Comments on “Risk of mortality of node-negative, ER/PR/HER2 breast cancer subtypes in T1, T2, and T3 tumors” by Parise CA and Caggiano V, Breast Cancer Res Treat, 2017.

El texto completo de este trabajo no está disponible en el Repositorio Académico UPC por restricciones de la casa editorial donde ha sido publicado.We would like to express our opinion regarding a Parise and Caggiano paper recently published in your journal. We certainly believe this is a great contribution, since it found that node-negative HER2 (+) breast cancer patients have better survival contrary to the common knowledge. This finding could reflect the consequences of targeted therapies that are changing the natural history of the disease. However, we think that such an interesting analysis could also have been done with stage III and IV patients, since this group of people could benefit greatly from these findings. In fact, new guidelines now recommend the use of HER2-specific therapy for stage IV patients with positive markers, even for life if they do not show signs of progression. Additionally, we would like to discuss the value of adding the Ki-67 marker to the classification proposed by the authors, because several papers consider it an important prognostic factor. © 2017 Springer Science+Business Media, LLC, part of Springer NatureRevisión por pare

The need of a comprehensive approach to the nutritional status of the elderly

El texto completo de este trabajo no está disponible en el Repositorio Académico UPC por restricciones de la casa editorial donde ha sido publicado.“Cartas al editor”Revisión por pare

Efecto de los ácidos húmico y fúlvico en el crecimiento de Passiflora ligularis cultivada en condiciones de invernadero

Se evaluó el efecto de los ácidos húmico y fulvico en el crecimiento de plantas de Passiflora ligularis “granadilla” en condiciones ecológicas estables (invernadero). Para llevar a cabo el ensayo, plantas de granadilla de 10 cm de altura fueron colocadas en macetas de plástico con sustrato arena y musgo, para establecer cuatro tratamientos: el primero, que recibió solamente solución nutritiva la Molina y el resto, que recibieron, además de la solución antes mencionada, ácidos húmico y fúlvico en las siguientes proporciones (T2= 1%  T3= 3%), respectivamente, con tres repeticiones. Los ácidos húmico y fúlvico influenciaron en el crecimiento de las plantas de granadilla (p<0,05), con un incremento en el T3 de 48.35% y 57.46% en peso fresco y seco de plantas, respectivamente; 51.66%  en longitud de planta y 45.98 % en diámetro de tallo y  55.68 % en área foliar  respecto al control (T1). Se concluye que los ácidos húmico y fúlvico incrementan el peso seco, la longitud y área foliar de P. ligularis.Palabras claves: Acidos húmico y fúlvico, Passiflora ligularis, crecimient

Las pruebas de laboratorio para la identificación de sars-cov-2 en tiempos de pandemia en el Perú: Algunas precisiones acerca del «rendimiento diagnóstico»

Carta al editorRevisión por pare

Statistical analyses in disease surveillance systems

The performance of disease surveillance systems is evaluated and monitored using a diverse set of statistical analyses throughout each stage of surveillance implementation. An overview of their main elements is presented, with a specific emphasis on syndromic surveillance directed to outbreak detection in resource-limited settings. Statistical analyses are proposed for three implementation stages: planning, early implementation, and consolidation. Data sources and collection procedures are described for each analysis

Clinical and Parasite Species Risk Factors for Pentavalent Antimonial Treatment Failure in Cutaneous Leishmaniasis in Peru

Background. Treatment for cutaneous leishmaniasis (CL) with standard pentavalent antimonial therapy is hampered by cumbersome administration, toxicity, and potential failure. Knowledge of factors influencing treatment outcome is essential for successful management. Methods. A case-control study of incident cases was performed with patients experiencing their first CL episode. The standard treatment for CL for these patients was 20 mg/kg/day of sodium stibogluconate for 20 days. Clinical and epidemiological data were recorded, and parasite isolates were species typed. Patients were followed up for 6 months to assess treatment outcome. Clinical cure was defined as complete wound closure and re-epithelization without inflammation or infiltration; new lesions, wound reopening, or signs of activity were classified as treatment failure. Descriptive, bivariate, and logistic regression analyses were performed. Results. One hundred twenty-seven patients were recruited; 63 (49.6%) were infected with Leishmania (Viannia) peruviana, 29 (22.8%) were infected with Leishmania (Viannia) braziliensis, 27 (21.3%) were infected with Leishmania (Viannia) guyanensis, and 8 (6.3%) were infected with other species. Only patients infected with the 3 most common species were selected for risk-factor analysis (n=119). Final failure rate at 6 months was 24.4% (95% confidence interval [CI], 16.5%-32.1%), with 96% of failures occurring within the first 3 months of follow-up assessment. Risk factors for treatment failure identified in the final multivariate model were age (per year, odds ratio [OR], 0.95; 95% CI, 0.92-0.99; P=.017), stay of <72 months in area of disease acquisition (OR, 30.45; 95% CI, 2.38-389.25; P=.009), duration of disease <5 weeks (OR, 4.39; 95% CI, 1.12-17.23; P=.034), additional lesion (per lesion, OR, 2.06; 95% CI, 1.3-3.28; P=.002), infection with L. (V.) peruviana (OR, 9.85; 95% CI, 1.01-95.65; P=.049), and infection with L. (V.) braziliensis (OR, 22.36; 95% CI, 1.89-263.96; P=.014). Conclusions. The identification of parasite species and clinical risk factors for antimonial treatment failure should lead to an improved management of CL in patients in Per

Contenido de prolina en Solanum lycopersicum pretratado con glicina betaina y sometido a estrés salino

Las plantas han desarrollado varios mecanismos protectores para contrarrestar el estrés salino, uno de ellos es la acumulación de solutos compatibles como prolina y glicina betaina. Sin embargo, algunos cultivos como el tomate no acumulan glicina betaina, ante esto surge la alternativa de la aplicación exógena de estos compuestos. En este trabajo, se propuso evaluar el contenido de prolina en relación al estado hídrico en plántulas de Solanum lycopersicum  var. Río Grande “tomate” pretratado con diferentes concentraciones de glicina betaina y cultivadas en diferentes niveles de salinidad.  Plántulas fueron tratadas con glicina betaina a concentraciones de 0, 1 y 10 mM, y luego sometidas a cloruro de sodio: 0, 100 y 200 mM agregada esta sal a la solución de riego. Después de 10 días de tratamiento se cuantificó prolina y contenido relativo de agua. El contenido de prolina aumentó con el grado de salinidad y la aplicación de Glicina betaina 1 mM produjo un aumento significativo en NaCl 100mM.Palabras clave: prolina, glicina betaina, estrés salino, Solanu