Miguel Pizarro: un intermediario entre España y Japón

El presente trabajo versa sobre la vida y obra de Miguel Pizarro Zambrano, autor que mantuvo una estrecha relación con escritores como Federico García Lorca o María Zambrano y actuó como nexo entre España y Japón durante más de una década. Asimismo, se analiza la presencia de valores estéticos japoneses en su producción literaria y cómo los imbricó con los españoles

Aprender a programar jugando

Hace algunos años, parecía impensable que alguien que no fuera un gran informático pudiera aprender a manifestar sus ideas en lenguaje computacional. Pero en la actualidad, la constante evolución tecnológica ha expandido el uso de código informático a la mayoría de campos profesionales. La programación se ha convertido en una herramienta muy importante en la sociedad y prueba de ello es la aparición de multitud de lenguajes de programación aplicados a numerosos campos, a la vez que progresa el avance tecnológico. Ahora no solamente generan código los ingenieros e informáticos. Economistas, matemáticos, físicos o geógrafos son ejemplos de profesiones que han ido transformándose para poder satisfacer los nuevos retos que surgen hoy en día. La programación se ha convertido en un instrumento esencial en muchos de los caminos laborales. Pero no exclusivamente en este ámbito. Conscientes de este gran auge, numerosos países han introducido en sus escuelas asignaturas de fundamentos de la informática y la programación para que los niños puedan descubrir todo lo que ofrece este mundo y así poder elaborar sus primeros códigos. La sociedad se adentra cada vez más y más en la era digital. La tecnología avanza a pasos agigantados y con ello el deseo y la curiosidad de muchas personas por este mundo. Por ello hay una gran cantidad de gente que, a pesar de no dedicarse en su vida profesional a desarrollar código, ha encontrado en la programación un pasatiempo o una manera de dar forma a sus ideas. Existen multitud de posibilidades para empezar a aprender a programar. Tutoriales gratuitos o de pago, videos en plataformas multimedia, cursos online o presenciales, permiten que cualquier persona puede realizar su primer programa en el lenguaje deseado. A su vez, han aparecido páginas web que ofrecen divertidos juegos para que los niños aprendan a programar. Aprovechando que los niños se inician en el uso de aparatos electrónicos a una edad cada más temprana, estos juegos son una opción muy acertada para que los niños desde una tablet, un ordenador o un smartphone, puedan obtener algunos conocimientos sobre este tema. Aprender a dominar un lenguaje de programación está al alcance de todos. Y a partir de esas ideas surge este proyecto. En este trabajo se quieren desarrollar una serie de juegos que ayuden al jugador a aprender algunos conocimientos de programación. Estos juegos se solucionarán mediante bloques visuales de código que simularán algunos conceptos de programación. Pero para realizar este proyecto primero hay que hacer un estudio sobre las diferentes herramientas que implementan bloques visuales de código, sobre las distintas maneras que hay de realizar un juego y sobre las distintas webs que ofrecen juegos para aprender a programar. Una vez se haya recopilado toda esta información podremos elegir las herramientas más adecuadas para realizar tanto los juegos como sus bloques de código visuales para crear sus soluciones además de conseguir que ambos interactúen entre sí. Así mismo, en esta memoria se pretende mostrar el proceso de creación de juegos con la finalidad de que el usuario aprenda algunos conocimientos de programación mediante la resolución de los mismos con bloques visuales de programación. Ya lo dijo Steve Jobs y parece que cada vez más personas son conscientes de ello: “Everybody in this country should learn to program a computer, because it teaches you how to think”

Controlador de velocidad de una máquina de C.C.: etapa de potencia y regulador

El principal objetivo de este proyecto es la de diseñar un controlador que debe de cumplir las siguientes características: 1. El sistema tendrá una fuente de alimentación de 200 voltios de continua que no admite disipación. 2. La máquina deberá poder trabajar en 4 cuadrantes. 3. Deberá estar provisto de resistencias de frenado. 4. La máquina podrá conectarse a cargas con un momento de inercia 5 veces superior al de la propia máquina. 5. El par de la máquina será capaz de pasar del 0 al par nominal en un tiempo inferior a los 10ms. 6. La maquina deberá tener un comportamiento estable para los diferentes momentos de inercia indicados. 7. Tendrá un mecanismo que limite la velocidad de variación de la velocidad de referencia. 8. El rango de variación de velocidad será de 0 a 100%. 9. Requiere control de par y protección de sobre corriente. 10. Dispondrá de una entrada analógica que variará entre ± 10V para controlar la velocidadEscuela Técnica Superior de Ingeniería IndustrialUniversidad Politécnica de Cartagen

Derivation of HVR1, HVR2 and HVR3 human embryonic stem cell lines from IVF embryos after preimplantation genetic diagnosis (PGD) for monogenic disorder

From 106 human blastocyts donate for research after in vitro fertilization (IVF) and preimplantation genetic diagnosis (PGD) for monogenetic disorder, 3 human embryonic stem cells (hESCs) HVR1, HVR2 and HVR3 were successfully derived. HVR1 was assumed to be genetically normal, HVR2 carrying Becker muscular dystrophy and HVR3 Hemophilia B. Despite the translocation t(9;15)(q34.3;q14) detected in HVR2, all the 3 cell lines were characterised in vitro and in vivo as normal hESCs lines and were registered in the Spanish Stem Cell Bank.Junta de Andalucía FEDER TCMR0021/06, PI246-2008Instituto de Salud Carlos III (FEDER) RD12/0019/0028, RD012/0036/0017, PI10/00964, PI11/02923, PI14/0101

Ultrasound, Echocardiography, MRI, and Genetic Analysis of a Fetus with Congenital Diaphragmatic Hernia and Partial 11q Trisomy

Congenital diaphragmatic hernia (CDH) is a serious birth defect with a significant mortality and morbidity. The current and constant progress in ultrasound techniques has led to the improvement of the prenatal diagnosis of this malformation. CDH is a developmental defect whose etiology is heterogeneous and takes place when the pleuroperitoneal folds and septum transversum fail to converge and fuse. Survival depends on the extent of pulmonary hypoplasia and the disease may be potentially worsened by the presence of added congenital defects. 40% of CDH cases are associated with at least one additional anomaly. The ultrasound diagnosis is established with essential signs: loss of uniform echogenicity of lungs and marked mediastinal shift. We report the case of a fetus with isolated CDH diagnosed at 21 weeks of gestation by ultrasound and confirmed by RMI, whose genetic analysis of amniotic fluid cells identified a de novo partial trisomy of the long arm of chromosome 11. Different genetic causes have been associated with CDH. Moreover, it is expectable that the use of new techniques for prenatal diagnosis will reveal novel CNVs associated with CDH and will help us to estimate the recurrence risk for this defect as well as for other associated anomalies

Influencers on thyroid cancer onset: molecular genetic basis

Thyroid cancer, a cancerous tumor or growth located within the thyroid gland, is the most common endocrine cancer. It is one of the few cancers whereby incidence rates have increased in recent years. It occurs in all age groups, from children through to seniors. Most studies are focused on dissecting its genetic basis, since our current knowledge of the genetic background of the di erent forms of thyroid cancer is far from complete, which poses a challenge for diagnosis and prognosis of the disease. In this review, we describe prevailing advances and update our understanding of the molecular genetics of thyroid cancer, focusing on the main genes related with the pathology, including the di erent noncoding RNAs associated with the disease

Preimplantation Genetic Diagnosis in Europe

In vitro fertilisation (IVF) and preimplantation genetic diagnosis (PGD) are now well-established treatments and are provided in many European countries. However, regulations, practices, professional standards and accreditation requirements are often markedly different between Member States (MS). Differences between MS seem to be becoming especially pronounced because of the interface between assisted reproduction and genetics. To assess the extent of these differences and try to obtain an initial picture of the overall situation in Europe, in March 2005 the Institute for Prospective Technological Studies (IPTS) of the European Commission's Joint Research Centre (JRC), the European Society of Human Genetics (ESHG) and the European Society for Human Reproduction and Embryology (ESHRE) organised a workshop on the abovementioned interface . The two-day event brought together 50 experts from different specialities to review current practices in Europe and discuss potential needs in this area. The first thing that became clear was that no full picture was available of PGD practice and provision in Europe. Secondly, the lack of quality assurance for these services in general was perceived as a potential problem. The participants in the workshop unanimously agreed that European clinics should be certified or accredited and that licensing systems should be developed by professional self-regulation. Minimum quality standards should be set. The lack of common European rules and regulations to guarantee minimum standards was said to be adding to the problem. However, quality assurance and accreditation have taken on new significance in the light of the recent EU Directive 2004/23/EC on setting standards of quality and safety for the donation, procurement, testing, processing, preservation, storage and distribution of human tissues and cells. Thirdly, as a result of the abovementioned differences between MS, patients are travelling abroad to gain access to treatment which is not available in their own country. This, in turn, sometimes requires movements of gametes (oocytes and sperm) and embryos within the EU. Whilst it is known that couples and reproductive tissue are moving around Europe, the extent is not known – especially in the new MS. Lastly, an overview of how the different regulatory frameworks are having an impact on the actual practices of PGD services was deemed necessary in order to gain a better understanding of the trans-border flows. Having pinpointed some of the needs in this area, the IPTS launched this study in an effort to address them and to obtain the missing knowledge on provision of PGD services in Europe. The aims of this study are two-fold: 1)to obtain a clear picture of current PGD practice in Europe, including the quality of the services and cross-border activities (flows of couples or reproductive tissue); 2)to carry out a comparative review of the different regulatory frameworks at MS level and identify potential gaps at European level and the impact these might have.JRC.J.5-Agriculture and Life Sciences in the Econom

Epigenetic Mechanisms in Hirschsprung Disease

Hirschsprung disease (HSCR, OMIM 142623) is due to a failure of enteric precursor cells derived from neural crest (EPCs) to proliferate, migrate, survive or differentiate during Enteric Nervous System (ENS) formation. This is a complex process which requires a strict regulation that results in an ENS specific gene expression pattern. Alterations at this level lead to the onset of neurocristopathies such as HSCR. Gene expression is regulated by different mechanisms, such as DNA modifications (at the epigenetic level), transcriptional mechanisms (transcription factors, silencers, enhancers and repressors), postranscriptional mechanisms (30UTR and ncRNA) and regulation of translation. All these mechanisms are finally implicated in cell signaling to determine the migration, proliferation, differentiation and survival processes for correct ENS development. In this review, we have performed an overview on the role of epigenetic mechanisms at transcriptional and posttranscriptional levels on these cellular events in neural crest cells (NCCs), ENS development, as well as in HSCR.Instituto de Salud Carlos III (ISCIII) PI16/01422Spanish Ministry of Economy and competitiveness PI16/01422European Union PI16/0142