Estimación de predictor para el tiempo de parada del mantenimiento correctivo usando regresión lineal múltiple;

Objetivos Construir un predictor que permita estimar los valores de tiempo de cambio de estado (del ingles TAT) y usar técnicas de conglomerados para encontrar las posibles causas de los valores no deseados de TAT. Materiales y Métodos Para llevar a cabo esta investigación se realizaron los siguientes pasos: Selección, reducción y caracterización de los datos contenidos en la base de datos bajo estudio y Construcción del Indicador bajo estudio. El indicador bajo estudio fue el tiempo de cambio de estado (por sus siglas en inglés TAT). Resultados Se construyó el nuevo predictor para TAT basado en técnicas de regresión múltiple. Las variables que más contribuyeron a la construcción del nuevo predictor fueron tiempo de respuesta del departamento de IC (CErt), con un coeficiente 0,415 positivo, tiempo de respuesta de entrega de las piezas de repuesto (Stockrt), con un coeficiente de 0,734 positivo, nivel de prioridad del equipamiento (RL), con un coeficiente de 0,25 positivo, y tiempo de servicio de mantenimiento (ST), con un coeficiente de 0.06 positivo. La tecnica de regresión aplicada demostró una fuerte dependencia de las variables Stockrt, CErt, y PL en este orden. Las técnicas de conglomerados encontró las principales causas por las cuales el valor de TAT era demasiado alto. Conclusiones. El estudio demostró que es posible aplicar técnicas de minerías de datos para mejorar la eficiencia de las actividades que se desarrollan en los departamentos de Ingeniería de los hospitales.Objectives This research's main goals were to build a predictor for a turnaround time (TAT) indicator for estimating its values and use a numerical clustering technique for finding possible causes of undesirable TAT values. Materials and methods The following stages were used: domain understanding, data characterisation and sample reduction and insight characterisation. Building the TAT indicator multiple linear regression predictor and clustering techniques were used for improving corrective maintenance task efficiency in a clinical engineering department (CED). The indicator being studied was turnaround time (TAT). Results Multiple linear regression was used for building a predictive TAT value model. The variables contributing to such model were clinical engineering department response time (CErt, 0.415 positive coefficient), stock service response time (Stockrt, 0.734 positive coefficient), priority level (0.21 positive coefficient) and service time (0.06 positive coefficient). The regression process showed heavy reliance on Stockrt, CErt and priority, in that order. Clustering techniques revealed the main causes of high TAT values. Conclusions This examination has provided a means for analysing current technical service quality and effectiveness. In doing so, it has demonstrated a process for identifying areas and methods of improvement and a model against which to analyse these methods' effectiveness

Positioning systems in Minkowski space-time: Bifurcation problem and observational data

In the framework of relativistic positioning systems in Minkowski space-time, the determination of the inertial coordinates of a user involves the {\em bifurcation problem} (which is the indeterminate location of a pair of different events receiving the same emission coordinates). To solve it, in addition to the user emission coordinates and the emitter positions in inertial coordinates, it may happen that the user needs to know {\em independently} the orientation of its emission coordinates. Assuming that the user may observe the relative positions of the four emitters on its celestial sphere, an observational rule to determine this orientation is presented. The bifurcation problem is thus solved by applying this observational rule, and consequently, {\em all} of the parameters in the general expression of the coordinate transformation from emission coordinates to inertial ones may be computed from the data received by the user of the relativistic positioning system.Comment: 10 pages, 7 figures. The version published in PRD contains a misprint in the caption of Figure 3, which is here amende

Evidencias anatómicas de avenidas torrenciales en diferentes especies arbóreas

La caracterización de la respuesta anatómica de árboles afectados por avenidas torrenciales, resulta determinante a la hora de definir indicadores útiles para el estudio de la frecuencia y magnitud del proceso utilizando técnicas dendrogeomorfológicas. Con este propósito, se han analizado 96 muestras provenientes de diferentes especies arbóreas (Pinus pinaster Ait., Quercus pyrenaica Willd., Alnus glutinosa L, Fraxinus angustifolia Vahl. y Populus sp.), de la madera afectada por la carga sólida transportada durante el evento torrencial que tuvo lugar en 1997 en el arroyo Cabrera (Navaluenga, Sierra del Valle, Gredos Oriental). En campo, la toma de muestras consistió en obtener cuñas de madera con una sierra de mano y testigos cilíndricos con barrena Pressler, de aquellos árboles localizados en los bancos de orilla que presentaban descortezados por impacto. En laboratorio se prepararon, a partir de los tejidos vegetales, láminas delgadas obtenidas en sección transversal y con espesores comprendidos entre 10-15 μm. Posteriormente, se procedió a la adquisición de imágenes microscópicas (300 ppp, x 50 aumentos) para el análisis de los diversos parámetros anatómicos cuantitativos y cualitativos mediante el software WinCELL (Regent Instrument). Los resultados obtenidos muestran un cambio claro en los parámetros anatómicos analizados, como respuesta al daño producido por el evento torrencial de 1997. Dependiendo de cada especie, los principales indicadores tuvieron que ver con: el lumen celular de las traqueidas de la madera temprana así como el porcentaje y grosor de la pared celular (en pino); tamaño de los vasos (en aliso, fresno y roble) y dimensiones de las células de madera temprana acompañantes a vasos (aliso y álamo). Por último, también se observó la existencia de falsos anillos (alisos), depósitos gomosos (alisos, robles y fresnos) y presencia de tejidos desestructurados. Estos parámetros se presentan como indicadores útiles para la datación eventos pretéritos en esta zona de estudio y sectores análogos

Differential toxicity of antifungal protein AFP against mutants of Fusarium oxysporum

Antifungal protein (AFP) from Aspergillus giganteus was assayed for toxicity against the Fusarium oxysporum wild-type strain and mutants in genes involved in cell signaling (ΔpacC, pacCc Δfmk1) or cell-wall biogenesis (ΔchsV, Δchs7, Δgas1). The mutants were classified into two groups according to their sensitivity to AFP: ΔpacC, Δgas1 and Δchs7, which were significantly more resistant to AFP than the wild-type, and pacCC, Δfmk1 and ΔchsV, which were more sensitive. Western blot analysis revealed increased binding of AFP to the three resistant mutants, ΔpacC, Δgas1 and Δchs7, but also to ΔchsV, indicating that differential binding may not be a key determinant for sensitivity. Addition of Ca2+ or K+ dramatically reduced antifungal activity and binding of AFP, suggesting that these cations compete for the same targets as AFP at the surface of the fungal cell. [Int Microbiol 2009; 12(2):115-121

Ideal cardiovascular health and incident cardiovascular disease among adults: a systematic review and meta-analysis

Objective: To investigate the association between ideal cardiovascular health (CVH) metrics and incident cardiovascular disease (CVD) by conducting a systematic review and meta-analysis of prospective cohort studies. Methods: The MEDLINE, EMBASE, and CINAHL databases were searched from January 1, 2010 through July 31, 2017, for studies that met the following criteria: (1) prospective studies conducted in adults, (2) with outcome data on CVD incidence and (3) a measure of ideal CVH metrics. Results: Twelve studies (210,443 adults) were included in this analysis. Compared with adults who met 0 to 2 of the ideal CVH metrics (high-risk individuals), a significantly lower hazard for CVD incidence was observed in those who had 3 to 4 points for the ideal CVH metrics (hazard ratio [HR]=0.53; 95% CI, 0.47-0.59) and 5 to 7 points (HR=0.28; 95% CI, 0.23-0.33). Weaker associations were observed in studies with older individuals, suggesting that there is a positive relationship between age and HR. Conclusion: Although meeting 5 to 7 metrics is associated with the lowest hazard for CVD incidence, meeting 3 to 4 metrics still offers an important protective effect for CVD. Therefore, a realistic goal in the general population in the short term could be to promote at least an intermediate ideal CVH profile (3 to 4 metrics)

Evaluación de un panel de microsatélites para el control de filiación en razas caprinas españolas de aptitud cárnica

Hemos evaluado el potencial de 20 microsatélites para la realización de los controles de filiación (paternidad y/o maternidad) de las razas caprinas españolas de aptitud cárnica. En base a sus condi- ciones técnicas hemos seleccionado nueve para este fin para poder compatibilizar la eficiencia con el coste económico. La mayor parte de los marcadores son de origen bovino. De los marcadores seleccio- nados se han calculado los valores del Contenido de Información Polimórfica (PIC), y las probabilida- des de exclusión (PE), por marcador y conjuntas, de un progenitor falso dado como verdadero a partir de las frecuencias alélicas de 30 individuos no emparentados de cada una de las 6 razas caprinas espa- ñolas de aptitud cárnica estudiadas (un total de 180 individuos): Moncaína, Blanca Andaluza, Negra Serrana, Blanca Celtibérica, Pirenaica y Azpi Gorri. Todos los marcadores seleccionados han sido infor- mativos en estas razas. La probabilidad de exclusión conjunta cuando solo un progenitor es conocido ha oscilado entre el 96,4 % en la raza Moncaína y 98,9 % en la raza Blanca Celtibérica siendo en todos las razas superior al 99% cuando se conocen los dos progenitores y queremos testar si la descendencia está asignada correctamente.Assessment of a microsatellite marker set for parentage testing in six Spanish goat breeds We have analysed 20 microsatellite markers on six Spanish goat populations bred for meat produc- tion. Nine loci were selected for parentage testing due to technical reasons. Polymorphic Informative Content (PIC) and parentage exclusion probabilities per marker and for the whole marker set were computed on allele frequencies from a total of 180 unrelated individuals (30 per breed) belonging to six Spanish goat breeds: Moncaína, Blanca Andaluza, Negra Serrana, Blanca Celtibérica, Pirenaica and Azpi Gorri. The nine markers selected were informative. In order to quantify the usefulness of the microsatellite set for parentage testing, we calculated exclusion probabilities for the two most likely scenarios: a) combined probability of exclusion of a parent when the other is known; and b) combined probability of exclusion when both parent are known and one of them is false. The exclusion proba- bility for the scenario a) varied from 96.4 % (Moncaína breed) to 98,9 % (Blanca Celtibérica breed); the exclusion probabilities for the scenario b) were always higher than 99%Ministerio de Educación y Ciencia RZ01-010-

Teaching and learning musical instruments through ICT: the impact of the COVID-19 pandemic lockdown

The COVID-19 lockdown in education institutions required music teachers to use ICTto continue teaching. This research study, with the use of a Likert type online questionnaire, analyses the ICT activities carried out during this period and the learning conceptions they reflect. The questionnaire consisted of the description of activities which varied, depending on the learning promoted (reproductive or constructive), the learning outcomes (verbal, procedural, or attitudinal), the type of assessment to which the activities were directed, and the presence of cooperative activities. The teachers had to indicate the frequency with which they carried out these activities. The questionnaire was completed by 254 instrumental music teachers from different types of institutions and different levels. The main study outcome was that teachers used reproductive activities more frequently than constructive ones. We also found that most activities were those favouring verbal learning and assessment. The cooperative activities were the least frequent. Finally, through a cluster analysis, we identified three teaching profiles depending on the frequency and type of ICT used: Passive, Active, and Interpretative. The variable that produced the most consistent differences was previous ICT useThis work was supported by Ministerio de Ciencia e Innovacion of Spain (PID2020-114177RB-I00). Guadalupe Lopez- Iñiguez was also supported by the Senior Researcher grant “Expanding reflexivity of professional education in music in times of crises” awarded by the Jenny and Antti Wihuri Foundation in Finlan

Nanopartículas metálicas funcionalizadas con el neuropéptido VIP y procedimiento de preparación

Nanopartículas metálicas funcionalizadas con el neuropéptido VIP y procedimiento de preparación. Constituye el objeto de la presente invención nanopartículas metálicas funcionalizadas con el neuropéptido VIP, así como el procedimiento de preparación de dichas nanopartículas. Las nanopartículas objeto de la presente invención presentan uniones selectivas de nanopartículas a péptidos en dos orientaciones posibles, grupo NH2 o grupo COOH. En esta última orientación, los péptidos si son reconocidos por los receptores de membranas celulares, lo que proporciona una herramienta que permite discernir efectos dependientes e independientes de receptor. El péptido empleado ha sido el VIP, mediante el cual se obtiene un amplio espectro de funciones biológicas, incluida inmunomodulación, actuando predominantemente como un potente anti-inflamatorio y un agente inhibidor de la respuesta del Th1 en el sistema inmunitario y emergiendo como un importante factor terapéutico para el tratamiento de enfermedades con componentes inflamatorias y autoinmunes.Universidad Pablo de Olavide, Universidad de Sevilla, Consejo Superior de Investigaciones Científicas (España), Fundación Reina Mercedes para la Investigación SanitariaA1 Solicitud de patentes con informe sobre el estado de la técnic

Retinal-Image Quality and Night-Vision Performance after Alcohol Consumption

Purpose. To evaluate the influence of alcohol consumption on the retinal-image quality and visual performance under surrounding low-illumination conditions. Methods. A volunteer sample of 67 subjects was analyzed. Optical quality of the eye was evaluated by means of the Strehl ratio, the Objective Scattering Index (OSI), and the tear-film quality. We used the visual disturbance index (VDI) to evaluate visual performance under low-illumination conditions and we measured the pupil size under these conditions. The tear-film volume was also measured. All measurements were made before and after alcohol consumption and patients were classified into two groups depending on their breath alcohol content (BrAC): low-alcohol (BrAC < 0.25 mg/L) and high-alcohol content (BrAC ≥ 0.25 mg/L). Results. The VDI was significantly higher after alcohol consumption: the higher the BrAC, the higher the deterioration of the visual discrimination capacity. The pupil size increased significantly for the high-BrAC group. Parameters evaluating optical quality deteriorated after alcohol consumption. Conclusion. The visual performance under low-illumination conditions and the retinal-image quality were deteriorated after alcohol consumption, especially for the high-alcohol group. Furthermore, some physiological changes were observed under effects for high-alcohol contents, such as an increase in the pupil size and disturbances in the tear film, which deteriorated optical quality

ECM deposition is driven by caveolin-1-dependent regulation of exosomal biogenesis and cargo sorting.

The composition and physical properties of the extracellular matrix (ECM) critically influence tumor progression, but the molecular mechanisms underlying ECM layering are poorly understood. Tumor-stroma interaction critically depends on cell communication mediated by exosomes, small vesicles generated within multivesicular bodies (MVBs). We show that caveolin-1 (Cav1) centrally regulates exosome biogenesis and exosomal protein cargo sorting through the control of cholesterol content at the endosomal compartment/MVBs. Quantitative proteomics profiling revealed that Cav1 is required for exosomal sorting of ECM protein cargo subsets, including Tenascin-C (TnC), and for fibroblast-derived exosomes to efficiently deposit ECM and promote tumor invasion. Cav1-driven exosomal ECM deposition not only promotes local stromal remodeling but also the generation of distant ECM-enriched stromal niches in vivo. Cav1 acts as a cholesterol rheostat in MVBs, determining sorting of ECM components into specific exosome pools and thus ECM deposition. This supports a model by which Cav1 is a central regulatory hub for tumor-stroma interactions through a novel exosome-dependent ECM deposition mechanism.This study was supported by the Ministerio de Ciencia, Innovación y Universidades (CSD2009-0016, SAF2014-51876-R, SAF2017-83130-R, BFU2016-81912-REDC, and IGP-SO-MINSEV1512-07-2016); the Fundació La Marató de TV3 (385/C/2019); the Worldwide Cancer Research Foundation (AICR 15-0404); and Fondo Europeo de Desarrollo Regional “Una manera de hacer Europa” (to M.Á. del Pozo). M.Á. del Pozo’s group received funding from the European Union Horizon 2020 research and innovation program under Marie Sklodowska-Curie grant agreement no. 641639. M.Á. del Pozo is a member of the Tec4Bio consortium (ref. S2018/NMT4443; Actividades de I+D entre Grupos de Investigación en Tecnologías, Comunidad Autónoma de Madrid/FEDER, Spain). J. Balsinde was supported by Ministerio de Ciencia, Innovación y Universidades grants SAF2013-48201-R and SAF2016-80883-R, and G. Orend was supported by Institut National de la Santé et de la Recherche Médicale, the University of Strasbourg, the Ligue Contre le Cancer, and the Institut National du Cancer (ref. TENPLAMET). L. Albacete-Albacete was supported by a Ministerio de Ciencia, Innovación y Universidades predoctoral fellowship associated with the Severo Ochoa Excellence program (ref. SVP-2013-06789). I. Navarro-Lérida was supported by a postdoctoral fellowship from the Asociación Española Contra el Cáncer (ref. INVES191NAVA). The Centro Nacional de Investigaciones Cardiovasculares Carlos III is supported by the Ministerio de Ciencia e Innovación and the Pro CNIC Foundation and is a Severo Ochoa Center of Excellence (SEV-2015-0505).S