Organising anarchy spatial strategy prefiguration and the politics of everyday life

PhDThis research is an analysis of efforts to develop a politics of everyday life through embedding anarchist and left-libertarian ideas and practices into community and workplace organisation. It investigates everyday life as a key terrain of political engagement, interrogating the everyday spatial strategies of two emerging forms of radical politics. The community dimension of the research focuses on two London-based social centre collectives, understood as community-based, anarchist-run political spaces. The Industrial Workers of the World (IWW), an international trade union that organises along radical left-libertarian principles, comprises the workplace element. The empirical research was conducted primarily through an activist-ethnographic methodology. Based in a politically-engaged framework, the research opens up debates surrounding the role of place-based class politics in a globalised world, and how such efforts can contribute to our understanding of social relations, place, networks, and political mobilisation and transformation. The research thus contributes to and provides new perspectives on understanding and enacting everyday spatial strategies. Utilising Marxist and anarchist thought, the research develops a distinctive theoretical framework that draws inspiration from both perspectives. Through an emphasis on how groups seek to implement particular radical principles, the research also explores the complex interactions between theory and practice in radical politics. I argue that it is in everyday spaces and practices where we find the most powerful sources for political transformation. Grassroots politics are most 3 effective when enacted through everyday place-based relations. Prefigurative spatial strategies enacted by the groups studied not only strive to create relations fit for a post-capitalist society, but also seek to mobilise and articulate their politics in ways that are tailored to the specific context of struggle. Thus, groups such as social centres and the IWW can tell us a lot about how utopian ideas can be directly relevant to immediate everyday material needs and experiences

Sustainability Leadership For The Energy Transition: A Case Study Of Role-Playing To Enhance Authentic Learning

To lead the energy transition, effective sustainability leadership requires a spectrum of skills, knowledge and understanding across technical, financial and even political disciplines. An innovative, authentic learning initiative has been designed and implemented in which Master of Sustainable Energy students conducted team-based role-playing activities, responding to a realistic, hypothetical energy policy scenario in the form of a government announcement and other mock collateral. Groups were assigned the personas of a range of industry stakeholders and prepared presentations (and accompanying media statements and position papers) for a mock online media conference. The initiative leveraged the diversity of the cohort, enabling constructive interactions and an appreciation of the impacts of energy policy on a variety of organisations and wider society. Entry and exit surveys affirmed that participants gained a deeper understanding of key issues, constraints, alternative views and approaches involved in navigating the policy pathways to sustainability. The teaching staff also observed a high level of student engagement. Challenges of group dynamics and teaching effort were felt to be outweighed by the benefits reaped by students, particularly in terms of deeper conceptual knowledge and an understanding of perspectives in the energy transition. The case study also found that the online nature of the media conference enhanced student innovation and engagement. The framework of the case study may nudge other educators towards greater use of role-playing activities in sustainability leadership pedagogy

Hearing through your eyes: neural basis of audiovisual cross-activation, revealed by transcranial alternating current stimulation

Some people experience auditory sensations when seeing visual flashes or movements. This prevalent synaesthesia-like ‘visual-evoked auditory response’ (vEAR) could result either from over-exuberant cross-activation between brain areas, and/or reduced inhibition of normally-occurring cross-activation. We have used transcranial alternating current stimulation (tACS) to test these theories. We applied tACS at 10Hz (alpha-band frequency) or 40Hz (gamma-band), bilaterally either to temporal or occipital sites, while measuring same/different discrimination of paired auditory (A) versus visual (V) 'Morse code' sequences. At debriefing, participants were classified as vEAR or non-vEAR depending on whether they reported 'hearing' the silent flashes. In non-vEAR participants, temporal 10Hz tACS caused impairment of A performance, which correlated with improved V; conversely under occipital tACS, poorer V performance correlated with improved A. This reciprocal pattern suggests that sensory cortices are normally mutually inhibitory, and that alpha-frequency tACS may bias the balance of competition between them. vEAR participants showed no tACS effects, consistent with reduced inhibition, or enhanced cooperation between modalities. In addition, temporal 40Hz tACS impaired V performance, specifically in individuals who showed a performance advantage for V (relative to A). Gamma-frequency tACS may therefore modulate the ability of these individuals to benefit from recoding flashes into the auditory modality, possibly by disrupting cross-activation of auditory areas by visual stimulation. Our results support both theories, suggesting that vEAR may depend on disinhibition of normally-occurring sensory cross-activation, which may be expressed more strongly in some individuals. Furthermore, endogenous alpha and gamma-frequency oscillations may function respectively to inhibit or promote this cross-activation

A New Study of the Polarized Parton Densities in the Nucleon

We present a new next-to-leading order QCD analysis of the world data on inclusive polarized deep inelastic lepton-nucleon scattering adding to the old set of data the final SMC results, the HERMES proton and very recent SLAC/E155 deuteron data. We find an excellent fit to the data and present results for the polarized parton densities in different factorization schemes. These results are in a good agreement with what follows from the theory. We have also found that the main effect of the newly incorporated data is a better determination of the polarized gluon density.Comment: 9 pages, latex, 5 ps figures Presented at the 7th International Workshop on Deep Inelastic Scattering and QCD, Zeuthen, Germany, April 19-23, 199

High Corticosterone, Not High Energy Cost, Correlates with Reproductive Success in the Burrow-Nesting Ancient Murrelet

Theory and observations suggest that offspring abandonment in animals may occur when the costs to future reproductive output of current reproductive effort outweigh the fitness benefits of rearing the current brood. While hormonal cues (i.e. corticosterone) or energy reserves are believed to be involved, few studies have directly focused on the proximate cues influencing behaviours directly related to reproductive success. To address this information gap, we determined the incubation metabolic rates and corticosterone (CORT) levels of naturally fasting and freely incubating ancient murrelets (Synthliboramphus antiquus). Respiratory quotient (RQ) increased with date, suggesting that incubating ancient murrelets shifted from strictly lipid-based metabolism towards more protein-based metabolism as incubation progressed. Birds that hatched only one nestling had higher levels of circulating CORT than those which hatched two, suggesting that birds which laid only a single egg found incubation more stressful than those which laid two. However, CORT levels and incubation shift lengths were not correlated, suggesting that birds that undertook prolonged incubation shifts did so only when their energy stores were not jeopardized

Road and bridge construction across gypsum karst in England

Gypsum karst problems in the Permian and Triassic sequences of England have caused difficult conditions for bridge and road construction. In Northern England, the Ripon Bypass crosses Permian strata affected by active gypsum karst and severe subsidence problems. Here, the initial borehole site investigation for the road was supplemented by resistivity tomography studies. The roadway was reinforced with two layers of tensile membrane material within the earth embankment. This will prevent dangerous catastrophic collapse, but will allow sagging to show where problems exist. The River Ure Bridge was constructed across an area of subsidence pipes filled with alluvial deposits. It was built with extra strength, larger than normal foundations. If one pier fails, the bridge is designed for adjacent arches to span the gap without collapse. The bridge piers are also fitted with electronic load monitoring to warn of failure. In the Midlands area of England, road construction over Triassic gypsum has required a phase of ground improvement on the Derby Southern Bypass. Here, the gypsum caps a hill where it was formerly mined; it dips through a karstic dissolution zone into an area of complete dissolution and collapse. The road and an associated flyover were built across these ground conditions. A major grouting program before the earthworks began treated the cavities in the mine workings and the cavernous margin of the gypsum mass. Within the karstic dissolution zone, gypsum blocks and cavities along the route were identified by conductivity and resistivity geophysical surveys, excavated and backfilled. In the areas of complete dissolution and collapse, the road foundation was strengthened with vibrated stone columns and a reinforced concrete road deck was used

A mixture of U.S. Food and Drug Administration-approved monoaminergic drugs protects the retina from light damage in diverse models of night blindness

Purpose: The purpose of this study was to test the extent of light damage in different models of night blindness and apply these paradigms in testing the therapeutic efficacy of combination therapy by drugs acting on the Gi, Gs, and Gq protein-coupled receptors. Methods: Acute bright light exposure was used to test susceptibility to light damage in mice lacking the following crucial phototransduction proteins: rod transducin (GNAT1), cone transducin (GNAT2), visual arrestin 1 (ARR1), and rhodopsin kinase 1 (GRK1). Mice were intraperitoneally injected with either vehicle or drug combination consisting of metoprolol (β1-receptor antagonist), bromocriptine (dopamine family-2 receptor agonist) and tamsulosin (α1-receptor antagonist) before bright light exposure. Light damage was primarily assessed with optical coherence tomography and inspection of cone population in retinal whole mounts. Retinal inflammation was assessed in a subset of experiments using autofluorescence imaging by scanning laser ophthalmoscopy and by postmortem inspection of microglia and astrocyte activity. Results: The Gnat1-/- mice showed slightly increased susceptibility to rod light damage, whereas the Gnat2-/- mice were very resistant. The Arr1-/- and Grk1-/- mice were sensitive for both rod and cone light damage and showed robust retinal inflammation 7 days after bright light exposure. Pretreatment with metoprolol + bromocriptine + tamsulosin rescued the retina in all genetic backgrounds, starting at doses of 0.2 mg/kg metoprolol, 0.02 mg/kg bromocriptine, and 0.01 mg/kg tamsulosin in the Gnat1-/- mice. The therapeutic drug doses increased in parallel with light-damage severity. Conclusions: Our results suggest that congenital stationary night blindness and Oguchi disease patients can be at an elevated risk of the toxic effects of bright light. Furthermore, systems pharmacology drug regimens that stimulate Gi signaling and attenuate Gs and Gq signaling present a promising disease-modifying therapy for photoreceptor degenerative diseases

Intercontinental transport of pollution manifested in the variability and seasonal trend of springtime O3 at northern middle and high latitudes

Observations (0–8 km) from the Tropospheric Ozone Production about the Spring Equinox (TOPSE) experiment are analyzed to examine air masses contributing to the observed variability of springtime O3 and its seasonal increase at 40°–85°N over North America. Factor analysis using the positive matrix factorization and principal component analysis methods is applied to the data set with 14 chemical tracers (O3, NOy, PAN, CO, CH4, C2H2, C3H8, CH3Cl, CH3Br, C2Cl4, CFC-11, HCFC-141B, Halon-1211, and 7Be) and one dynamic tracer (potential temperature). Our analysis results are biased by the measurements at 5–8 km (70% of the data) due to the availability of 7Be measurements. The identified tracer characteristics for seven factors are generally consistent with the geographical origins derived from their 10 day back trajectories. Stratospherically influenced air accounts for 14 ppbv (35–40%) of the observed O3 variability for data with O3concentrations \u3c100 ppbv at middle and high latitudes. It accounts for about 2.5 ppbv/month (40%) of the seasonal O3 trend at midlatitudes but for only 0.8 ppbv/month (\u3c20%) at high latitudes, likely reflecting more vigorous midlatitude dynamical systems in spring. At midlatitudes, reactive nitrogen-rich air masses transported through Asia are much more significant (11 ppbv in variability and 3.5 ppbv/month in trend) than other tropospheric contributors. At high latitudes the O3 variability is significantly influenced by air masses transported from lower latitudes (11 ppbv), which are poor in reactive nitrogen. The O3 trend, in contrast, is largely defined by air masses rich in reactive nitrogen transported through Asia and Europe across the Pacific or the Arctic (3 ppbv/month). The influence from the stratospheric source is more apparent at 6–8 km, while the effect of O3 production and transport within the troposphere is more apparent at lower altitudes. The overall effect of tropospheric photochemical production, through long-range transport, on the observed O3 variability and its seasonal trend is more important at high latitudes relative to more photochemically active midlatitudes

Body Reprogramming for fibromyalgia and central sensitivity syndrome: A preliminary evaluation

Objectives: Central sensitivity syndrome disorders such as fibromyalgia, provoke continued debate, highlighting diagnostic and therapeutic uncertainty. The Hyland model provides a way of understanding and treating the medically unexplained symptoms of central sensitivity syndromes using complexity theory and principles of adaption in network systems. The body reprogramming is a multi-modal intervention based on the Hyland model designed for patients living with medically unexplained symptoms. This preliminary, naturalistic and single-arm service evaluation set out to evaluate outcome after attending a body reprogramming course in patients living with fibromyalgia or central sensitivity syndrome. Methods: Patients diagnosed with fibromyalgia or central sensitivity syndrome were recruited. The body reprogramming courses consisting of eight sessions, each 2.5 h in length, were run at two study sites in England. Data were collected at baseline, post course and 3-months post course using questionnaires assessing symptomatology (FIQR/SIQR), Depression (PHQ9), Anxiety (GAD7) and quality of life (GQoL). Repeated measures t-tests were used, and all comparisons were conducted on an intention to treat basis. Results: In total, 198 patients with a mean age of 47.73 years were enrolled on the body reprogramming courses. Statistically and clinically significant improvement were observed in the FIQR from baseline to post course (mean change: 11.28) and baseline to follow-up (mean change: 15.09). PHQ9 scores also improved significantly from baseline to post course (mean reduction 3.72) and baseline to follow-up (mean reduction 5.59). Conclusions: Our study provides first evidence that the body reprogramming intervention is an effective approach for patients living with fibromyalgia or central sensitivity syndromes on a variety of clinical measures. Besides these promising results, important limitations of the study are discussed, and larger randomized controlled trials are clearly warranted