Self-Microemulsifying System

Oral route is preferred for drug administration; however according to the recent scenario 40% of new drug candidates have poor water solubility and low bioavailability. One of the biggest challenges in drug delivery science is to improve low oral bioavailability problem which is associated with the hydrophobic drugs due to their unprecedented potential as a drug deliver with the broad range of application. Self-emulsifying systems have been proved as highly useful technological innovations to vanquish such bioavailability problem by virtue of their diminutive globule size, higher solubilization tendency for hydrophobic drugs, robust formulation advantages, and easy to scale up. Self-microemulsifying systems are isotropic mixers of oil, surfactant, drug and co-emulsifier or solubilizer, which spontaneously form transparent micro-emulsions with oil droplets ranging between 100 and 250 nm. Micro emulsified drug can be easily absorbed through the lymphatic pathway and it bypasses the hepatic first-pass effect. Self-microemulsifying system is a thermodynamically stable system and overcomes the drawback of layering of emulsions after sitting for a long period of time. The present literature gives exhaustive information on the formulation design and characterization of self-microemulsifying systems

Broadband X-ray properties of black holes GRS 1758-258 and 1E 1740.7-2942: AstroSat and NuSTAR results

We present the results on broadband X-ray properties of persistent black hole binaries GRS 1758$-$258 and 1E 1740.7$-$2942 using AstroSat, NuSTAR and Swift-XRT observations carried out during 2016$-$2022. We perform spectral modeling of both sources after eliminating the contamination in their \textit{LAXPC} spectra from nearby X-ray sources. Preliminary spectral modelling using Comptonization and line emission ($\sim$ 6.4 keV) models suggest that GRS 1758$-$258 occupies both dim-soft state ($kT_{bb}=0.37\pm0.01$ keV, $\Gamma\sim5.9$, $L_{bol}=1$ of Eddington luminosity L$_{Edd}$) and hard state ($\Gamma=1.64-2.22$, $kT_{e}$=4$-$45 keV, $L_{bol}$=1$-$5 % L$_{Edd}$) that requires a multi-colour disc blackbody model ($kT_{in}=0.54\pm0.01$ keV) occasionally. 1E 1740.7$-$2942 instead is found only in hard state ($\Gamma$=1.67$-$2.32, $kT_{e}$=5$-$16 keV, $L_{bol}$=1$-$2 % L$_{Edd}$). Reflection properties of both sources are studied by applying relativistic reflection model RELXILL to the broadband spectra. Our results from \textit{AstroSat} and \textit{NuSTAR} consistently unveiled the presence of a Comptonizing region along with an ionized reflection region (ionization parameter $log\xi$=2.7$-$3.8 and 2.7$-$4.7 erg cm s$^{-1}$ in GRS 1758$-$258 and 1E 1740.7$-$2942 respectively) in both sources. Reflection modeling revealed GRS 1758$-$258 to have a high metal abundance ($A_{fe}=3.9^{+0.4}_{-0.3}$ times solar metal abundance) and inclination angle ($i$) of $61\pm2^{\circ}$. In case of 1E 1740.7$-$2942, $i$ is constrained to be $55\pm1^{\circ}$. Finally, we discuss the implication of our findings in the context of accretion dynamics by comparing our results with the previous studies.Comment: Accepted for publication in MNRA

Long- and short-range correlations and their event-scale dependence in high-multiplicity pp collisions at 1as = 13 TeV

Two-particle angular correlations are measured in high-multiplicity proton-proton collisions at s = 13 TeV by the ALICE Collaboration. The yields of particle pairs at short-( 06\u3b7 3c 0) and long-range (1.6 < | 06\u3b7| < 1.8) in pseudorapidity are extracted on the near-side ( 06\u3c6 3c 0). They are reported as a function of transverse momentum (pT) in the range 1 < pT< 4 GeV/c. Furthermore, the event-scale dependence is studied for the first time by requiring the presence of high-pT leading particles or jets for varying pT thresholds. The results demonstrate that the long-range \u201cridge\u201d yield, possibly related to the collective behavior of the system, is present in events with high-pT processes as well. The magnitudes of the short- and long-range yields are found to grow with the event scale. The results are compared to EPOS LHC and PYTHIA 8 calculations, with and without string-shoving interactions. It is found that while both models describe the qualitative trends in the data, calculations from EPOS LHC show a better quantitative agreement for the pT dependency, while overestimating the event-scale dependency. [Figure not available: see fulltext.

Observation of flow angle and flow magnitude fluctuations in Pb-Pb collisions at sNN=5.02TeV at the CERN Large Hadron Collider

This Letter reports on the first measurements of transverse momentum dependent flow angle n and flow magnitude vn fluctuations determined using new four-particle correlators. The measurements are performed for various centralities in Pb–Pb collisions at a center-of-mass energy per nucleon pair of √s NN = 5.02 TeV with ALICE at the CERN Large Hadron Collider. Both flow angle and flow magnitude fluctuations are observed in the presented centrality ranges and are strongest in the most central collisions and for a transverse momentum pT > 2 GeV/c. Comparison with theoretical models, including iEBE-VISHNU, MUSIC, and AMPT, show that the measurements exhibit unique sensitivities to the initial state of heavy-ion collisions

First measurement of Ωc 0 production in pp collisions at s=13 TeV

The inclusive production of the charm–strange baryon Omega_c^0 is measured for the first time via its hadronic decay into Omega-pi+ at midrapidity (|y|<0.5) in proton–proton (pp) collisions at the centre-of-mass energy sqrt(s) = 13 TeV with the ALICE detector at the LHC. The transverse momentum (pT) differential cross section multiplied by the branching ratio is presented in the interval 2 < pT < 12 GeV/c . The pT dependence of the Omega_C^0-baryon production relative to the prompt D^0-meson and to the prompt Csi_C^0-baryon production is compared to various models that take different hadronisation mechanisms into consideration. In the measured pT interval, the ratio of the pT-integrated cross sections of Omega_c^0 and prompt Lambda_c^+ baryons multiplied by the Omega- pi+ branching ratio is found to be larger by a factor of about 20 with a significance of about 4σ when compared to e+e- collisions

Charged-particle multiplicity fluctuations in Pb–Pb collisions at √sNN = 2.76 TeV

Measurements of event-by-event fluctuations of charged-particle multiplicities in Pb–Pb collisions at √sNN = 2.76 TeV using the ALICE detector at the CERN Large Hadron Collider (LHC) are presented in the pseudorapidity range |η|<0.8 and transverse momentum 0.2<pT<2.0 GeV/c. The amplitude of the fluctuations is expressed in terms of the variance normalized by the mean of the multiplicity distribution. The η and pT dependences of the fluctuations and their evolution with respect to collision centrality are investigated. The multiplicity fluctuations tend to decrease from peripheral to central collisions. The results are compared to those obtained from HIJING and AMPT Monte Carlo event generators as well as to experimental data at lower collision energies. Additionally, the measured multiplicity fluctuations are discussed in the context of the isothermal compressibility of the high-density strongly-interacting system formed in central Pb–Pb collisions.publishedVersio