Национальная идентичность СМИ: ретроспективное исследование распространённости русскоязычных СМИ в Восточной Европе

The research focuses on the issues, concerning the national identity of mass media in the era of globalization. It was the attempt to examine the linguistic situation in the multi-ethnic society, which consists of clearly defined groups of national minorities. Revealing the problems and consequences of language groups’ shift through mass media became the main objective of the research. The retrospective data on the Russian language mass media prevalence in the Eastern European countries (for example, of Estonia) were used as an analytical background. In Estonia, almost half of the Russian-speaking population cannot follow mass media due to limited knowledge of the language. These particularities for 1998-2013 were described in this article. The obtained results led to the conclusion that the major part of the Russian-speaking population of Estonia mainly follows the Russian television channels and, therefore, is more integrated in the Russian information realm than in Estonian. The multidirectional dynamics of mass media activity on prevalence was revealed. The contradictions between the Russian and Estonian mass media, Estonia and the EU on multilingual social mass media role were highlighted in the article.El estudio se centra en la identidad nacional de los medios de comunicación de masas en la era de la globalización. Se ha tratado de examinar la situación lingüística en la sociedad pluricultural en que existen grupos de minorías nacionales bien definidos. El observatorio principal del estudio fue la identificación de los problemas y las consecuencias del desplazamiento de los grupos lingüísticos a través de los medios de comunicación de masas. Como la base analítica, se utilizaron los datos retrospectivos sobre la prevalencia de los medios de comunicación de masas rusos en Estonia, donde alrededor de la mitad de la población que habla el idioma ruso no puede seguir los medios de comunicación de masas en Estonia debido a la falta de conocimiento del idioma. Trataremos de hacer un seguimiento de estas características durante el período 1998-2013. Los resultados han llevado a la conclusión de que gran parte de la población que habla el idioma ruso de Estonia está principalmente siguiendo los canales de televisión rusos y, por lo tanto, está más integrada en el campo de información de Rusia que de Estonia. Se ha identificado la dinámica diversificada en la actividad de los medios de comunicación de masas por el tipo de distribución. El artículo destaca las contradicciones entre los medios de comunicación de masas estonios y rusos, entre Estonia y la UE sobre el papel de los medios de comunicación de masas públicos multilingües.Исследование посвящено вопросам национальной идентичности средств массовой информации в эпоху глобализации. Предпринята попытка рассмотреть языковую ситуацию в полиэтническом обществе, где имеются четко выраженные группы национальных меньшинств. Основной целью исследования стало выявление проблем и последствий смещения языковых групп населения через СМИ. В качестве аналитической базы использовалось ретроспективные данные о распространённости русскоязычных СМИ в Эстонии, где около половины русскоязычного населения не могут следить за средствами массовой информации на эстонском языке из-за недостаточного знания языка. Мы постараемся проследить эти особенности за период 1998-2013 годов. Полученные результаты привели к выводу, что большая часть русскоговорящего населения Эстонии в основном следит за российскими телеканалами и поэтому более интегрирована в информационное поле России, чем в эстонское. Выявлена разнонаправленная динамика в активности СМИ по типу распространения. В статье подчеркиваются противоречия между эстонскими и русскоязычными СМИ, между Эстонией и ЕС относительно роли мультиязычных общественных СМИ

Means of Influence on Public Opinion in Political Context: Speech Manipulation in the Media

The manipulation problem in the media has been still pressing. Processes and techniques intended for making an influence on public opinion and behaviors are in ongoing improvement, making it difficult to access an objective image of the world. Therefore, this research aims at emphasizing the importance of speech (language) means that form a basis of manipulations in mass communications. To achieve this, authors have provided the systematization of social influence processes in the media and made techniques and means of speech influence clearer. Authors provided a content analysis of texts of 2018 from the media using news resources of different countries ('Russia Today', 'RIA Novosti', 'Ukrinform' and 'Fox News Channel') as an example. The research subject consists of news materials of a politico-social nature on Russia’s participation in the Syrian conflict. Authors have empirically revealed a clear desire to influence readers of the media resources using covert means of the manipulative influence. In total, they have found five types of manipulative speech influence in texts of the media. There are self-presentation, semantic speech strategies, persuasive strategies, hit piece and information manipulation. A lexical toolkit of speech manipulation includes euphemisms, dysphemisms, slogan words, speech metaphorization, etc. Media texts have become more and more complicated as they contain hints, precedent phenomena, irony, as well as metamessages of informative presentation. Each media of the selected ones more or less uses means of speech manipulation in varying degrees. Applications of such methods of influence (in number) almost directly depend on a political attitude towards an object

Mathematical model of elastic ribbed shell dynamics interaction with viscous liquid under vibration

The mechanical model of the system, formed by two surfaces of the coaxial cylindrical shells interacting with viscous incompressible liquid between them under vibration, is considered. The outer shell is geometrically irregular, and inner one is an absolutely rigid cylinder. The mathematical model of this system, consisting of differential equations in partial derivatives for describing dynamics of viscous incompressible liquid and an elastic ribbed shell together with boundary conditions is constructed. The expressions for amplitude frequency characteristics of outer geometrically irregular shell are discovered

Means of Influence on Public Opinion in Political Context: Speech Manipulation in the Media

The manipulation problem in the media has been still pressing. Processes and techniques intended for making an influence on public opinion and behaviors are in ongoing improvement, making it difficult to access an objective image of the world. Therefore, this research aims at emphasizing the importance of speech (language) means that form a basis of manipulations in mass communications. To achieve this, authors have provided the systematization of social influence processes in the media and made techniques and means of speech influence clearer. Authors provided a content analysis of texts of 2018 from the media using news resources of different countries (‘Russia Today,’ ‘RIA Novosti,’ ‘Ukrinform’ and ‘Fox News Channel’) as an example. The research subject consists of news materials of a politico-social nature on Russia’s participation in the Syrian conflict. Authors have empirically revealed a clear desire to influence readers of the media resources using covert means of the manipulative influence. In total, they have found five types of manipulative speech influence in texts of the media. There are self-presentation, semantic speech strategies, persuasive strategies, hit piece and information manipulation. A lexical toolkit of speech manipulation includes euphemisms, dysphemisms, slogan words, speech metaphorization, etc. Media texts have become more and more complicated as they contain hints, precedent phenomena, irony, as well as metamessages of informative presentation. Each media of the selected ones more or less uses means of speech manipulation in varying degrees. Applications of such methods of influence (in number) almost directly depend on a political attitude towards an object

The Alternatively Spliced Acid Box Region Plays a Key Role in FGF Receptor Autoinhibition

SummaryUncontrolled fibroblast growth factor (FGF) signaling can lead to human malignancies necessitating multiple layers of self-regulatory control mechanisms. Fibroblast growth factor receptor (FGFR) autoinhibition mediated by the alternatively spliced immunoglobulin (Ig) domain 1 (D1) and the acid box (AB)-containing linker between D1 and Ig domain 2 (D2) serves as the first line of defense to minimize inadvertent FGF signaling. In this report, nuclear magnetic resonance and surface plasmon resonance spectroscopy are used to demonstrate that the AB subregion of FGFR electrostatically engages the heparan sulfate (HS)-binding site on the D2 domain in cis to directly suppress HS-binding affinity of FGFR. Furthermore, the cis electrostatic interaction sterically autoinhibits ligand-binding affinity of FGFR because of the close proximity of HS-binding and primary ligand-binding sites on the D2 domain. These data, together with the strong amino acid sequence conservation of the AB subregion among FGFR orthologs, highlight the universal role of the AB subregion in FGFR autoinhibition

The Mechanisms of the Regulation of Immune Response in Patients with Comorbidity of Chronic Obstructive Pulmonary Disease and Asthma

Background. Comorbidity of chronic obstructive pulmonary disease (COPD) and asthma (asthma COPD overlap syndrome, ACOS) is a significant problem in pulmonary practice, whose pathogenetic issues are not clarified yet. Objective. To study the features of the regulation of immune response in patients with comorbid COPD and asthma. Methods. We assessed the levels of CD3+, CD4+, CD8+, CD4+/CD8+, CD19+, CD25+, HLA-DR, total IgE, TNF-α, IL-4, IFN-γ, TXB2, and LTB4 in patients with comorbid COPD and asthma. Results. The study involved 44 people with COPD, 39 people with asthma, and 12 people with comorbid COPD and asthma. The specific features in comorbid COPD and asthma were lymphocytosis, increased absolute count of T-helper cells, increased cytotoxic T-lymphocytes in relative and absolute count, increased relative and absolute numbers of B-lymphocytes, and high levels of total IgE. The elevated levels of TNF-α and IL-4 and inhibition of IFN-γ production were detected. The content of LTB4 was maximal; TXB2 levels were higher than in control group but lower than in COPD and asthma. Conclusion. In comorbid COPD and asthma inflammation increased even during stable period. High levels of eicosanoids, low production of Th1-type cytokines, and active synthesis of opposition IL-4, along with increased IgE, indicate the activation of Th2-type immune response

Anticoagulant selection in relation to the SAMe-TT2R2 score in patients with atrial fibrillation. the GLORIA-AF registry

Aim: The SAMe-TT2R2 score helps identify patients with atrial fibrillation (AF) likely to have poor anticoagulation control during anticoagulation with vitamin K antagonists (VKA) and those with scores >2 might be better managed with a target-specific oral anticoagulant (NOAC). We hypothesized that in clinical practice, VKAs may be prescribed less frequently to patients with AF and SAMe-TT2R2 scores >2 than to patients with lower scores. Methods and results: We analyzed the Phase III dataset of the Global Registry on Long-Term Oral Antithrombotic Treatment in Patients with Atrial Fibrillation (GLORIA-AF), a large, global, prospective global registry of patients with newly diagnosed AF and ≥1 stroke risk factor. We compared baseline clinical characteristics and antithrombotic prescriptions to determine the probability of the VKA prescription among anticoagulated patients with the baseline SAMe-TT2R2 score >2 and ≤ 2. Among 17,465 anticoagulated patients with AF, 4,828 (27.6%) patients were prescribed VKA and 12,637 (72.4%) patients an NOAC: 11,884 (68.0%) patients had SAMe-TT2R2 scores 0-2 and 5,581 (32.0%) patients had scores >2. The proportion of patients prescribed VKA was 28.0% among patients with SAMe-TT2R2 scores >2 and 27.5% in those with scores ≤2. Conclusions: The lack of a clear association between the SAMe-TT2R2 score and anticoagulant selection may be attributed to the relative efficacy and safety profiles between NOACs and VKAs as well as to the absence of trial evidence that an SAMe-TT2R2-guided strategy for the selection of the type of anticoagulation in NVAF patients has an impact on clinical outcomes of efficacy and safety. The latter hypothesis is currently being tested in a randomized controlled trial. Clinical trial registration: URL: https://www.clinicaltrials.gov//Unique identifier: NCT01937377, NCT01468701, and NCT01671007

The Changing Landscape for Stroke\ua0Prevention in AF: Findings From the GLORIA-AF Registry Phase 2

Background GLORIA-AF (Global Registry on Long-Term Oral Antithrombotic Treatment in Patients with Atrial Fibrillation) is a prospective, global registry program describing antithrombotic treatment patterns in patients with newly diagnosed nonvalvular atrial fibrillation at risk of stroke. Phase 2 began when dabigatran, the first non\u2013vitamin K antagonist oral anticoagulant (NOAC), became available. Objectives This study sought to describe phase 2 baseline data and compare these with the pre-NOAC era collected during phase 1. Methods During phase 2, 15,641 consenting patients were enrolled (November 2011 to December 2014); 15,092 were eligible. This pre-specified cross-sectional analysis describes eligible patients\u2019 baseline characteristics. Atrial fibrillation disease characteristics, medical outcomes, and concomitant diseases and medications were collected. Data were analyzed using descriptive statistics. Results Of the total patients, 45.5% were female; median age was 71 (interquartile range: 64, 78) years. Patients were from Europe (47.1%), North America (22.5%), Asia (20.3%), Latin America (6.0%), and the Middle East/Africa (4.0%). Most had high stroke risk (CHA2DS2-VASc [Congestive heart failure, Hypertension, Age  6575 years, Diabetes mellitus, previous Stroke, Vascular disease, Age 65 to 74 years, Sex category] score  652; 86.1%); 13.9% had moderate risk (CHA2DS2-VASc = 1). Overall, 79.9% received oral anticoagulants, of whom 47.6% received NOAC and 32.3% vitamin K antagonists (VKA); 12.1% received antiplatelet agents; 7.8% received no antithrombotic treatment. For comparison, the proportion of phase 1 patients (of N = 1,063 all eligible) prescribed VKA was 32.8%, acetylsalicylic acid 41.7%, and no therapy 20.2%. In Europe in phase 2, treatment with NOAC was more common than VKA (52.3% and 37.8%, respectively); 6.0% of patients received antiplatelet treatment; and 3.8% received no antithrombotic treatment. In North America, 52.1%, 26.2%, and 14.0% of patients received NOAC, VKA, and antiplatelet drugs, respectively; 7.5% received no antithrombotic treatment. NOAC use was less common in Asia (27.7%), where 27.5% of patients received VKA, 25.0% antiplatelet drugs, and 19.8% no antithrombotic treatment. Conclusions The baseline data from GLORIA-AF phase 2 demonstrate that in newly diagnosed nonvalvular atrial fibrillation patients, NOAC have been highly adopted into practice, becoming more frequently prescribed than VKA in Europe and North America. Worldwide, however, a large proportion of patients remain undertreated, particularly in Asia and North America. (Global Registry on Long-Term Oral Antithrombotic Treatment in Patients With Atrial Fibrillation [GLORIA-AF]; NCT01468701