Agriculture in the Karakum: An archaeobotanical analysis from Togolok 1, southern Turkmenistan (ca. 2300–1700 B.C.)

Southern Central Asia witnessed widespread expansion in urbanism and exchange, between roughly 2200 and 1500 B.C., fostering a new cultural florescence, sometimes referred to as the Greater Khorasan Civilization. Decades of detailed archeological investigation have focused on the development of urban settlements, political systems, and inter-regional exchange within and across the broader region, but little is known about the agricultural systems that supported these cultural changes. In this paper, we present the archaeobotanical results of material recovered from Togolok 1, a proto-urban settlement along the Murghab River alluvial fan located in southeastern Turkmenistan. This macrobotanical assemblage dates to the late 3rd - early 2nd millennia B.C., a time associated with important cultural transformations in southern Central Asia. We demonstrate that people at the site were cultivating and consuming a diverse range of crops including, barley, wheat, legumes, grapes, and possibly plums and apples or pears. This, together with the associated material culture and zooarchaeological evidence, suggest a regionally adapted mixed agropastoral economy. The findings at Togolok 1 contribute to the ongoing discussion of dietary choices, human/landscape interactions, and the adaptation of crops to diverse ecosystems in prehistoric Central Asia

Strength and hypertrophy responses to constant and decreasing rest intervals in trained men using creatine supplementation

<p>Abstract</p> <p>Background</p> <p>The purpose of the current study was to compare strength and hypertrophy responses to resistance training programs that instituted constant rest intervals (CI) and decreasing rest intervals (DI) between sets over the course of eight weeks by trained men who supplemented with creatine monohydrate (CR).</p> <p>Methods</p> <p>Twenty-two recreationally trained men were randomly assigned to a CI group (n = 11; 22.3 ± 1 years; 77.7 ± 5.4 kg; 180 ± 2.2 cm) or a DI group (n = 11; 22 ± 2.5 years; 75.8 ± 4.9 kg; 178.8 ± 3.4 cm). Subjects in both groups supplemented with CR; the only difference between groups was the rest interval instituted between sets; the CI group used 2 minutes rest intervals between sets and exercises for the entire 8-weeks of training, while the DI group started with a 2 minute rest interval the first two weeks; after which the rest interval between sets was decreased 15 seconds per week (i.e. 2 minutes decreasing to 30 seconds between sets). Pre- and post-intervention maximal strength for the free weight back squat and bench press exercises and isokinetic peak torque were assessed for the knee extensors and flexors. Additionally, muscle cross-sectional area (CSA) of the right thigh and upper arm was measured using magnetic resonance imaging.</p> <p>Results</p> <p>Both groups demonstrated significant increases in back squat and bench press maximal strength, knee extensor and flexor isokinetic peak torque, and upper arm and right thigh CSA from pre- to post-training (p ≤ 0.0001); however, there were no significant differences between groups for any of these variables. The total volume for the bench press and back squat were significantly greater for CI group versus the DI group.</p> <p>Conclusions</p> <p>We report that the combination of CR supplementation and resistance training can increase muscular strength, isokinetic peak torque, and muscle CSA, irrespective of the rest interval length between sets. Because the volume of training was greater for the CI group versus the DI group, yet strength gains were similar, the creatine supplementation appeared to bolster adaptations for the DI group, even in the presence of significantly less volume. However, further research is needed with the inclusion of a control group not receiving supplementation combined and resistance training with decreasing rest intervals to further elucidate such hypotheses.</p

Copper binding to the Alzheimer’s disease amyloid precursor protein

Alzheimer’s disease is the fourth biggest killer in developed countries. Amyloid precursor protein (APP) plays a central role in the development of the disease, through the generation of a peptide called Aβ by proteolysis of the precursor protein. APP can function as a metalloprotein and modulate copper transport via its extracellular copper binding domain (CuBD). Copper binding to this domain has been shown to reduce Aβ levels and hence a molecular understanding of the interaction between metal and protein could lead to the development of novel therapeutics to treat the disease. We have recently determined the three-dimensional structures of apo and copper bound forms of CuBD. The structures provide a mechanism by which CuBD could readily transfer copper ions to other proteins. Importantly, the lack of significant conformational changes to CuBD on copper binding suggests a model in which copper binding affects the dimerisation state of APP leading to reduction in Aβ production. We thus predict that disruption of APP dimers may be a novel therapeutic approach to treat Alzheimer’s disease

Image_1_Agriculture in the Karakum: An archaeobotanical analysis from Togolok 1, southern Turkmenistan (ca. 2300–1700 B.C.).pdf

Southern Central Asia witnessed widespread expansion in urbanism and exchange, between roughly 2200 and 1500 B.C., fostering a new cultural florescence, sometimes referred to as the Greater Khorasan Civilization. Decades of detailed archeological investigation have focused on the development of urban settlements, political systems, and inter-regional exchange within and across the broader region, but little is known about the agricultural systems that supported these cultural changes. In this paper, we present the archaeobotanical results of material recovered from Togolok 1, a proto-urban settlement along the Murghab River alluvial fan located in southeastern Turkmenistan. This macrobotanical assemblage dates to the late 3rd - early 2nd millennia B.C., a time associated with important cultural transformations in southern Central Asia. We demonstrate that people at the site were cultivating and consuming a diverse range of crops including, barley, wheat, legumes, grapes, and possibly plums and apples or pears. This, together with the associated material culture and zooarchaeological evidence, suggest a regionally adapted mixed agropastoral economy. The findings at Togolok 1 contribute to the ongoing discussion of dietary choices, human/landscape interactions, and the adaptation of crops to diverse ecosystems in prehistoric Central Asia.</p

Table_1_Agriculture in the Karakum: An archaeobotanical analysis from Togolok 1, southern Turkmenistan (ca. 2300–1700 B.C.).xlsx

Southern Central Asia witnessed widespread expansion in urbanism and exchange, between roughly 2200 and 1500 B.C., fostering a new cultural florescence, sometimes referred to as the Greater Khorasan Civilization. Decades of detailed archeological investigation have focused on the development of urban settlements, political systems, and inter-regional exchange within and across the broader region, but little is known about the agricultural systems that supported these cultural changes. In this paper, we present the archaeobotanical results of material recovered from Togolok 1, a proto-urban settlement along the Murghab River alluvial fan located in southeastern Turkmenistan. This macrobotanical assemblage dates to the late 3rd - early 2nd millennia B.C., a time associated with important cultural transformations in southern Central Asia. We demonstrate that people at the site were cultivating and consuming a diverse range of crops including, barley, wheat, legumes, grapes, and possibly plums and apples or pears. This, together with the associated material culture and zooarchaeological evidence, suggest a regionally adapted mixed agropastoral economy. The findings at Togolok 1 contribute to the ongoing discussion of dietary choices, human/landscape interactions, and the adaptation of crops to diverse ecosystems in prehistoric Central Asia.</p

Table_2_Agriculture in the Karakum: An archaeobotanical analysis from Togolok 1, southern Turkmenistan (ca. 2300–1700 B.C.).xlsx

Southern Central Asia witnessed widespread expansion in urbanism and exchange, between roughly 2200 and 1500 B.C., fostering a new cultural florescence, sometimes referred to as the Greater Khorasan Civilization. Decades of detailed archeological investigation have focused on the development of urban settlements, political systems, and inter-regional exchange within and across the broader region, but little is known about the agricultural systems that supported these cultural changes. In this paper, we present the archaeobotanical results of material recovered from Togolok 1, a proto-urban settlement along the Murghab River alluvial fan located in southeastern Turkmenistan. This macrobotanical assemblage dates to the late 3rd - early 2nd millennia B.C., a time associated with important cultural transformations in southern Central Asia. We demonstrate that people at the site were cultivating and consuming a diverse range of crops including, barley, wheat, legumes, grapes, and possibly plums and apples or pears. This, together with the associated material culture and zooarchaeological evidence, suggest a regionally adapted mixed agropastoral economy. The findings at Togolok 1 contribute to the ongoing discussion of dietary choices, human/landscape interactions, and the adaptation of crops to diverse ecosystems in prehistoric Central Asia.</p