Gravitational lensing by wave dark matter halos

Wave Dark Matter (WaveDM) has recently gained attention as a viable candidate to account for the dark matter content of the Universe. In this paper we explore the extent to which dark matter halos in this model, and under what conditions, are able to reproduce strong lensing systems. First, we analytically explore the lensing properties of the model -- finding that a pure WaveDM density profile, a soliton profile, produces a weaker lensing effect than other similar cored profiles. Then we analyze models with a soliton embedded in an NFW profile, as has been found in numerical simulations of structure formation. We use a benchmark model with a boson mass of $m_a=10^{-22}{\rm eV}$, for which we see that there is a bi-modality in the contribution of the external NFW part of the profile, and actually some of the free parameters associated with it are not well constrained. We find that for configurations with boson masses $10^{-23}$ -- $10^{-22}{\rm eV}$, a range of masses preferred by dwarf galaxy kinematics, the soliton profile alone can fit the data but its size is incompatible with the luminous extent of the lens galaxies. Likewise, boson masses of the order of $10^{-21}{\rm eV}$, which would be consistent with Lyman-$\alpha$ constraints and consist of more compact soliton configurations, necessarily require the NFW part in order to reproduce the observed Einstein radii. We then conclude that lens systems impose a conservative lower bound $m_a > 10^{-24}$ and that the NFW envelope around the soliton must be present to satisfy the observational requirements.Comment: 26 pages, 7 figures, Publishe

A phase II trial of weekly nab-paclitaxel for progressive and symptomatic desmoid tumors

Desmoid tumors; Phase II trial; PaclitaxelTumores desmoides; Ensayo de fase II; PaclitaxelTumors desmoides; Assaig de fase II; PaclitaxelDesmoid fibromatosis (DF) are mesenchymal neoplasms, with potential aggressive course and relevant clinical impact. New systemic therapy modalities are needed in this symptomatic/progressive population. In this multicenter, phase II trial (NCT03275818), patients with symptomatic/progressing DF received three cycles of weekly nab-paclitaxel. Brief pain inventory short form (BPI-SF) was collected at baseline and in every visit. MRI was performed every 3 months. Primary composite endpoint was RECIST 1.1 overall response rate (ORR) and/or clinical response (improvement ≥ 2 points in BPI-SF). If 40% of patients achieved clinical/radiological response, further investigation would be warranted. Toxicity, progression-free survival (PFS), pattern of response and its correlation with clinical best response and BPI, variation of physical function, and analgesic consumption were secondary endpoints. The translational research reported was not a pre-specified secondary outcome. Forty eligible patients started therapy, being 35 radiologically and clinically evaluable. The study achieved its primary endpoint, as 7(20%) patients obtained RECIST partial response, whereas 31(89%) experienced pain reduction of ≥2 points in BPI-SF worst pain. Therapy was well tolerated. With a median follow-up of 30(14–44) months, median 12 and 24-months PFS rates were 91%(CI 95%, 82–100) and 84%(CI 95%, 71–97). For clinical progression, 12 and 24-months PFS rates were 85% (CI 95%, 73–97) and 74% (CI 95%, 58–90) respectively. Short course of nab-paclitaxel is active, safe and achieves quick and durable responses in progressing/symptomatic DF patients.The authors would like to thank the Spanish group for Research on Sarcomas (GEIS) for supporting the study and BMS/ Celgene (study ID AX-CL-GEIS-007345) for providing drug supply. The sponsor (GEIS) has been in charge of study design, data collection, analysis and manuscript writing. The authors also thank the donors and the University Hospital Virgen del Rocío for participating in patient recruitment. The authors would like to thank Araceli Rodriguez Morales and Gabriela Golab for Data Management. David S. Moura is recipient of a Sara Borrell postdoctoral fellowship funded by the National Institute of Health Carlos III (ISCIII) (CD20/00155). The authors would also like to thank SELNET project. SELNET has received funding from the European Union’s Horizon 2020 research and innovation program under grant agreement No. 825806

Desarrollo de un modelo basado en mimería de datos aplicando el algoritmo Association Rules en la empresa múltiples Equipos y Servicios de Managua en el II Semestre 2015

En el presente trabajo se muestra el análisis e implementación de una solución de minería de datos para la empresa Múltiples Equipos y servicios. Primeramente se analizaron los procesos que realiza la empresa mediante los métodos de recolección de la información, identificando las necesidades y problemas presentes con respecto al flujo de la información, lo que sirvió como base para la creación de la solución. Después del análisis realizado anteriormente se planteó una justificación para en donde se determinó el propósito de este proyecto y que áreas vendría a solucionar con la implementación de esta solución de minería. Una vez ya planteada la justificación para este proyecto se detallan los objetivos planteados. Se detallan una serie de conceptos, características y herramientas utilizadas o con el objetivo de obtener más conocimiento sobre el tema a implementarse en el proyecto. Se describen los métodos de recolección de información utilizados así como también la toma de muestra que se tomó al momento de la entrevista. Luego se muestran los resultados del análisis y el desarrollo de la solución de minería de datos, en donde se presentó la solución a cada objetivo anteriormente planteado. Como primer resultado se presenta el análisis sobre los procesos de las áreas de venta y mercadeo así como la base de datos transaccional que utiliza la empresa, en nuestro segundo resultado se presenta los diferentes proceso que se realizaron para llegar a la implementación del algoritmo de clúster y como nuestro tercer resultado se muestra la evaluación por parte del usuario final. Finalmente se realizó una conclusión sobre el proyecto y se brindaron una serie de recomendaciones para el buen manejo de la solució

Drell-Yan Bounds on Gapped Continuum Spectra

Theories with gapped continuum spectra have gotten some attention, either as pure 4D models like unparticles, or in 5D realizations as certain soft walls constructions. In this paper, we derive experimental bounds from Drell-Yan processes ($pp \to \ell^+\ell^-$, $pp \to \ell^\pm \nu$) in a particular scenario where the electroweak bosons propagate in an extra dimension that produces a propagator with a continuum spectrum, on top of the isolated corresponding Standard Model pole. Using current LHC data we put a lower bound on the gap of 4.2 TeV (expected), 6.2 TeV (observed, bins with $< 10$ events combined) at 95\% CL, with some dependence in the observed limit on how low statistics bins are treated. We also study the limits for HL-LHC.Comment: 12 pages, 3 figure

Laser shock processing as a method of decreasing fatigue of a die-casting die made of maraging steel

Laser Shock Processing (LSP) is a process of laser treatment with a pulsed beam of high-power density. The process generates locally limited mechanical waves that increase the through-depth density of dislocations. This entails a change in mechanical properties, particularly at the workpiece surface. The treatment with laser-induced shock waves is suitable for structural parts and machine elements subjected to high thermo-dynamical loads. LSP can substantially improve the wear resistance, which is of exceptional significance to die-casting tools made of maraging steel. The paper describes the effects of LSP on chosen 12% Ni maraging steel, which is suitable also for the manufacture of tools for die casting of aluminium alloys. After laser treatment, measurements of residual stresses and microhardness and other properties, including surface defects at the micro level, were carried out. The results of the study confirmed that exceptionally favourable residual stresses and microhardness could be obtained

Recent GRBs observed with the 1.23m CAHA telescope and the status of its upgrade

We report on optical observations of Gamma-Ray Bursts (GRBs) followed up by our collaboration with the 1.23m telescope located at the Calar Alto observatory. The 1.23m telescope is an old facility, currently undergoing upgrades to enable fully autonomous response to GRB alerts. We discuss the current status of the control system upgrade of the 1.23m telescope. The upgrade is being done by the ARAE our group, based on members of IAA (Instituto de Astrofiisica de Andalucia). Currently the ARAE group is responsible to develop the BOOTES network of robotic telescopes based on the Remote Telescope System, 2nd Version (RTS2), which controls the available instruments and interacts with the EPICS database of Calar Alto. Currently the telescope can run fully autonomously or under observer supervision using RTS2. The fast reaction response mode for GRB reaction (typically with response times below 3 minutes from the GRB onset) still needs some development and testing. The telescope is usually operated in legacy interactive mode, with periods of supervised autonomous runs under RTS2. We show the preliminary results of several GRBs followed up with observer intervention during the testing phase of the 1.23m control software upgrade.Comment: 15 pages, 7 figures. Accepted for publication in the Special issue "Robotic Astronomy" of Advances in Astronomy. It includes two iterations with the referee

La Teoría de Juegos en la toma de decisiones militares

En este Trabajo de Fin de Grado se expone la rama de las matemáticas conocida como Teoría de Juegos para que pueda ser entendida por un lector sin ningún conocimiento previo de la materia y, una vez explicados los fundamentos, se presentan diversos ejemplos del mundo castrense analizados a través del prisma de dicha teoría. En primer lugar se analizan tres hechos históricos: “La quema de las naves” por Hernán Cortés al desembarcar en México en 1519; “La crisis de los misiles de Cuba”, que enfrentó a los Estados Unidos y a la Unión de Repúblicas Socialistas Soviéticas en 1962; y el conflicto entre la coalición internacional y los talibanes en Afganistán, ya en el siglo XXI. Posteriormente se estudian decisiones militares más habituales, como la organización de un ataque a una posición defensiva enemiga. Por último se explican algunas decisiones militares de bajo nivel, como los duelos con pistola, y se enlaza con las posibles implementaciones de modelos matemáticos en máquinas que puedan sustituir a los soldados en un futuro.<br /

Degradation of 4-Chlorophenol in a Batch Electrochemical Reactor Using BDD Electrodes

The influence of current density (j) (0.25, 0.30, 0.25 and 0.40 A/cm2), initial pH (2.6, 6.5 and 12), stirring speed (As) (400, 500 and 600 rpm), and initial concentration of 4-chlorophenol ([4-CP]0) (300, 500 and 700 mg/L) on degradation of persistent pollutant in a batch electrochemical cell without divisions is presented in this paper. The electrochemical cell was composed of two boron-doped diamond electrodes (BDD). The results of the study showed that best conditions for total degradation of 4-CP were: j of 0.40 A/cm , initial pH of 6.5, As of 500 rpm, and [4-CP]0 of 500 mg/L, after 150 min of reaction time. Removal of total organic carbon (TOC) was 83% at these conditions. The byproducts were identified by UHPLC. This allowed for the proposal of a degradation pathway of 4-CP at the best conditions. Furthermore, these results demonstrate that the electrochemical method employed in this study allows high percentages (96%) of degradation of 4-CP and that the process is applicable to wastewater treatment.CONACYT 26909

Automatización del llenado del tanque de agua en el Hogar Zacarías Guerra

El presente trabajo tiene como objetivo el diseño y construcción de un modelo a escala para el sensado de los tanques del Hogar Zacarías Guerrera, con el objetivo principal de mitigar el gasto económico en los recursos de agua y energía eléctrica, apoyado de herramientas de automatización y control