The development of an instrument for assessing information security in organizations: Examining the content validity using quantitative methods

Content validity, the extent to which a measurement reflects the specific intended domain of content, is a basic type of validity for a valid measurement. It has usually been examined using qualitative methods and has not been given as much attention as the other psychometric properties such as internal consistency reliability, indicator reliability and construct validity in the IS field. In this paper, a quantitative approach including the proportion of substantive agreement (PSA), and substantive validity (CSV) was used to examine content validity for 80 items covering eighth domains related to organizational and individual perspectives of information security. The content validity for the organizational perspective was examined using data from a total of 56 content domain experts. Data from 51 experts were further used to examine content validity for the individual perspective of information security. 31 items did not have an adequate content validity, leaving the instrument with 49 items that have been evaluated for their content validity and can be used in future empirically tests of hypotheses in the information security field. To the knowledge of the authors this quantitative method to assess content validity of items in the process of developing instruments hasn’t yet been applied in the field information security

Using motivational techniques to reduce cardiometabolic risk factors in long term psychiatric inpatients: A naturalistic interventional study

Background People with severe mental illness have markedly reduced life expectancy; cardiometabolic disease is a major cause. Psychiatric hospital inpatients have elevated levels of cardiometabolic risk factors and are to a high degree dependent of the routines and facilities of the institutions. Studies of lifestyle interventions to reduce cardiometabolic risk in psychiatric inpatients are few. The current study aimed at assessing the feasibility and effects of a lifestyle intervention including Motivational Interviewing (MI) on physical activity levels, cardiometabolic risk status and mental health status in psychotic disorder inpatients. Methods Prospective naturalistic intervention study of 83 patients at long term inpatient psychosis treatment wards in South-Eastern Norway. Patients were assessed 3–6 months prior to, at start and 6 months after a life-style intervention program including training of staff in MI, simple changes in routines and improvements of facilities for physical exercise. Assessments were done by clinical staff and included level of physical activity, motivation, life satisfaction, symptom levels (MADRS, AES-C, PANSS, and GAF) as well as anthropometric and biochemical markers of cardiometabolic risk. A mixed model was applied to analyze change over time. Results A total of 88% of patients received MI interventions, with a mean of 2.5 MI interventions per week per patient. The physical activity level was not increased, but activity level was positively associated with motivation and negatively associated with positive symptoms. Triglyceride levels and number of smokers were significantly reduced and a significant decrease in symptom levels was observed. Conclusions The current results suggest that a simple, low cost life-style intervention program focusing on motivational change is feasible and may reduce symptoms and improve lifestyle habits in psychosis patients in long term treatment facilities. Similar programs may easily be implemented in other psychiatric hospitals.submittedVersio

Information security knowledge sharing in organizations : Investigating the effect of behavioral information security governance and national culture

This paper presents an empirical investigation on what behavioral information security governance factors drives the establishment of information security knowledge sharing in organizations. Data was collected from organizations located in different geographic regions of the world, and the amount of data collected from two countries – namely, USA and Sweden – allowed us to investigate if the effect of behavioral information security governance factors on the establishment of security knowledge sharing differs based on national culture. The study followed a mixed methods research design, wherein qualitative data was collected to both establish the study’s research model and develop a survey instrument that was distributed to 578 information security executives. The results suggest that processes to coordinate implemented security knowledge sharing mechanisms have a major direct influence on the establishment of security knowledge sharing in organizations; the effect of organizational structure (e.g., centralized security function to develop and deploy uniform firm-wide policies, and use of steering committees to facilitate information security planning) is slightly weaker, while business-based information security management has no significant direct effect on security knowledge sharing. A mediation analysis revealed that the reason for the non-significant direct relation between business-based information security management and security knowledge sharing is the fully mediating effect of coordinating information security processes. Thus, the results disentangles the interrelated influences of behavioral information security governance factors on security knowledge sharing by showing that information security governance sets the platform to establish security knowledge sharing, and coordinating processes realize the effect of both the structure of the information security function and the alignment of information security management with business needs. A multigroup analysis identified that national culture had a significant moderating effect on the association between four of the six proposed relations. In Sweden – which is seen as a less individualist, feminine country – managers tend to focus their efforts on implementing controls that are aligned with business activities and employees’ need; monitoring the effectiveness of the implemented controls, and assuring that the controls are not too obtrusive to the end user. On the contrary, US organizations establish security knowledge sharing in their organization through formal arrangements and structures. These results imply that Swedish managers perceive it to be important to involve, or at least know how their employees cope with the decisions that have been made, thus favoring local participation in information security management, while US managers may feel the need to have more central control when running their information security function. The findings suggest that national culture should be taken into consideration in future studies – in particular when investigating organizations operating in a global environment – and understand how it affects behaviors and decision-making. QC 20140520</p

Information security knowledge sharing in organizations : Investigating the effect of behavioral information security governance and national culture

This paper presents an empirical investigation on what behavioral information security governance factors drives the establishment of information security knowledge sharing in organizations. Data was collected from organizations located in different geographic regions of the world, and the amount of data collected from two countries – namely, USA and Sweden – allowed us to investigate if the effect of behavioral information security governance factors on the establishment of security knowledge sharing differs based on national culture. The study followed a mixed methods research design, wherein qualitative data was collected to both establish the study’s research model and develop a survey instrument that was distributed to 578 information security executives. The results suggest that processes to coordinate implemented security knowledge sharing mechanisms have a major direct influence on the establishment of security knowledge sharing in organizations; the effect of organizational structure (e.g., centralized security function to develop and deploy uniform firm-wide policies, and use of steering committees to facilitate information security planning) is slightly weaker, while business-based information security management has no significant direct effect on security knowledge sharing. A mediation analysis revealed that the reason for the non-significant direct relation between business-based information security management and security knowledge sharing is the fully mediating effect of coordinating information security processes. Thus, the results disentangles the interrelated influences of behavioral information security governance factors on security knowledge sharing by showing that information security governance sets the platform to establish security knowledge sharing, and coordinating processes realize the effect of both the structure of the information security function and the alignment of information security management with business needs. A multigroup analysis identified that national culture had a significant moderating effect on the association between four of the six proposed relations. In Sweden – which is seen as a less individualist, feminine country – managers tend to focus their efforts on implementing controls that are aligned with business activities and employees’ need; monitoring the effectiveness of the implemented controls, and assuring that the controls are not too obtrusive to the end user. On the contrary, US organizations establish security knowledge sharing in their organization through formal arrangements and structures. These results imply that Swedish managers perceive it to be important to involve, or at least know how their employees cope with the decisions that have been made, thus favoring local participation in information security management, while US managers may feel the need to have more central control when running their information security function. The findings suggest that national culture should be taken into consideration in future studies – in particular when investigating organizations operating in a global environment – and understand how it affects behaviors and decision-making. QC 20140520</p

Biological Evaluations, NMR Analyses, Molecular Modeling Studies, and Overview of the Synthesis of the Marine Natural Product (−)-Mucosin

Natural products obtained from marine organisms continue to be a rich source of novel structural architecture and of importance in drug discovery, medicine, and health. However, the success of such endeavors depends on the exact structural elucidation and access to sufficient material, often by stereoselective total synthesis, of the isolated natural product of interest. (−)-Mucosin (1), a fatty acid derivative, previously presumed to contain a rare cis-bicyclo[4.3.0]non-3-ene moiety, has since been shown to be the trans-congener. Analytically, the fused bicyclic ring system in (−)-1 constitutes a particular challenge in order to establish its relative and absolute stereochemistry. Herein, data from biological evaluations, NMR and molecular modeling studies of (−)-1 are presented. An overview of the synthetic strategies enabling the exact structural elucidation of (−)-mucosin (1) is also presented

Cardiometabolic risk factors, physical activity and psychiatric status in patients in long-term psychiatric inpatient departments

Purpose: Cardiovascular diseases are a major cause for the markedly reduced life expectancy in people with severe mental illness (SMI). Hospital departments should provide adequate prevention of cardiometabolic risk by optimizing prevention and treatment. Characteristics of cardiometabolic risk factors in inpatients are still not well known. We aimed to describe the status of cardiometabolic risk factors in inpatients with SMI and identify associations with psychiatric status and treatment. Methods: A cross sectional descriptive study of inpatients with SMI from long term psychosis treatment wards in South Eastern Norway was performed. Comprehensive assessments of cardiometabolic risk factors, physical activity, lifestyle habits, symptoms, life satisfaction and treatment were made. Associations and potential prognostic factors were analyzed using linear and logistic regressions. Results: A total of 83 patients were included in the study, but many individual datasets were incomplete. Over half of the subjects had unhealthy eating habits. Obesity (class 1–3) was found in 44%, 23% had elevated fasting triglycerides, 26% had elevated blood pressure and 78% smoked daily. Low levels of physical activity were significantly associated with higher levels of depression (p = .007). A nominal increase in cardiometabolic risk factors was found for olanzapine and clozapine users. Conclusion: Inpatients in long term psychosis treatment wards have alarmingly high cardiometabolic risk. Level of physical activity was associated with both psychiatric and somatic health. Focus on lifestyle and somatic health should be an integral part of the treatment for hospitalized SMI patients.submittedVersio