Prediction of the preeclampsia: a view of biochemical markers

Preeclampsia is a diverse, multiorgan group of related disease processes that occurs in up to 5%-8% of pregnancies after 20 weeks’ gestation and it is one of the leading causes of maternal and fetal morbidity and mortality. Many molecular mechanisms are contributed to the pathogenesis of preeclampsia. Although it is unknown whether the mechanisms act independently or have synergistic effects. This review describes review of primary papers investigating blood based biomarker such as PAP-A, Inhibin A, sFlt1, and PP13 in general and first trimester biochemical markers and combinations of them specifically for preeclampsia

Technical Aspects and Clinical Limitations of Sperm DNA Fragmentation Testing in Male Infertility: A Global Survey, Current Guidelines, and Expert Recommendations

PURPOSE: Sperm DNA fragmentation (SDF) is a functional sperm abnormality that can impact reproductive potential, for which four assays have been described in the recently published sixth edition of the WHO laboratory manual for the examination and processing of human semen. The purpose of this study was to examine the global practices related to the use of SDF assays and investigate the barriers and limitations that clinicians face in incorporating these tests into their practice. MATERIALS AND METHODS: Clinicians managing male infertility were invited to complete an online survey on practices related to SDF diagnostic and treatment approaches. Their responses related to the technical aspects of SDF testing, current professional society guidelines, and the literature were used to generate expert recommendations via the Delphi method. Finally, challenges related to SDF that the clinicians encounter in their daily practice were captured. RESULTS: The survey was completed by 436 reproductive clinicians. Overall, terminal deoxynucleotidyl transferase deoxyuridine triphosphate Nick-End Labeling (TUNEL) is the most commonly used assay chosen by 28.6%, followed by the sperm chromatin structure assay (24.1%), and the sperm chromatin dispersion (19.1%). The choice of the assay was largely influenced by availability (70% of respondents). A threshold of 30% was the most selected cut-off value for elevated SDF by 33.7% of clinicians. Of respondents, 53.6% recommend SDF testing after 3 to 5 days of abstinence. Although 75.3% believe SDF testing can provide an explanation for many unknown causes of infertility, the main limiting factors selected by respondents are a lack of professional society guideline recommendations (62.7%) and an absence of globally accepted references for SDF interpretation (50.3%). CONCLUSIONS: This study represents the largest global survey on the technical aspects of SDF testing as well as the barriers encountered by clinicians. Unified global recommendations regarding clinician implementation and standard laboratory interpretation of SDF testing are crucial

Technical aspects and clinical limitations of sperm DNA fragmentation testing in male infertility: A global survey, current guidelines, and expert recommendations

Purpose Sperm DNA fragmentation (SDF) is a functional sperm abnormality that can impact reproductive potential, for which four assays have been described in the recently published sixth edition of the WHO laboratory manual for the examination and processing of human semen. The purpose of this study was to examine the global practices related to the use of SDF assays and investigate the barriers and limitations that clinicians face in incorporating these tests into their practice. Materials and Methods Clinicians managing male infertility were invited to complete an online survey on practices related to SDF diagnostic and treatment approaches. Their responses related to the technical aspects of SDF testing, current professional society guidelines, and the literature were used to generate expert recommendations via the Delphi method. Finally, challenges related to SDF that the clinicians encounter in their daily practice were captured. Results The survey was completed by 436 reproductive clinicians. Overall, terminal deoxynucleotidyl transferase deoxyuridine triphosphate Nick-End Labeling (TUNEL) is the most commonly used assay chosen by 28.6%, followed by the sperm chromatin structure assay (24.1%), and the sperm chromatin dispersion (19.1%). The choice of the assay was largely influenced by availability (70% of respondents). A threshold of 30% was the most selected cut-off value for elevated SDF by 33.7% of clinicians. Of respondents, 53.6% recommend SDF testing after 3 to 5 days of abstinence. Although 75.3% believe SDF testing can provide an explanation for many unknown causes of infertility, the main limiting factors selected by respondents are a lack of professional society guideline recommendations (62.7%) and an absence of globally accepted references for SDF interpretation (50.3%). Conclusions This study represents the largest global survey on the technical aspects of SDF testing as well as the barriers encountered by clinicians. Unified global recommendations regarding clinician implementation and standard laboratory interpretation of SDF testing are crucial

Computer-aided simulation using finite element analysis of protect against to coronavirus (COVID-19) of custom-made new mask design

The Covid-19 virus has been recognized by the World Health Organization to be creating Pandemic worldwide. It has been determined that the virus spreads very quickly and has a fatal risk in people with chronic disease. As the virus vaccine and medications to be used for treatment are not fully developed, alternative ways to protect human being from the virus are being investigated. In this study, a custom-made mask design was developed to prevent infection of the virus and computer-aided simulations were performed. Three-dimensional model of the custom-made face mask was created with the SolidWorks software. The analyses were performed using Ansys Workbench Explicit Dynamics module. The load, boundary conditions and material were defined in the Ansys Workbench. As a result of the simulations, it has been determined that custom-made designed masks have a much lower risk of virus infection than conventional masks

Liderin Fiziksel Mesafesi, Sanal Kaytarma ve Sosyal Kontrol ilişkisinde Hiyerarşi Kültürünün Etkisi: Bir Düzenlenmiş Aracılık Modeli

Productivity is the main goal of every organisation. Some deviant behaviors can easily reduce the productivity in organizations. Cyberloafing is the one of the deviant behaviors. In cyberloafing, personnel use computer work non-work purposes. In this research, we focused on preventing of cyberloafing in the specific municipality. To understand preventing, we test moderated mediation model and in our model, hierarchy culture moderates the relationship of mediation model amongst physical distance of leader, social control and cyberloafing. We gather data from 161 bureau personnel in municipality. According to results of mediation analysis, physical distance of leader can reduce cyberloafing behavior but social control act as a supressor variable that increase the cyberloafing behavior. In moderation process, hierarchy culture significantly moderates the relationship between physical distance of leader and social control. The results show that social control mechanism is not effective than physical distance of leader. Also, These social control mechanisms supress the leaders effectiveness and hierachy culture increase the indirect effect of social control.Üretkenlik bütün organizasyonların temel amacıdır. Bazı sapkın davranışlar kolay bir şekilde üretkenliği azaltabilir. Sanal kaytarma da bu sapkın davranışlardan biridir. Sanal kaytarma davranışında, personel bilgisayarı iş amaçları dışında kullanır. Bu araştırma da sanal kaytarmayı belli bir kurumda engelleme üzerine odaklanılacaktır. Engellemeyi anlamak için liderin fiziksel yakınlığı, sosyal kontrol ve sanal kaytarma değişkenleri arasındaki aracılık ilişkisinde hiyerarşi kültürünün düzenleyici etkisi test edilecektir. Belediyedeki 161 büro personelinden veri toplanmıştır. Aracılık testi sonuçlarına göre liderin fiziksel mesafesi sanal kaytarmayı azaltmaktadır ama sosyal kontrol sanal kaytarmayı arttıran bastırıcı değişkenlik yapmaktadır. Düzenleyicilik analizinde ise, hiyerarşi kültürü sosyal kontrol ve sanal kaytarma arasındaki ilişkiyi anlamlı bir şekilde düzenlemektedir. Sonuçlar göstermektedir ki sosyal kontrol mekanizması sanal kaytarmayı engelleme de liderin fiziksel mesafesi kadar etkili değildir. Üstelik, bu sosyal kontrol mekanizmaları liderin etkililiğini bastırmaktadır ve hiyerarşi kültür ü bu dolaylı etkiyi güçlendirmektedir

COVID-19 crisis in the context of conditional dependence theory: The case of hotel management

Today, due to global crisis COVID-19 pandemic, countries have taken various measures to overcome this crisis with the least damage and have had to implement many restrictions that disrupt economic and social life. Pandemics and restrictions have been affected deeply, especially to tourism industry, which almost collapsed. In this context, tourism enterprises have had to implement various crisis management processes in order to ensure their sustainability. The purpose of study to reveal different crisis management processes applied by hotel management within the framework of the contingency theory. Research data was obtained from the interviews with business managers from different corporeate structures and management mechanisms. Using qualitative research methods, the data were subjected to content analysis and findings were obtained. Results shows that external environmental factors, technological adaptation and the effects of crisis themes stand out in menagerial processes. It is intended contributing the literature by examining crisis management in hospitality businesses within the framework of the contingency theory

Effect of Frying, Grilling, and Steaming on Amino Acid Composition of Marine Fishes

Amino acid and proximate compositions were determined in six raw and cooked marine fish species that are commonly consumed in Turkey. The changes in amino acid and proximate content were found to be significant for all cooking methods in all fish species. Cooking did, in general, significantly increase the contents of essential, semiessential, and other amino acids compared with raw fish species. Grilled Atlantic bonito, anchovy, and bluefish and fried mullet and hake appeared to be more valuable fish dishes for obtaining the officially recommended appropriate daily intake of essential amino acids for humans. Moisture, fat, ash, and carbohydrate contents of raw fish ranged between 48.01% and 83.05%, 0.87% and 30.48%, 1.10% and 1.61%, and 0.09% and 8.70%, respectively. All fresh fish investigated were high in protein: 11.20-17.14 g/100 g. Wide variations in protein content (18.11-25.65 g/100 g) between species and methods of cooking were observed. Fried fish had intermediate fat values, whereas grilled and steamed fishes had a comparatively low value