Reprodutibilidade de três classificações de fraturas na região proximal do úmero

OBJECTIVE: To propose a new system for classifying proximal humeral neck fractures, and to evaluate intra- and interobserver agreement using the Neer system that is the most commonly used in the area and the Arbeit Gemeinschaft für Osteosynthesefragen system created by an European group, and a new classification system proposed by the authors of this study. METHODS: A total of 56 patients with proximal humeral fractures were selected, and submitted to digitized simple radiography in antero-posterior shoulder and scapular profile. Radiographs were analyzed by three observers at time one, and then three and six weeks later. The kappa coefficient modified by Fleiss was used for the analysis. RESULTS: The mean intra-observer Kappa agreement index (k=0.687) of the new classification, was higher than both the Neer classification (k=0.362) and the Arbeit Gemeinschaft für Osteosynthesefragen (k=0.46). The mean interobserver Kappa agreement index (0.446) of the new classification, also had better results than both the Neer classification (k=0.063) and the Arbeit Gemeinschaft für Osteosynthesefragen (k=0.028). CONCLUSION: the new classification considering bone compression had higher results for intra- and interobserver compared to the Neer system, and the Arbeit Gemeinschaft für Osteosynthesefragen system.OBJETIVO: Propor um novo sistema para classificação das fraturas que envolvem o colo do úmero e avaliar a concordância intra e interobservador do sistema de classificação de Neer (a mais utilizada em nosso meio), do sistema proposto pelo grupo europeu Arbeit Gemeinschaft für Osteosynthesefragen e de um novo sistema de classificação proposto pelos autores. MÉTODOS: Foram selecionados 56 pacientes com fraturas da região proximal do úmero, com radiografias simples digitalizadas nas incidências anteroposterior do ombro e perfil da escápula. Quatro observadores avaliaram as imagens radiográficas em três momentos diferentes, com intervalos de 3 semanas. Os dados foram analisados segundo o coeficiente de concordância kappa, modificado por Fleiss. RESULTADOS: O índice de concordância kappa intraobservador médio da nova classificação (k=0,687) foi superior ao da classificação de Neer (k=0,362) e da Arbeit Gemeinschaft für Osteosynthesefragen (k=0,46). O índice de concordância kappa interobservador da nova classificação (k=0,446) também apresentou um valor médio maior que o da classificação de Neer (k=0,063) e da Arbeit Gemeinschaft für Osteosynthesefragen (k=0,028). CONCLUSÃO: A nova classificação, que considera o conceito de compressão óssea, apresentou melhores resultados inter e intraobservador, em relação às classificações de Neer e Arbeit Gemeinschaft für Osteosynthesefragen.Hospital Israelita Albert EinsteinUniversidade Federal de São Paulo (UNIFESP)UNIFESPSciEL

A prática ginástica e o esporte: a cultura física e o corpo belo na história das mulheres. Argentina 1900-1930

Este artículo reflexiona sobre la relación entre cultura física y cuerpo femenino durante las primeras décadas del siglo XX en Argentina. El objetivo es mostrar cómo se cruzan diferentes sensibilidades femeninas a favor del cuerpo bello, a través de las prácticas de gimnasia y deporte. Para ello, se indagan las representaciones que los textos y la iconografía construyeron en la prensa ilustrada sobre la experiencia del ejercicio femenino. Se concluye que la relación propuesta resulta un lugar complejo de construcciones simbólicas en el que se cruzan visiones médico-científicas, hábitos y comportamientos, ritos de moralidad y virtud, cánones estéticos y de moda, imaginarios y representaciones sociales alrededor de la mujer.This article reflects on the relationship between physical culture and the female body during the first decades of the 20th century in Argentina. The objective is to show how different feminine sensitivities intersect in favor of the beautiful body, through the practices of gymnastics and sports. For this purpose, it explores the representations constructed through texts and iconography in the illustrated press regarding the experience of exercise among women. It concludes that the proposed relationship turns out to be a complex site of symbolic constructions in which medical-scientific visions intersect with habits and behaviors, rites of morality and virtue, aesthetic canons, imaginaries and social representations revolving around women.Este artigo reflete sobre a relação entre cultura física e corpo feminino durante as primeiras décadas do século XX na Argentina. O objetivo é mostrar como se cruzam diferentes sensibilidades femininas a favor do corpo belo por meio das práticas de ginástica e de esporte. Para isso, indaga-se a respeito das representações que os textos e a iconografia construíram na imprensa ilustrada sobre a experiência do exercício feminino. Conclui-se que a relação proposta resulta um lugar complexo de construções simbólicas no qual se fusionam visões médico-científicas, hábitos e comportamentos, ritos de moralidade e virtude, cânones estéticos e de moda, imaginários e representações sociais ao redor da mulher.Fil: Kaczan, Gisela Paola. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Mar del Plata. Facultad de Arquitectura, Urbanismo y Diseño. Instituto de Estudios de Historia, Patrimonio y Cultura Material; Argentin

Common variants in Alzheimer’s disease and risk stratification by polygenic risk scores

Funder: Funder: Fundación bancaria ‘La Caixa’ Number: LCF/PR/PR16/51110003 Funder: Grifols SA Number: LCF/PR/PR16/51110003 Funder: European Union/EFPIA Innovative Medicines Initiative Joint Number: 115975 Funder: JPco-fuND FP-829-029 Number: 733051061Genetic discoveries of Alzheimer's disease are the drivers of our understanding, and together with polygenetic risk stratification can contribute towards planning of feasible and efficient preventive and curative clinical trials. We first perform a large genetic association study by merging all available case-control datasets and by-proxy study results (discovery n = 409,435 and validation size n = 58,190). Here, we add six variants associated with Alzheimer's disease risk (near APP, CHRNE, PRKD3/NDUFAF7, PLCG2 and two exonic variants in the SHARPIN gene). Assessment of the polygenic risk score and stratifying by APOE reveal a 4 to 5.5 years difference in median age at onset of Alzheimer's disease patients in APOE ɛ4 carriers. Because of this study, the underlying mechanisms of APP can be studied to refine the amyloid cascade and the polygenic risk score provides a tool to select individuals at high risk of Alzheimer's disease

Multiancestry analysis of the HLA locus in Alzheimer’s and Parkinson’s diseases uncovers a shared adaptive immune response mediated by HLA-DRB1*04 subtypes

Across multiancestry groups, we analyzed Human Leukocyte Antigen (HLA) associations in over 176,000 individuals with Parkinson’s disease (PD) and Alzheimer’s disease (AD) versus controls. We demonstrate that the two diseases share the same protective association at the HLA locus. HLA-specific fine-mapping showed that hierarchical protective effects of HLA-DRB1*04 subtypes best accounted for the association, strongest with HLA-DRB1*04:04 and HLA-DRB1*04:07, and intermediary with HLA-DRB1*04:01 and HLA-DRB1*04:03. The same signal was associated with decreased neurofibrillary tangles in postmortem brains and was associated with reduced tau levels in cerebrospinal fluid and to a lower extent with increased Aβ42. Protective HLA-DRB1*04 subtypes strongly bound the aggregation-prone tau PHF6 sequence, however only when acetylated at a lysine (K311), a common posttranslational modification central to tau aggregation. An HLA-DRB1*04-mediated adaptive immune response decreases PD and AD risks, potentially by acting against tau, offering the possibility of therapeutic avenues

El proceso de capitalización de campesinos argentinos

Archetti Eduardo P. El proceso de capitalización de campesinos argentinos. In: Cahiers du monde hispanique et luso-brésilien, n°28, 1977. La terre et les paysans en Amérique latine. pp. 123-140

Ideología y organización de las ligas agrarias del norte de Santa Fe, 1971-1976

El movimiento de las Ligas Agrarias en el Noroeste argentino se consolidó a partir de 1970. Este trabajo analiza la organización social de las Ligas Agrarias del norte de Santa Fe y, de un modo más específico, la colonia Santa Cecilia, donde el autor realizó un trabajo de campo durante 1973 y 1974Área de Economí

Nationalisme, football et polo : tradition et créolisation dans la construction de l'Argentine moderne

Traduit de l'anglais par Christian Ghasarian En décembre 1993, Paul McCartney se rendit pour la première fois de sa vie à Buenos Aires, afin d'y donner un grand concert. Les journalistes lui adressèrent les questions traditionnellement posées aux célébrités de passage : « Que savez-vous de l'Argentine ? »« A quoi l'Argentine vous fait-elle penser ? »Paul McCartney leur répondit sans trop d'hésitations : « Au football, à la Coupe du monde, pour être honnête, aux Malouines, aux chevaux, au pol..