Objetivos y expectativas del WWDV'94. (Puestos de trabajo equipados con videoterminales)

Sin resume

A method for spreading and cutting flexible sheet materials

Accordingly with the invention, during the spreading phase, plies stacked in each cutting position can be sep- arated into different groups by applying one flexible film ply, called "separator film" between groups. The appli- cation of the separator film is provided by means of a "separating spreader". It is desirable to provide an appa- ratus for separating plies that is efficient and does not increase sheet material spreading time. It is an object of the present invention in its preferred embodiment at least to provide a method for applying separating film that min- imize the time required for spread separating film. It is a further object of the present invention in its preferred em- bodiment at least to provide a method for accommodates a separating film at different heights at different cutting positions in the lay-up. It is a another object of the present invention in its preferred embodiment at least to provide a method that ensure that the separating film is applied without both stopping the sheet material spreading and requiring a spreader set-up operation. Moreover in ac- cordance with the present invention, the spreader is pro- vided by an innovative operating method oriented to the minimization of the number of lay-ups formed Indeed, the lower are the spreading time and the cutting time spent to process the current workload, the higher are the productivity performance of the system. Since the cutting patterns are pre-established, it is an object of the present invention to provide a method to compose single lay-up in order to maximize the length of spread plies (i.e. to minimize supply roll changes and the number of distinct spreading operations) as well as to maximize cutting po- sitions heights (i.e. minimize of the number of cutting po- sitions)

An exact solution to the TLP problem in a NC Machine

This paper considers a job sequencing problem for a single numerical controlled machining center. It is assumed that all the considered jobs must be processed on a single machine provided with a tool magazine with C positions, that no job requires more than C tools to be completely machined and that the tools may be loaded and unloaded from the tool magazine only when the machining operations for each job are completed. The decisional problem is referred to as the tool loading problem (TLP) and it determines the jobs machining sequence as well as the tools to load in the machine tool magazine before the machining operations on each job may start. In industrial cases where the tool switching time is both significant relative to job processing time and proportional to the number of tool switches, the performance criterion is the minimization of the number of tool switches. This paper demonstrates that the TLP is a symmetric sequencing problem. The authors enrich a branch-and-bound algorithm proposed in literature for the TLP with the new symmetric formulation. Computational experiments show the significant improvement obtained by the novel symmetric formulation of the TLP

Robust Batch Process Scheduling in Pharmaceutical Industries: A Case Study

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A significantly improved polymer||Ni(OH)2 alkaline rechargeable battery using anthraquinone-based conjugated microporous polymer anode

Alkaline rechargeable batteries (ARBs) are predicted to be an attractive solution for large-scale electrochemical energy storage applications. However, their advancement is greatly hindered by the lack of high-performance and sustainable anode that can stably operate in less-corroding, low electrolyte concentration. Herein, we report the first example of polymer ARB able to operate in low concentrate electrolyte (1м potassium hydroxide [KOH]) due to the employment of a robust anthraquinone-based conjugated microporous polymer (IEP-11) as anode. The assembled IEP-11||Ni(OH)2 achieves high cell voltage (0.98 V), high gravimetric/areal capacities (150 mAh/g/7.2 mAh/cm2 at 3.5 and 65 mg/cm2, respectively), long cycle life (22,730 cycles, 960 h, 75% capacity retention at 20C), excellent rate performance (75 mAh/g at 50C) and low temperature operativity (75 mAh/g at −10 \ub0C). Furthermore, rate capability, low-temperature performance and ability to prepare high mass loading anodes, along with low self-discharge is improved compared to conventional linear poly (anthraquinone sulfide) (PAQS) in commonly used 10 м KOH. This overall performance for IEP-11||Ni(OH)2 is not only far superior to that of PAQS||Ni(OH)2 owing to porous polymer\u27s high specific surface area, combined micro-/mesoporosity and robust and mechanically stable three-dimensional (3D) architecture compared to the linear PAQS, but also surpass most of the reported organic||nickel [Ni]/cobalt [Co]/manganese [Mn] alkaline rechargeable batteries (ARBs)

On the Use of Self-Organizing Map for Text Clustering in Engineering Change Process Analysis: A Case Study

In modern industry, the development of complex products involves engineering changes that frequently require redesigning or altering the products or their components. In an engineering change process, engineering change requests (ECRs) are documents (forms) with parts written in natural language describing a suggested enhancement or a problem with a product or a component. ECRs initiate the change process and promote discussions within an organization to help to determine the impact of a change and the best possible solution. Although ECRs can contain important details, that is, recurring problems or examples of good practice repeated across a number of projects, they are often stored but not consulted, missing important opportunities to learn from previous projects. This paper explores the use of Self-Organizing Map (SOM) to the problem of unsupervised clustering of ECR texts. A case study is presented in which ECRs collected during the engineering change process of a railways industry are analyzed. The results show that SOM text clustering has a good potential to improve overall knowledge reuse and exploitation

Urantide Conformation and Interaction with the Urotensin-II Receptor

Urotensin II (U-II) is a disulfide bridged peptide hormone identified as the ligand of a G protein-coupled receptor. Human U-II (H-Glu-Thr-Pro-Asp-c[Cys-Phe-Trp-Lys-Tyr-Cys]-Val-OH) has been described as the most potent vasoconstrictor compound identified to date. We have previously identified the compound termed urantide (H-Asp-c[Pen-Phe-DTrp-Orn-Tyr-Cys]-Val-OH), which is the most potent UT receptor (UTR) antagonist described to date. Urantide may have potential clinical value in the treatment of atherosclerosis. In the present study, we studied the conformational preferences of urantide in DPC micelles and developed a urantide/UTR interaction model. This model can help the design of novel peptides and small molecules as UTR antagonists

Acute hepatitis caused by a natural lipid-lowering product: When "alternative" medicine is no "alternative" at all

Background/Aims The general public's growing mistrust of the pharmaceutical industry and its perception of the lack of adverse effects of "natural" therapy have lead to the increasing use of "alternative drugs" for hypercholesterolemia. Methods A sixty-three year old woman presented with severe hypertransaminasemia that had developed progressively over a few weeks. For six months she had been taking Equisterol ® , an over-the-counter lipid-lowering product containing guggulsterol and red yeast rice extract. The product had been prescribed for hypercholesterolemia because the patient had developed hepatotoxicity while on lovastatin. Results Liver biopsy revealed severe lobular necroinflammatory changes with an eosinophilic infiltrate. The episode was regarded as an adverse drug reaction after exclusion of other possible causes of acute liver disease and the prompt normalization of liver function tests after Equisterol ® had been discontinued. Red yeast rice extract's cholesterol-lowering properties are largely due to fungal metabolites known as monacolins, one of which – monacolin K – is identical to lovastatin. Conclusions The choice of an alternative medicine approach in this case subjected the patient to "re-challenge" with the official medicine agent that had previously caused mild hepatotoxicity. Physicians should keep in mind that "alternative" medicine is not always the safest alternative and sometimes it is not even "alternative.

DEVIL'S HERB

We describe a case of Mandragora autumnalis poisoning which occurred in a 72-year-old female patient who had eaten the venenous M. Autumnalis, picked near her home, mistaking it for the edible Borago Officinalis. M. Autumnalis is a solanaceous plant, common in the Sicilian countryside, which contains a variable concentration of solanum alkaloids, causing gastrointestinal irritation, and tropane alkaloids, with anticholinergic properties. Unluckily, M. Autumnalis is often mistaken for the edible B. Officinalis, likewise widespread in Sicilian countryside. The diagnosis of Mandragora poisoning was made on the basis of clinical symptoms and signs of anticholinergic syndrome associated with a history of vegetable meal of uncontrolled origin, moreover analysing the vegetable obtained from gastric lavage. Decontamination and symptomatic treatment were useful in our patient to control acute poisoning