Dual task effects on functional performance in community-dwelling elderly

The purpose was to assess the effect of six different dual tasks in community dwelling elderly. Thirty-five volunteers (aged 69.6±7.1 years) were submitted to the Timed Up and Go test (TUG) and to further five tasks wherein TUG was associated to two motor tasks - carrying a glass of water (TUGM1) and transferring coins from one pocket to another (TUGM2); to two cognitive tasks - repeating a sentence (TUGC1) and saying weekdays backwards (TUGC2); and to a motor-cognitive task, of carrying a glass of water while repeating a sentence (TUGMC). Time spent, failure and success in each task were counted. Results showed a significant decrease in average time (in seconds) spent in TUG when associated with all tasks; and a significant correlation from moderate (r=0.676) to almost perfect (r=0.953) between the times of each association with TUG. The number of transferred coins in TUGM2 and the number of days of the week correctly said in TUGC2 showed a correlation with the time spent in all the other tasks. These two tasks most affected the time spent to accomplish TUG (pO objetivo deste estudo foi avaliar o efeito de seis diferentes tarefas duplas no desempenho funcional de idosos da comunidade. Em 35 idosos com idade média de 69,6±7,1 anos foi aplicado o teste de levantar e caminhar cronometrado (TLCC, Timed up and go ou TUG) simples (TLCCS) e associado a duas tarefas motoras - carregar um copo com água (TLCCM1) e transferir moedas de um bolso para o outro (TLCCM2) - e duas cognitivas, repetir uma frase (TLCCC1) e falar os dias da semana em ordem inversa (TLCCC2), sendo aferidos os acertos e erros nessas tarefas. Houve piora significativa da média do tempo em segundos no TLCC nas tarefas duplas, independente da tarefa, e correlação significativa, de moderada (r=0,676) a quase perfeita (r=0,953), entre os tempos de cada tipo de TLCC. O número de moedas transferidas no TLCCM2 e o número de dias na semana dito em ordem inversa no TLCCC2 apresentaram correlação com o tempo gasto para realizar todas as outras tarefas. Essas duas tarefas foram as que mais afetaram o tempo do TLCC (

COVID-19 and mental health of pregnant women in Ceará, Brazil

OBJECTIVE To assess the perceptions of pregnant women about COVID-19 and the prevalence of common mental disorders during the implemented social distancing period. METHODS This was an observational, cross-sectional study using digital media, of pregnant women exposed to social distancing due to the COVID-19 pandemic, in Fortaleza, Ceará, Northeastern Brazil. Common mental disorders were estimated using the modified Self-Report Questionnaire-20 (SRQ-20) scale, and the feelings towards COVID-19 were assessed using the Fear of COVID-19 scale through telephone calls made in May 2020. COX multivariate regression models were used to verify the associations. RESULTS Of the 1,041 pregnant women, 45.7% (95%CI: 42.7–48.8) had common mental disorders (CMD). All items of the Fear of COVID-19 Scale showed a significant association with the prevalence of CMD (p < 0.001). A CMD risk gradient was observed, going from a prevalence ratio of 1.52 (95%CI: 1.13–2.04) in pregnant women with two positive items to 2.70 (95%CI: 2.08–3.51) for those with four positive items. Early gestational age and the lack of prenatal care were also associated with CMD. CONCLUSIONS The prevalence of common mental disorders in pregnant women was high during the period of social distancing and was aggravated by negative feelings towards COVID-19

A Importância dos Estilos de Formatação de Trabalhos Acadêmicos: uma revisão de literatura

ntroduction: Scientific research aims to generate new knowledge, to contribute to the various segments of society and provide a better quality of life for the population, using specific methods and techniques for this purpose. For the dissemination of this knowledge to occur ethically and effectively, the researcher must be aware of some important aspects, such as scientific writing, which includes bibliographic references and standardization of scientific papers. Objective: To describe the main characteristics of the formatting styles of scientific works: ABNT, APA, Chicago, MLA, Vancouver. Material and Method: A bibliographic review was carried out in the Scientific Electronic Library (SCIELO), Virtual Health Library Brazil (BVS) and Google Scholar databases. Literature Review: Standardizations are important, as they contribute to the standardization and structuring of inputs for technological and scientific development, effectively and with quality. Final Considerations: It is expected that the compiled content will guide the reader/researcher as to the applicability of the technical norms for standardization of the styles of standardization of scientific papers commonly recommended by national and international journals to reach and disseminate the knowledge produced.Introdução: A pesquisa científica tem por objetivo gerar novos conhecimentos, de forma a contribuir com os diversos segmentos da sociedade e proporcionar melhor qualidade de vida para a população, utilizando de métodos e técnicas específicas para esta finalidade. Para que a disseminação destes conhecimentos ocorra de forma ética e eficaz, o pesquisador deve estar atento a alguns aspectos importantes, como a redação científica, a qual inclui as referências bibliográficas e a normatização dos trabalhos científicos. Objetivo: Descrever as principais características dos estilos de formatação de trabalhos científicos: ABNT, APA, Chicago, MLA e Vancouver. Material e Método: Foi realizada uma revisão bibliográfica no banco de dados Scientific Electronic Library (SCIELO), Biblioteca Virtual em Saúde Brasil (BVS) e Google Acadêmico. Revisão de Literatura: As normatizações são importantes, pois contribuem com a padronização e estruturação dos insumos do desenvolvimento tecnológico e científico, de forma eficaz e com qualidade. Considerações Finais: Espera-se que o conteúdo compilado oriente o leitor/pesquisador quanto a aplicabilidade das normas técnicas de normalização dos estilos de padronização de trabalhos científicos comumente recomendados por periódicos nacionais e internacionais com o intuito de ter um alcance e disseminar o conhecimento produzido

Social distancing measures to control the COVID-19 pandemic: potential impacts and challenges in Brazil.

The COVID-19 pandemic has challenged researchers and policy makers to identify public safety measures forpreventing the collapse of healthcare systems and reducingdeaths. This narrative review summarizes the available evidence on the impact of social distancing measures on the epidemic and discusses the implementation of these measures in Brazil. Articles on the effect of social distancing on COVID-19 were selected from the PubMed, medRXiv and bioRvix databases. Federal and state legislation was analyzed to summarize the strategies implemented in Brazil. Social distancing measures adopted by the population appear effective, particularly when implemented in conjunction with the isolation of cases and quarantining of contacts. Therefore, social distancing measures, and social protection policies to guarantee the sustainability of these measures, should be implemented. To control COVID-19 in Brazil, it is also crucial that epidemiological monitoring is strengthened at all three levels of the Brazilian National Health System (SUS). This includes evaluating and usingsupplementary indicators to monitor the progression of the pandemic and the effect of the control measures, increasing testing capacity, and making disaggregated notificationsand testing resultstransparentand broadly available

Clear cell odontogenic carcinoma: case report with immunohistochemical findings adding support to the challenging diagnosis

Clear cell odontogenic carcinoma (CCOC) is a rare odontogenic tumor associated with aggressive clinical behavior, metastasis, and low survival. We report a case of CCOC affecting the mandible of a 39-year-old man. The tumor presented a biphasic pattern composed of clear cell nests intermingled with eosinophilic cells and separated by collagenous stroma. Immunoreactivity to cytokeratin (CK), specifically AE1/AE3 and CK 8, 14, 18, and 19 was found, as well as to epithelial membrane antigen (EMA). The tumor cells were negative for S100 protein, CK 13, vimentin, smooth muscle actin, laminin and type IV collagen. Low labeling indices for the proliferation markers Ki-67 and proliferating cell nuclear antigen and to p53 protein might predict a favorable prognosis for the lesion. A surgical resection was performed, followed by adjuvant radiotherapy. A 2-year follow-up has shown no signs of recurrence. The significance of histochemical and immunohistochemical resources in the correct diagnosis of CCOC is analyzed

Teaching NeuroImages: Brucellosis mimicking demyelinating disease

Univ Fed Sao Paulo, Dept Neurol & Neurocirurgia, BR-04039000 Sao Paulo, BrazilUniv Fed Sao Paulo, Dept Med, BR-04039000 Sao Paulo, BrazilUniv Fed Sao Paulo, Dept Neurol & Neurocirurgia, BR-04039000 Sao Paulo, BrazilUniv Fed Sao Paulo, Dept Med, BR-04039000 Sao Paulo, BrazilWeb of Scienc

Antitumour efficacy of Piper tuberculatum and piplartine based on the hollow fiber assay

Submitted by Ana Maria Fiscina Sampaio ([email protected]) on 2015-03-16T18:31:34Z No. of bitstreams: 1 Bezerra DP Antitumour.pdf: 108528 bytes, checksum: eb1c963dd7f2c3c7b250e37c82423fb8 (MD5)Approved for entry into archive by Ana Maria Fiscina Sampaio ([email protected]) on 2015-03-16T18:31:43Z (GMT) No. of bitstreams: 1 Bezerra DP Antitumour.pdf: 108528 bytes, checksum: eb1c963dd7f2c3c7b250e37c82423fb8 (MD5)Approved for entry into archive by Ana Maria Fiscina Sampaio ([email protected]) on 2015-03-16T19:04:06Z (GMT) No. of bitstreams: 1 Bezerra DP Antitumour.pdf: 108528 bytes, checksum: eb1c963dd7f2c3c7b250e37c82423fb8 (MD5)Made available in DSpace on 2015-03-16T19:04:06Z (GMT). No. of bitstreams: 1 Bezerra DP Antitumour.pdf: 108528 bytes, checksum: eb1c963dd7f2c3c7b250e37c82423fb8 (MD5) Previous issue date: 2015Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilUniversidade Federal do Piauí. Departamento de Biofísica e Fisiologia. Programa de Pós-Graduação em Ciências Farmacêuticas. Teresina, PI, BrasilUniversidade de São Paulo. Faculdade de Medicina. Departamento de Radiologia. São Paulo, SP, BrasilUniversidade Federal do Ceará. Departamento de Química Orgânica. Fortaleza, CE, BrasilUniversidade Federal do Ceará. Departamento de Química Orgânica. Fortaleza, CE, BrasilUniversidade de São Paulo. Faculdade de Medicina. Departamento de Radiologia. São Paulo, SP, BrasilUniversidade Federal do Ceará. Faculdade de Medicina. Departamento de Fisiologia e Farmacologia. Fortaleza, CE, Brasil / Fundação Oswaldo Cruz. Fortaleza, CE, BrasilPiper tuberculatum, popularly known in Brazil as “jaborandi falso” and “pimenta darta”, is widely used in folk medicine for the treatment of several diseases. In this study, the in vivo hollow fiber assay was used to investigate the antitumour efficacy of the crude extract and piplartine obtained from P. tuberculatum roots. Human glioblastoma (SF-295) and colon carcinoma (HCT-8) cell lines were used. In vitro cytotoxicity was assayed by the MTT assay. In the hollow fiber assay, nude mice implantedwith tumour cells in hollow fibers were treated for four consecutive days via the intraperitoneal route, and tumour cell populations were assessed by the MTT assay. Both the crude extract and piplartine displayed cytotoxicity. In the hollow fiber assay, tumour growth inhibition rates were 24.6–54.8% for the crude extract and 33.7–62.2% for piplartine. No signal of toxicity was noticed. In conclusion, the crude extract and piplartine obtained from P. tuberculatum roots displayed in vitro and in vivo anticancer efficacy

Genetic risk factors for nonsyndromic cleft lip with or without cleft palate in a brazilian population with high african ancestry

Nonsyndromic cleft lip with or without cleft palate (NSCL +/- P) is the most common orofacial birth defect, exhibiting variable prevalence around the world, often attributed to ethnic and environmental differences. Linkage analyses and genome-wide association studies have identified several genomic susceptibility regions for NSCL +/- P, mostly in European-derived or Asian populations. Genetic predisposition to NSCL +/- P is ethnicity-dependent, and the genetic basis of susceptibility to NSCL +/- P likely varies among populations. The population of Brazil is highly admixed, with highly variable ancestry; thus, the genetic determinants of NSCL +/- P susceptibility may be quite different. This study tested association of 8 single-nucleotide polymorphisms (SNPs), previously identified by genome-wide studies in other populations, with NSCL +/- P in a Brazilian population with high African ancestry. SNPs rs560426, rs642961, rs1530300, rs987525, rs3758249, rs7078160, rs17085106, and rs13041247 were genotyped in 293 Brazilian patients with NSCL +/- P and 352 unaffected Brazilian controls. Each sample was also genotyped for 40 biallelic short insertion/deletion polymorphic markers to characterize genetic ancestry. The average African ancestry background was 31.1% for the NSCL +/- P group and 36.7% for the control group. After adjustment for ancestry and multiple testing, the minor alleles of rs3758249 (OR: 1.58, 95% CI: 1.25-2.01, P=0.0001) and rs7078160 (OR: 1.59, 95% CI: 1.21-2.07, P=0.0002) were significantly associated with risk of NSCL +/- P. Polymorphisms located in IRF6 (rs642961) and 8q24 (rs1530300 and rs987525) showed marginal associations in this Brazilian population with high African ancestry. These results indicate that rs3758249 at 9q22 and rs7078160 at 10q25.3 represent risk loci for NSCL +/- P in the Brazilian population with high African ancestry1671023442349CONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICO - CNPQFUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DA BAHIA - FAPESBFUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULO - FAPESP470606/2011-8; 484292/2013-700007/014470606/2011-8; 484292/2013-