher moments of the nucleon spin structure functions
and to nucleon spin polarizabilities. We compare our results with the
most recent experimental data, and find a good description of these available
data within the unitary isobar model. We proceed to extract the twist-4 matrix
element which appears in the suppressed term in the twist
expansion of the spin structure function for proton and neutron.Comment: 30 pages, 7 figure
Forecasting Intermittent Demand by Hyperbolic-Exponential Smoothing
Croston's method is generally viewed as superior to exponential smoothing
when demand is intermittent, but it has the drawbacks of bias and an inability
to deal with obsolescence, in which an item's demand ceases altogether. Several
variants have been reported, some of which are unbiased on certain types of
demand, but only one recent variant addresses the problem of obsolescence. We
describe a new hybrid of Croston's method and Bayesian inference called
Hyperbolic-Exponential Smoothing, which is unbiased on non-intermittent and
stochastic intermittent demand, decays hyperbolically when obsolescence occurs
and performs well in experiments.Comment: Earlier versions of this work were presented at the 25th European
Conference on Operations Research, 2012; and at the 54th Annual Conference of
the UK Operational Research Society, 2012. A journal version is in
preparatio
Forward genetic screen of human transposase genomic rearrangements
BACKGROUND: Numerous human genes encode potentially active DNA transposases or recombinases, but our understanding of their functions remains limited due to shortage of methods to profile their activities on endogenous genomic substrates. RESULTS: To enable functional analysis of human transposase-derived genes, we combined forward chemical genetic hypoxanthine-guanine phosphoribosyltransferase 1 (HPRT1) screening with massively parallel paired-end DNA sequencing and structural variant genome assembly and analysis. Here, we report the HPRT1 mutational spectrum induced by the human transposase PGBD5, including PGBD5-specific signal sequences (PSS) that serve as potential genomic rearrangement substrates. CONCLUSIONS: The discovered PSS motifs and high-throughput forward chemical genomic screening approach should prove useful for the elucidation of endogenous genome remodeling activities of PGBD5 and other domesticated human DNA transposases and recombinases
Self-optimization, community stability, and fluctuations in two individual-based models of biological coevolution
We compare and contrast the long-time dynamical properties of two
individual-based models of biological coevolution. Selection occurs via
multispecies, stochastic population dynamics with reproduction probabilities
that depend nonlinearly on the population densities of all species resident in
the community. New species are introduced through mutation. Both models are
amenable to exact linear stability analysis, and we compare the analytic
results with large-scale kinetic Monte Carlo simulations, obtaining the
population size as a function of an average interspecies interaction strength.
Over time, the models self-optimize through mutation and selection to
approximately maximize a community fitness function, subject only to
constraints internal to the particular model. If the interspecies interactions
are randomly distributed on an interval including positive values, the system
evolves toward self-sustaining, mutualistic communities. In contrast, for the
predator-prey case the matrix of interactions is antisymmetric, and a nonzero
population size must be sustained by an external resource. Time series of the
diversity and population size for both models show approximate 1/f noise and
power-law distributions for the lifetimes of communities and species. For the
mutualistic model, these two lifetime distributions have the same exponent,
while their exponents are different for the predator-prey model. The difference
is probably due to greater resilience toward mass extinctions in the food-web
like communities produced by the predator-prey model.Comment: 26 pages, 12 figures. Discussion of early-time dynamics added. J.
Math. Biol., in pres
Strange quark matter in a chiral SU(3) quark mean field model
We apply the chiral SU(3) quark mean field model to investigate strange quark
matter. The stability of strange quark matter with different strangeness
fraction is studied. The interaction between quarks and vector mesons
destabilizes the strange quark matter. If the strength of the vector coupling
is the same as in hadronic matter, strangelets can not be formed. For the case
of beta equilibrium, there is no strange quark matter which can be stable
against hadron emission even without vector meson interactions.Comment: 19 pages, 8 figure
Superfluidity of flexible chains of polar molecules
We study properties of quantum chains in a gas of polar bosonic molecules
confined in a stack of N identical one- and two- dimensional optical lattice
layers, with molecular dipole moments aligned perpendicularly to the layers.
Quantum Monte Carlo simulations of a single chain (formed by a single molecule
on each layer) reveal its quantum roughening transition. The case of finite
in-layer density of molecules is studied within the framework of the J-current
model approximation, and it is found that N-independent molecular superfluid
phase can undergo a quantum phase transition to a rough chain superfluid. A
theorem is proven that no superfluidity of chains with length shorter than N is
possible. The scheme for detecting chain formation is proposed.Comment: Submitted to Proceedings of the QFS2010 satellite conference "Cold
Gases meet Many-Body Theory", Grenoble, August 7, 2010. This is the expanded
version of V.
Kinetic Turbulence
The weak collisionality typical of turbulence in many diffuse astrophysical
plasmas invalidates an MHD description of the turbulent dynamics, motivating
the development of a more comprehensive theory of kinetic turbulence. In
particular, a kinetic approach is essential for the investigation of the
physical mechanisms responsible for the dissipation of astrophysical turbulence
and the resulting heating of the plasma. This chapter reviews the limitations
of MHD turbulence theory and explains how kinetic considerations may be
incorporated to obtain a kinetic theory for astrophysical plasma turbulence.
Key questions about the nature of kinetic turbulence that drive current
research efforts are identified. A comprehensive model of the kinetic turbulent
cascade is presented, with a detailed discussion of each component of the model
and a review of supporting and conflicting theoretical, numerical, and
observational evidence.Comment: 31 pages, 3 figures, 99 references, Chapter 6 in A. Lazarian et al.
(eds.), Magnetic Fields in Diffuse Media, Astrophysics and Space Science
Library 407, Springer-Verlag Berlin Heidelberg (2015
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