Development and Confirmatory Factor Analysis of the Non‐Violent and Violent Offending Behavior Scale (NVOBS)

both male and female participants in general (non‐forensic) samples. Potential items were selected from existing measures. A sample of 653 British university students completed all items, and their responses were analyzed using exploratory factor analysis and validated with confirmatory factor analysis. There were five separate factors (general violence, drug‐related offenses, partner violence, theft, and criminal damage), which were confirmed with acceptable fit indices. The five‐factor model applied to both males and females. Each subscale demonstrated good internal consistency, with alphas for each factor ranging from moderate to good. This new measure is a potentially valuable research tool for investigating people’s involvement in violent and non‐violent offending. The importance of examining the psychometric properties of scales, and confirming the category groupings using CFA of the items is outlined

A space of goals: the cognitive geometry of informationally bounded agents

Traditionally, Euclidean geometry is treated by scientists as a priori and objective. However, when we take the position of an agent, the problem of selecting a best route should also factor in the abilities of the agent, its embodiment and particularly its cognitive effort. In this paper we consider geometry in terms of travel between states within a world by incorporating information processing costs with the appropriate spatial distances. This induces a geometry that increasingly differs from the original geometry of the given world as information costs become increasingly important. We visualise this "cognitive geometry" by projecting it onto 2- and 3-dimensional spaces showing distinct distortions reflecting the emergence of epistemic and information-saving strategies as well as pivot states. The analogies between traditional cost-based geometries and those induced by additional informational costs invite a generalisation of the notion of geodesics as cheapest routes towards the notion of infodesics. In this perspective, the concept of infodesics is inspired by the property of geodesics that, travelling from a given start location to a given goal location along a geodesic, not only the goal, but all points along the way are visited at optimal cost from the start.Comment: Includes supplementary material, 6 figures in the main document, 5 figures in the supplementary material. Replacing preprint with author accepted manuscrip

A space of goals: the cognitive geometry of informationally bounded agents

© 2022 The Authors. Published by the Royal Society under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/Traditionally, Euclidean geometry is treated by scientists as a priori and objective. However, when we take the position of an agent, the problem of selecting a best route should also factor in the abilities of the agent, its embodiment and particularly its cognitive effort. In this paper, we consider geometry in terms of travel between states within a world by incorporating information processing costs with the appropriate spatial distances. This induces a geometry that increasingly differs from the original geometry of the given world as information costs become increasingly important. We visualize this ‘cognitive geometry’ by projecting it onto two- and three-dimensional spaces showing distinct distortions reflecting the emergence of epistemic and information-saving strategies as well as pivot states. The analogies between traditional cost-based geometries and those induced by additional informational costs invite a generalization of the notion of geodesics as cheapest routes towards the notion of infodesics. In this perspective, the concept of infodesics is inspired by the property of geodesics that, travelling from a given start location to a given goal location along a geodesic, not only the goal, but all points along the way are visited at optimal cost from the start.Peer reviewe

Trends in the recording of anxiety in UK primary care:a multi-method approach

PURPOSE: Anxiety disorders are common. Between 1998 and 2008, in the UK, GP recording of anxiety symptoms increased, but the recording of anxiety disorders decreased. We do not know whether such trends have continued. This study examined recent trends in the recording of anxiety and explored factors that may influence GPs’ coding of anxiety. METHODS: We used data from adults (n = 2,569,153) registered with UK general practices (n = 176) that contributed to the Clinical Practice Research Datalink between 2003 and 2018. Incidence rates and 95% confidence intervals were calculated for recorded anxiety symptoms and diagnoses and were stratified by age and gender. Joinpoint regression was used to estimate the years trends changed. In addition, in-depth interviews were conducted with 15 GPs to explore their views and management of anxiety. Interviews were audio-recorded, transcribed verbatim and analysed thematically. RESULTS: The incidence of anxiety symptoms rose from 6.2/1000 person-years at risk (PYAR) in 2003 to 14.7/1000 PYAR in 2018. Between 2003 and 2008, the incidence of anxiety diagnoses fell from 13.2 to 10.1/1000 PYAR; markedly increasing between 2013 and 2018 to 15.3/1000 PYAR. GPs mentioned that they preferred using symptom codes to diagnostic codes to avoid assigning potentially stigmatising or unhelpful labels, and commented on a rise in anxiety in recent years, especially in young adults. CONCLUSION: Recent increases in the recording of both anxiety diagnoses and symptoms may reflect increased presentation to primary care, especially in young adults. There is a clear need to understand the reasons for this, and this knowledge may be critical in the prevention and treatment of anxiety. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s00127-021-02131-8

Polymorphisms in the circadian expressed genes PER3 and ARNTL2 are associated with diurnal preference and GNβ3 with sleep measures

Sleep and circadian rhythms are intrinsically linked, with several sleep traits, including sleep timing and duration, influenced by both sleep homeostasis and the circadian phase. Genetic variation in several circadian genes has been associated with diurnal preference (preference in timing of sleep), although there has been limited research on whether they are associated with other sleep measurements. We investigated whether these genetic variations were associated with diurnal preference (Morningness-Eveningness Questionnaire) and various sleep measures, including: the global Pittsburgh Sleep Quality index score; sleep duration; and sleep latency and sleep quality. We genotyped 10 polymorphisms in genes with circadian expression in participants from the G1219 sample (n = 966), a British longitudinal population sample of young adults. We conducted linear regressions using dominant, additive and recessive models of inheritance to test for associations between these polymorphisms and the sleep measures. We found a significant association between diurnal preference and a polymorphism in period homologue 3 (PER3) (P < 0.005, recessive model) and a novel nominally significant association between diurnal preference and a polymorphism in aryl hydrocarbon receptor nuclear translocator-like 2 (ARNTL2) (P < 0.05, additive model). We found that a polymorphism in guanine nucleotide binding protein beta 3 (GNβ3) was associated significantly with global sleep quality (P < 0.005, recessive model), and that a rare polymorphism in period homologue 2 (PER2) was associated significantly with both sleep duration and quality (P < 0.0005, recessive model). These findings suggest that genes with circadian expression may play a role in regulating both the circadian clock and sleep homeostasis, and highlight the importance of further studies aimed at dissecting the specific roles that circadian genes play in these two interrelated but unique behaviours

Understanding how appraisal of doctors produces its effects: a realist review protocol

INTRODUCTION: UK doctors are now required to participate in revalidation to maintain their licence to practise. Appraisal is a fundamental component of revalidation. However, objective evidence of appraisal changing doctors' behaviour and directly resulting in improved patient care is limited. In particular, it is not clear how the process of appraisal is supposed to change doctors' behaviour and improve clinical performance. The aim of this research is to understand how and why appraisal of doctors is supposed to produce its effect. METHODS AND ANALYSIS: Realist review is a theory-driven interpretive approach to evidence synthesis. It applies realist logic of inquiry to produce an explanatory analysis of an intervention that is, what works, for whom, in what circumstances, in what respects. Using a realist review approach, an initial programme theory of appraisal will be developed by consulting with key stakeholders in doctors' appraisal in expert panels (ethical approval is not required), and by searching the literature to identify relevant existing theories. The search strategy will have a number of phases including a combination of: (1) electronic database searching, for example, EMBASE, MEDLINE, the Cochrane Library, ASSIA, (2) 'cited by' articles search, (3) citation searching, (4) contacting authors and (5) grey literature searching. The search for evidence will be iteratively extended and refocused as the review progresses. Studies will be included based on their ability to provide data that enable testing of the programme theory. Data extraction will be conducted, for example, by note taking and annotation at different review stages as is consistent with the realist approach. The evidence will be synthesised using realist logic to interrogate the final programme theory of the impact of appraisal on doctors' performance. The synthesis results will be written up according to RAMESES guidelines and disseminated through peer-reviewed publication and presentations. TRIAL REGISTRATION NUMBER: The protocol is registered with PROSPERO 2014:CRD42014007092.UK Department of HealthNational Institute for Health Research (NIHR

Genes of the serotonergic and dopaminergic pathways and their interaction affect the expression of Behavioural and Psychological Symptoms in Dementia (BPSD).

Although there is evidence for the involvement of genes of serotonergic and dopaminergic systems in the manifestation of the Behavioural and Psychological Symptoms in Dementia (BPSD), genetic association studies are contradictory. We used 1008 probable AD patients from the UK and applied a Multiple Indicators Multiple Causes (MIMIC) approach to investigate the effect of 11 polymorphisms in the serotonergic and dopaminergic systems, on four behavioural sub-phenotypes, namely &#x22;psychosis&#x22;,&#x22; moods&#x22;, &#x22;agitation&#x22; and &#x22;behavioural dyscontrol&#x22;, as well as on 12 NPI items. Significant findings included the association of DRD1 A48G with &#x22;psychosis&#x22; (p=0.037), the association of DAT1 VNTR with &#x22;agitation&#x22; (p=0.006) and the association of DRD4 with &#x22;moods&#x22; sub-phenotype (p=0.008). In addition, associations were identified between DRD1 A48G and DAT1 VNTR with aberrant motor behaviour (AMB) symptoms (p=0.001 and p=0.015 respectively), between DRD4 and sleep disturbances (p=0.018) and between 5HTTLPR and apathy (p=0.033). Finally, significant interactions were observed between COMT Val158Met and 5HTTLPR with &#x22;psychosis&#x22; (p=0.026), between HTTLPR and STin2 with &#x22;psychosis&#x22; (p=0.005), between DAT1 3&#x27;UTR VNTR and COMT Val158Met with &#x22;agitation&#x22; (p=0.0001) and between DAT1 3&#x27;UTR VNTR and 5HTTLPR with the &#x22;moods&#x22; factor (p=0.0027). The complexity of the interrelations between genetic variation, behavioural symptoms and clinical variables was efficiently captured by this MIMIC model

Environmental surveillance identifies multiple introductions of MRSA CC398 in an Equine Veterinary Hospital in the UK, 2011-2016

Bacterial environmental and surgical site infection (SSI) surveillance was implemented from 2011-2016 in a UK Equine Referral Veterinary Hospital and identified 81 methicillin-resistant Staphylococcus aureus (MRSA) isolates. A cluster of MRSA SSIs occurred in early 2016 with the isolates confirmed as ST398 by multilocus sequence typing (MLST), which prompted retrospective analysis of all MRSA isolates obtained from the environment (n = 62), SSIs (n = 13) and hand plates (n = 6) in the past five years. Sixty five of these isolates were typed to CC398 and a selection of these (n = 38) were further characterised for resistance and virulence genes, SCCmec and spa typing. Overall, MRSA was identified in 62/540 (11.5%) of environmental samples, 6/81 of the hand-plates (7.4%) and 13/208 of the SSIs (6.3%). spa t011 was the most frequent (24/38) and Based Upon Repeat Pattern (BURP) analysis identified spa t011 as one of the two group founders of the main spa CC identified across the five years (spa CC011/3423). However, 3 singletons (t073, t786, t064) were also identified suggesting separate introductions into the hospital environment. This long-term MRSA surveillance study revealed multiple introductions of MRSA CC398 in a UK Equine Hospital, identifying an emerging zoonotic pathogen so far only sporadically recorded in the UK