ALP-LEFT Interference and the Muon (g−2)(g-2)

The low-energy effective field theory (LEFT) provides the appropriate framework to describe particle interactions below the scale of electroweak symmetry breaking, $\mu_w\sim v$. By matching the Standard Model onto the LEFT, non-zero Wilson coefficients of higher-dimensional operators are generated, suppressed by the corresponding power of $1/v$. An axion or axion-like particle (ALP) with mass $m_a\ll\mu_w$ that interacts with the Standard Model via classically shift-invariant dimension-five operators would also contribute to the LEFT Wilson coefficients, since it can appear as a virtual particle in divergent Green's functions and thus has an impact on the renormalization of the LEFT operators. We present the full set of one-loop ALP-induced source terms modifying the renormalization-group evolution equations of the LEFT Wilson coefficients up to dimension-six order. Our framework allows for model-independent ALP searches at low energies from current bounds on LEFT Wilson coefficients. As a concrete application, we present an improved prediction for ALP effects on the anomalous magnetic moment of the muon.Comment: 30 pages, 6 figures, 1 table, 1 appendi

Rolle der Isoenzyme COX-1 und COX-2 bei der Entstehung und Aufrechterhaltung entzündungsinduzierter Hyperexzitabilität nozizeptiver Hinterhornneurone

In der vorliegenden Arbeit erfolgte am Modell der Kaolin/Carrageenan-induzierten akuten Arthritis bei der Ratte die Untersuchung der Beteiligung der Isoenzyme COX-1 bzw. 2 an der Entstehung und Aufrechterhaltung spinaler Übererregbarkeit. Dabei standen die direkten spinalen Effekte einer Reihe von COX-Hemmstoffen in verschiedenen Entzündungsstadien, nämlich einerseits während der Entstehung einer zentralen Sensibilisierung und andererseits wenn die spinalen Neurone bereits sensibilisiert waren im Mittelpunkt. Mittels extrazellulärer Ableitung wurden Veränderungen im Antwortverhalten von Hinterhornneuronen mit nozizeptivem Eingang aus dem Knie auf mechanische Reize nicht-noxischer und noxischer Intensität gemessen

K−→π−aK^-\to\pi^- a at Next-to-Leading Order in Chiral Perturbation Theory

The weak decay $K^-\to\pi^- a$ is a powerful probe of axion-like particles (ALPs). In this work, we provide a comprehensive analysis of this process within chiral perturbation theory, extending existing calculations by including complete next-to-leading order (NLO) contributions and isospin-breaking corrections at first order in $(m_u-m_d)$. We show that the consistent incorporation of ALPs in the QCD and weak chiral Lagrangians requires a non-trivial extension of the corresponding operator bases, which we describe in detail. Furthermore, we show that in the presence of an ALP the so-called weak mass term, which is unobservable in the Standard Model, is non-redundant already at leading order. We find that NLO corrections associated with flavor-violating ALP couplings modify the leading-order result by a few percent, with only small uncertainties. On the contrary, the NLO corrections proportional to flavor-conserving ALP couplings lead to an $\mathcal{O}(20\%)$ reduction relative to the leading-order predictions. These corrections are accompanied by a large uncertainties mainly originating from the QCD low-energy constant $L_{4,r}$ as well as from the presence of various unknown weak low-energy constants. We emphasize the importance of a precise determination of these coupling parameters for the successful study of new physics in light meson decays.Comment: 35 pages, 8 figure

A global analysis of axion-like particle interactions using SMEFT fits

In the presence of an axion or axion-like particle (ALPs) that couples to the Standard Model via dimension-five interactions, dimension-six SMEFT interactions are generated via renormalization-group evolution. As many of these SMEFT contributions are experimentally tightly constrained, this "ALP-SMEFT interference" can be used to derive indirect bounds on the ALP couplings to the Standard Model particles. We present a global analysis of the Wilson coefficients of the ALP effective Lagrangian based on Higgs, top, and low-energy data. The obtained bounds are model independent and are competitive or even stronger than direct bounds in the GeV to TeV ALP-mass range.Comment: 18 pages, 5 figure

Quantification and mitigation of the instrument effects and uncertainties of the airborne limb imaging FTIR GLORIA

The Gimballed Limb Observer for Radiance Imaging of the Atmosphere (GLORIA) is an infrared imaging FTS (Fourier transform spectrometer) with a 2-D infrared detector that is operated on two high-flying research aircraft. It has flown on eight campaigns and measured along more than 300 000 km of flight track.This paper details our instrument calibration and characterization efforts, which, in particular, almost exclusively leverage in-flight data. First, we present the framework of our new calibration scheme, which uses information from all three available calibration sources (two blackbodies and upward-pointing “deep space” measurements). Part of this scheme is a new algorithm for correcting the erratically changing nonlinearity of a subset of detector pixels and the identification of the remaining bad pixels.Using this new calibration, we derive a 1σ bound of 1 % on the instrument gain error and a bound of 30 nW cm−2 sr−1 cm on the instrument offset error. We show how we can examine the noise and spectral accuracy for all measured atmospheric spectra and derive a spectral accuracy of 5 ppm on average. All these errors are compliant with the initial instrument requirements.We also discuss, for the first time, the pointing system of the GLORIA instrument. Combining laboratory calibration efforts with the measurement of astronomical bodies during the flight, we can achieve a pointing accuracy of 0.032∘, which corresponds to one detector pixel.The paper concludes with a brief study of how these newly characterized instrument parameters affect temperature and ozone retrievals. We find that the pointing uncertainty and, to a lesser extent, the instrument gain uncertainty are the main contributors to the error in the result

Biomass burning pollution in the South Atlantic upper troposphere: GLORIA trace gas observations and evaluation of the CAMS model

In this study, we present simultaneous airborne measurements of peroxyacetyl nitrate (PAN), ethane (C2H6), formic acid (HCOOH), methanol (CH3OH), and ethylene (C2H4) above the South Atlantic in September and October 2019. Observations were obtained from the Gimballed Limb Observer for Radiance Imaging of the Atmosphere (GLORIA), as two-dimensional altitude cross sections along the flight path. The flights were part of the SouthTRAC (Transport and Composition in the Southern Hemisphere Upper Troposphere/Lower Stratosphere) campaign with the German High Altitude and Long Range Research Aircraft (HALO). On two flights (8 September 2019 and 7 October 2019), large enhancements of all these substances were found between 7 and 14 km altitude with maximum volume mixing ratios (VMRs) of 1000 pptv for PAN, 1400 pptv for C2H6, 800 pptv for HCOOH, 4500 pptv for CH3OH, and 200 pptv for C2H4. One flight showed a common filamentary structure in the trace gas distributions, while the second flight is characterized by one large plume. Using backward trajectories, we show that measured pollutants likely reached upper troposphere and lower stratosphere (UTLS) altitudes above South America and central Africa, where elevated PAN VMRs are visible at the surface layer of the Copernicus Atmosphere Monitoring Service (CAMS) model during the weeks before both measurements. In comparison to results of the CAMS reanalysis interpolated onto the GLORIA measurement geolocations, we show that the model is able to reproduce the overall structure of the measured pollution trace gas distributions. For PAN, the absolute VMRs are in agreement with the GLORIA measurements. However, C2H6 and HCOOH are generally underestimated by the model, while CH3OH and C2H4, the species with the shortest atmospheric lifetimes of the pollution trace gases discussed, are overestimated by CAMS. The good agreement between model and observations for PAN suggests that the general transport pathways and emissions locations are well captured by the model. The poorer agreement for other species is therefore most likely linked to model deficiencies in the representation of loss processes and emission strength

Implementation of health-related quality of life in the German TraumaRegister DGU® - first results of a pilot study

BACKGROUND Approximately 30,000 people are affected by severe injuries in Germany each year. Continuous progress in prehospital and hospital care has significantly reduced the mortality of polytrauma patients. With increasing survival rates, the functional outcome, health-related quality (hrQoL) of life and ability to work are now gaining importance. Aim of the study is, the presentation of the response behavior of seriously injured patients on the one hand and the examination of the factors influencing the quality of life and ability to work 12 months after major trauma on the other hand. Building on these initial results, a standard outcome tool shall be integrated in the established TraumaRegister DGU® in the future. METHODS In 2018, patients [Injury Severity Score (ISS) ≥ 16; age:18-75 years] underwent multicenter one-year posttraumatic follow-up in six study hospitals. In addition to assessing hrQoL by using the Short-Form Health Survey (SF-12), five additional questions (treatment satisfaction; ability to work; trauma-related medical treatment; relevant physical disability, hrQoL as compared with the prior to injury status) were applied. RESULTS Of the 1,162 patients contacted, 594 responded and were included in the analysis. The post-injury hrQoL does not show statistically significant differences between the sexes. Regarding age, however, the younger the patient at injury, the better the SF-12 physical sum score. Furthermore, the physically perceived quality of life decreases statistically significantly in relation to the severity of the trauma as measured by the ISS, whereas the mentally perceived quality of life shows no differences in terms of injury severity. A large proportion of severely injured patients were very satisfied (42.2%) or satisfied (39.9%) with the treatment outcome. It should be emphasized that patients with a high injury severity (ISS > 50) were on average more often very satisfied with the treatment outcome (46.7%). A total of 429 patients provided information on their ability to work 12 months post-injury. Here, 194 (45.2%) patients had a full employment, and 58 (13.5%) patients were had a restricted employment. CONCLUSION The present results show the importance of a structured assessment of the postinjury hrQoL and the ability to work after polytrauma. Further studies on the detection of influenceable risk factors on hrQoL and ability to work in the intersectoral course of treatment should follow to enable the best possible outcome of polytrauma survivors

The German National Registry of Primary Immunodeficiencies (2012-2017)

Introduction: The German PID-NET registry was founded in 2009, serving as the first national registry of patients with primary immunodeficiencies (PID) in Germany. It is part of the European Society for Immunodeficiencies (ESID) registry. The primary purpose of the registry is to gather data on the epidemiology, diagnostic delay, diagnosis, and treatment of PIDs. Methods: Clinical and laboratory data was collected from 2,453 patients from 36 German PID centres in an online registry. Data was analysed with the software Stata® and Excel. Results: The minimum prevalence of PID in Germany is 2.72 per 100,000 inhabitants. Among patients aged 1–25, there was a clear predominance of males. The median age of living patients ranged between 7 and 40 years, depending on the respective PID. Predominantly antibody disorders were the most prevalent group with 57% of all 2,453 PID patients (including 728 CVID patients). A gene defect was identified in 36% of patients. Familial cases were observed in 21% of patients. The age of onset for presenting symptoms ranged from birth to late adulthood (range 0–88 years). Presenting symptoms comprised infections (74%) and immune dysregulation (22%). Ninety-three patients were diagnosed without prior clinical symptoms. Regarding the general and clinical diagnostic delay, no PID had undergone a slight decrease within the last decade. However, both, SCID and hyper IgE- syndrome showed a substantial improvement in shortening the time between onset of symptoms and genetic diagnosis. Regarding treatment, 49% of all patients received immunoglobulin G (IgG) substitution (70%—subcutaneous; 29%—intravenous; 1%—unknown). Three-hundred patients underwent at least one hematopoietic stem cell transplantation (HSCT). Five patients had gene therapy. Conclusion: The German PID-NET registry is a precious tool for physicians, researchers, the pharmaceutical industry, politicians, and ultimately the patients, for whom the outcomes will eventually lead to a more timely diagnosis and better treatment