7 research outputs found
Stereoselective Synthesis of 2-Oxyenamides
- Publication venue
- Publication date
- 06/07/2022
- Field of study
An improved route for the highly stereoselective synthesis of (Z)-2-oxyenamides is reported. The desired products can be accessed in only three steps from aminoacetaldehyde dimethyl acetal as common, readily available building block in a highly modular fashion. The improved procedure has been applied to the synthesis of various acylated and sufonylated oxyenamides. Mechanistic and theoretical studies provide a conclusive rationale for the observed stereoselectivities
Stereoselective Synthesis of 2-Oxyenamides
- Publication venue
- WILEY-V C H VERLAG GMBH
- Publication date
- 01/01/2022
- Field of study
An improved route for the highly stereoselective synthesis of (Z)-2-oxyenamides is reported. The desired products can be accessed in only three steps from aminoacetaldehyde dimethyl acetal as common, readily available building block in a highly modular fashion. The improved procedure has been applied to the synthesis of various acylated and sufonylated oxyenamides. Mechanistic and theoretical studies provide a conclusive rationale for the observed stereoselectivities
Incidence of severe critical events in paediatric anaesthesia (APRICOT): a prospective multicentre observational study in 261 hospitals in Europe
- Author
- Aantaa Riku
- Abdel-Hafiz Mostafa
- Abdelaal Amr
- Abou-Samra Mark
- Absalom Anthony
- Acevedo Bambaren Ismael
- Adam Christian
- Adriaens Veronique
- Afshari Arash
- Ahmed Samira
- Alanoglu Zekeriyya
- Albarello Raffaella
- Albokrinov Andrew
- Alders David
- Alderson Peter
- Alexandri Bogdan
- Ali Eissa Eid Mohamed
- Alkis Neslihan
- Allen Claire
- Allison Celia
- Almenrader Nicole
- Amaral Rosa
- Amory Catherine
- Ancupans Agris
- Anders Kroken Bjørn
- Anders Nicola
- Angadi Pradeep
- Angeles Sanz M.
- Anselmi Irene
- Anselmi Luciano
- Antonio Idone Francesco
- Anuncia Escontrela Rodríguez Blanca
- Armoniene Inesa
- Artes David
- Aslami Hamid
- Astuto Marinella
- Audren Noémie
- Aurilio Caterina
- Ayyash Reema
- Babici Remus
- Badarau Victoria
- Badeti Rodica
- Baethge Sabine
- Bakken Boerke Wenche
- Balamat Stefania
- Bandrabur Daniela
- Banerjee Indrani
- Banus Ester
- Bapat Smita
- Baraggia Paolo
- Barak Yuri
- Baranowski Artur
- Barber Nicola
- Barbera Cinzia
- Barbunc Danut
- Bari Francoise
- Baris Sibel
- Barlow Victoria
- Barr Katharine
- Bartholomew Karen
- Bartkowska-Sniatkowska Alicja
- Barzdina Arta
- Basiewicz Ewa
- Basov Mikhail
- Bassett Mike
- Batoz Hélène
- Bauer Annette
- Bauer Martin
- Bauer Michael
- Baujard Catherine
- Bauwman Arthur
- Beate Solas Anne
- Becke Karin
- Becke Karin
- Begec Zekine
- Bekavac Ivan
- Bell Graham
- Bell Sarah J
- Benito Pilar
- Berger Jelena
- Berghmans Johan
- Bergland Unni
- Bergsma Margot
- Bermede Onat
- Bernhard Eich Christoph
- Bernotiene Aurelija
- Berton Jerome
- Bevilacqua Michela
- Bew Stephanie
- Bird Victoria
- Birliba Mihaela-Petronela
- Biskupova Vera
- Bloomfield Tom
- Blythe Elizabeth
- Boda Krisztina
- Boda Krisztina B
- Boegli Yann
- Bollinger Matthias
- Book Malte
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- Bortone Luciano
- Boryshkevych Ivanna
- Bourdaud Nathalie
- Boyd Matthew
- Boyle David
- Bracci Paolo
- Brackhahn Michael
- Bradbury Carol L.
- Breschan Christian
- Brezac Gilles
- Briggs Sandra
- Brotatsch Philipp
- Browning Mike
- Budic Ivana
- Buhre Wolfgang
- Busche René
- Busi Ilaria
- Bussolin Leonardo
- Butkovic Diana
- Butler Patrick
- Byers Gordon
- Börjesson Glenda
- Bøttger Morten
- Cabanova Barbora
- Cagney Brid
- Cakar Turhan K. Sanem
- Calderini Edoardo
- Calvao Santos Carolina
- Camporesi Anna
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- Chapotte Catherine
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- Checuti Sarah
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- Chirichiello Luca
- Chizhov Dmitri
- Chlopin Mikhail
- Chloropoulou Pelagia
- Christian Nilsson Jens
- Chrysi Mpratzou
- Cigdem Tütüncü Ayse
- Cillis Annagrazia
- Cimpeanu Luminita
- Cindea Iulia
- Ciobanu Tudor
- Clausen Nicola G.
- Cloherty Marianne
- Cnudde Steven
- Cohen Marc
- Colbus Laurent
- Coppens Marc
- Corouge Julien
- Cortegiani Andrea
- Coucke Patricia
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- Cristina Mondardini Maria
- Cuciuc Veaceslav
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- Domingas Patuleia M.
- Domínguez Fernando
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- Eberl Susanne
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- Ellekvist Marguerite B.
- Ellerkmann Richard
- Ellwood James
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- Eniko Kovacs
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- Gutierrez Ignacio
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- Gymoese Berthelsen Kasper
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- Habre Walid
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- Hamonic Yann
- Hannie J.
- Hansen Tom G
- Hansen Tom G.
- Hanula Miloslav
- Happo Johanna
- Harden Alison
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- McKee Lesley
- Megens A. M.
- Meijer Patrick
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- Russell William
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- Stevens France
- Stevens Markus F
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- Steward Heather
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- Taylor Matthew
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- Teresa Rocha Maria
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- Thil Elke
- Thomas Alun
- Thomas Deborah
- Thomson Wendy
- Tielens Luc
- Tognon Costanza
- Tolasov Konstantin
- Toller Wolfgang
- Tomlinson William
- Tonise Virge
- Tore Altun Gülbin
- Trabkin Evelina
- Trante Irinel
- Trieschmann Uwe
- Trifan Oana
- Trikash Nikolay
- Tsiotou Adelais
- Turner Nigel M.
- Uhrig Lynn
- Ullensvang Kyrre
- Ulrici Johanna
- Umuroglu Tumay
- Underhill Helen
- Urbanec René
- Vaidyanath Chandra
- Vail Hannah
- Vaitoskaite Agne
- Vallejo Tarrat Andrea
- Valzan Silvia
- van de Riet Yvette
- Van de Velde Anne
- Van Deenen Denise
- Van Den Eynde Nancy
- van der Knijff - van Dortmont Anouk
- van der Marel Caroline
- van der Schatte Olivier Roelof
- Van Der Werff Désirée B. M.
- van der Zwan Tim
- van Doorn Thea
- Van Hecke Rachel
- Van Limmen Jurgen
- Van Mossevelde Veerle
- van Osch Rob
- Van Reeth Veronique
- van Stijn Mireille F M
- Vanpeteghem Caroline
- Varyvoda Mykhailo
- Vason Milo
- Velcev Ana
- Veldhuizen Marianne
- Verchere-Montmayeur Juliette
- Vermeulen Petronella M
- Vermeulen Petronella M
- Veyckemans Francis
- Veyckemans Francis
- Viacava Rosanna
- Viken Oddbjorn
- Vilo Sanna
- Virag Katalin
- Vittinghoff Maria
- Vittori Alessandro
- Vodianytskyi Sergii
- Voet Marieke
- Volger Hauke
- Volkers Martin
- Volpe Claudia
- Vons Mark Hendriks Kristy
- Vossen Carine
- Wai Carolynn
- Wappler Frank
- Wasiluk Malgorzata
- Watson Karen
- Weber Stefan
- Weinlichova Stanislava
- Weiss Katja
- Wellesley Hugo
- Wensing Renee T. M.
- Weyland Andreas
- Whiteside Jeanette
- Whiteside Jonathan
- Whyte Emma
- Wieczorek Pawel
- Wiefelspütz Christina
- Wilkins Andrew
- Wilson Catharine
- Wilson Graham
- Wilson-Smith Elaine
- Wodey Eric
- Wojciechowski Dariusz
- Wolfe Barry Juliet
- Wolfler Andrea
- Woodward Tom
- Wossner Stephanie
- Wright Dave
- Wyffels Piet
- Yagudaev Irena
- Yamamoto Tomohiro
- Yildirim Guclu Cigdem
- Zadra Nicola
- Zaghet Brigitte
- Zalewska Dorota
- Zammit Simone
- Zanaboni Clelia
- Zang Aurélien
- Zangl Gregor
- Zani Gianluca
- Zederer Nicole
- Zeitlin Deborah
- Zeitlin Yelena
- Zettl Angelika
- Ziegler Bernhard
- Zielinska Marzena
- Zielinska Marzena
- Zoppellari Roberto
- Zundane Anda
- Zunser Igor
- Zurawska Magdalena
- Žurek Jirí
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2017
- Field of study
Background Little is known about the incidence of severe critical events in children undergoing general anaesthesia in Europe. We aimed to identify the incidence, nature, and outcome of severe critical events in children undergoing anaesthesia, and the associated potential risk factors. Methods The APRICOT study was a prospective observational multicentre cohort study of children from birth to 15 years of age undergoing elective or urgent anaesthesia for diagnostic or surgical procedures. Children were eligible for inclusion during a 2-week period determined prospectively by each centre. There were 261 participating centres across 33 European countries. The primary endpoint was the occurence of perioperative severe critical events requiring immediate intervention. A severe critical event was defined as the occurrence of respiratory, cardiac, allergic, or neurological complications requiring immediate intervention and that led (or could have led) to major disability or death. This study is registered with ClinicalTrials.gov, number NCT01878760. Findings Between April 1, 2014, and Jan 31, 2015, 31â127 anaesthetic procedures in 30â874 children with a mean age of 6·35 years (SD 4·50) were included. The incidence of perioperative severe critical events was 5·2% (95% CI 5·0â5·5) with an incidence of respiratory critical events of 3·1% (2·9â3·3). Cardiovascular instability occurred in 1·9% (1·7â2·1), with an immediate poor outcome in 5·4% (3·7â7·5) of these cases. The all-cause 30-day in-hospital mortality rate was 10 in 10â000. This was independent of type of anaesthesia. Age (relative risk 0·88, 95% CI 0·86â0·90; p<0·0001), medical history, and physical condition (1·60, 1·40â1·82; p<0·0001) were the major risk factors for a serious critical event. Multivariate analysis revealed evidence for the beneficial effect of years of experience of the most senior anaesthesia team member (0·99, 0·981â0·997; p<0·0048 for respiratory critical events, and 0·98, 0·97â0·99; p=0·0039 for cardiovascular critical events), rather than the type of health institution or providers. Interpretation This study highlights a relatively high rate of severe critical events during the anaesthesia management of children for surgical or diagnostic procedures in Europe, and a large variability in the practice of paediatric anaesthesia. These findings are substantial enough to warrant attention from national, regional, and specialist societies to target education of anaesthesiologists and their teams and implement strategies for quality improvement in paediatric anaesthesia. Funding European Society of Anaesthesiology
Incidence of severe critical events in paediatric anaesthesia (APRICOT): a prospective multicentre observational study in 261 hospitals in Europe
- Author
- Aantaa Riku
- Abdel-Hafiz Mostafa
- Abdelaal Amr
- Abou-Samra Mark
- Absalom Anthony
- Acevedo Bambaren Ismael
- Adam Christian
- Adriaens Veronique
- Afshari Arash
- Ahmed Samira
- Alanoglu Zekeriyya
- Albarello Raffaella
- Albokrinov Andrew
- Alders David
- Alderson Peter
- Alexandri Bogdan
- Ali Eissa Eid Mohamed
- Alkis Neslihan
- Allen Claire
- Allison Celia
- Almenrader Nicole
- Amaral Rosa
- Amory Catherine
- Ancupans Agris
- Anders Kroken Bjørn
- Anders Nicola
- Angadi Pradeep
- Angeles Sanz M.
- Anselmi Irene
- Anselmi Luciano
- Antonio Idone Francesco
- Anuncia Escontrela Rodríguez Blanca
- Armoniene Inesa
- Artes David
- Aslami Hamid
- Astuto Marinella
- Audren Noémie
- Aurilio Caterina
- Ayyash Reema
- Babici Remus
- Badarau Victoria
- Badeti Rodica
- Baethge Sabine
- Bakken Boerke Wenche
- Balamat Stefania
- Bandrabur Daniela
- Banerjee Indrani
- Banus Ester
- Bapat Smita
- Baraggia Paolo
- Barak Yuri
- Baranowski Artur
- Barber Nicola
- Barbera Cinzia
- Barbunc Danut
- Bari Francoise
- Baris Sibel
- Barlow Victoria
- Barr Katharine
- Bartholomew Karen
- Bartkowska-Sniatkowska Alicja
- Barzdina Arta
- Basiewicz Ewa
- Basov Mikhail
- Bassett Mike
- Batoz Hélène
- Bauer Annette
- Bauer Martin
- Bauer Michael
- Baujard Catherine
- Bauwman Arthur
- Beate Solas Anne
- Becke Karin
- Becke Karin
- Begec Zekine
- Bekavac Ivan
- Bell Graham
- Bell Sarah J.
- Benito Pilar
- Berger Jelena
- Berghmans Johan
- Bergland Unni
- Bergsma Margot
- Bermede Onat
- Bernotiene Aurelija
- Berton Jerome
- Bevilacqua Michela
- Bew Stephanie
- Bird Victoria
- Birliba Mihaela-Petronela
- Biskupova Vera
- Bloomfield Tom
- Blythe Elizabeth
- Boda Krisztina
- Boda Krisztina B.
- Boegli Yann
- Bollinger Matthias
- Book Malte
- Bordes Maryline
- Bortone Luciano
- Boryshkevych Ivanna
- Bourdaud Nathalie
- Boyd Matthew
- Boyle David
- Bracci Paolo
- Brackhahn Michael
- Bradbury Carol L.
- Breschan Christian
- Brezac Gilles
- Briggs Sandra
- Brotatsch Philipp
- Browning Mike
- Budic Ivana
- Buhre Wolfgang
- Busche René
- Busi Ilaria
- Bussolin Leonardo
- Butkovic Diana
- Butler Patrick
- Byers Gordon
- Börjesson Glenda
- Bøttger Morten
- Cabanova Barbora
- Cagney Brid
- Cakar Turhan K. Sanem
- Calderini Edoardo
- Calvao Santos Carolina
- Camporesi Anna
- Camus Blandine
- Capusan Alin
- Carachi Peter
- Carre Anne-Charlotte
- Cartal Marielle
- Casaer Sari
- Castellheim Albert
- Casutt Mattias
- Catalina Ionescu Gabriela
- Cavalier Alison
- Cecini Mariateresa
- Cento Valeria
- Cerati Giorgia
- Cerne Uros
- Cerutti Elisabetta
- Cettler Maciej
- Ceuca Daniela
- Ceyda Meco Basak
- Chapotte Catherine
- Chazelet Chantal
- Checinska Magdalena
- Checuti Sarah
- Chee Lew-Chin
- Childs Sophie
- Chirichiello Luca
- Chizhov Dmitri
- Chlopin Mikhail
- Chloropoulou Pelagia
- Christian Nilsson Jens
- Chrysi Mpratzou
- Cigdem Tütüncü Ayse
- Cillis Annagrazia
- Cimpeanu Luminita
- Cindea Iulia
- Ciobanu Tudor
- Clausen Nicola G.
- Clement Maria Gabriella Elena
- Cloherty Marianne
- Cnudde Steven
- Cohen Marc
- Colbus Laurent
- Coppens Marc
- Corouge Julien
- Cortegiani Andrea
- Coucke Patricia
- Crawford Michael
- Cristina Mondardini Maria
- Cuciuc Veaceslav
- Cucui-Cozma Cosmina
- Cullen Julia
- Cullen Pauline
- Cumming Craig
- D'Alessandro Sandra
- Dadure Christophe
- Dahmani Souhayl
- Dalton Andrew
- Dalton Mark
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- Davidescu Irina
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- del Río Cristina
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- Dolci Mirko
- Dolinaj Vladimir
- Domingas Patuleia M.
- Domínguez Fernando
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- Dorman Teresa
- Draskovic Biljana
- Druot Emilie
- Duflo Frédéric
- Dumitru Rusu Florin
- Dupont Hervé
- Eberl Susanne
- Ecoffey Claude
- Ehm Birgit
- Eich Christoph Bernhard
- Eisner Christoph
- Eissa Ayman
- Elena Malos Anca
- Elizabeth Biercamp Claire
- Ellekvist Marguerite B.
- Ellerkmann Richard
- Ellwood James
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- Engelhardt Thomas
- Eniko Kovacs
- Ephraim Erik
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- Gestautaite Dalia
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- Guddo Annamaria
- Guedes Isabel
- Guericke Holger
- Guerin Christilynn
- Guido Locatelli Bruno
- Guillier Marion
- Gurita Adriana
- Gurita Adriana
- Guskov Igor
- Gutierrez Valcarcel Andrea
- Gutierrez Ignacio
- Gutmann Anton
- Guzman Ines
- Gymoese Berthelsen Kasper
- Habre Walid
- Habre Walid
- Hammerschlag Jacinda
- Hamonic Yann
- Hannie J.
- Hansen Tom G.
- Hansen Tom G.
- Hanula Miloslav
- Happo Johanna
- Harden Alison
- Hare Alison
- Harlet Pierre
- Harmen Herrema Idse
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- Hedlund Lars
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- Hopman Geranne A. J.
- Horhota Lucian
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- Hullatt Laurence
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- Wiefelspütz Christina
- Wilkins Andrew
- Wilson Catharine
- Wilson Graham
- Wilson-Smith Elaine
- Wodey Eric
- Wojciechowski Dariusz
- Wolfe Barry Juliet
- Wolfler Andrea
- Woodward Tom
- Wossner Stephanie
- Wright Dave
- Wyffels Piet
- Yagudaev Irena
- Yamamoto Tomohiro
- Yildirim Guclu Cigdem
- Zadra Nicola
- Zaghet Brigitte
- Zalewska Dorota
- Zammit Simone
- Zanaboni Clelia
- Zang Aurélien
- Zangl Gregor
- Zani Gianluca
- Zederer Nicole
- Zeitlin Deborah
- Zeitlin Yelena
- Zettl Angelika
- Ziegler Bernhard
- Zielinska Marzena
- Zielinska Marzena
- Zoppellari Roberto
- Zundane Anda
- Zunser Igor
- Zurawska Magdalena
- Žurek Jirí
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2017
- Field of study
Background Little is known about the incidence of severe critical events in children undergoing general anaesthesia in Europe. We aimed to identify the incidence, nature, and outcome of severe critical events in children undergoing anaesthesia, and the associated potential risk factors. Methods The APRICOT study was a prospective observational multicentre cohort study of children from birth to 15 years of age undergoing elective or urgent anaesthesia for diagnostic or surgical procedures. Children were eligible for inclusion during a 2-week period determined prospectively by each centre. There were 261 participating centres across 33 European countries. The primary endpoint was the occurence of perioperative severe critical events requiring immediate intervention. A severe critical event was defined as the occurrence of respiratory, cardiac, allergic, or neurological complications requiring immediate intervention and that led (or could have led) to major disability or death. This study is registered with ClinicalTrials.gov, number NCT01878760. Findings Between April 1, 2014, and Jan 31, 2015, 31 127 anaesthetic procedures in 30 874 children with a mean age of 6.35 years (SD 4.50) were included. The incidence of perioperative severe critical events was 5.2% (95% CI 5.0-5.5) with an incidence of respiratory critical events of 3.1% (2.9-3.3). Cardiovascular instability occurred in 1.9% (1.7-2.1), with an immediate poor outcome in 5.4% (3.7-7.5) of these cases. The all-cause 30-day in-hospital mortality rate was 10 in 10 000. This was independent of type of anaesthesia. Age (relative risk 0.88, 95% CI 0.86-0.90; p<0.0001), medical history, and physical condition (1.60, 1.40-1.82; p<0.0001) were the major risk factors for a serious critical event. Multivariate analysis revealed evidence for the beneficial effect of years of experience of the most senior anaesthesia team member (0.99, 0.981-0.997; p<0.0048 for respiratory critical events, and 0.98, 0.97-0.99; p=0.0039 for cardiovascular critical events), rather than the type of health institution or providers. Interpretation This study highlights a relatively high rate of severe critical events during the anaesthesia management of children for surgical or diagnostic procedures in Europe, and a large variability in the practice of paediatric anaesthesia. These findings are substantial enough to warrant attention from national, regional, and specialist societies to target education of anaesthesiologists and their teams and implement strategies for quality improvement in paediatric anaesthesia
Prospective observational cohort study on grading the severity of postoperative complications in global surgery research
- Author
- Abayasinghe Chamika
- Abbas Muntadhar
- Abbott T. E. F.
- Abbott Tom
- Abdullah Noor Hairiza
- Abdur-Rahman Lukman
- Abeloos Jacques
- Abernethy Caroline
- Abidin Ucu Nurhadiat
- Abrunhosa Alexandra
- Absar Mohammed
- Adam Suwayba
- Adams George
- Adamson Michael
- Adekola Oyebola
- Adelaja Yemi
- Ademola Adeyinka
- Adenekan Anthony
- Adenike Odewabi
- Adeolu Augustine A
- Adetoye Adedapo
- Adewale Badru
- Adigun Tinuola
- Adolfsson Anne
- Aflori Laura
- Africander Cucu
- Afshari Arash
- Agarwal Vandana
- Agodirin Olayide
- Aguzzoli Crisitiano
- Ahmad Abdurrahman
- Ahmad Norfaizan
- Ahmad T.
- Ahmad Tahania
- Ahmad Yousra
- Ahmed Ahmed
- Ahmed Jamil
- Ahmed Tahania
- Ai Yanqiu
- Aignatoaie Mariana
- Aimoniotou-Georgiou Eleni
- Akanmu Olanrewaju
- Akerman Nik
- Akinwale Mukaila
- Al Amri Khalid
- Al Hussaini Sabah
- Al-Soudaine Yassr
- Aladin Hafiz
- Alagbe-Briggs Olubusola
- Albaj Safauldeensalem
- Alcock David
- Alcock Liam
- Aldecoa Cesar
- Aldecoa Cesar
- Aleixo Fábia Berganton
- Alexander Hazel
- Alexander Maini
- Alexander-Sefre Farhad
- Alherz Fadhel
- Ali Hani
- Ali Marlynn
- Ali Sarah
- Alias Abdul Hafiz
- Alias Anita
- Alias Raja Liza Raja
- Allen Samantha
- Allen Sara Jane
- Allison Joanna
- Alloj Chiara
- Allorto Nikki Leigh
- Allsop Joanne
- Almeida William
- Alonso Eduardo
- Alonso José Ignacio
- Alphonsus Christella
- Alvares Danielle
- Alves Maria Joao
- Amador Juan Carlos Bravo
- Ameer Yusuf
- Amendola Cristina Prata
- Ami Noam
- Amstrup-Hansen Louise
- Anagnou Athina
- Andersen Cheme
- Anderson Charlotte
- Anderson Colette
- Anderson Frank
- Anderson Philip
- Andreadaki Evangelia
- Andreou Alexandros
- Andreou Prematie
- Andrew Alyson
- Andrews Emma
- Angel Miguel Paludi
- Angermair Stefan
- Angus Kirsty
- Anillo Victor
- Anizi Mashel Al
- Antal Oana
- Antill Philip
- Antoniadou Eleni
- Apagaki Eymorfia
- Apostolou Konstantinos
- Applewhaite Christopher
- Applewhaite Christopher
- Aquino Laura Patricia González
- Ar Praburaj
- Araujo Daniela Marques
- Arawwawala Dilshan
- Ardern Diane
- Argue Ruth
- Aribawa Mahaalit Alit
- Arkalaki Eleni
- Armaganidis Apostolos
- Armstrong John
- Armstrong Richard
- Arnaoutoglou Christina
- Arnaoutoglou Elena
- Arnold Glenn
- Arrandale Lindsay
- Arrich James
- Arrigo Mario
- Arshad Homa
- Arshad Mohammed Asif
- Artiles Tania Socorro
- Arumugam Swarna
- Arustei Mirela
- Arvaniti Kostoula
- Arvaniti Kostoula
- Arya Aryabiantara
- Arya Shobhit
- Asimakos Andreas
- Aslam M
- Asudo Felicia
- Athanasakis Elias
- Atiku Mamuda
- Attrill Elizabeth
- Attwood Clare
- Auer Patrick
- Avidan Michael
- Avila Erendira Jocelin Dominguez
- Avis Joanne
- Awad Hadi
- Axioti Elena
- Azam Ummi Azmira Ahmad
- Azambuja Pedro
- Azevedo Caroline
- Aziz Faizal Zuhri
- Baas Peter
- Baghirzada Leyla
- Bai Hui-Ping
- Baillie Shelley
- Baines Duncan
- Baio Thalissa Hermínia
- Bairaktari Aggeliki
- Baker Gerard
- Baker Katie-Anne
- Baker Paul
- Balain Birender
- Balajonda Naraida
- Balanescu Andreea
- Balasubramaniam Madhu
- Baldisserotto Sérgio
- Baldwin Jacqueline
- Baldwin Matthew
- Balfoussia Danai
- Bali Christina
- Bandeira Maria Expedito
- Banerjee Robin
- Bankewitz Carla
- Banner-Goodspeed Valerie
- Bao Qi
- Barcraft-Barnes Helena
- Barneto Lisa
- Barnett Andrew
- Barraclough James
- Barras Jean-Pierre
- Barrett Stephen
- Barrett Wendy Joan
- Basanth Sujith
- Batchelor Nick
- Bateman Brian
- Bates Alexander
- Bates Sarah
- Batista Hugo Dias
- Bauchmuller Kris
- Bauer Marlene
- Baumgarten Georg
- Baxter Linden
- Beaton Ceri
- Beattie Scott
- Beattie Scott
- Beattie Scott
- Beavis Vanessa
- Beavis Vanessa
- Bechan Sudha
- Beer Johan
- Bejia Tarek
- Belciu Ioana
- Belda Margarita Tormo
- Bell Gillian
- Bell Rachel
- Bell Rachel
- Bell Stephanie
- Bellandi Mattia
- Bello Jibril
- Beloeil Helene
- Belskiy Vladislav
- Beltran Anna Valle
- Ben-Menachem Erez
- Benavent Pau
- Benevento Angelo
- Bengeri Sheshagiri
- Bennett Cambell
- Bennett Michael
- Bennett Rachael
- Bennett Victoria
- Bentley Conor
- Beretta Luigi
- Berg Andrew
- Berg Bianca
- Bergin Colin
- Bernard Andre
- Bernard Andre
- Bernard Andre
- Bernat Maria Jose
- Berntsen Emer
- Berntsen Emer
- Bertram Wendy
- Bester Delia
- Bester Marlet
- Bettega Fernanda
- Bettinelli Alessandra
- Bhardwaj Neeraj
- Bhatia Kailash
- Bhula Chettan
- Bi Yanbing
- Biais M.
- Biais Matthieu
- Biais Matthieu
- Biccard Bruce
- Biccard Bruce M
- Bidd Heena
- Bidd Heena
- Bidgoli Jawad
- Biffen Andrew
- Bignami Elena
- Bilolikar Anjali
- Birch Julie
- Bishop David Gray
- Biyase Thuli
- Bizios Christol
- Blackwell Clare
- Blackwood Douglas
- Blaj Mihaela
- Blakemore Stephen P
- Bland Martin
- Blunt Mark
- Blyth Katharine
- Bocchino Speranza
- Bodansky Daniella
- Bodger Phoebe
- Boer Christa
- Boer Hans Donald
- Boereboom Catherine
- Boggiano Victoria
- Bokkel-Andela Janneke
- Bolaji Benjamin
- Bolton David
- Boone Myles
- Boschi Luca
- Boshier Piers
- Botes Marisa
- Botis Ioannis
- Bottini Corrado
- Bottrill Fiona
- Bouchez Stefaan
- Boulton Kerenza
- Bouris Vasilios
- Bourner Lynsey
- Boutsikos Georgios
- Bouwman Arthur
- Bouwman Arthur
- Bowrey Sarah
- Boxall Leigh
- Boyd Christine
- Bradburn Mike
- Bradburn Mike
- Bradley Jacqueline
- Branagan Graham
- Branco Teresa
- Brand Bastiaan
- Brandsborg Birgitte
- Breitenstein Stefan
- Brennan Andrew
- Brennan Emma
- Brenner Laura
- Brincat Maximilian
- Briscoe Richard
- Bristogiannis Sotirios
- Brooke Jenny
- Brookes Jamie
- Brookes Morag
- Brooks Carolyn
- Broomby Rupert
- Brotto Ana Flavia
- Brown Andrew
- Brown Caroline Wrey
- Brown Gemma
- Brown Jamie
- Brown Janette
- Brown Lynne
- Brown Richard
- Brown Robyn
- Browning Julie
- Bruma Dana
- Brunete Tamara
- Brunswicker Annemarie
- Bryant Helen
- Bua Emmanuel
- Buccimazza Ines
- Buckley Sarah
- Buerkle Christian
- Buhre Wolfgang
- Buhre Wolfgang
- Builu Pierre Monji
- Buise Marc
- Bullock Clare
- Bunwarie Bimalshakth
- Burns Karen
- Burrows Lorna
- Burrows Tom
- Burston Ben
- Burtenshaw Andrew
- Burton Megan
- Busuioc Mihai
- Butryn Izabella
- Butt Georgina
- Byrne Kelly
- Bührer Thomas
- Cabezuelo Estefania
- Cabral Raquel
- Cabrini Luca
- Cacala Sharon
- Cai Fang
- Cai Yunfei
- Cain Helen
- Cairns Carel
- Cakova Veronika
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- Callaghan Mark
- Campbell Debbie
- Campbell Doug
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- Campey Lorraine
- Campos Ferreira Mariana Fosch
- Camsooksai Julie
- Cancho David
- Candido Keulle
- Cang Jing
- Cannavo Maurizio
- Cao Jianqiao
- Cao Ying
- Cao Zhongming
- Cardellino Silvano
- Cardosa Jorge
- Cardoso Gutemberg
- Cardy Jon
- Carmino Livio
- Carp Cristina Paula
- Carr Adrienne
- Carrera Ronald
- Carroll Christine
- Carroll Jo
- Caser Eliana
- Castaño Beatriz
- Castle Gail
- Castro Gabriel Isaac Pereira
- Cavanagh Sarah
- Cawthorn Louise
- Cernea Daniela Denisa
- Chaddock Mark
- Chaloulis Panagiotis
- Chan Alexander
- Chan Hey Man Heymans
- Chan Mathew
- Chan Matthew
- Chan Matthew
- Chan Peter
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- Chan Weng Ken
- Chan Yik Lam
- Chande Shiv
- Chandler Ben
- Chandra Susilo
- Chandra Susilo
- Chandrasekharan Shardha
- Chang Yuan Hsuan
- Chaniotaki Fotini
- Charitos Efthimios
- Charlalampidoy Alexandra
- Charles Rob
- Chatterjee Devnandan
- Chatterjee Jayanta
- Chatzimichali Aikaterini
- Chau Simon
- Chazova Elena
- Cheah Clarissa
- Cheah Seleen
- Cheeseman Michelle
- Cheing Yushio
- Chen Chao
- Chen Chen
- Chen Feifei
- Chen Fumei
- Chen Hong
- Chen James
- Chen Junping
- Chen Lee-lynn
- Chen Lee-lynn
- Chen Linbi
- Chen Liyong
- Chen Pushan
- Chen Qiang
- Chen Rong
- Chen Shasha
- Chen Shiyu
- Chen Sijia
- Chen Yaqiu
- Chen Yijiao
- Chen Yijun
- Chen Yongjie
- Chen Zhang
- Cheng Baoli
- Cheng Ka Ho
- Cherian Ritchie
- Cherrett Veronica
- Chetty Rubendraj R
- Chew Michelle
- Chew Michelle
- Chhabra Ashok
- Chicken Dennis-Wayne
- Chilinciuc Ion
- Chin Im Im
- Chirkut Subash
- Chlorou Dimitra
- Choi Hyun-min David
- Choi Stephen
- Chow Lorraine
- Christian Rachel
- Christiansen Ida Cecilie
- Christmas Natasha
- Christodoulidis Gregory
- Christodoulopoulou Theodora
- Christofaki Maria
- Christoforidis Dimitri
- Chronis Christos
- Chu Hiu Man
- Chu Susanna
- Chua Pandora
- Chukkambotla Srikanth
- Chung Chun Kwong Eric
- Cifra Elna
- Ciobanu Cristina
- Ciobotaru Oana Roxana
- Cirstea Emanuel
- Clark Richard
- Clarkson Aisling
- Clavien Pierre-Alain
- Claxton Andrew
- Clemmons Karen
- Cloro Luigi Maria
- Clyde Antony
- Cobzaru Isabelle
- Codita Anisoara
- Colangelo Antonio
- Colangelo Chiara
- Colling Kerry
- Collins Michelle
- Collins Nwokoro
- Colvin Carolyn
- Commey Thelma
- Comptaer Nicolas
- Conceição Soares Maria
- Conde Carlos
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- Constantin Kathryn
- Cook Tim
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- Cooper Lucy
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- Currow Helen
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- De Kegel Dirk
- De Meyer Jenine N
- De Oliveira Mirella Cristine
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- Deja Maria
- Del Valle Santiago Garcia
- Delgado García David R
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- Futier Emmanuel
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- Ganter Donna Louise
- Ganter Michael T
- Gao Hong
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- Gardiner Matthew
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- Geddoa Emad
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- George Ronald
- George Ronald
- George Ronald
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- Gercek Yuksel
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- Gratrix Karen
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- Greaves Rosanna
- Green Garyth M
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- Haddow James
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- Hamzah Zulkarnain
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- Hariharan Vimal
- Harrichandparsad R
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- Hering Jens Peter
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- Hernandez Miguel
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- Hesketh Sue
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- Hewson Russell
- Heyse Bjorn
- Hicks Catherine
- Hidayatullah Rahmat
- Hiesmayr Michael
- Higgie Kushlin
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- Hills Vicky
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- Hinther Ashley
- Hinxman Honor
- Hitchcock Rachael
- Hoare Siobhan
- Hobrok Maria
- Hodgkiss Tracey
- Hodgson Richard E
- Hodzovic Emil
- Hoedt Marielle
- Hoeft Andreas
- Hoeft Andreas
- Hofer Christoph
- Hofer Christoph
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- Holliger Stephan
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- Zapata Darcy Danitza Mari
- Zbitnew Geoff
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- Zeng Qiuting
- Zettergren Jan
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- Zhang Ye
- Zhang Yuan
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- Zhao Bo
- Zhao Chong
- Zhao Jiashi
- Zhao Jinning
- Zhao Lei
- Zhao Shuna
- Zhao Ting
- Zhao Weihong
- Zhao Weilu
- Zhao Xiaoying
- Zhen Jungang
- Zheng Kang
- Zheng Lina
- Zheng Tianzhao
- Zhong Yi
- Zhou Ce
- Zhou Dachun
- Zhou Haidong
- Zhou Haiyan
- Zhou Jiali
- Zhou Jialong
- Zhou Jing
- Zhou Xian-jin
- Zhu Xiaomao
- Zhu Yi
- Zhu Zhipeng
- Zhuang Xiuxiu
- Zilis Georgios
- Zin Nor Hafizah Mohd
- Zingerle Nicolette
- Zingg Urs
- Zoerner Frank
- Zonneveldt Harry
- Zou Xiaohua
- Zoulamoglou Menelaos
- Zsisku Lajos
- Zundert Tom
- Zyl Rebekka
- åkring Irene
- Ögren Katrin
- Publication venue
- 'Wiley'
- Publication date
- 22/10/2018
- Field of study
Background
The Clavien–Dindo classification is perhaps the most widely used approach for reporting postoperative complications in clinical trials. This system classifies complication severity by the treatment provided. However, it is unclear whether the Clavien–Dindo system can be used internationally in studies across differing healthcare systems in high- (HICs) and low- and middle-income countries (LMICs).
Methods
This was a secondary analysis of the International Surgical Outcomes Study (ISOS), a prospective observational cohort study of elective surgery in adults. Data collection occurred over a 7-day period. Severity of complications was graded using Clavien–Dindo and the simpler ISOS grading (mild, moderate or severe, based on guided investigator judgement). Severity grading was compared using the intraclass correlation coefficient (ICC). Data are presented as frequencies and ICC values (with 95 per cent c.i.). The analysis was stratified by income status of the country, comparing HICs with LMICs.
Results
A total of 44 814 patients were recruited from 474 hospitals in 27 countries (19 HICs and 8 LMICs). Some 7508 patients (16·8 per cent) experienced at least one postoperative complication, equivalent to 11 664 complications in total. Using the ISOS classification, 5504 of 11 664 complications (47·2 per cent) were graded as mild, 4244 (36·4 per cent) as moderate and 1916 (16·4 per cent) as severe. Using Clavien–Dindo, 6781 of 11 664 complications (58·1 per cent) were graded as I or II, 1740 (14·9 per cent) as III, 2408 (20·6 per cent) as IV and 735 (6·3 per cent) as V. Agreement between classification systems was poor overall (ICC 0·41, 95 per cent c.i. 0·20 to 0·55), and in LMICs (ICC 0·23, 0·05 to 0·38) and HICs (ICC 0·46, 0·25 to 0·59).
Conclusion
Caution is recommended when using a treatment approach to grade complications in global surgery studies, as this may introduce bias unintentionally
Critical care admission following elective surgery was not associated with survival benefit: prospective analysis of data from 27 countries
- Author
- A T Landers
- Aaron Lawson McLean
- Abbey Paton
- Abdel Razzaq Khalaf
- Abdul Hafiz Alias
- Abdurrahman Ahmad
- Abegail Salvana
- Abigail Keen
- Abigail Patrick
- Abraham Hulst
- Acela G Lopez
- Adam Evans
- Adam Rehak
- Adamu Muhammad Sarki
- Ade Nurkacan Dursin
- Ade Susanti
- Adela Ruiz
- Adeline Rankin
- Ademola Talabi
- Adenekan Adetoye
- Adeoluwa Tayo
- Adeyinka Ademola
- Aditi Kulkarni
- Aditi Naik
- Aditi Shrivastava
- Adriana Krepil
- Adrianna Woolsey
- Adrianna Woolsey
- Adrienne Carr
- Afolabi Owojuyigbe
- Aggeliki Bairaktari
- Agoritsa Tsioka
- Agostino Roasio
- Ahamed Khader
- Ahmad Sufian Ab Rahman
- Ahmed Ahmed
- Ahmed El-Sayed
- Ahmed Saloojee
- Ahmed Sayeed
- Aida Tantri
- Aida Tantri
- Aikaterini Chatzimichali
- Aikaterini Kyparissi
- Aikaterini Makatounaki
- Aisling Clarkson
- Ajay Gupta
- Akanmu Durodola
- Akbar Vohra
- Akbar Vohra
- Akbar Vohra
- Akbar Vohra
- Akram Fuad
- Alae Conradie
- Alasdair Scott
- Alastair Rose
- Alba Perez Gonzalez
- Albert Tsui
- Alberto Lisi
- Alberto Premoli
- Alberto Ramirez
- Alberto Zangrillo
- Alda Martins
- Aleaxandra Moustaka
- Alejandra Romero Rodrigo
- Alejandro Duca
- Alejandro Suarez-de-la-Rica
- Aleksandr Iurin
- Aleksandr Molkov
- Aleksandr Samoilenko
- Aleksandr Tchekulaev
- Alessandra Bettinelli
- Alessandro Gatta
- Alessandro Marchesi
- Alex Looseley
- Alex Ragan
- Alexander Bates
- Alexander Chan
- Alexander Durst
- Alexander Fowler
- Alexander Freethy
- Alexander Ishimaru
- Alexander Kulikov
- Alexander Tolmasov
- Alexandra Abrunhosa
- Alexandra Charlalampidoy
- Alexandra Dumitrescu
- Alexandra Papaioannou
- Alexandra Torborg
- Alexandra Williams
- Alexandra Wolfer
- Alexandra Wolfer
- Alexandre Ouattara
- Alexandros Andreou
- Alexey Karelov
- Alfonso Munoz-López
- Alhafidz Hamdan
- Alhassan Datti Mohammed
- Ali Elabib
- Ali Vahedi
- Aliaksandra Parashchanka
- Alice Stevens
- Alifia Tameem
- Alison Donna
- Alison Ghosh
- Alison Knaggs
- Alison Liddle
- Alison Paton
- Alison Wilson
- Alistair Hellewell
- Alycon Walker
- Alyson Andrew
- Amabra Dodiyi-Manuel
- Amanda Cowton
- Amanda Datson
- Amanda Finch
- Amanda Jansen van Vuuren
- Amanda Lofting
- Amanda Lyle
- Amanda Miñana
- Amos Obobolo
- Amy Stevens
- Ana Cristina Miranda Martins Costa
- Ana Flavia Brotto
- Ana Izquierdo Palomares
- Ana Margarida Santos
- Ana Maria Vilela Dos Santos
- Anahi Perlas
- Anastasia Koutsikou
- Anastasia Spartinou
- Anastasia Vachlioti Vachlioti
- Anastasios Katsourakis
- Anders Oldner
- Andre Bernard
- Andre Bernard
- Andre Bernard
- Andrea Sibilio
- Andrea Stocker
- Andreas Asimakos
- Andreas Eichwalder
- Andreas Filippopoulos
- Andreas Fleischer
- Andreas Flossos
- Andreas Hoeft
- Andreas Hoeft
- Andreas Weyland
- Andreea Balanescu
- Andreea Stefan
- Andreu Cueva
- Andrew Barnett
- Andrew Berg
- Andrew Biffen
- Andrew Brennan
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- Andrew Burtenshaw
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- Andri Kurnia
- Andriy Krystopchuk
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- Andy Kwok
- Anette Barbre Pedersen
- Angela Freschini
- Angela King
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- Angelantonio Pascazio
- Angeliki Tsagkaraki
- Angelo Benevento
- Angelo Porto
- Angels Lozano
- Angie Dempster
- Angus Turner
- Angus Turner
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- Arlo Whitehouse
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- Arrash Yassaee
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- Artem Dunay
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- Arthur Bouwman
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- Arvind Karthikeyan
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- Arystarch Makowski
- Asako Shida
- Ashish Dasrath
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- Aspasia Papailia
- Asuncion Marques Parra
- Athanasia Tsirogianni
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- Athena Lavrentieva
- Athina Anagnou
- Athina Lavrentieva
- Atideb Mitra
- Atideb Mitra
- Attila Jonas
- Atul Garg
- Atul Kulkarni
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- Audrey Pospiech
- Augustine A Adeolu
- Aurélien Venara
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- Avesh Singh
- Axe Robert
- Axel Ramminger
- Axel Sylvan
- Ayyaz Hussain
- Babatunde Babasola Osinaike
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- Baoli Cheng
- Baoling Zhang
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- Bas van Zaane
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- Beth Port
- Bhagwan Singh
- Bhagyashree Netke
- Bhagyesh Shah
- Bhavesh Raithatha
- Bhavika Daya
- Bianca Purcarin
- Bianca van den Berg
- Bimalshakth Bunwarie
- Bin Li
- Binbin Ji
- Bing Zhao
- Birender Balain
- Birgitte Brandsborg
- Bisola Onajin-Obembe
- Bjorn Heyse
- Blaylock Heather
- Bo Li
- Bo Lu
- Bo Meng
- Bo Zhao
- Bobby Krishnachetty
- Bodil Steen Rasmussen
- Bonita Funk
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- Bosun Hong
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- Yan Pan
- Yan Zhang
- Yana Ilyina
- Yanbing Bi
- Yanfei Xia
- Yang Liu
- Yang Yang
- Yangwen Ou
- Yangyang Han
- Yanling Li
- Yanming Huang
- Yanqiu Ai
- Yapping Zhang
- Yaqi Li
- Yaqiu Chen
- Yassr Al-Soudaine
- Yavor Metodiev
- Yazhou Wen
- Yazhuo Yuan
- Ye Zhang
- Yelong Ren
- Yemi Adelaja
- Yetong Li
- Yew Ching Lee
- Yi Liu
- Yi Zhong
- Yi Zhu
- Yijiao Chen
- Yijun Chen
- Yik Lam Chan
- Ying Cao
- Yingfen Xiong
- Yingping Liang
- Yixiu Yan
- Yiyi Shi
- Yonghao Yu
- Yongjie Chen
- Yongqing Guo
- Yongtao Sun
- Yongzhong Tang
- Yoni van Duivenvoorde
- Youliang Tong
- Yousif Saeed
- Yousra Ahmad
- Yu Fan
- Yu Sun
- Yuan Hsuan Chang
- Yuan Liang Woon
- Yuan Zhang
- Yuanming Pan
- Yuanyuan Pan
- Yue Fei
- Yuehong Qi
- Yuejiang Liu
- Yuelan Wang
- Yugang Shi
- Yuhong Li
- Yuksel Gercek
- Yun Bai
- Yun Ren
- Yunbin Fu
- Yunchang Mo
- Yunfei Cai
- Yunlin Feng
- Yunzhi Ling
- Yurui Yao
- Yushio Cheing
- Yusuf Ameer
- Yuting Wang
- Yves Jaquet
- Yvonne Hack
- Yvonne Selibea
- Zaheer Moolla
- Zaid Makzal
- Zane Farina
- Zhang Chen
- Zhen Dan Peng
- Zhen Wang
- Zhen Wang
- Zheng Guo
- Zhengyuan Liu
- Zhenrong Ji
- Zhi Wang
- Zhipeng Wang
- Zhipeng Zhu
- Zhisong Li
- Zhiting Wen
- Zhong-Yuan Xia
- Zhongming Cao
- Zi-Ying Shen
- Zin Nico
- Ziqiang Miao
- Zoe Davies
- Zoe Drinkwater
- Zoe Whitman
- Zulkarnain Hamzah
- Álvaro Réa-Neto
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2017
- Field of study
This was an investigator initiated study funded by Nestle Health Sciences through an unrestricted research grant, and by a National Institute for Health Research (UK) Professorship held by RP. The study was sponsored by Queen Mary University of London
The surgical safety checklist and patient outcomes after surgery: a prospective observational cohort study, systematic review and meta-analysis
- Author
- Ab Majid Mohd Azuan
- Ab Rahman Ahmad Sufian
- Ab Rahman Rusnah
- Abayasinghe Chamika
- Abbas Muntadhar
- Abbott T. E. F.
- Abbott Tom
- Abd Ghafar Fara Nur Idayu
- Abd Hadi Husni Zaeem
- Abdel Goad Ehab Helmy
- Abdullah Noor Hairiza
- Abdur-Rahman Lukman
- Abeloos Jacques
- Abernethy Caroline
- Abidin Ucu Nurhadiat
- Abrunhosa Alexandra
- Absar Mohammed
- Adam Suwayba
- Adams David
- Adams George
- Adamson Michael
- Adekola Oyebola
- Adelaja Yemi
- Ademola Adeyinka
- Adenekan Anthony
- Adenike Odewabi
- Adeolu Augustine A.
- Adetoye Adedapo
- Adewale Badru
- Adigun Tinuola
- Adolfsson Anne
- Africander Cucu
- Afshari Arash
- Agarwal Vandana
- Agodirin Olayide
- Aguzzoli Crisitiano
- Ahamed khader null
- Ahmad Azam Ummi Azmira
- Ahmad Abdurrahman
- Ahmad Norfaizan
- Ahmad T.
- Ahmad Tahania
- Ahmad Yousra
- Ahmed Ahmed
- Ahmed Jamil
- Ahmed Tahania
- Ai Yanqiu
- Aignatoaie Mariana
- Aimoniotou-Georgiou Eleni
- Akanmu Olanrewaju
- Akerman Nik
- Akinwale Mukaila
- Al Anizi Mashel
- Al hussaini Sabah
- Al'Amri Khalid
- Al-Soudaine Yassr
- Aladin Hafiz
- Alagbe-Briggs Olubusola
- Albaj Safauldeensalem
- Alberto Lisi Zaheer Moolla
- AlbertoVolta Carlo
- Alcock David
- Alcock Liam
- Aldecoa Cesar
- Aleixo Fábia Berganton
- Alexander Hazel
- Alexander Maini
- Alexander-Sefre Farhad
- Alherz Fadhel
- Ali Hani
- Ali Marlynn
- Ali Sarah
- Alias Abdul Hafiz
- Alias Anita
- Alit Mahaalit Aribawa
- Allen Samantha
- Allen Sara Jane
- Allison Joanna
- Alloj Chiara
- Allorto Nikki Leigh
- Allsop Joanne
- Almeida William
- Alonso Eduardo
- Alonso José Ignacio
- Alphonsus Christella
- Alvares Danielle
- Alves Maria Joao
- Amador Juan Carlos Bravo
- Ameer Yusuf
- Amendola Cristina Prata
- Ami Noam
- Amstrup-Hansen Louise
- Anagnou Athina
- Andersen Cheme
- Anderson Charlotte
- Anderson Colette
- Anderson Frank
- Anderson Philip
- Andreadaki Evangelia
- Andreou Alexandros
- Andreou Prematie
- Andrew Alyson
- Andrews Emma
- Angermair Stefan
- Angus Kirsty
- Anillo Victor
- Antal Oana
- Antill Philip
- Antoniadou Eleni
- Antonina Webombesa
- Apagaki Eymorfia
- Apostolou Konstantinos
- Applewhaite Christopher
- Aquino Laura Patricia González
- Ar Praburaj
- Arawwawala Dilshan
- Ardern Diane
- Argue Ruth
- Arkalaki Eleni
- Arlo whitehouse null
- Armaganidis Apostolos
- Armstrong John
- Armstrong Richard
- Arnaoutoglou Christina
- Arnaoutoglou Elena
- Arnold Glenn
- Arrandale Lindsay
- Arrich James
- Arrigo Mario
- Arshad Homa
- Arshad Mohammed Asif
- Artiles Tania Socorro
- Arumugam Swarna
- Arustei Mirela
- Arvaniti Kostoula
- Arya Aryabiantara
- Arya Shobhit
- Asimakos Andreas
- Aslam F Noorbhai M.
- Asudo Felicia
- Athanasakis Elias
- Atiku Mamuda
- Attrill Elizabeth
- Attwood Clare
- Auer Patrick
- Avidan Michael
- Avila Erendira Jocelin Dominguez
- Avis Joanne
- Awad Hadi
- Axioti Elena
- Azambuja Pedro
- Azevedo Caroline
- Aziz Faizal Zuhri
- Baas Peter
- Baghirzada Leyla
- Bai Hui-Ping
- Bai Yun
- Baillie Shelley
- Baines Duncan
- Baio Thalissa Hermínia
- Bairaktari Aggeliki
- Baker Gerard
- Baker Katie-Anne
- Baker Paul
- Balain Birender
- Balaji Packianathaswamy
- Balajonda Naraida
- Balanescu Andreea
- Balasubramaniam Madhu
- Baldisserotto Sérgio
- Baldwin Jacqueline
- Baldwin Matthew
- Balfoussia Danai
- Bali Christina
- Bandeira Maria Expedito
- Banerjee Robin
- Bankewitz Carla
- Banner-Goodspeed Valerie
- Bao Qi
- Barcraft-Barnes Helena
- Barneto Lisa
- Barnett Andrew
- Baroselli Antonio
- Barraclough James
- Barras Jean-Pierre
- Barrett Stephen
- Barrett Wendy Joan
- Basanth Sujith
- Batchelor Nick
- Bateman Brian
- Bates Alexander
- Bates Sarah
- Batista Hugo Dias
- Bauchmuller Kris
- Bauer Marlene
- Baumgarten Georg
- Baxter Linden
- Beaton Ceri
- Beattie Scott
- Beavis Vanessa
- Beavis Vanessa
- Bechan Sudha
- Bejia Tarek
- Belciu Ioana
- Belda Margarita Tormo
- Bell Gillian
- Bell Rachel
- Bell Stephanie
- Bellandi Mattia
- Bello Jibril
- Beloeil Helene
- Belskiy Vladislav
- Beltran Anna Valle
- Ben-Menachem Erez
- Benavent Pau
- Benedikt Preckel Osne Kirzner
- Benevento Angelo
- Bengeri Sheshagiri
- Bennett Cambell
- Bennett Michael
- Bennett Rachael
- Bennett Victoria
- Bentley Conor
- Beretta Luigi
- Berg Andrew
- Bergin Colin
- Bernard Andre
- Bernat Maria Jose
- Berntsen Emer
- Bertram Wendy
- Bester Delia
- Bester Marlet
- Bettega Fernanda
- Bettinelli Alessandra
- Bhardwaj Neeraj
- Bhatia Kailash
- Bhula Chettan
- Bi Yanbing
- Biais Matthieu
- Biccard B. M.
- Biccard Bruce
- Biccard Bruce M.
- Bidd Heena
- Bidgoli Jawad
- Biffen Andrew
- Bignami Elena
- Bilolikar Anjali
- Bin Mustapha Mohd Tarmimi
- Birch Julie
- Bishop David Gray
- Biyase Thuli
- Bizios Christol
- Blackwell Clare
- Blackwood Douglas
- Blaj Mihaela
- Blakemore Stephen P.
- Bland Martin
- Blunt Mark
- Blyth Katharine
- Bocchino Speranza
- Bodansky Daniella
- Bodger Phoebe
- Boer Christa
- Boereboom Catherine
- Boggiano Victoria
- Bogner Gerhard
- Bokkel-Andela Janneke ten
- Bolaji Benjamin
- Bolton David
- Boone Myles
- Boschi Luca
- Boshier Piers
- Botes Marisa
- Botis Ioannis
- Bottini Corrado
- Bottrill Fiona
- Bouchez Stefaan
- Boulton Kerenza
- Bouris Vasilios
- Bourner Lynsey
- Boutsikos Georgios
- Bouwman Arthur
- Bowrey Sarah
- Boxall Leigh
- Boyd Christine
- Bradburn Mike
- Bradley Jacqueline
- Branagan Graham
- Branco Teresa
- Brand Bastiaan
- Brandsborg Birgitte
- Breitenstein Stefan
- Brennan Andrew
- Brennan Emma
- Brenner Laura
- Brincat Maximilian
- Briscoe Richard
- Bristogiannis Sotirios
- Brooke Jenny
- Brookes Jamie
- Brookes Morag
- Brooks Carolyn
- Broomby Rupert
- Brotto Ana Flavia
- Brown Andrew
- Brown Caroline Wrey
- Brown Gemma
- Brown Jamie
- Brown Janette
- Brown Lynne
- Brown Richard
- Brown Robyn
- Browning Julie
- Bruma Dana
- Brunete Tamara
- Brunswicker Annemarie
- Bryant Helen
- Bua Emmanuel
- Buccimazza Ines
- Buckley Sarah
- Buerkle Christian
- Buhre Wolfgang
- Builu Pierre Monji
- Buise Marc
- Bullock Clare
- Bunwarie Bimalshakth
- Burns Karen
- Burrows Lorna
- Burrows Tom
- Burston Ben
- Burtenshaw Andrew
- Burton Megan
- Busuioc Mihai
- Butryn Izabella
- Butt Georgina
- Byrne Kelly
- Bührer Thomas
- Cabezuelo Estefania
- Cabral Raquel
- Cabral Tiago do Nascimento
- Cabrini Luca
- Cacala Sharon
- Cai Fang
- Cai Yunfei
- Cain Helen
- Cairns Carel
- Cakova Veronika
- Calderwood Claire
- Callaghan Mark
- Campbell Debbie
- Campbell Doug
- Campbell Douglas
- Campbell Gill
- Campbell Graham
- Campbell Kathleen
- Campbell Marta
- Campbell Tara
- Campey Lorraine
- Camsooksai Julie
- Cancho David
- Candido Keulle
- Cang Jing
- Cannavo' Maurizio
- Cao Jianqiao
- Cao Ying
- Cao Zhongming
- Cardellino Silvano
- Cardosa Jorge
- Cardoso Gutemberg
- Cardy Jon
- CarmenVaida Laura Aflori
- Carmino Livio
- Carp Cristina Paula
- Carr Adrienne
- Carrera Ronald
- Carroll Christine
- Carroll Jo
- Caser Eliana
- Castaño Beatriz
- Castle Gail
- Cavanagh Sarah
- Cawthorn Louise
- Cernea Daniela Denisa
- Chaddock Mark
- Chaloulis Panagiotis
- Chan Alexander
- Chan Mathew
- Chan Matthew
- Chan Peter
- Chan Vincent
- Chan Wai Kit Jacky
- Chan Weng Ken
- Chan Yik Lam
- Chande Shiv
- Chandler Ben
- Chandra Susilo
- Chandrasekharan Shardha
- Chang Yuan Hsuan
- Chaniotaki Fotini
- Charitos Efthimios
- Charlalampidoy Alexandra
- Charles Rob
- Chatterjee Devnandan
- Chatterjee Jayanta
- Chatzimichali Chatzimichali Aikaterini
- Chau Simon
- Chazova Elena
- Cheah Clarissa
- Cheah Seleen
- Cheeseman Michelle
- Cheing Yushio
- Chen Chao
- Chen Chen
- Chen Feifei
- Chen Fumei
- Chen Hong
- Chen James
- Chen Junping
- Chen Lee-lynn
- Chen Linbi
- Chen Liyong
- Chen Pushan
- Chen Qiang
- Chen Rong
- Chen Shasha
- Chen Shiyu
- Chen Sijia
- Chen Yaqiu
- Chen Yijiao
- Chen Yijun
- Chen Yongjie
- Chen Zhang
- Cheng Baoli
- Cheng Ka Ho
- Cheng Zhonggui
- Cheong Edward
- Cherian Ritchie
- Cherrett Veronica
- Chetty Rubendraj R.
- Chew M. S.
- Chew Michelle
- Chhabra Ashok
- Chicken Dennis-Wayne
- Chilinciuc Ion
- Chin Im Im
- Chirkut Subash
- Chlorou Dimitra
- Choi Hyun-min David
- Choi Stephen
- Chow Lorraine
- Christian Rachel
- Christiansen Ida Cecilie
- Christmas Natasha
- Christodoulidis Gregory
- Christodoulopoulou Theodora
- Christofaki Maria
- Christoforidis Dimitri
- Chronis Christos
- Chu Hiu Man
- Chu Susanna
- Chua Pandora
- Chukkambotla Srikanth
- Chung Chun Kwong Eric
- Cifra Elna
- Ciobanu Cristina
- Ciobotaru Oana Roxana
- Cirstea Emanuel
- Clark Richard
- Clarkson Aisling
- Clarkson Rachel
- Clavien Pierre-Alain
- Claxton Andrew
- Clemmons Karen
- Cloro Luigi Maria
- Clyde Antony
- Cobzaru Isabelle
- Codita Anisoara
- Colangelo Antonio
- Colangelo Chiara
- Colling Kerry
- Collins Hannah
- Collins Michelle
- Collins Nwokoro
- Colvin Carolyn
- Commey Thelma
- Comptaer Nicolas
- Conde Carlos
- Conradie Alae
- Constantin Kathryn
- Cook Tim
- Cooper Lauren
- Cooper Lucy
- Cooper Mariese
- Cooper Richard
- Cooper Sarah
- Copaciu Elena
- Cope Jennifer
- Copetti Elisa
- Copley Edward
- Copotoiu Sanda Maria
- Coppens Marc
- Corneci Dan
- Cornell Jonathan
- Cornish Julie
- Correia da Silva Rui Freitas Mendonça
- Corti Daniele
- Costa Ana Cristina Miranda Martins
- Costanzo Eleonora
- Costelloe Hannah
- Cotter Rochelle
- Cotterell Sharon
- Cotterill Donna
- Coughlan Elaine
- Coulter Ian
- Coulter Suzanne
- Coutinho Francisco
- Cowton Amanda
- Cox Hannah
- Cozar Octavian Ionut
- Craig Jayne
- Craven Rachael
- Craw Nicholas
- Craw Sarah
- Creary Thais
- Cripps Heather
- Critchley Rebecca
- Cronje Larissa
- Cruickshank Ross
- Cruikshanks Andrew
- Cruz Salome
- Cuenca Vicente Chisbert
- Cueva Andreu
- Cunha Pedro
- Curley Gerard
- Currow Helen
- Czepanski Carolyn
- Czeslick Elke
- D'Andrea Rocco
- Dafnios Nikolaos
- Dai Hanying
- Dai Qingqing
- Dai Qinxue
- Dai Si Yuan
- Daikou Panagoula
- Dalamagka Maria
- Dalampini Eleftheria
- Dali-Kemmery Lola
- Dalton Emma
- Damant Rose
- Daniel Conway
- Daniel Gayatri Daniel
- Daniel Harvey
- Daniel Hull
- Daniel Sonya
- Dankl Daniel
- Darko Julia
- Darwish Sharif
- Das Suparna
- Dasrath Ashish
- Datson Amanda
- Daubeny Thomas
- Daugaard Morten
- Davari Maria
- Dave Tejal
- Davies Charlotte
- Davies Helen
- Davies Keith
- Davies Kirsty
- Davies Leigh
- Davies Zoe
- Davis Edward
- Davis Fiona
- Davis Simon
- Daya Bhavika
- De Andrés Ibanez José Antonio
- De Baerdemaeker Luc
- de Beer Johan
- de Boer Hans Donald
- De Bruyne Ann
- de Fretes Jennifer
- de Gasperi Julia
- de Hert Stefan
- De Jongh Karen
- De Kegel Dirk
- De Meyer Jenine N.
- De Oliveira Mirella Cristine
- de Rudnicki Stéphane
- de Swardt Mathew
- de Vasconcellos Kim
- de Villiers Martin
- de Wet Jacques
- Deacon Matthew
- Deblaere Isabel
- Dedemadi Georgia
- Deen Tariq
- Deepak Shantal
- Deighton Kerry
- Deja Maria
- Del Valle Santiago Garcia
- Delgado García David R.
- Della Rocca Giorgio
- Demartines Nicolas
- Dempsey Ged
- Dempster Angie
- Denham Samuel
- Dent Kathy
- Dermitzaki Despina
- Desbordes Jacques
- Despotidis Vasileios
- Diaconescu Ciresica
- Diago Lorena Gómez
- Dias Fernando
- Dias Sandra
- Dickson Jane
- Ditai James
- Divatia Jigeeshu
- Dixon Liane
- Dobson Gary
- Docherty Philip
- Dodiyi-Manuel Amabra
- Dodsworth Kerry
- Dolan Rachael
- Dominguez Saul Velaz
- Doncel Ma Sherezade Tovar
- Dong Beibei
- Donohue Roana
- Donovan Andrew
- Douglas Jeanene
- Doumos Rodamanthos
- Downes Charlotte
- Doyle Donna
- Dragnea Dragos
- Dragoescu Nicoleta Alice
- Drake Matthew
- Drimala Maria
- Drinkwater Zoe
- Drummond Leanne
- Du Fang
- Du Xindan
- Duarte Célia
- Dube Nokukhanya Z.
- Duca Alejandro
- Dudgeon Lucy
- Dudson Rosie
- Duenser Martin
- Dumitrascu Clementina Oana
- Dumitrescu Alexandra
- Dunay Artem
- Dunk Nigel
- Durant Emma
- Durodola Adekunle
- Dursin Ade Nurkacan
- Durst Alexander
- Duttchen Kaylene
- Dutu Madalina
- Dwyer Heather
- Dylst Dimitri
- Dzhamullaev Parvin
- Dzulkipli Norizawati
- Echem Richard
- Edmond Holly
- Edwards Jayne
- Edwards Marc
- Edwards Mark
- Efthymiadi Andromachi
- Egan Thomas
- Eggleston Christopher
- Eichwalder Andreas
- Eikman Johan
- Ekelund Kim
- El-Sayed Ahmed
- Elabib Ali
- Elena Gkonezou
- Elferink-Vonk Renske
- Elgasim Magdi
- Ellis Jessica
- Ellis Kate
- Elna Cifra
- Emma Temlett
- Endersby Simon
- Eneje Philip
- Eng Kristen
- English Duane
- English Rose
- Epodoi Joseph
- Ernesto Ernesto Pastor Martinez
- Eskildsen Katrine Zwicky
- Esteves Simao
- Ethgen Sabine
- Evans Adam
- Evans Chris
- Everingham Kirsty
- Ewe Renee
- Ezekiel Emmanuel
- Ezike Humphrey
- Fagerlund Malin Jonsson
- Faina Lais
- Falk Elke
- Fan Hao
- Fan Lihua
- Fan Yu
- Fanfani Lucia Caterina
- Fang Xiangming
- Faponle Folayemi
- Faria e Maia Dionisio
- Faria Filomena
- Farid Nahla
- Farina Zane
- Farrell Helen
- Farrow Mehreen
- Fasina Oluyemi
- Fatungase Oluwabunmi Motunrayo
- Faulds Matthew
- Fei Yue
- Fellinger Paul
- Feng Yunlin
- Fengas Lior
- Fergey Lauren
- Ferguson Marissa
- Fernández Salvador
- Ferrando Carlos
- Ferreira da Costa Fischer Bruna
- Filipescu Daniela
- Filippopoulos Andreas
- Finch Amanda
- Fiorentza Klara
- Fischbach Norbert
- Flatt Jim
- Fleischer Andreas
- Fleisher Lee
- Fleisher Lee A.
- Flores Armando Adolfo Alvarez
- Flores Kathrina
- Flossos Andreas
- Foers William
- Foglia Julena
- Foley Julia
- Fonck Kristine
- Foord Denise
- Foot Helen
- Foot Jayne
- Ford David
- Forget Patrice
- Forsans Emma
- Forstner Karin
- Fosch de Campos Ferreira Mariana
- Foster Rebecca
- Foubert Luc
- Fouracres Anna
- Fowler A. J.
- Fowler Alexander
- Fowler Carolyn
- Fraga Julia Merladete
- Fragandreas George
- Francis Daren
- Franklin John
- Franks Romilla
- Frantzeskos Georgios
- Freeman David
- Freeman Victoria
- Freethy Alexander
- Freitas Katie
- Freschini Angela
- Freschini David
- Frewer Natasha
- Fritsch Gerhard
- Frost Victoria
- Fu Kaiwen
- Fu Shuying
- Fu Yunbin
- Fuad Akram
- Fuentes Isabel
- Fulton Graham
- Funk Bonita
- Funk Duane
- Furrer Markus
- Futier Emmanuel
- Gaitanakis Stylianos
- Gall Lewis
- Gallacher Pete
- Gallard Sian
- Gallego Laura
- Gama N. Sibusiso
- Gambhir Rajiv
- Ganter Donna Louise
- Ganter Michael T.
- Gao Hong
- Garcia Juliana
- Garcia-Saiz Irene
- García-Pérez Maria Luisa
- Gardikou Varvara Vanessa
- Gardiner Matthew
- Garg Atul
- Garg Sameer
- Garg Sanjeev
- Garrett Emily
- Gastaldi Christian
- Gatta Alessandro
- Gaudin Christophe
- Gavril Laura
- Gbolahan Olalere
- Ge Xiaodong
- Geddoa Burair
- Geddoa Emad
- Geisen Martin
- Geldenhuys Jacques
- Gemert Ankie Koopman-van
- Geng Wujun
- Georgakakis Georgios
- George Ronald
- Georgiou Georgios
- Georgopoulou Eleni
- Gercek Yuksel
- Germann Reinhard
- Geromarkaki Elisavet
- Ghignone Federico
- Ghosh Alison
- Ghushe Neil
- Giancarlo Luigi
- Giannaki Chrysavgi
- Gibson-Lapsley Hannah
- Giles Julian
- Gill James
- Gill Satwant
- Gill Talvinder
- Gille Jochen
- Gillespie David
- Gillies M.
- Gillies Michael
- Gilmore Jemma
- Gilmour Fiona
- Gkini Konstantia-Paraskevi
- Gkiokas Georgios
- Gkioni Panagiota
- Glasbey James
- Glasgow Emma
- Glister Georgina
- Glover Lyn
- Goebel Ulrich
- Goga Ismail E.
- Goga Riaz
- Goldberg Olivia
- Golder Kim
- Gondo Prisca
- Gong Haixia
- Gonzalez Alba Perez
- Gordon Paul
- Goss Harry
- Gouws Hanni
- Govender Komalan
- Govindasamy Vishendran
- Grace Anuforo
- Gracia Estefania
- Gradwohl-Matis Ilse
- Granum Simon Nørgaard
- Graterol Juan
- Gratrix Karen
- Graves Lynne
- Gray Carol
- Gray Catherine
- Gray Sophie
- Greaves Rosanna
- Green Garyth M.
- Green-Thompson Randolph
- Greene Michael
- Gregory Peter
- Grey Ben
- Griffiths Ewen
- Grigoras Ioana
- Grigoryev Evgeny
- Grintescu Ioana
- Grishkowez Elena
- Grocott Mike
- Grosu Ramona - Mihaela
- Grubmueller Karl Gernot
- Gudaca Mariethel
- Guimarães Mario
- Guizeline Jaqueline
- Gunn Jacqueline
- Guo Baolei
- Guo Fengying
- Guo Huinan
- Guo Yongqing
- Guo Zheng
- Guok Eng Ching
- Gupta Ajay
- Gupta Janesh Kumar
- Guttenthaler Vera
- Guy Kramer
- Gätke Mona Ring
- Haberl Claudia
- Habicher Marit
- Hack Yvonne
- Haddow James
- Hadebe Bernard
- Hadfield Daniel
- Hagau Natalia
- Haigh Kathryn
- Haisjackl Markus
- Hales Dawn
- Hall Andrew Macalister
- Hall Kathryn
- Hall Richard
- Hall Roger
- Halliwell Richard
- Hambidge Oliver
- Hamdan Alhafidz
- Hamilton Caroline
- Hamzah Zulkarnain
- Han Kunyuan
- Han Yangyang
- Handayani Dini
- Hanna George
- Harden Catherine
- Hare Gregory
- Hariharan Vimal
- Harper Mark
- Harrichandparsad R.
- Harries Rhiannon
- Harris Benjamin
- Harris Clair
- Harris James
- Harris Meredyth
- Harris Rudy
- Harris Sarah
- Harrison Jonathan
- Harsan Cristian Remus
- Hartmann Andreas
- Hartmann Cristina
- Haselberger Simone
- Hatton Jonathan
- Haunch Kirsty
- Hawes Elizabeth
- Hawkins Lesley
- Hay David
- Hayes Katia
- Hayes Morgan Philip
- He Changlin
- He Jie
- He Long
- He Miao
- He Xin
- Heather Blaylock
- Hedin Annika
- Heintzelmann Simon Bisgaard
- Helen Bryant
- Hellewell Alistair
- Helliwell Laurence
- Hellstrom Johanna
- Helmy Naeder
- Hennings Charles
- Hering Jens Peter
- Hernandez Carlos B.
- Hernandez Miguel
- Hesketh Sue
- Hewson R.
- Hewson Russ
- Hewson Russell
- Heymans Chan Hey Man
- Heyse Bjorn
- Hicks Catherine
- Hidayatullah Rahmat
- Hiesmayr Michael
- Higgie Kushlin
- Hill Gillian
- Hill Simon
- Hillermann Thomas
- Hills Vicky
- Hinther Ashley
- Hinxman Honor
- Hitchcock Rachael
- Hoare Siobhan
- Hobrok Maria
- Hodgkiss Tracey
- Hodgson Richard E.
- Hodzovic Emil
- Hoedt Marielle den
- Hoeft Andreas
- Hoelzenbein Thomas
- Hofer Christoph
- Hoffer Franz
- Hoffmann João
- Holaubek Caroline
- Holden Douglas
- Hollands Heidi
- Holliger Stephan
- Hollmann Markus
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- Zerman Luiza
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- Zhang Yuan
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- Zhao Jinning
- Zhao Lei
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- Zhao Weilu
- Zhao Xiaoying
- Zhen Jungang
- Zheng Kang
- Zheng Lina
- Zheng Tianzhao
- Zhong Yi
- Zhou Ce
- Zhou Dachun
- Zhou Haidong
- Zhou Haiyan
- Zhou Jiali
- Zhou Jialong
- Zhou Jing
- Zhou Xian-jin
- Zhu Xiaomao
- Zhu Xiaoping
- Zhu Yi
- Zhu Zhipeng
- Zhuang Xiuxiu
- Zilis Georgios
- Zingerle Nicolette
- Zingg Urs
- Zoerner Frank
- Zonneveldt Harry
- Zou Xiaohua
- Zoulamoglou Menelaos
- Zsisku Lajos
- Åkring Irene
- Ögren Katrin
- Publication venue
- Health Sciences Research Commons
- Publication date
- 30/10/2017
- Field of study
© 2017 British Journal of Anaesthesia Background: The surgical safety checklist is widely used to improve the quality of perioperative care. However, clinicians continue to debate the clinical effectiveness of this tool. Methods: Prospective analysis of data from the International Surgical Outcomes Study (ISOS), an international observational study of elective in-patient surgery, accompanied by a systematic review and meta-analysis of published literature. The exposure was surgical safety checklist use. The primary outcome was in-hospital mortality and the secondary outcome was postoperative complications. In the ISOS cohort, a multivariable multi-level generalized linear model was used to test associations. To further contextualise these findings, we included the results from the ISOS cohort in a meta-analysis. Results are reported as odds ratios (OR) with 95% confidence intervals. Results: We included 44 814 patients from 497 hospitals in 27 countries in the ISOS analysis. There were 40 245 (89.8%) patients exposed to the checklist, whilst 7508 (16.8%) sustained ≥1 postoperative complications and 207 (0.5%) died before hospital discharge. Checklist exposure was associated with reduced mortality [odds ratio (OR) 0.49 (0.32–0.77); P\u3c0.01], but no difference in complication rates [OR 1.02 (0.88–1.19); P=0.75]. In a systematic review, we screened 3732 records and identified 11 eligible studies of 453 292 patients including the ISOS cohort. Checklist exposure was associated with both reduced postoperative mortality [OR 0.75 (0.62–0.92); P\u3c0.01; I2=87%] and reduced complication rates [OR 0.73 (0.61–0.88); P\u3c0.01; I2=89%). Conclusions: Patients exposed to a surgical safety checklist experience better postoperative outcomes, but this could simply reflect wider quality of care in hospitals where checklist use is routine