576 research outputs found
Nanowires for Room-Temperature Mid-Infrared Emission
InAs-based nanowires hold a promise to offer transformational technologies for infrared photonic applications. Site-controlled InAs nanowire growth on low-cost Si substrates offers the practical integration advantages that silicon photonics benefits from. This includes the realisation of cheap photonic circuitries, light emitters and detectors that are otherwise expensive to realise with III/V material-based substrates. This chapter details the growth development of advanced faceted multi-quantum well structures within InAs nanowires using molecular beam epitaxy. We review the crystal structure for the faceted quantum wells along with an analysis of their optical emission characteristics which shows quantum confinement and localisation of the carriers on the quantum well nanostructure. This enables tuning of the emission wavelength and enhanced emission intensity up to the technologically important room-temperature operation point
A noninvasive multi-analyte diagnostic assay: Combining protein and DNA markers to stratify bladder cancer patients
Purpose: The authors recently reported the development of a noninvasive diagnostic assay using urinary matrix metalloproteinases (MMPs) as monitors of disease-free status and bladder cancer in high-risk populations. Using an approach called clinical intervention determining diagnostic (CIDD), they identified with high confidence those patients who could be excluded from additional intervention. To maximize performance, MMPs were combined with DNAbased markers and CIDD was applied to a population of patients undergoing monitoring for recurrence. Patients and methods: Urine samples were obtained from 323 patients, 48 of whom had a recurrence and 275 of whom did not have cancer upon cytoscopic evaluation. Twist1 and Nid2 methylation status was determined using methylation-specific polymerase chain reaction, FGFR3 mutational status by quantitative PCR, and MMP levels by enzyme-linked immunosorbent assay. Results: Using a combination of these DNA and protein markers, the authors identified with high confidence (97% negative predicted value) those patients who do not have cancer. Cutoffs were adjusted such that at 92% sensitivity, 51% of disease-free patients might be triaged from receiving further tests. Conclusion: The multi-analyte diagnostic readout assay described here is the first to combine protein and DNA biomarkers into one assay for optimal clinical performance. Using this approach, the detection of FGFR3 mutations and Twist1 and Nid2 methylation in the urine of patients undergoing bladder cancer recurrence screening increase the sensitivity and negative predictive value at an established MMP protein cutoff. This noninvasive urinary diagnostic assay could lead to the more efficient triage of patients undergoing recurrence monitoring
A real quaternion spherical ensemble of random matrices
One can identify a tripartite classification of random matrix ensembles into
geometrical universality classes corresponding to the plane, the sphere and the
anti-sphere. The plane is identified with Ginibre-type (iid) matrices and the
anti-sphere with truncations of unitary matrices. This paper focusses on an
ensemble corresponding to the sphere: matrices of the form \bY= \bA^{-1} \bB,
where \bA and \bB are independent matrices with iid standard
Gaussian real quaternion entries. By applying techniques similar to those used
for the analogous complex and real spherical ensembles, the eigenvalue jpdf and
correlation functions are calculated. This completes the exploration of
spherical matrices using the traditional Dyson indices .
We find that the eigenvalue density (after stereographic projection onto the
sphere) has a depletion of eigenvalues along a ring corresponding to the real
axis, with reflective symmetry about this ring. However, in the limit of large
matrix dimension, this eigenvalue density approaches that of the corresponding
complex ensemble, a density which is uniform on the sphere. This result is in
keeping with the spherical law (analogous to the circular law for iid
matrices), which states that for matrices having the spherical structure \bY=
\bA^{-1} \bB, where \bA and \bB are independent, iid matrices the
(stereographically projected) eigenvalue density tends to uniformity on the
sphere.Comment: 25 pages, 3 figures. Added another citation in version
Crkva sv. Križa u Križevcima
When invasive species become integrated within a food web, they may have numerous direct and indirect impacts on the native community by creating novel trophic links, and modifying or disrupting existing ones. Here we discuss these impacts by drawing on examples from freshwater ecosystems, and argue that future research should quantify changes in such trophic interactions (i.e. the links in a food web), rather than simply focusing on traditional measures of diversity or abundance (i.e. the nodes in a food web). We conceptualise the impacts of invaders on trophic links as either direct consumption, indirect trophic effects (e.g. cascading interactions, competition) or indirect nontrophic effects (e.g. behaviour mediated). We then discuss how invader impacts on trophic links are context-dependent, varying with invader traits (e.g. feeding rates), abiotic variables (e.g. temperature, pH) and the traits of the receiving community (e.g. predators or competitors). Co-occurring invasive species and other environmental stressors, such as climate change, will also influence invader impacts on trophic links. Finally, we discuss the available methods to identify new food web interactions following invasion and to quantify how invasive species disrupt existing feeding links. Methods include direct observations in the field, laboratory trials (e.g. to quantify functional responses) and controlled mesocosm experiments to elucidate impacts on food webs. Field studies which use tracer techniques, such as stable isotope analyses, allow diet characterisation of both invaders and interacting native species in the wild. We conclude that invasive species often drastically alter food webs by creating and disrupting trophic links, and future research should be directed particularly towards disentangling the effects of invaders from other environmental stressors
Tetracycline Treatment Retards the Onset and Slows the Progression of Diabetes in Human Amylin/Islet Amyloid Polypeptide Transgenic Mice
Nuclear shadowing in polarized DIS on ^6LiD at small x and its effect on the extraction of the deuteron spin structure function g_{1}^{d}(x,Q^2)
We consider the effect of nuclear shadowing in polarized deep inelastic
scattering (DIS) on ^6LiD at small Bjorken x and its relevance to the
extraction of the deuteron spin structure function g_{1}^{d}(x,Q^2). Using
models, which describe nuclear shadowing in unpolarized DIS, we demonstrate
that the nuclear shadowing correction to g_{1}^{d}(x,Q^2) is significant.Comment: 17 pages, 2 figure
A-dependence of nuclear transparency in quasielastic A(e,e'p) at high Q^2
The A-dependence of the quasielastic A(e,e'p) reaction has been studied at
SLAC with H-2, C, Fe, and Au nuclei at momentum transfers Q^2 = 1, 3, 5, and
6.8 (GeV/c)^2. We extract the nuclear transparency T(A,Q^2), a measure of the
average probability that the struck proton escapes from the nucleus A without
interaction. Several calculations predict a significant increase in T with
momentum transfer, a phenomenon known as Color Transparency. No significant
rise within errors is seen for any of the nuclei studied.Comment: 5 pages incl. 2 figures, Caltech preprint OAP-73
The Hamiltonian limit of (3+1)D SU(3) lattice gauge theory on anisotropic lattices
The extreme anisotropic limit of Euclidean SU(3) lattice gauge theory is
examined to extract the Hamiltonian limit, using standard path integral Monte
Carlo (PIMC) methods. We examine the mean plaquette and string tension and
compare them to results obtained within the Hamiltonian framework of Kogut and
Susskind. The results are a significant improvement upon previous Hamiltonian
estimates, despite the extrapolation procedure necessary to extract
observables. We conclude that the PIMC method is a reliable method of obtaining
results for the Hamiltonian version of the theory. Our results also clearly
demonstrate the universality between the Hamiltonian and Euclidean formulations
of lattice gauge theory. It is particularly important to take into account the
renormalization of both the anisotropy, and the Euclidean coupling ,
in obtaining these results.Comment: 10 pages, 11 figure
Measurement of the Neutron Spin Structure Function with a Polarized ^3He Target
Results are reported from the HERMES experiment at HERA on a measurement of
the neutron spin structure function in deep inelastic scattering
using 27.5 GeV longitudinally polarized positrons incident on a polarized
He internal gas target. The data cover the kinematic range
and . The integral evaluated at a fixed of is . Assuming Regge behavior at low , the first
moment is .Comment: 4 pages TEX, text available at
http://www.krl.caltech.edu/preprints/OAP.htm
Measurement of the B0-anti-B0-Oscillation Frequency with Inclusive Dilepton Events
The - oscillation frequency has been measured with a sample of
23 million \B\bar B pairs collected with the BABAR detector at the PEP-II
asymmetric B Factory at SLAC. In this sample, we select events in which both B
mesons decay semileptonically and use the charge of the leptons to identify the
flavor of each B meson. A simultaneous fit to the decay time difference
distributions for opposite- and same-sign dilepton events gives ps.Comment: 7 pages, 1 figure, submitted to Physical Review Letter
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