Sistematización de la experiencia productiva de huertas caseras en el asentamiento Álvaro Uribe Vélez de la comuna 10 de la ciudad de Neiva.

Sistematizar la experiencia productiva de huertas caseras de las familias del asentamiento Álvaro Uribe Vélez como prácticas alternativas de soberanía alimentaria.El presente trabajo de sistematización se ubica en el contexto social de una comunidad en la ciudad de Neiva, integrada por personas que han sido afectadas por el conflicto armado colombiano, mediante el cual, se interpreta una experiencia basada en la creación de huertas caseras desde la lógica de la soberanía alimentaria de familias pertenecientes al asentamiento Álvaro Uribe Vélez. De esta manera, se avanzó en la descripción de la experiencia productiva de huertas caseras como alternativa de autoconsumo y generación de ingresos de las familias del asentamiento, desde la reconstrucción de antecedentes, orígenes y la particular evolución en los contextos sociohistóricos de la comunidad. De igual forma, se realizó la identificación de los logros, tensiones, posibilidades y limitaciones en el desarrollo de las huertas caseras, como también en el análisis de las prácticas de desarrollo sostenible de las familias a partir de la experiencia productiva de las huertas caseras desde las propias vivencias de la población a partir de las emociones, costumbres, valores y sentimientos que condicionan su actuar en los escenarios sociales y culturales

Comunidad activa y participativa en el barrio la Gaitana de Villavicencio

La presente investigación orienta la siguiente problemática ¿Cómo se construye una comunidad activa y participativa en el barrio la Gaitana de Villavicencio?, su objetivo es contribuir con el proceso de construcción de comunidad participativa en el barrio la Gaitana, para un mejor desarrollo psicosocial mediante la sensibilización y participación de la misma. Se realiza a través de la metodología de la Investigación Acción Participativa ( IAP) y bajo el enfoque del diseño de Guy Le Botert teniendo en cuenta las siguientes fases:- primera fase: Montaje institucional y metodológico de la investigación participativa;- segunda fase: Estudio preliminar de la zona y la población en estudio;- tercera fase: Análisis crítico de los problemas considerados como prioritarios y que los encuestados quieren estudiar;- Cuarta fase: Programación y ejecución de un plan de acción para contribuir a enfrentar los problemas. Dicha información fue obtenida a través de la observación participante, encuestas, entrevistas, censo poblacional, estrategias educativas y charlas informales, en un lapso de tiempo comprendido entre agosto de 1999 a diciembre de 2000. Para la realización de esta investigación se tuvo en cuenta la población del barrio la Gaitana de Villavicencio, que está constituido por 558 habitantes, la muestra con que se trabajó fue de 83 habitantes que equivale al 15% de la población total, cuyas edades oscilan entre 15 y 74 años y equivale a la edad promedio de 33 años, presentándose que existe apatía de la comunidad en la participación en eventos que conlleven a desarrollar estrategias de cambio social para el bienestar de la comunidad; con la intervención comunitaria se logró como resultado el intercambio de conocimientos y experiencias y clarificar el poder de decisión y el compromiso de la comunidad en la gestión, programación y desarrollo en las gestiones conjuntas; se promovió la participación comunitaria a ir más allá de intereses particulares y a unirse para sustentar los derechos que conciernen a la comunidad como una entidad.Does the present investigation guide the following one problematic How it is built an active community and participativa in the neighborhood the Gaitana of Villavicencio?, their objective is to contribute with the process of construction of community participativa in the neighborhood the Gaitana, for a better development psicosocial by means of the sensitization and participation of the same one. She/he is carried out through the methodology of the Investigación Acción Participativa (IAP) and under the focus of the design of Guy Le Botert keeping in mind the following phases: - first phase: institutional and methodological Assembly of the investigation participativa; - second phase: I Study preliminary of the area and the population in study; - third phase: critical Analysis of the problems considered as high-priority and that those interviewed want to study; - Fourth phase: Programming and execution of an action plan to contribute to face the problems. This information was obtained through the participant observation, surveys, interviews, populational census, educational strategies and informal chats, in a lapse of time understood among August from 1999 to December of 2000. For the realization of this investigation one kept in mind the population of the neighborhood the Gaitana of Villavicencio that is constituted by 558 inhabitants, the sample with which one worked it belonged to 83 inhabitants that it is equal to the total population's 15% whose ages oscillate between 15 and 74 years and it is equal to the age 33 year-old average, being presented that apathy of the community exists in the participation in events that bear to develop strategies of social change for the well-being of the community; with the community intervention it was achieved the exchange of knowledge and experiences as a result and to clarify the power of decision and the commitment of the community in the administration, programming and development in the combined administrations; the community participation was promoted to go beyond interests matters and to unite to sustain the rights that concern to the community like an entity

Sistematización de la experiencia productiva de huertas caseras en el asentamiento Álvaro Uribe Vélez de la comuna 10 de la ciudad de Neiva.

Sistematizar la experiencia productiva de huertas caseras de las familias del asentamiento Álvaro Uribe Vélez como prácticas alternativas de soberanía alimentaria.El presente trabajo de sistematización se ubica en el contexto social de una comunidad en la ciudad de Neiva, integrada por personas que han sido afectadas por el conflicto armado colombiano, mediante el cual, se interpreta una experiencia basada en la creación de huertas caseras desde la lógica de la soberanía alimentaria de familias pertenecientes al asentamiento Álvaro Uribe Vélez. De esta manera, se avanzó en la descripción de la experiencia productiva de huertas caseras como alternativa de autoconsumo y generación de ingresos de las familias del asentamiento, desde la reconstrucción de antecedentes, orígenes y la particular evolución en los contextos sociohistóricos de la comunidad. De igual forma, se realizó la identificación de los logros, tensiones, posibilidades y limitaciones en el desarrollo de las huertas caseras, como también en el análisis de las prácticas de desarrollo sostenible de las familias a partir de la experiencia productiva de las huertas caseras desde las propias vivencias de la población a partir de las emociones, costumbres, valores y sentimientos que condicionan su actuar en los escenarios sociales y culturales

A multicenter case-control study of the effect of e-nos VNTR polymorphism on upper gastrointestinal hemorrhage in NSAID users

[EN]Bleeding in non-steroidal anti-inflammatory drug (NSAID) users limited their prescription. This first multicenter full case-control study (325 cases and 744 controls), explored the association of e-NOS intron 4 variable number tandem repeat (VNTR) polymorphism with upper gastrointestinal hemorrhage (UGIH) in NSAID exposed and unexposed populations and assessed any interaction between this polymorphism and NSAIDs. NSAID users carrying e-NOS intron 4 wild type genotype or VNTR polymorphism have higher odds of UGIH than those unexposed to NSAIDs [Odds Ratio (OR): 6.62 (95% Confidence Interval (CI): 4.24, 10.36) and OR: 5.41 (95% CI 2.62, 11.51), respectively], with no effect modification from VNTR polymorphism-NSAIDs interaction [Relative Excess Risk due to Interaction (RERI): -1.35 (95% CI -5.73, 3.03); Synergism Index (S): 0.77 (95% CI 0.31, 1.94)]. Similar findings were obtained for aspirin exposure. Non-aspirin NSAID users who carry e-NOS intron 4 VNTR polymorphism have lower odds of UGIH [OR: 4.02 (95% CI 1.85, 8.75) than those users with wild type genotype [OR: 6.52 (95% CI 4.09, 10.38)]; though the interaction estimates are not statistically significant [RERI: -2.68 (95% CI -6.67, 1.31); S: 0.53 (95% CI 0.18, 1.55)]. This exploratory study suggests that the odds of UGIH in NSAID or aspirin users does not modify according to patient ' s e-NOS intron 4 genotype.This work was supported by a grant from Instituto de Salud Carlos III [PI12/02414]/Plan Estatal de I + D + I 2012-2016; Fondo Europeo de Desarrollo Regional (FEDER); the Novartis, Pfizer and Dr Esteve pharmaceutical companies; the Health Research Fund/Fondo de Investigacion Sanitaria [PI021512, PI021364, PI020661, PI021572]; Ministry of Health & Consumer Affairs, Spain [SAF2002-04057]; Galician Regional Authority, Spain [PGIDIT03PXIC20806PN]; Department of Health of the Basque Country [03/11092 and 11/111103]; and Fundacion vasca de innovacin e investigacin sanitarias [OSIBG19/002 and OSIBG18/105]. The genotyping service was carried out at CEGEN-PRB3-ISCIII; Instituto de Salud Carlos III and ERDF [PT17/0019, of the PE I + D + I 2013-2016]

Haplotypes in the GC, CYP2R1 and CYP24A1 Genes and Biomarkers of Bone Mineral Metabolism in Older Adults

Candidate gene studies have analyzed the effect of specific vitamin D pathway genes on vitamin D availability; however, it is not clear whether genetic variants also affect overall bone metabolism. This study evaluated the association between genetic polymorphisms in GC, CYP2R1 and CYP24A1 and serum levels of total 25(OH)D, iPTH and other mineral metabolism biomarkers (albumin, total calcium and phosphorus) in a sample of 273 older Spanish adults. We observed a significant difference between CYP2R1 rs10741657 codominant model and total 25(OH)D levels after adjusting them by gender (p = 0.024). In addition, the two SNPs in the GC gene (rs4588 and rs2282679) were identified significantly associated with iPTH and creatinine serum levels. In the case of phosphorus, we observed an association with GC SNPs in dominant model. We found a relationship between haplotype 2 and 25(OH)D levels, haplotype 4 and iPTH serum levels and haplotype 7 and phosphorus levels. In conclusion, genetic variants in CYP2R1 and GC could be predictive of 25(OH)D and iPTH serum levels, respectively, in older Caucasian adults. The current study confirmed the role of iPTH as one of the most sensitive biomarkers of vitamin D activity in vivo

Polymorphisms Involved in Platelet Activation and Inflammatory Response on Aspirin-Related Upper Gastrointestinal Bleeding : A Case-Control Study

Despite the wide benefits of aspirin and its cost-effectiveness, aspirin prescriptions have been reduced due to idiosyncratic responses in susceptible individuals. Low-dose aspirin and single-nucleotide polymorphisms (SNPs) are independently associated with increased risk of gastrointestinal hemorrhage; however, to-date, no studies investigated the SNP-aspirin interaction effect on upper gastrointestinal hemorrhage (UGIH). Therefore, we aimed to evaluate the role of 25 SNPs in multiple genes involved in platelet activation, angiogenesis and inflammatory response in aspirin-related UGIH. A multicenter, full case-control study was conducted in patients exposed and unexposed to aspirin. Three hundred twenty-six cases diagnosed with UGIH were matched with 748 controls (1:3) by age, gender, health center, and recruitment date. Only adults of European origin were included. Participants were stratified by aspirin exposure and genotype [(Aspirin, wild -type), (Aspirin, wild -type), (Aspirin, genetic variation), (Aspirin, genetic variation)]. For each SNP, the Odds Ratio of UGIH and their 95% confidence intervals were estimated in each subgroup by using the generalized linear mixed models for dependent binomial variables. SNP-aspirin interaction effect was estimated through Relative Excess Risk due to Interaction (RERI) measures. We observed two categories of SNPs that might modify the risk magnitude of UGIH in aspirin consumers. Seven SNPs (rs1387180 A > G, rs2238631 T > C, rs1799964 T > C, rs5050 T > C/T > G, rs689466 T > C, rs1799983 T > A/T > G, and rs7756935 C > A) were "positive modifiers" associated with an excess of risk from aspirin exposure and carrying that genetic variation (1.75 ≤ RERI ≤ 4.95). On the contrary, the following nine SNPs (rs2243086 G > T, rs1131882 G > A, rs4311994 C > T, rs10120688 G > A, rs4251961 T > C, rs3778355 G > C, rs1330344 C > T, rs5275 A > G/A > T, and rs3779647 C > T) were "negative modifiers" and associated with a reduced risk in aspirin users (−2.74 ≤ RERI ≤ −0.95). This preliminary study suggests that polymorphisms in genes involved in platelets activity, angiogenesis and inflammatory response might modify the risk of aspirin-related UGIH. Further studies with larger sample size and in different populations are needed to confirm our findings. If confirmed, this might have great impact on public health, thanks to aspirin's prophylactic properties in diseases of high incidence and severit

Synergism interaction between genetic polymorphisms in drug metabolizing enzymes and NSAIDs on upper gastrointestinal haemorrhage : a multicenter case-control study

Interindividual genetic variations contribute to differences in patients' response to drugs as well as to the development of certain disorders. Patients who use non-steroidal anti-inflammatory drugs (NSAIDs) may develop serious gastrointestinal disorders, mainly upper gastrointestinal haemorrhage (UGIH). Studies about the interaction between NSAIDs and genetic variations on the risk of UGIH are scarce. Therefore, we investigated the effect of 16 single nucleotide polymorphisms (SNPs) involved in drug metabolism on the risk of NSAIDs-induced UGIH. We conducted a multicenter case-control study of 326 cases and 748 controls. Participants were sub-grouped into four categories according to NSAID exposure and genetic profile. We estimated odds ratios (ORs) and their 95% confidence intervals (CI) using generalized linear mixed models for dependent binomial variables and then calculated the measures of interaction, synergism index (S), and relative excess risk due to interaction (RERI). We undertook stratified analyses by the type of NSAID (aspirin, non-aspirin). We observed an excess risk of UGIH due to an interaction between any NSAID, non-aspirin NSAIDs or aspirin and carrying certain SNPs. The greatest excess risk was observed for carriers of: rs2180314:C>G [any NSAID: S = 3.30 (95%CI: 1.24-8.80), RERI = 4.39 (95%CI: 0.70-8.07); non-aspirin NSAIDs: S = 3.42 (95%CI: 1.12-10.47), RERI = 3.97 (95%CI: 0.44-7.50)], and rs4809957:A>G [any NSAID: S = 2.11 (95%CI: 0.90-4.97), RERI = 3.46 (95%CI: −0.40-7.31)]. Aspirin use by carriers of rs6664:C>T is also associated with increased risk of UGIH [OR: 2.22 (95%CI: 0.69-7.17) vs. OR: 7.72 (95%CI: 2.75-21.68)], yet larger sample size is needed to confirm this observation. The joint effect of the SNPs s2180314:C>G and rs4809957:A>G and NSAIDs are more than three times higher than the sum of their individual effects. Personalized prescriptions based on genotyping would permit a better weighing of risks and benefits from NSAID consumptio