5,691 research outputs found

    Rhythms and Archetypes of Contemplation: An Afro-Boricua Experience

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    A critical appropriation of the prophetic imagination can orient us to emergent strategies for a more interdependent commons. Given the precarious times of the Anthropocene in which we are living, a contemplative hermeneutic that responds to enduring oppressive relational practices is necessary. This reflective treatise expounds on three archetypes that underpin the exploration of an Afro-Caribbean experience that is also a contemplative practice: the Barril de Bomba, Bomba, and Flamboyán. I argue these archetypes as poetics can orient us to new relational possibilities

    Features or forensic pathology in sudden cardiac death: are there histologic indicators of acute myocardial ischemia?

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    Thesis (M.S.)--Boston UniversityThe following thesis proposes the question if current scientific data supports the hypothesis that an acute myocardial infarction, not identified by gross symptoms, can be visualized by using apoptotic signaling biomarkers as a diagnostic tool to complement a post-mortem autopsy. The biochemistry and mechanisms of irreversible cellular death is presented and supported through published experimental, clinical and case studies. Furthermore, the aforesaid biomarkers have been observed in the cardiac myocyte in elevated levels associated with hypoxic ischemia. In addition, the physical characteristic of DNA fragmentation is addressed to visualize apoptotic injury due to hypoxic ischemic conditions. Although the quality of evidence lacked published data to suggest one immunochemical staining method positively identifies a myocardial infarction, there is adequate data to suggest that a combination of staining methods can be utilized as a tool to positively identify and diagnose an acute myocardial infarction

    Collaboration in the Context of Teaching, Scholarship, and Language Revitalization: Experience from the Chatino Language Documentation Project

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    We describe our own experience of linguist-community collaboration over the last ten years in our Chatino Language Documentation Project, focused on the Chatino languages (Otomanguean; Oaxaca, Mexico). We relate episodes in the emergence and evolution of the collaboration between ourselves, and of the collaboration among ourselves and the Chatino communities with which we have worked. Our experience has several special features. First, our own collaboration began as native Chatino-speaking Ph.D. student and her teacher in a program focused on training speakers of Latin American indigenous languages in linguistics and anthropology, and developed into a larger collaboration among students and faculty where the student had a major leadership role. Second, our approach was documentary-descriptive and comparative, but it was also socially engaged or ‘activist,’, in that we sought to promote interest, awareness, and respect for the Chatino languages, to teach and support Chatino literacy, and to preserve and offer access to spoken Chatino, especially traditional verbal art. Our approach had synergies with local interests in writing and in honoring traditional speech ways, but it also led to conflicts over our roles as social actors, and the traditionally activist roles of indigenous teachers. Third, we experienced plasticity in the collaborative roles we played. Between ourselves, we were student and teacher, but also initiator and follower as we became engaged in revitalization. At the same time, the native speaker linguist found herself occupying a range of positions along a continuum from “insider” to “outsider” respect to her own community. *This paper is in the series Language Documentation in the Americas edited by Keren Rice and Bruna FranchettoNational Foreign Language Resource Cente

    Finding a way into a family of tone languages: The story and methods of the Chatino Language Documentation Project

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    We give a narrative description of our ten-year path into the elaborate tonal systems of the Chatino languages (Otomanguean; Oaxaca, Mexico), and of some of the methods we have used and recommend, illustrated with specific examples. The work, ongoing at the time of writing, began when one of us (Cruz), a native speaker of San Juan Quiahije Chatino, entered the University of Texas at Austin as a Ph.D. student and formed, together with the other of us (Woodbury), a professor there, the Chatino Language Documentation Project, ultimately incorporating five other Ph.D. students and two other senior researchers. We argue for the importance of an interplay among speaker and non-speaker perspectives over the long course of work; a mix of introspection, hypothesis-testing, natural speech recording, transcription, translation, grammatical analysis, and dictionary-making as research methods and activities; an emphasis on community training as an active research context; the simultaneous study of many varieties within a close-knit language family to leverage progress; and the use of historical-comparative methods to get to know tonal systems and the roles they play at a deeper level. *This paper is in the series How to Study a Tone Language, edited by Steven Bird and Larry HymanNational Foreign Language Resource Cente

    Start-up vibration analysis for novelty detection on industrial gas turbines

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    This paper focuses on industrial application of start-up vibration signature analysis for novelty detection with experimental trials on industrial gas turbines (IGTs). Firstly, a representative vibration signature is extracted from healthy start-up vibration measurements through the use of an adaptive neuro-fuzzy inference system (ANFIS). Then, the first critical speed and the vibration level at the critical speed are located from the signature. Finally, two (s- and v-) health indices are introduced to detect and identify different novel/fault conditions from the IGT start-ups, in addition to traditional similarity measures, such as Euclidean distance and cross-correlation measures. Through a case study on IGTs, it is shown that the presented approach provides a convenient and efficient tool for IGT condition monitoring using start-up field data

    Extracellular ATP triggers proteolysis and cytosolic Ca²⁺ rise in Plasmodium berghei and Plasmodium yoelii malaria parasites.

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    BACKGROUND: Plasmodium has a complex cell biology and it is essential to dissect the cell-signalling pathways underlying its survival within the host. METHODS: Using the fluorescence resonance energy transfer (FRET) peptide substrate Abz-AIKFFARQ-EDDnp and Fluo4/AM, the effects of extracellular ATP on triggering proteolysis and Ca²⁺ signalling in Plasmodium berghei and Plasmodium yoelii malaria parasites were investigated. RESULTS: The protease activity was blocked in the presence of the purinergic receptor blockers suramin (50 μM) and PPADS (50 μM) or the extracellular and intracellular calcium chelators EGTA (5 mM) and BAPTA/AM (25, 100, 200 and 500 μM), respectively for P. yoelii and P. berghei. Addition of ATP (50, 70, 200 and 250 μM) to isolated parasites previously loaded with Fluo4/AM in a Ca²⁺-containing medium led to an increase in cytosolic calcium. This rise was blocked by pre-incubating the parasites with either purinergic antagonists PPADS (50 μM), TNP-ATP (50 μM) or the purinergic blockers KN-62 (10 μM) and Ip5I (10 μM). Incubating P. berghei infected cells with KN-62 (200 μM) resulted in a changed profile of merozoite surface protein 1 (MSP1) processing as revealed by western blot assays. Moreover incubating P. berghei for 17 h with KN-62 (10 μM) led to an increase in rings forms (82% ± 4, n = 11) and a decrease in trophozoite forms (18% ± 4, n = 11). CONCLUSIONS: The data clearly show that purinergic signalling modulates P. berghei protease(s) activity and that MSP1 is one target in this pathway

    The Spacing Effect in Remote Information-Integration Category Learning

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    The present study examined whether the temporal distribution of procedural category learning experiences would impact learning outcomes. Participants completed the remote category learning study on a smartphone in one of two learning conditions: Massed (control) or distributed. Consistent with expectations, distributed learners reached higher accuracy levels. This effect disappeared after accounting for reaction time differences, suggesting that it was driven by attentional mechanisms. Distribution may have made participants more likely discover the optimal categorization strategy and more robust to sensory habituation. Counter to previous findings, participants favored distributed learning. These results suggest that adult category learning is facilitated by temporal spacing. Future work may further explore the effects of temporal and contextual distinctiveness of learning experiences on category learning outcomes

    The Relationship Between Parental Involvement and the Persistence of First-Generation Hispanic Millennial College Students

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    This dissertation was undertaken to answer the following research question: What is the relationship between parental involvement and college generation status with the persistence of Hispanic Millennial college students? Social capital theory (Coleman, 1988) was used as a theoretical framework to analyze and gain a greater understanding of the factors that correlated with the persistence of first-generation Hispanic Millennial college students. This dissertation used an ex post facto with hypothesis research design. The research hypothesis was that parental involvement would be positively related with the second-year persistence of first-generation Hispanic Millennial college students. This dissertation used the data collected from 1179 Hispanic students who participated in the ELS: 2002 and enrolled in college. Logistic regression analysis of data from 972 of the students with completed surveys were used to examine the relationship between the dependent variable, which was student persistence to the second year, and the following independent variables: socio-economic status, family income, high school grade point average, gender, financial aid, highest degree ever expected, academic engagement, social engagement, college generation, and parental involvement. This dissertation’s findings show that parental involvement was not statistically associated with persistence to the second year of college, but that high school grade point average, highest degree expected, academic engagement, and the interaction between parental involvement and college generation were. While the findings do not support the hypothesis, they provide some evidence that may be supportive of the argument that recommendations that may affect degree expectations, high school GPA, and academic engagement of first generation Hispanic Millennial college students may be positively related to their college persistence

    Development of a steady-state thermodynamic model in Microsoft Excel for performance analysis of industrial gas turbines

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    In this paper, an off-design performance prediction model for a single shaft industrial gas turbine (IGT) using Microsoft Excel with Visual Basic for Applications (VBA) programming is presented. The modelling architecture is comprised of fundamental thermodynamic equations describing the performance of IGTs. A graphical user interface has been constructed to allow an easy interaction of the model to predict IGT performance at different operating conditions. Component characteristic maps for the compressor and turbine with a bilinear interpolation method have been implemented in the Excel modelling architecture. A commercial thermodynamic toolbox (Thermolib, EUtech Scientific Engineering GmbH) which is compatible with Simulink environment has been considered to validate Excel model of the IGT system. This Excel modelling architecture could be a valuable reference tool for engineers and students to understand IGT performance at different ambient and operating conditions

    The use of remotely sensed environmental parameters for spatial and temporal schistosomiasis prediction across climate zones in Ghana

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    Schistosomiasis control in sub-Saharan Africa is enacted primarily through preventive chemotherapy. Predictive models can play an important role in filling knowledge gaps in the distribution of the disease and help guide the allocation of limited resources. Previous modeling approaches have used localized cross-sectional survey data and environmental data typically collected at a discrete point in time. In this analysis, 8 years (2008-2015) of monthly schistosomiasis cases reported into Ghana's national surveillance system were used to assess temporal and spatial relationships between disease rates and three remotely sensed environmental variables: land surface temperature (LST), normalized difference vegetation index (NDVI), and accumulated precipitation (AP). Furthermore, the analysis was stratified by three major and nine minor climate zones, defined using a new climate classification method. Results showed a downward trend in reported disease rates (~ 1% per month) for all climate zones. Seasonality was present in the north with two peaks (March and September), and in the middle of the country with a single peak (July). Lowest disease rates were observed in December/January across climate zones. Seasonal patterns in the environmental variables and their associations with reported schistosomiasis infection rates varied across climate zones. Precipitation consistently demonstrated a positive association with disease outcome, with a 1-cm increase in rainfall contributing a 0.3-1.6% increase in monthly reported schistosomiasis infection rates. Generally, surveillance of neglected tropical diseases (NTDs) in low-income countries continues to suffer from data quality issues. However, with systematic improvements, our approach demonstrates a way for health departments to use routine surveillance data in combination with publicly available remote sensing data to analyze disease patterns with wide geographic coverage and varying levels of spatial and temporal aggregation.Accepted manuscrip
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