Prevalence and genotype distribution of cervical human papilomavirus infection in the pre-vaccination era: a population-based study in the Canary Islands

Objective: National Spanish studies show that prevalence of cervical human papillomavirus (HPV) infection in the female population is increasingly frequent, with an overall estimate of 14% in women aged 18-65 years. The objective of this study is to know the prevalence and distribution of HPV types in the female population of the Canary Islands prior to the introduction of HPV vaccines and to investigate the associated clinical and sociodemographic factors. Methods: Based on the Primary Health Care database, a sample of adult women (aged 18-65 years) of Gran Canaria (GC) and Tenerife (TF) stratified into nine age groups was carried out between 2002 and 2007. Women were contacted by postal letter and telephone call and were visited in their primary care centre. A clinical-epidemiological survey was completed and cervical samples were taken for cytological study and HPV detection. HPV prevalence and its 95% CI were estimated, and multivariate analyses were performed using logistic regression to identify factors associated with the infection. Results: 6010 women participated in the study, 3847 from GC and 2163 from TF. The overall prevalence of HPV infection was 13.6% (CI 12.8%-14.5%) and 11.1% (CI 10.3%-11.9%) for high-risk types. The most frequent HPV type was 16 followed by types 51, 53, 31, 42 and 59. HPV types included in the nonavalent vaccine were detected in 54.1% of infected women. Factors associated with an increased risk of infection were: young ages (18-29 years), the number of sexual partners throughout life, not being married, being a smoker, and having had previous cervical lesions or genital warts. Conclusions: It is confirmed that prevalence of HPV infection in the female population of the Canary Islands is high, but similar to that of Spain, HPV 16 being the most frequent genotype. The determinants of infection are consistent with those of other populations

Implementation of a mindfulness-based crisis intervention for frontline healthcare workers during the COVID-19 outbreak in a public general hospital in Madrid, Spain

Introduction: The COVID-19 outbreak is having an impact on the well-being of healthcare workers. Mindfulness-based interventions have shown effectiveness in reducing stress and fostering resilience and recovery in healthcare workers. There are no studies examining the feasibility of brief mindfulness-based interventions during the COVID-19 outbreak. Materials and Methods: This is an exploratory study with a post intervention assessment. We describe an on-site brief mindfulness intervention and evaluate its helpfulness, safety, and feasibility. Results: One thousand out of 7,000 (14%) healthcare workers from La Paz University Hospital in Madrid (Spain) participated in at least one session. One hundred and fifty out of 1,000 (15%) participants filled out a self-report questionnaire evaluating the helpfulness of the intervention for on-site stress reduction. Ninety two subjects (61%) participated in more than one session. Most of the participants were women (80%) with a mean age of 38.6 years. Almost half of the sample were nurses (46%). Sessions were perceived as being helpful with a mean rating of 8.4 on a scale from 0 to 10. Only 3 people (2%) reported a minor adverse effect (increased anxiety or dizziness). Discussion: Our data supports the utility, safety and feasibility of an on-site, brief mindfulness-based intervention designed to reduce stress for frontline health workers during a crisis. There is a need to continue testing this type of interventions, and to integrate emotion regulation strategies as an essential part of health workers' general training. Clinical Trial Registration number: NCT04555005

Construcción de modelos de simulación en FlexSim que implementen herramientas Lean Manufacturing en una línea de ensamblaje

El Lean Manufacturing es una herramienta muy extendida en las empresas para mejorar sus sistemas productivos, por lo que es necesario promover su estudio en las carreras de ingeniería industrial. El presente trabajo busca ayudar en esta labor empleando otra herramienta clave utilizada para apoyar la toma de decisiones: la simulación. En concreto, en el proyecto se han construido múltiples modelos ficticios mediante el software de simulación FlexSim, un simulador 3D orientado a objetos, lo que permite una mejor visualización de la implementación de las técnicas Lean y de sus resultados. Partiendo de un modelo inicial, se identifican las fuentes de despilfarros y se seleccionan las técnicas Lean más adecuadas para su mejora, lo que da lugar a nuevos modelos en los que se logra mejorar distintos parámetros operativos de forma gradual.Companies use the Lean Manufacturing in order to improve their production system. As a result, it is essential to learn it in industrial engineering careers. This project seeks to help in this work using key tool used to support decision making: simulation. In this project, multiple fictitious models have been built using the FlexSim simulation software. FlexSim is an object-oriented 3D simulator which allows a better visualisation of the implementation of Lean techniques and their results. In the initial model, the sources of waste are identified and the Lean techniques are chosen for their improvement. This gives rise to new models in which different operating parameters are gradually improved.Departamento de Organización de Empresas y Comercialización e Investigación de MercadosGrado en Ingeniería en Organización Industria

Sequential intrastromal corneal ring segment and monofocal intraocular lens implantation for keratoconus and cataract: Long-term follow-up

Purpose: To evaluate the efficacy, safety, predictability, and stability of sequential Ferrara intrastromal corneal ring segment (ICRS) and intraocular lens (IOL) implantation in patients with keratoconus and cataract. Setting: Fernández-Vega Ophthalmological Institute, Oviedo, Spain. Design: Retrospective case series. Methods: This study comprised patients with keratoconus and cataract who had ICRS implantation followed 6 months later by IOL implantation. The uncorrected (UDVA) and corrected (CDVA) distance visual acuities and residual refractive errors, analyzed using vector analysis, were recorded preoperatively, 6 months after ICRS implantation, 6 months after IOL implantation, and 3 years and 5 years thereafter. Results: Seventy eyes of 47 patients were studied. The mean UDVA was 1.08 logMAR ± 0.24 (SD) preoperatively, 0.95 ± 0.31 logMAR 6 months after ICRS implantation (P = .03), and 0.44 ± 0.29 logMAR 6 months after IOL implantation (P .05). The spherical equivalent (SE) and the refractive cylinder declined steeply after IOL implantation (P .05). Conclusion: Sequential ICRS and IOL implantation provided good visual and refractive outcomes and was an effective, safe, predictable, and stable procedure for the treatment of patients with keratoconus and cataract

Bilateral implantation of the Acri.LISA bifocal intraocular lens in myopic eyes

PURPOSE. To asses visual quality after bilateral implantation of the Acri.LISA 366D intraocular lens (IOL) (Carl Zeiss Meditec) in patients with high and low-moderate myopia. METHODS. A total of 304 eyes of 152 patients had bilateral implantation of the Acri.LISA 366D IOL. The patients were divided into 2 groups: low-moderate myopia (IOL power from 15 to 20.5 D) and high myopia (IOL power from 0 to 14.5 D). Monocular and binocular best-corrected distance visual acuity (BCVA) and best distance-corrected near visual acuity (BCNVA), binocular best distance-corrected intermediate visual acuity (BCIVA), and distance contrast sensitivity (CS) under photopic (85 cd/m(2)) and mesopic (5 cd/m2) conditions were determined. RESULTS. At the 6-month postoperative visit, there were no statistically significant differences in monocular and binocular BCVA (p=0.13 and p=0.22, respectively). Monocular and binocular BCNVA was comparable between the groups (p=0.26 and p=0.09, respectively). The mean binocular BCIVA changed significantly as a function of the distance of the test (p0.01). CONCLUSIONS. Bilateral implantation of the Acri.LISA 366D in high myopic eyes provides a satisfactory full range of vision comparable to that obtained in low-moderate myopic eyes. (Eur J Ophthalmol 2010; 20: 83-9)0.980 JCR (2010) Q3, 39/56 Ophthalmolog

Bilateral Implantation of the Acri.LISA Bifocal Intraocular Lens in Myopic Eyes

PURPOSE. To asses visual quality after bilateral implantation of the Acri.LISA 366D intraocular lens (IOL) (Carl Zeiss Meditec) in patients with high and low-moderate myopia. METHODS. A total of 304 eyes of 152 patients had bilateral implantation of the Acri.LISA 366D IOL. The patients were divided into 2 groups: low-moderate myopia (IOL power from 15 to 20.5 D) and high myopia (IOL power from 0 to 14.5 D). Monocular and binocular best-corrected distance visual acuity (BCVA) and best distance-corrected near visual acuity (BCNVA), binocular best distance-corrected intermediate visual acuity (BCIVA), and distance contrast sensitivity (CS) under photopic (85 cd/m(2)) and mesopic (5 cd/m2) conditions were determined. RESULTS. At the 6-month postoperative visit, there were no statistically significant differences in monocular and binocular BCVA (p=0.13 and p=0.22, respectively). Monocular and binocular BCNVA was comparable between the groups (p=0.26 and p=0.09, respectively). The mean binocular BCIVA changed significantly as a function of the distance of the test (p0.01). CONCLUSIONS. Bilateral implantation of the Acri.LISA 366D in high myopic eyes provides a satisfactory full range of vision comparable to that obtained in low-moderate myopic eyes. (Eur J Ophthalmol 2010; 20: 83-9)0.980 JCR (2010) Q3, 39/56 Ophthalmolog

The Effect of Intracorneal Ring Segments Implantation for Keratoconus on In Vivo Corneal Biomechanics Assessed With the Corvis ST

PURPOSE:To evaluate the effect of the implantation of intracorneal ring segments (ICRS) in keratoconus on the dynamic corneal response (DCR) parameters obtained with the Corvis ST (Oculus Optikgeräte GmbH). METHODS:This prospective clinical study included patients who underwent ICRS implantation for keratoconus over a period of 1 year. On the day of the surgery and at least 1 month after ICRS implantation, the following measurements were made: corrected and uncorrected distance visual acuity, corneal tomography indices with the Pentacam (Oculus Optikgeräte GmbH), biomechanically corrected intraocular pressure (bIOP), Corvis ST DCR parameters, integrated inverse concave radius (1/R), deformation amplitude ratio (DA ratio), stiffness parameter at first applanation (SP-A1), stress–strain index (SSI), and highest concavity radius (HRC). RESULTS:Fifty-one eyes of 40 patients were included with a median follow-up time of 3 months (interquartile ratio [IQR]: 2 to 6 months). Statistical analysis showed that ICRS implantation did not affect corneal biomechanical measurements evaluated with the Corvis ST, which was demonstrated by non-significant changes in the SP-A1 (P = .637), 1/R (P = .647), HRC (P = .177), DA ratio (P = .735), and SSI (P = .501). Additionally, the results showed that bIOP measurements were not significantly affected by ICRS implantation (P = .113). CONCLUSIONS:ICRS implantation does not affect corneal biomechanical measurements in early follow-up

Effect of intrastromal corneal ring segments on in vivo corneal biomechanics in keratoconus: 1-year results.

PurposeTo evaluate the 1-year effects of the implantation of intrastromal corneal ring segments (ICRS) in keratoconus (KC) on the dynamic corneal response (DCR) parameters obtained with the Corvis.SettingFernández-Vega Ophthalmological Institute, Oviedo, Spain.DesignProspective, single-center, clinical study.MethodsIncluded were patients who underwent ICRS implantation for KC over a period of 1 year. On the day of the surgery and at least 6 months after ICRS implantation, the following measurements were made: corrected distance and uncorrected distance visual acuity, corneal tomography indices with the Pentacam, biomechanically corrected intraocular pressure and the Corvis DCRs (integrated inverse concave radius, deformation amplitude ratio, stiffness parameter at first applanation, stress-strain index [SSI] and the highest concavity radius).Results30 eyes were included with a mean follow-up time of 15 months. Statistical analysis showed that ICRS implantation induced significant improvements in corneal biomechanics measurements between preoperative and long-term follow-up as demonstrated by a significant increase in SSI (P = .003). To confirm that this difference was actually induced due to a stiffening between early postoperative (previously published) and long-term an additional t-test was done between month 1 and late follow-up which confirmed a significant stiffening in the value of SSI (P = .01).ConclusionsPatients implanted with ICRS alone for KC showed a significantly stiffer response due to increased structural support compared with preoperative values and 1 month postoperative

A Proposal to Classify and Assess Ecological Status in Mediterranean Temporary Rivers: Research Insights to Solve Management Needs

The biomonitoring methods implemented by water authorities are mostly developed for perennial rivers, and do not apply to temporary rivers (TRs). We propose a new classification for TRs to better assess their ecological status. It arises from the LIFE+ TRivers project, which was conducted in the Catalan and the Júcar Mediterranean river basin districts (RBD). The European Water Framework Directive (WFD) provided two systems to set river types (systems A or B from Annex II), which have been officially used by water authorities across Europe to set “national river types” (NRTs). However, essential hydrological variables for TRs are largely omitted. NRTs established according to the WFD were compared with TR categories obtained by using a rainfall-runoff model, “natural flows prescribed regimes” (NFPRs), and with “aquatic phases regimes” (APRs) calculated by using TREHS software. The biological quality indices currently used in Spain, based on macroinvertebrates and diatoms (IBMWP, IMMI-T, and IPS), were compared with a “general degradation” gradient in order to analyze the two TR river classification procedures (NFPR and APR). The results showed that NRTs did not properly classify TRs, and that the APR classification identified ecologically meaningful categories, especially those related to stagnant phases. Four “management temporary river categories” based on APRs are proposed to be used for water managers to properly assess the ecological status of TRs.This research is based on TRivers LIFE + Project outcomes (LIFE13 ENV/ES/000341). The Catalan and Júcar RBDs provided funds for monitoring and data treatment.Peer reviewe

Aularium

Resumen tomado de la revistaComo proyecto final del curso La Educación en Valores a través del proceso de Educación Artística, un grupo de profesores, en su mayoría del C. P. Ciudad de Roma, organizaron en 1999 un acto para celebrar el Día de la Paz en el que participaron todos los alumnos y profesores del colegio. Este artículo recoge el guión elaborado, desarrollado y escenificado de los cuatro actos escénicos de los que constó el espectáculo. Todos ellos transcurrieron en el contexto de la actividad artística grupal en diversas facetas: música, expresión plástica, representación teatral, expresión corporal y recitación; lográndose un emotivo ambiente y un estupendo nivel artístico en la realización..MadridES