6 research outputs found
Genetic mechanisms of critical illness in COVID-19.
- Author
- A A Roger Thompson
- A Abraheem
- A Agasou
- A Ahmed
- A Ali
- A Allan
- A Altabaibeh
- A Alvaro
- A Aspinwall
- A Ayers
- A Bamford
- A Barron
- A Bashyal
- A Bellini
- A Bociek
- A Botello
- A Bowes
- A Brady
- A Brayne
- A Brown
- A Brown
- A Butler
- A Campbell
- A Carter
- A Collins
- A Cowley
- A Cowton
- A Cowton
- A Cox
- A Crew
- A Dance
- A Daniel
- A Daniels
- A Dela Rosa
- A Drummond
- A Durie
- A E Heron
- A Easthope
- A Easthope
- A Evans
- A Fofano
- A Gales
- A Ganesan
- A Gardner
- A Garg
- A Gherman
- A Gordon
- A Gratrix
- A Gulati
- A Gupta
- A Haigh
- A Haldeos
- A Harrison
- A Harvey
- A Hayes
- A Higham
- A Higham
- A Hilldrith
- A Holden
- A Hormis
- A Hutcheon
- A Javaid
- A Joseph
- A Kaliappan
- A Katary
- A Kay
- A Kayani
- A Kent
- A Kirkby
- A Knight
- A Kubisz-Pudelko
- A Kuravi
- A Lewis
- A Loveridge
- A Lyle
- A Mayer
- A McAlpine
- A McCarthy
- A McGregor
- A McGregor
- A Meikle
- A Mitchell
- A Mitra
- A Morris
- A Morrison
- A Naranjo
- A Nicholson
- A Nicholson
- A Nilsson
- A Noakes
- A Patel
- A Pickard
- A Poole
- A Price
- A Puxty
- A Quinn
- A Quinn
- A Raithatha
- A Rattray
- A Reddy
- A Reed
- A Reyes
- A Rose
- A Rose
- A Rostron
- A Roy
- A Roynon-Reed
- A S Raj
- A Salberg
- A Sanderson
- A Serrano-Ruiz
- A Solesbury
- A Sukha
- A Swain
- A Tariq
- A Thomas
- A Thomas
- A Todd
- A Tomas
- A Tridente
- A Tucci
- A Turnbull
- A Uriel
- A Ustianowski
- A Vochin
- A Vuylsteke
- A Waite
- A Walden
- A Whileman
- A Wilkinson
- A Williams
- A Williams
- A Wilson
- A Zak
- A Zaki
- Achille Iolascon
- Adam Auton
- Adam Brown
- Agnese Verzuri
- Agostino Ognibene
- Agostino Riva
- Ailsa Golightly
- Alan Maclean
- Alessandra
- Alessandra Stella
- Alessandra Vergori
- Alessia Giorli
- Alexander J Mentzer
- Alice Donati
- Alison M Meynert
- Alistair Nichol
- Ana da Silva Filipe
- Andrea Antinori
- Andrea Cossarizza
- Andrea Ganna
- Andrea Tommasi
- Andrew Rambaut
- Andrew Stenhouse
- Andy Law
- Anjali J Shastri
- Anna Canaccini
- Anna Maria Pinto
- Annarita Giliberti
- Annemarie B Docherty
- Antonella D'Arminio Monforte
- Antonia Ying Wai Ho
- Antonio Di Biagio
- Antony Symons
- Arianna Emiliozzi
- Arianna Gabrieli
- Audrey Coutts
- B Anwar
- B Attwood
- B Baines
- B Blackledge
- B Borislavova
- B Chandler
- B Charles
- B Creagh-Brown
- B David
- B Deacon
- B Deacon
- B Digby
- B Faulkner
- B Fuller
- B Gumbrill
- B Gurung
- B Hadebe
- B Hairsine
- B Hopkins
- B Johnston
- B Lenagh
- B Masunda
- B Ogg
- B Patel
- B Player
- B Purewal
- B Scholefield
- B Shelley
- B Sloan
- B Thomas
- B Wadams
- B Welsh
- B Wilkinson
- B Winter-Goodwin
- B Yates
- Baillie J Kenneth
- Barbara Rossetti
- Beale Rupert
- Beatrice Alex
- Benjamin Bach
- Bretherick Andrew D
- Bruno Frediani
- C Adams
- C Ahmed
- C Almaden-Boyle
- C Ashbrook-Raby
- C Basikolo
- C Battle
- C Beazley
- C Beith
- C Borra
- C Brandwood
- C Brantwood
- C Burnett
- C Castro Delgado
- C Clark
- C Clulow
- C Collins
- C Cruz
- C Davis
- C Demetriou
- C Dennis
- C Dexter
- C Downes
- C Dunmore
- C Eastgate
- C Eckbad
- C Finch
- C Gibson
- C Gorman
- C Hays
- C Hewitt
- C Holl
- C Howcroft
- C Humphrey
- C Jackson
- C Jardine
- C Jennings
- C Jones
- C Kaye
- C Lynch
- C Lyons
- C McCulloch
- C McParland
- C McParland
- C Murphy
- C Parmar
- C Pawley
- C Phillips
- C Phillips
- C Pothecary
- C Pothecary
- C Prendergast
- C Price
- C Rishton
- C Sell
- C Shovelton
- C Sicat
- C Stuart
- C Summers
- C Swan
- C Thompson
- C Thorpe
- C Tibke
- C Tierney
- C Vigurs
- C Wells
- C Whitton
- C Whyte
- C Wrey Brown
- Cameron J Fairfield
- Carmelo Piscopo
- Carmen Marciano
- Caroline Abernathy
- Carrol Gamble
- Caterina Lo Rizzo
- Catherine A Shaw
- Catherine H Weldon
- Caulfield Mark
- Ceilia Boz
- Cesira Nencioni
- Chelsea Ye
- Chiara Fallerini
- Chiara Gabbi
- Chiara Spertilli
- Chloe Donohue
- Chris Ponting
- Christoper A Green
- Cinthia E Jannes
- Clare Jackson
- Clohisey Sara
- Cristina Mussini
- D Antcliffe
- D Bakthavatsalam
- D Banach
- D Baptista
- D Bell
- D Branney
- D Brealey
- D Brealey
- D Butcher
- D Butcher
- D Childs
- D Clarke
- D Collier
- D Collier
- D Cristiano
- D Dawson
- D Donaldson
- D Duffin
- D Fottrell-Gould
- D Golden
- D Griffin
- D Hamilton
- D Hawcutt
- D Hope
- D Horner
- D Kallon
- D Kaye
- D Kelly
- D Loader
- D Lomas
- D Martin
- D McGlynn
- D McLaughlanv
- D Melia
- D Menzies
- D Mullan
- D Pogson
- D Potla
- D Potoczna
- D Purohit
- D Raynard
- D Salutous
- D Salutous
- D Scaletta
- D Shaw
- D Skinner
- D Smyth
- D Strachan
- D Tetla
- D Thornton
- D Trodd
- D Vedage
- D Walker
- D Warren
- D Williams
- D Wood
- D Wright
- Daniela Francisci
- Daniella Coker
- Danilo Tacconi
- David A van Heel
- David Bennet
- David L Robertson
- David Stuart
- Dawn Law
- Debby Bogaert
- Derek Murphy
- Domenico A Coviello
- E Abaleke
- E Allan
- E Anastasescu
- E Andrews
- E Apetri
- E B Jude
- E Beech
- E Beranova
- E Bevan
- E Black
- E Brinkworth
- E Collins
- E Combes
- E Davies
- E Dobson
- E Dooks
- E Fisher
- E Gendall
- E Goff
- E Goodwin
- E Gordon
- E Heeney
- E Horsley
- E Hughes
- E Johnson
- E Knights
- E Lee
- E London
- E Maccacari
- E Massey
- E McKenna
- E Meadows
- E Moncur
- E Morino
- E Mwaura
- E Peasgood
- E Perkins
- E Radford
- E Raith
- E Raith
- E Salciute
- E Smith
- E Smithson
- E Stoddard
- E Stones
- E Thomas
- E Tilney
- E Timlick
- E Treus Gude
- E Virgilio
- E Watson
- E Wilby
- Edoardo Conticini
- Egle Saviciute
- Elena Bargagli
- Elena Desanctis
- Elisa Benetti
- Elisa Frullanti
- Elisabetta Menatti
- Elisabetta Schiaroli
- Ellie Mcmaster
- Emma C Thomson
- Emmanuelle Marques
- Enrico Martinelli
- Esther Duncan
- Esther Merlini
- Ewen M Harrison
- F Anderson
- F Auld
- F Bibi
- F Davies
- F Farquhar
- F Fisher
- F Hurford
- F Kibutu
- F McNeela
- F Moore
- F Nasir
- F Trim
- F Wakinshaw
- F Williams
- Fabio Lena
- Fawkes Angie
- Federico Anedda
- Federico Franchi
- Ferdinando Giannattasio
- Filip Taneski
- Filippo Aucella
- Filippo Biscarini
- Floriana Valentino
- Fourman Max Head
- Francesca Andretta
- Francesca Fava
- Francesca Gatti
- Francesca Mari
- Francesca Montagnani
- Francesco Castelli
- Francesco Raimondi
- Furniss James
- G Andrew
- G Arbane
- G Bell
- G Bercades
- G Croston
- G Debreceni
- G Durrant
- G Hambrook
- G Hobden
- G Houston
- G Hughes
- G Jones
- G Lubimbi
- G Maloney
- G Martir
- G Millen
- G Mills
- G O'Connor
- G Padden
- G Randell
- G Sadera
- G Seddon
- G Sera Howe
- G Sloane
- G Subramanian
- G Tsinaslanidis
- G Turner
- G Watson
- G Wray
- Gabriella Coiro
- Gabriella Doddato
- Gail Carson
- Gardar Sveinbjornsson
- Gary Leeming
- Genni Spargi
- Georgios Pollakis
- Giacomo Zanelli
- Gian Piero Caldarelli
- Giancarlo Bosio
- Giuseppe Fiorentino
- Giuseppe Merla
- Gountouna Elvina
- Graham S Cooke
- Griffiths Fiona
- Grimes Graeme
- H Bancroft
- H Bates
- H Belfield
- H Blackman
- H Blakemore
- H Brooke
- H Button
- H Coles
- H Curgenven
- H Filipe
- H Fox
- H Golding
- H Hill
- H Holcombe
- H Houlden
- H Jeffrey
- H Kent
- H Langton
- H McGuinness
- H Meghari
- H Millward
- H Moore
- H Parker
- H Pearson
- H Prady
- H Quinn
- H Rangarajan
- H Rehman
- H Reschreiter
- H Riley
- H Sainsbury
- H Savill
- H Sturgeon
- H T-Michael
- H Tench
- H Tiveran
- H Turner
- H Whittle
- H Willis
- H Wood
- Haley Chris
- Hanning Mal
- Harrison David
- Hayley Hardwick
- Hayward Caroline
- Helen Szoor-McElhinney
- Hinds Charles
- Ho Antonia
- Horby Peter
- I Ali Mohamed Ali
- I Balagosa
- I Birkinshaw
- I Burn
- I Chadbourn
- I D Clement
- I Edmond
- I Frost
- I Hass
- I Hussain
- I Lancoma-Malcolm
- I Leadbitter
- I Nagra
- I Otahal
- I Otahal
- I Turner-Bone
- I Welters
- I White
- I Wynter
- Ilaria Meloni
- Immacolata Andolfo
- Isabella Zanella
- J Allan
- J Barker
- J Bewley
- J Biddle
- J Birch
- J Birch
- J Bradley-Potts
- J Brown
- J Bryant
- J Butler
- J Camsooksai
- J Carter
- J Caterson
- J Cebrian Suarez
- J Cockerill-Taylor
- J Cole
- J Colley
- J Cooper
- J Cupitt
- J Cuttler
- J Daglish
- J Dasgin
- J Dawson
- J Dearden
- J Deery
- J Donnachie
- J Dykes
- J Easton
- J Egan
- J Fernandez Roman
- J Finn
- J Fletcher
- J Frankham
- J Gaylard
- J Gill
- J Godden
- J Goodsell
- J Gregory
- J Greig
- J Gurasashvili
- J Hardy
- J Harris
- J Hatton
- J Hawes
- J Highgate
- J Hornsby
- J Hulme
- J Hunt
- J Hutter
- J Ingham
- J Jones
- J Jones
- J K Baillie
- J Kassam
- J Kenneth Baillie
- J Kenneth Baillie
- J Keshet-Price
- J Liew
- J Little
- J Mallinson
- J Martin
- J Matthews
- J McCormick
- J Medhora
- J Melville
- J Moreno Cuesta
- J Morgan
- J Naisbitt
- J Norris
- J North
- J Parkin
- J Pendlebury
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- J Perry
- J Pheby
- J Philbin
- J Pinnell
- J Queiroz
- J Radhakrishnan
- J Reid
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- J Scriven
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- J Tebbutt
- J Texeira
- J Thomas
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- J Tomlinson
- J Valentine
- J Whiteside
- J Wilkins
- J Willson
- J Zamikula
- Jake Dunning
- Jane Weaver
- Janet Harrison
- Janet T Scott
- Janie F Shelton
- Jen Meikle
- Jo Dalton
- Johnny Millar
- Jorge Esparza-Gordillo
- Jose E Krieger
- Julian A Hiscox
- K Archer
- K Austin
- K Baines
- K Bauchmuller
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- K Connolly
- K Convery
- K Criste
- K Dale
- K Darlington
- K Davies
- K Dent
- K Douglas
- K Duffy
- K Elliott
- K Elston
- K English
- K Fernandes
- K Fletcher
- K Gilbert
- K Golder
- K Hammerton
- K Hanson
- K Hanson
- K Hard
- K Harrington
- K Hayes
- K Holding
- K Holdroyd
- K Howard
- K Hugill
- K Inweregbu
- K Jackson-Lawrence
- K Karthik
- K King
- K Knowles
- K Lang
- K Liyanage
- K Manso
- K Netherton
- K Postlethwaite
- K Potts
- K Prager
- K Praman
- K Priestley
- K Pritchard
- K Puxty
- K Reid
- K Riches
- K Rooney
- K Sellick
- K Shuker
- K Simpson
- K Simpson
- K Slevin
- K Smith
- K Sollesta
- K Stammers
- K Stroud
- K Sweet
- K Tatham
- K Turner
- K Webster
- K White
- K Williams
- K Xavier
- Katarzyna Hafezi
- Keating Sean
- Kenneth A Mclean
- Kirstie Morrice
- Klaric Lucija
- Klenerman Paul
- Knight Julian
- Kousathanas Athanasios
- L Abel
- L Akeroyd
- L Allen
- L Armstrong
- L Barclay
- L Benham
- L Botfield
- L Bough
- L Brimfield
- L Bunni
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- L Folkes
- L Foster
- L Garner
- L Gemmell
- L George
- L Glass
- L Glass
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- L Grauslyte
- L Grimmer
- L Gurr
- L Harrison
- L Hodgson
- L Hudig
- L Keating
- L Kittridge
- L Lankester
- L Lennon
- L Lim
- L Ma
- L Marshall
- L Matupe
- L McMorrow
- L McQuillan
- L Mew
- L Mostoles
- L Mwaura
- L Newey
- L O'Brien
- L O'Malley
- L O'Neill
- L Ortiz-Ruiz de Gordoa
- L Ortiz-Ruiz de Gordoa
- L Park
- L Pippard
- L Prentice
- L Rad
- L Ramos
- L Riddles
- L Roche
- L Roche
- L Rooney
- L Rosaroso
- L Shaw
- L Smith
- L Stevenson
- L Symon
- L Thomis
- L Thornton
- L Thrasyvoulou
- L Ting
- L Tonks
- L Turner
- L van Koutrik
- L Wilcox
- L Wild
- L Wilding
- L Woods
- L Wren
- L Zitter
- Lance C W Turtle
- Laura Bergantini
- Laura Di Sarno
- Laura Marsh
- Laura Merson
- Law Andrew
- Leonardo Croci
- Lia Crotti
- Ling Lowell
- Lisa Norman
- Lorenzo Salerni
- Lorna Donnelly
- Louise Cullum
- Louise Macgillivray
- Louise Sigfrid
- Luca Cantarini
- Luca Guidelli
- Luca Masucci
- Luisa Tavecchia
- M Abdelrazik
- M Al-Moasseb
- M Balasubramaniam
- M Bates
- M Bellamy
- M Birt
- M Blunt
- M Bokhari
- M Bolton
- M Brady
- M Breekes
- M Brett
- M Bromley
- M Bruce
- M Brunton
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- M Callaghan
- M Carmody
- M Carnahan
- M Casey
- M Caswell
- M Chablani
- M Clapham
- M Clark
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- M Coulding
- M Croft
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- M Davey
- M Davies
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- M Elsaadany
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- M Frise
- M Gellamucho
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- M MacMahon
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- Maaike Swets
- Mahdad Noursadeghi
- Manu Shankar-Hari
- Marco Castori
- Marco Feri
- Marco Gori
- Marco Mandalà
- Marco Sita
- Margherita Baldassarri
- Mari E K Niemi
- Mari Ward
- Maria Antonietta Mazzei
- Maria Antonietta Mencarelli
- Maria Bandini
- Maria Eugenia Quiros-Roldan
- Maria Palmieri
- Maria Zambon
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- Mario Capasso
- Mario U Mondelli
- Marta Corridi
- Maslove David
- Massimiliano Fabbiani
- Massimo Carella
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- Matteo Bassetti
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- Meera Chand
- Meynert Alison
- Michelle Girvan
- Millar Jonathan
- Mirella Bruttini
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- S Gopal
- S Greer
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- Turtle Lance
- U Poultney
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- Wei Shen Lim
- Wendy S Barclay
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- Z Prime
- Z Scott
- Zechner Marie
- Zhai Ranran
- Zheng Chenqing
- Publication venue
- Nature
- Publication date
- 01/01/2020
- Field of study
Host-mediated lung inflammation is present1, and drives mortality2, in the critical illness caused by coronavirus disease 2019 (COVID-19). Host genetic variants associated with critical illness may identify mechanistic targets for therapeutic development3. Here we report the results of the GenOMICC (Genetics Of Mortality In Critical Care) genome-wide association study in 2,244 critically ill patients with COVID-19 from 208 UK intensive care units. We have identified and replicated the following new genome-wide significant associations: on chromosome 12q24.13 (rs10735079, P = 1.65 × 10-8) in a gene cluster that encodes antiviral restriction enzyme activators (OAS1, OAS2 and OAS3); on chromosome 19p13.2 (rs74956615, P = 2.3 × 10-8) near the gene that encodes tyrosine kinase 2 (TYK2); on chromosome 19p13.3 (rs2109069, P = 3.98 × 10-12) within the gene that encodes dipeptidyl peptidase 9 (DPP9); and on chromosome 21q22.1 (rs2236757, P = 4.99 × 10-8) in the interferon receptor gene IFNAR2. We identified potential targets for repurposing of licensed medications: using Mendelian randomization, we found evidence that low expression of IFNAR2, or high expression of TYK2, are associated with life-threatening disease; and transcriptome-wide association in lung tissue revealed that high expression of the monocyte-macrophage chemotactic receptor CCR2 is associated with severe COVID-19. Our results identify robust genetic signals relating to key host antiviral defence mechanisms and mediators of inflammatory organ damage in COVID-19. Both mechanisms may be amenable to targeted treatment with existing drugs. However, large-scale randomized clinical trials will be essential before any change to clinical practice
Learning arithmetic blocks: a concrete model for teaching decimals
- Author
- Publication venue
- Department of Science and Mathemtics Education
- Publication date
- 01/01/2006
- Field of study
Copyright confirmation in progress. Any queries to [email protected] booklet is an introduction to using the LAB model with your students. It outlines a number of activities using LAB to assist students in gaining an understanding of the decimal number system
Lesson ideas and activities for teaching decimals
- Author
- Publication venue
- Department of Science and Mathematics Education
- Publication date
- 01/01/2006
- Field of study
Copyright confirmation in progress. Any queries to [email protected] information regarding the book is available at http://staff.edfac.unimelb.edu.au/~kayecs/projects/decprojlink.htmThe Department of Science and Mathematics Education has produced this booklet to assist teachers with students learning to work confidently with decimal numbers. It contains many classroom activities that will motivate and engage students making the teaching and learning of decimals both enjoyable and effective
Volume changes in Alzheimer's disease and mild cognitive impairment: cognitive associations.
- Author
- Abdel Douiri
- BH Ridha
- C Frost
- Casper Nielsen
- CP Ferri
- CR Jack Jr
- CR Jack Jr
- CR Jack Jr
- CR Jack Jr
- D Chan
- D Mungas
- D Rueckert
- D Wang
- EB Lewis
- G McKhann
- H Braak
- HA Archer
- J Jovicich
- JA Kaye
- JC Mazziotta
- JD Sluimer
- JG Sled
- JM Schott
- Josephine Barnes
- JT O’Brien
- Kelvin K. Leung
- LC Silbert
- Lois G. Kim
- Matthew C. Evans
- Melanie Blair
- MF Folstein
- NC Fox
- NC Fox
- NC Fox
- NC Fox
- Nick C. Fox
- PA Freeborough
- PA Freeborough
- PA Narayana
- PS Aisen
- RC Petersen
- RI Scahill
- RI Scahill
- Richard G. Boyes
- RM Reitan
- RP Woods
- S Lehericy
- Sebastien Ourselin
- Shona L. Clegg
- SM Nestor
- WG Rosen
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2010
- Field of study
OBJECTIVE: To assess the relationship between MRI-derived changes in whole-brain and ventricular volume with change in cognitive scores in Alzheimer's disease (AD), mild cognitive impairment (MCI) and control subjects. MATERIAL AND METHODS: In total 131 control, 231 MCI and 99 AD subjects from the Alzheimer's Disease Neuroimaging Initiative (ADNI) cohort with T1-weighted volumetric MRIs from baseline and 12-month follow-up were used to derive volume changes. Mini mental state examination (MMSE), Alzheimer's disease assessment scale (ADAS)-cog and trails test changes were calculated over the same period. RESULTS: Brain atrophy rates and ventricular enlargement differed between subject groups (p < 0.0005) and in MCI and AD were associated with MMSE changes. Both measures were additionally associated with ADAS-cog and trails-B in MCI patients, and ventricular expansion was associated with ADAS-cog in AD patients. Brain atrophy (p < 0.0005) and ventricular expansion rates (p = 0.001) were higher in MCI subjects who progressed to AD within 12 months of follow-up compared with MCI subjects who remained stable. MCI subjects who progressed to AD within 12 months had similar atrophy rates to AD subjects. CONCLUSION: Whole-brain atrophy rates and ventricular enlargement differed between patient groups and healthy controls, and tracked disease progression and psychological decline, demonstrating their relevance as biomarkers
Students' participation in collaborative research should be recognised
- Author
- Aashay Vaidya
- Abbas Palkhi
- Abdul Badran
- Abdulmajid Ali
- Abdurrahman Islim
- Abhi Sharma
- Abhishek Chitnis
- Abiola Adeogun
- Abraham Francis
- Ace Mcdermott
- Adam Gwozdz
- Adam Williams
- Adeeb Naasan
- Aditya Borakati
- Aditya Kale
- Adnan Ali
- Adreana Zulkifli
- Ahmad Chaudhry
- Ahmed Daoub
- Ahmed Hassane
- Ahmed Kerwan
- Ahmed Soualhi
- Aidan Mellan
- Ailin Rogers
- Aishah Azri Yahaya
- Ajay Mohite
- Ajit Kishore
- Akashdeep Dhillon
- Alec Engledow
- Alejandro Marcos Rodrigo
- Alethea Tang
- Alex Boddy
- Alex Fowler
- Alex Rogers
- Alex von Roon
- Alex Ward
- Alex Wilkins
- Alexa Lazarou
- Alexander Baldwin
- Alexander Light
- Alexander Mehta
- Alexander Smith
- Alexandra Thatcher
- Alexandra Urquhart
- Alexandros Charalabopoulos
- Ali Ghaffar
- Alia Al-Mousawi
- Alice Castle
- Alice Mortimer
- Alice Ormrod
- Alisha Burman
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- Amanda Gilbert
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- Amogh Patil
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- Anand Alagappan
- Anand Radhakrishnan
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- Andrea Gonzalez-Ciscar
- Andreas Luhmann
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- Andrew Gaukroger
- Andrew Logan
- Andrew Simon
- Andrew Williamson
- Andrew Wilson
- Aneel Bhangu
- Angela Yan
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- Sanchit Turaga
- Sandra Mcallister
- Sanjay Chaudhri
- Sara Aeyad
- Sara Griffiths
- Sara Venturini
- Sarah Adams
- Sarah Choi
- Sarah Cumming
- Sarah Duff
- Sarah Easby
- Sarantos Kaptanis
- Satheesh Yalamarthi
- Saurabh Verma
- Scott Mccain
- Scott McKinstry
- Scott Smith
- Sebastian Owczarek
- Sebi Kukran
- Sevi Kukran
- Shafaque Shaikh
- Shahab Khan
- Shahram Shirazi
- Shaikh Sanjid Seraj
- Shamira Ghouse
- Shams Mustafa
- Sharif Omara
- Shashank Iyer
- Shazia Hafiz
- Shiva Dindyal
- Shoaib Fahad Hussain
- Shona Gardner
- Shreya Goel
- Shubhangi Govil
- Shyam Gokani
- Siddharth Basetti
- Sidhartha Sinha
- Simi George
- Simon Bach
- Simon Beecroft
- Simon Cole
- Sivesh K. Kamarajah
- Siyin Liu
- Sobia Akhtar
- Sohaib Mallick
- Sona Mistry
- Sophie Carlson
- Sophie Dupre
- Sophie Emesih
- Sreelata Periketi
- Sri Palaniappan
- Stefan Klimach
- Stephanie Rees
- Stephen Chapman
- Stephen Fenwick
- Stephen O'Neill
- Stephen Robinson
- Steve Hornby
- Steven Arnell
- Stuart Fergusson
- Stuart Gallagher
- Su Oh
- Sudhakar Mangam
- Sufyan Mansoor
- Suji Kim
- Sultana Azam
- Sumetha Rajendran
- Sung-Hee Kim
- Sunil Francis
- Surabhika Lunawat
- Suzanne Harrogate
- Swati Vara
- Syed Rahman
- Syeda Hussain
- Taher Fatayer
- Tahira Mohamed
- Talisa Ross
- Tamara Ali
- Tanya Dhir
- Tapani Pratumsuwan
- Tara Bergara
- Tara Dogra
- Tatiana Zhelezniakova
- Teresa Fung
- Tharindri Wijekoon
- Theophilus Anyomih
- Thomas Gower
- Thomas Hawthorne
- Thomas Lewis
- Thomas M. Drake
- Thomas Oakley
- Thomas Pinkney
- Thomas Stringfellow
- Thomas Ward
- Tiago Martins
- Tim White
- Tim Wilson
- Timen Swartbol
- Tinaye Mandishona
- Toby Jackman
- Toby Noton
- Tom Malik
- Tom Newman
- Tomas Urbonas
- Tonia Forjoe
- Tricia Yeoh
- Trupesh Patel
- Tseun Han James Kong
- Umarah Muhammad
- Ursula Mc Gee
- Usama Asif
- Vani Agarwal
- Vartan Balian
- Vasudev Zaver
- Veeru Kasivisvanathan
- Vicky Fretwell
- Victor Jones
- Victoria Dawe
- Vincent Ng
- Vladislav Kutuzov
- Waleed Al-Khyatt
- Wan Jane Liew
- Wenn Goh
- William Beasley
- William Bolton
- William English
- William Rook
- William Simpson
- Xue Wang
- Yan Ning Neo
- Yanish Poolovadoo
- Yao Ren Liew
- Yao Zong Tay
- Yasir Suleman
- Yat Wing Smart
- Yiwang Xu
- Ysabelle Embury-Young
- Yun Cao
- Yunzi Chen
- Yusuf Patrick
- Zainab Al-Nasser
- Zakaria Rob
- Zara Taylor
- Zehra Naqvi
- Zenab China
- Zhan Herr Ng
- Zhi Lim
- Zhi Min Soh
- Zhubene Mesbah
- Zoe Johnston
- Zong Lee
- Publication venue
- 'Elsevier BV'
- Publication date
- 04/02/2017
- Field of study
Letter to the editor
Whole-genome sequencing reveals host factors underlying critical COVID-19
- Author
- Abd Elghafar Mohamed S.
- Abdel-Aziz Mahmoud
- Abdelrazik Marwa
- Abdollahi Hamed
- Abdullah T.
- Abecasis Goncalo
- Abedalthagafi M.
- Abel Lynn
- Abernathy C.
- Abraheem Azmeralde
- Abul-Husn Noura S.
- Acquilini D.
- Adams C.
- Adams Emma L.
- Adams K.
- Adamsara Alireza
- Adanini Olurenke
- Adeleye O.
- Adra D.
- Afilalo J.
- Afilalo M.
- Afolabi D.
- Afrasiabi Z.
- Agasou A.
- Agrawal Shruti
- Agüero D.
- Ahmad N.
- Ahmadi Saeideh
- Ahmed A.
- Ahmed Cecilia
- Akeroyd L.
- Akhtar M.N.
- Akinkugbe O.
- Aksentijevich Alexandra
- Al-Afghani H.
- Al-Awdah L.
- Alaamery M.
- Alahmadey Z.Z.
- Alaverdian D.
- Alavere H.
- Albader A.
- Albaiceta G.M.
- Albakri J.K.
- AlBardis H.
- Albeladi M.
- Albesher N.
- Albrich W.
- AlDhawi N.
- Aldridge J.
- Aleagha Afshar Etemadi
- Alexander Peter.
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- Alghamdi B.
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- Ali Altaf
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- Publication venue
- Publication date
- 01/01/2022
- Field of study
Altres ajuts: Department of Health and Social Care (DHSC); Illumina; LifeArc; Medical Research Council (MRC); UKRI; Sepsis Research (the Fiona Elizabeth Agnew Trust); the Intensive Care Society, Wellcome Trust Senior Research Fellowship (223164/Z/21/Z); BBSRC Institute Program Support Grant to the Roslin Institute (BBS/E/D/20002172, BBS/E/D/10002070, BBS/E/D/30002275); UKRI grants (MC_PC_20004, MC_PC_19025, MC_PC_1905, MRNO2995X/1); UK Research and Innovation (MC_PC_20029); the Wellcome PhD training fellowship for clinicians (204979/Z/16/Z); the Edinburgh Clinical Academic Track (ECAT) programme; the National Institute for Health Research, the Wellcome Trust; the MRC; Cancer Research UK; the DHSC; NHS England; the Smilow family; the National Center for Advancing Translational Sciences of the National Institutes of Health (CTSA award number UL1TR001878); the Perelman School of Medicine at the University of Pennsylvania; National Institute on Aging (NIA U01AG009740); the National Institute on Aging (RC2 AG036495, RC4 AG039029); the Common Fund of the Office of the Director of the National Institutes of Health; NCI; NHGRI; NHLBI; NIDA; NIMH; NINDS.Critical COVID-19 is caused by immune-mediated inflammatory lung injury. Host genetic variation influences the development of illness requiring critical care or hospitalization after infection with SARS-CoV-2. The GenOMICC (Genetics of Mortality in Critical Care) study enables the comparison of genomes from individuals who are critically ill with those of population controls to find underlying disease mechanisms. Here we use whole-genome sequencing in 7,491 critically ill individuals compared with 48,400 controls to discover and replicate 23 independent variants that significantly predispose to critical COVID-19. We identify 16 new independent associations, including variants within genes that are involved in interferon signalling (IL10RB and PLSCR1), leucocyte differentiation (BCL11A) and blood-type antigen secretor status (FUT2). Using transcriptome-wide association and colocalization to infer the effect of gene expression on disease severity, we find evidence that implicates multiple genes-including reduced expression of a membrane flippase (ATP11A), and increased expression of a mucin (MUC1)-in critical disease. Mendelian randomization provides evidence in support of causal roles for myeloid cell adhesion molecules (SELE, ICAM5 and CD209) and the coagulation factor F8, all of which are potentially druggable targets. Our results are broadly consistent with a multi-component model of COVID-19 pathophysiology, in which at least two distinct mechanisms can predispose to life-threatening disease: failure to control viral replication; or an enhanced tendency towards pulmonary inflammation and intravascular coagulation. We show that comparison between cases of critical illness and population controls is highly efficient for the detection of therapeutically relevant mechanisms of disease