Goal-directed attention alters the tuning of object-based representations in extrastriate cortex

Humans survive in environments that contain a vast quantity and variety of visual information. All items of perceived visual information must be represented within a limited number of brain networks. The human brain requires mechanisms for selecting only a relevant fraction of perceived information for more in-depth processing, where neural representations of that information may be actively maintained and utilized for goal-directed behavior. Object-based attention is crucial for goal-directed behavior and yet remains poorly understood. Thus, in the study we investigate how neural representations of visual object information are guided by selective attention. The magnitude of activation in human extrastriate cortex has been shown to be modulated by attention; however, object-based attention is not likely to be fully explained by a localized gain mechanism. Thus, we measured information coded in spatially distributed patterns of brain activity with fMRI while human participants performed a task requiring selective processing of a relevant visual object category that differed across conditions. Using pattern classification and spatial correlation techniques, we found that the direction of selective attention is implemented as a shift in the tuning of object-based information representations within extrastriate cortex. In contrast, we found that representations within lateral prefrontal cortex (PFC) coded for the attention condition rather than the concrete representations of object category. In sum, our findings are consistent with a model of object-based selective attention in which representations coded within extrastriate cortex are tuned to favor the representation of goal-relevant information, guided by more abstract representations within lateral PFC

Masked alkynes for synthesis of threaded carbon chains

Polyynes are chains of sp1 carbon atoms with alternating single and triple bonds. As they become longer, they evolve towards carbyne, the 1D allotrope of carbon, and they become increasingly unstable. It has been anticipated that long polyynes could be stabilized by supramolecular encapsulation, by threading them through macrocycles to form polyrotaxanes—but, until now, polyyne polyrotaxanes with many threaded macrocycles have been synthetically inaccessible. Here we show that masked alkynes, in which the C≡C triple bond is temporarily coordinated to cobalt, can be used to synthesize polyrotaxanes, up to the C68 [5]rotaxane with 34 contiguous triple bonds and four threaded macrocycles. This is the length regime at which the electronic properties of polyynes converge to those of carbyne. Cyclocarbons constitute a related family of molecular carbon allotropes, and cobalt-masked alkynes also provide a route to [3]catenanes and [5]catenanes built around cobalt complexes of cyclo[40]carbon and cyclo[80]carbon, respectively

Seahorse Brood Pouch Transcriptome Reveals Common Genes Associated with Vertebrate Pregnancy

Viviparity (live birth) has evolved more than 150 times in vertebrates, and represents an excellent model system for studying the evolution of complex traits. There are at least 23 independent origins of viviparity in fishes, with syngnathid fishes (seahorses and pipefish) unique in exhibiting male pregnancy. Male seahorses and pipefish have evolved specialized brooding pouches that provide protection, gas exchange, osmoregulation, and limited nutrient provisioning to developing embryos. Pouch structures differ widely across the Syngnathidae, offering an ideal opportunity to study the evolution of reproductive complexity. However, the physiological and genetic changes facilitating male pregnancy are largely unknown. We used transcriptome profiling to examine pouch gene expression at successive gestational stages in a syngnathid with the most complex brood pouch morphology, the seahorse Hippocampus abdominalis. Using a unique time-calibrated RNA-seq data set including brood pouch at key stages of embryonic development, we identified transcriptional changes associated with brood pouch remodeling, nutrient and waste transport, gas exchange, osmoregulation, and immunological protection of developing embryos at conception, development and parturition. Key seahorse transcripts share homology with genes of reproductive function in pregnant mammals, reptiles, and other live-bearing fish, suggesting a common toolkit of genes regulating pregnancy in divergent evolutionary lineage

Luminosity distance and redshift in the Szekeres inhomogeneous cosmological models

The Szekeres inhomogeneous models can be used to model the true lumpy universe that we observe. This family of exact solutions to Einstein's equations was originally derived with a general metric that has no symmetries. In this work, we develop and use a framework to integrate the angular diameter and luminosity distances in the general Szekeres models. We use the affine null geodesic equations in order to derive a set of first-order ordinary differential equations that can be integrated numerically to calculate the partial derivatives of the null vector components. These equations allow the integration in all generality of the distances in the Szekeres models and some examples are given. The redshift is determined from simultaneous integration of the null geodesic equations. This work does not assume spherical or axial symmetry, and the results will be useful for comparisons of the general Szekeres inhomogeneous models to current and future cosmological data.Comment: 14 pages, 1 figure, matches JCAP accepted versio

Variable stars in the field of the old open cluster Melotte 66

We report the results of photometric monitoring of the Melotte 66 field in BVI filters. Ten variables were identified with nine being new discoveries. The sample includes eight eclipsing binaries of which four are W UMa type stars, one star is a candidate blue straggler. All four contact binaries are likely members of the cluster based on their estimated distances. Ten blue stars with U-B<-0.3 were detected inside a 14.8 x 22.8 arcmin^2 field centred on the cluster. Time series photometry for 7 of them showed no evidence for any variability. The brightest object in the sample of blue stars is a promising candidate for a hot subdwarf belonging to the cluster. We show that the anomalously wide main sequence of the cluster, reported in some earlier studies, results from a combination of two effects: variable reddening occuring across the cluster field and the presence of a rich population of binary stars in the cluster itself. The density profile of the cluster field is derived and the total number of member stars with 16<V<21 or 2.8<M_{V}<7.8 is estimated conservatively at about 1100.Comment: 8 pages, 12 figures, accepted to MNRAS - 29 June 200

Spaceflight Payload Design, Flight Experience G-408

Worcester Polytechnic Institute\u27s first payload of spaceflight experiments flew aboard Columbia, STS-40, during June of 1991 and culminated eight years of work by students and faculty. The Get Away Special (GAS) payload was installed on the GAS bridge assembly at the aft end of the cargo bay behind the Spacelab Life Sciences (SLS-l) laboratory. The experiments were turned on by astronaut signal after reaching orbit and then functioned for 72 hours. Environmental and experimental measurements were recorded on three cassette tapes which, together with zeolite crystals grown on orbit, formed the basis of subsequent analyses. The experiments were developed over a number of years by undergraduate students meeting their project requirements for graduation. The experiments included zeolite crystal growth, fluid behavior, and microgravity acceleration measurement in addition to environmental data acquisition. Preparation also included structural design, thermal design, payload integration, and experiment control. All of the experiments functioned on orbit and the payload system performed within design estimates

Chiral Extrapolations and Exotic Meson Spectrum

We examine the chiral corrections to exotic meson masses calculated in lattice QCD. In particular, we ask whether the non-linear chiral behavior at small quark masses, which has been found in other hadronic systems, could lead to large corrections to the predictions of exotic meson masses based on linear extrapolations to the chiral limit. We find that our present understanding of exotic meson decay dynamics suggests that open channels may not make a significant contribution to such non-linearities whereas the virtual, closed channels may be important.Comment: 13 pagers, 2 figure

Multidimensional quantum entanglement with large-scale integrated optics

The ability to control multidimensional quantum systems is key for the investigation of fundamental science and for the development of advanced quantum technologies. Here we demonstrate a multidimensional integrated quantum photonic platform able to robustly generate, control and analyze high-dimensional entanglement. We realize a programmable bipartite entangled system with dimension up to $15 \times 15$ on a large-scale silicon-photonics quantum circuit. The device integrates more than 550 photonic components on a single chip, including 16 identical photon-pair sources. We verify the high precision, generality and controllability of our multidimensional technology, and further exploit these abilities to demonstrate key quantum applications experimentally unexplored before, such as quantum randomness expansion and self-testing on multidimensional states. Our work provides a prominent experimental platform for the development of multidimensional quantum technologies.Comment: Science, (2018

Turbulent Magnetic Field Amplification from Spiral SASI Modes: Implications for Core-Collapse Supernovae and Proto-Neutron Star Magnetization

We extend our investigation of magnetic field evolution in three-dimensional flows driven by the stationary accretion shock instability (SASI) with a suite of higher-resolution idealized models of the post-bounce core-collapse supernova environment. Our magnetohydrodynamic simulations vary in initial magnetic field strength, rotation rate, and grid resolution. Vigorous SASI-driven turbulence inside the shock amplifies magnetic fields exponentially; but while the amplified fields reduce the kinetic energy of small-scale flows, they do not seem to affect the global shock dynamics. The growth rate and final magnitude of the magnetic energy are very sensitive to grid resolution, and both are underestimated by the simulations. Nevertheless our simulations suggest that neutron star magnetic fields exceeding $10^{14}$ G can result from dynamics driven by the SASI, \emph{even for non-rotating progenitors}.Comment: 28 pages, 17 figures, accepted for publication in the Ap