93 research outputs found

    Emotional intelligence: influencing factors and impact on nurses in intensive care

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    Objetivo : analisar as evidências sobre os fatores que influenciam a inteligência emocional dos enfermeiros de cuidados intensivos. Métodos : revisão sistemática da literatura. Recorreu-se às bases de dados CINAHL Complete, Academic Search Complete, MedicLatina, Psychology and Behavioral Sciences Collection, MedLine with Full Text (via EBSCO HOST), MedLine Complete (via PubMed), SCOPUS e outras fontes como Google Scholar, sites de registro de ensaios clínicos e busca manual-referências cruzadas. Foram encontrados 1.307 artigos publicados até abril de 2018, sendo incluídos nove. Resultados : os fatores que influenciaram a inteligência emocional dos enfermeiros foram a idade, sexo, experiência emocional, formação e personalidade; e o impacto da inteligência emocional traduziu-se a nível pessoal, profissional e no cuidar. Conclusão : a prática de enfermagem em unidades de cuidados intensivos é influenciada pela inteligência emocional do enfermeiro. Esta inteligência é afetada por diversos fatores e, por ser apreendida, deve ser estimulada em contextos formativos.Objective : to analyze the evidence on the factors that influence the emotional intelligence of intensive care nurses. Methods : systematic review of the literature. We used the databases CINAHL Complete, Academic Search Complete, MedicLatina, Psychology and Behavioral Sciences Collection, MedLine with Full Text (via EBSCO HOST), MedLine Complete (via PubMed), SCOPUS and other sources, such as Google Scholar, clinical trial registration sites and manual/cross-references search. A total of 1,307 articles were published until April 2018, and nine were included in the study. Results : the factors that influenced nurses’ emotional intelligence were age, sex, emotional experience, training and personality; and the impact of emotional intelligence was translated on a personal, professional and caring level. Conclusion : the practice of nursing in intensive care units is influenced by the nurse’s emotional intelligence. This intelligence is affected by several factors and, because it is learned, must be stimulated in formative contexts.info:eu-repo/semantics/publishedVersio

    Comparação entre modos de gestão nas diferentes estruturas organizacionais da construção civil

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    As pesquisas apontam a existência de três modos genéricos de lidar com as incertezas:controle, flexibilidade e folgas. São estes modos que garantem a robustez organizacional epermitem a gestão proativa e reativa frente aos eventos que ocorrem durante o projeto.Tradicionalmente, a gestão de obras tem sido fortemente baseada no exercício do controlecombinado ao uso de folgas. Contudo, o crescente reconhecimento da complexidade dosprojetos tem quebrado paradigmas e gerado mudanças estruturais fundamentadas emestratégias de flexibilidade. Uma destas estratégias baseia-se na formação de estruturasorganizacionais achatadas caracterizadas pela autonomação e descentralização, cuja facemais visível é a implantação de equipes multifuncionais trabalhando segundo o conceito decélula de produção. Neste artigo são analisadas as mudanças na estrutura organizacional ena tomada de decisão dos gestores decorrentes da implementação desta estratégia. Paraefeitos comparativos, o estudo foi realizado através de entrevistas em cinco empresasconstrutoras que adotam diferentes estruturas. Os resultados mostram que a implantaçãobem sucedida da estratégia de flexibilidade requer mudanças nos mecanismos de controle donível operacional e nas decisões sobre uso de folgas do nível tático.Palavras-chave: Estrutura organizacional, Robustez, Células de produçã

    The earlier Mousterian in westernmost Iberia: geoarchaeology of Cobrinhos site in the Tejo River terrace staircase of Vila Velha de Ródão (Portugal

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    Cobrinhos is a Middle Paleolithic site found during the construction of a paper factory, in the winter of 2014, in Vila Velha do Ródão, Central inland Portugal. In this region, the staircase terraces has six steps (T1 to T6), but Paleolithic is only found in the T4, T5 and T6. The T4 is dated of ca. 340 ka to 155 ka, with Acheulean at the basal levels (ca. 340 to 325 ka), later Acheulean at the middle levels (ca. 325 to 200 ka) and early Mousterian at the upper levels (ca. 165 to 155 ka). Cobrinhos is in a colluvium that links to the top of the T4 terrace, has the same geochemical component (reddish clay-sand sediments) that characterizes the T1 to T4 terraces, which is considerably different from that of the T5 and T6. Despite disturbed by recent plowing, the site shows an evenly distribution of sizes and shapes of the lithic assemblage, thousands of implements <30mm, a coherence the Mousterian assemblage and absence of Acheulean or Upper Paleolithic-on tools. The lithic assemblage comprises extensive, intensive and pre-determinate reductions. Extensive reduction was opportunistic and aimed the production of large flakes that were used as without retouch and as cores. Intensive reduction was mostly centripetal and unipoloar unidireccional for the production of medium and small flakes. Pre-determinate reduction includes Levallois preferential, Levallois recurrent and Discoidal for the production of medium and small Levallois flakes and points, Pseudo-levalois points and blades. The combination of data suggests that the colluvium unit is coeval of the deposition of the T4 topmost deposits and that Cobrinhos is in its original geomorphological context. Based on these, we believe to be possible to establish a probable age of ca. 165 to 155 ka for the site, but, this age needs to be supported by more finite absolute ages to be gathered in the near future. These results are of relevance in the scope of the investigation about the demise of archaic Pleistocene human populations and the proliferation of Neanderthal groups

    Ocupações pleistocénicas da margem esquerda do Baixo Minho (Miño/Minho2): objetivos e primeiros resultados de um projeto transfronteiriço

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    As mais antigas investigações arqueológicas no âmbito do Paleolítico da bacia hidrográfica do rio Minho (NW Peninsular) iniciaram-se na primeira metade do século XX. Por esta mesma altura realizaram-se também os primeiros estudos geomorfológicos na região, que permitiram correlacionar artefactos líticos com terraços fluviais.Durante a segunda metade daquele mesmo século, o estudo do Paleolítico ocorreu essencialmente na Galiza, ficando em Portugal reduzido a trabalhos pontuais e geograficamente circunscritos. A partir de 2010 assiste-se, igualmente na Galiza, ao desenvolvimento de um projecto de investigação que possibilitou não só a identificação de novos sítios arqueológicos, como também a sua datação absoluta, remetendo-os para o Plistocénico médio. A elaboração do projecto Miño-Minho, cujos primeiros resultados agora se apresentam, teve como principal objectivo dar continuidade na margem portuguesa a estes trabalhos iniciados no país vizinho.The earliest archaeological research on the Palaeolithic of the Minho River Basin (NW Iberia) took place in the first half of the 20th century. At the same time, geomorphological studies were developed in the region allowing the connection between lithic artefacts and fluvial terraces. In the second half of this century the studies on the Palaeolithic occurred mainly in Galicia, while in Portugal they were short-term and focused on geographically confined areas. From 2010 onwards, also in Galicia, a research project was developed which enabled the detection of new archaeological sites and their absolute dating, assigning them to the Middle Pleistocene. Thedevelopment of the Miño-Minho project, whose first results are now presented, had as its main objective to carry on in the Portuguese bank the research initiated in the neighboring country

    Genetic variation in PFKFB3 impairs antifungal immunometabolic responses and predisposes to Invasive Pulmonary Aspergillosis

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    Copyright © 2021 Gonçalves et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license.Activation of immune cells in response to fungal infection involves the reprogramming of their cellular metabolism to support antimicrobial effector functions. Although metabolic pathways such as glycolysis are known to represent critical regulatory nodes in antifungal immunity, it remains undetermined whether these are differentially regulated at the interindividual level. In this study, we identify a key role for 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 (PFKFB3) in the immunometabolic responses to Aspergillus fumigatus. A genetic association study performed in 439 recipients of allogeneic hematopoietic stem cell transplantation (HSCT) and corresponding donors revealed that the donor, but not recipient, rs646564 variant in the PFKFB3 gene increased the risk of invasive pulmonary aspergillosis (IPA) after transplantation. The risk genotype impaired the expression of PFKFB3 by human macrophages in response to fungal infection, which was correlated with a defective activation of glycolysis and the ensuing antifungal effector functions. In patients with IPA, the risk genotype was associated with lower concentrations of cytokines in the bronchoalveolar lavage fluid samples. Collectively, these findings demonstrate the important contribution of genetic variation in PFKFB3 to the risk of IPA in patients undergoing HSCT and support its inclusion in prognostic tools to predict the risk of fungal infection in this clinical setting. IMPORTANCE The fungal pathogen Aspergillus fumigatus can cause severe and life-threatening forms of infection in immunocompromised patients. Activation of glycolysis is essential for innate immune cells to mount effective antifungal responses. In this study, we report the contribution of genetic variation in the key glycolytic activator 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 (PFKFB3) to the risk of invasive pulmonary aspergillosis (IPA) after allogeneic hematopoietic stem cell transplantation. The PFKFB3 genotype associated with increased risk of infection was correlated with an impairment of the antifungal effector functions of macrophages in vitro and in patients with IPA. This work highlights the clinical relevance of genetic variation in PFKFB3 to the risk of IPA and supports its integration in risk stratification and preemptive measures for patients at high risk of IPA.This work was supported by the Fundação para a Ciência e Tecnologia (FCT) (PTDC/SAU-SER/29635/2017, PTDC/MED-GEN/28778/2017, UIDB/50026/2020, and UIDP/50026/2020), the Northern Portugal Regional Operational Program (NORTE 2020), under the Portugal 2020 Partnership Agreement, through the European Regional Development Fund (ERDF) (NORTE-01-0145-FEDER-000039), the Institut Mérieux (Mérieux Research Grant 2017), the European Society of Clinical Microbiology and Infectious Diseases (ESCMID Research Grant 2017), the European Union’s Horizon 2020 research and innovation program under grant agreement no. 847507, and the “la Caixa” Foundation (ID 100010434) and FCT under the agreement LCF/PR/HR17/52190003. Individual support was provided by FCT (SFRH/BD/136814/2018 to S.M.G., PD/BD/137680/2018 to D.A., CEECIND/04058/2018 to C.C., and CEECIND/03628/2017 to A.C.). M.G.N. was supported by an ERC Advanced Grant and a Spinoza Grant of the Netherlands Organization for Scientific Research.info:eu-repo/semantics/publishedVersio
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