ВИХОВНИЙ ПОТЕНЦІАЛ ЖІНКИ-МАТЕРІ В СТАНОВЛЕННІ МАЙБУТНЬОЇ ОСОБИСТОСТІ

The article analyses the influence of maternal education on the formation of a child’s personality. It has been found that disharmonious system of family upbringing and broken relationship between mother and child lead to the negative consequences such as the occurrence of mental and physical abnormalities in a young person, which complicates the process of socialization. There have been determined the conditions for the effectiveness of family education as well as psychological and pedagogical features of maternal education that one needs to consider when planning forms and methods of educational work. В статье проанализировано влияние материнского воспитания на формирование личности ребенка. Установлено, что негативными последствиями дисгармоничности системы семейного воспитания и нарушения отношений между матерью и ребенком является возникновение психических, физических отклонений у маленькой личности, что затрудняет процесс ее социализации. Определены условия эффективности семейного воспитания и выделены психолого-педагогические особенности материнского воспитания, которые необходимо учитывать при планировании форм и методов воспитательной работы.У статті проаналізовано вплив материнського виховання на формування особистості дитини. Встановлено, що негативними наслідками дисгармонійності системи сімейного виховання та порушення стосунків між матір’ю та дитиною є виникнення психічних, фізичних відхилень у маленької особистості, що ускладнює процес її соціалізації. Визначено умови ефективності сімейного виховання та виокремлено психолого-педагогічні особливості материнського виховання, які необхідно враховувати при плануванні форм і методів виховної роботи

Investigation of fibronectin expression by white blood cells in diffuse liver disease of viral etiology

The objectives of this paper were to investigate surfase-associated and intracellular FN expression by white blood cells in diffuse liver disease of viral etiology

Stress–Strain Behaviour of Reparable Composite Panel with Step-Variable Thickness

There is an urgent problem of finding an economically viable method of maintenance and restoration of the bearing capacity of structures of various applications. Repair of structures with patches made of polymeric composite materials is one of the most promising repair technologies. However, an improper choice of parameters of the composite patch leads to unjustified increase in the structure mass and the cost of its further operation. These situations result from the lack of reliable methods for developing the repair process, which take into account the influence of the patch geometry and conditions for performance of repair works on the bearing capacity of the repaired structure. The mathematical model of the reparable composite shell–type panel taking into account inhomogeneity of transverse shear deformations at stepped variation of its thickness has been developed. In contrast to the classical theory of layered shells, the model allows simplifying a three-dimensional problem by setting of the displacement field on the layers’ interfaces and their linear interpolation over thickness of the panel, as well as considering the transverse shear deformations resulting from the strength, temperature, or shrinkage loading. According to results, the maximum rise in stresses in the case of a notched panel occurs in the weakened layer, and it is from this layer the failure of the structure will start. In the event of the patch, the panel surface opposite the reinforcement is the most loaded (i.e., susceptible to failure) surface. To confirm the reliability of the developed model, we compared the analytical calculations with the results of experimental and numerical studies of the deformed state of a panel of step–variable thickness by the method of holographic interferometry and modelling by the finite element method. Displacement fields available from experiments correspond to the predicted theoretical results. The resulting maximum error does not exceed 7%. The data obtained during numerical modelling allowed us to conclude that the accuracy of theoretical calculations is sufficient for engineering practice. Results of the work can be used to solve the practical problems such as determination of stress–strain behaviour of a damaged structure or structure after repair, specification of the permissible delamination dimensions, and defining of parameters of the bonded repair process

Transboundary Cooperation Improves Endangered Species Monitoring and Conservation Actions: A Case Study of the Global Population of Amur Leopards

Political borders and natural boundaries of wildlife populations seldom coincide, often to the detriment of conservation objectives. Transnational monitoring of endangered carnivores is rare, but is necessary for accurate population monitoring and coordinated conservation policies. We investigate the benefits of collaboratively monitoring the abundance and survival of the critically endangered Amur leopard, which occurs as a single transboundary population across China and Russia. Country‐specific results overestimated abundance and were generally less precise compared to integrated monitoring estimates; the global population was similar in both years: 84 (70–108, 95% confidence interval). Uncertainty in country‐specific annual survival estimates were approximately twice the integrated estimates of 0.82 (0.69–0.91, 95% confidence limits). This collaborative effort provided a better understanding of Amur leopard population dynamics, represented a first step in building trust, and lead to cooperative agreements to coordinate conservation policies

Effects of the Temperature–Time Regime of Curing of Composite Patch on Repair Process Efficiency

Repair procedures with the use of composite patches are considered to be the most effective among the current technologies of repair of the structures of various applications. In the process of moulding-on of a patch made of polymeric composite material by means of curing, technological stresses arise in the patch. Determination of residual technological stresses is a priority task for the modelling of the repair process. Reduction of residual stresses can be achieved by optimization of the mode of repair patch curing. For meeting this objective, the method for determination of technological stresses, which arise in the structure under repair in the process of curing of a composite patch, has been developed. The method takes into account the shrinkage, change in physico-mechanical characteristics, rheological processes occurring in the binder during moulding process, and determination of stresses in the structure under repair at any time. Therefore, premature failure of the repair joint at the stage of repair can be avoided. It is shown that the method adequately describes the level of deformations and stresses in the structure being repaired at the stage of heating and holding of the composite patch. Increase in the moulding temperature leads to a reduction in residual stresses in the structure under repair. However, current stresses at the stages of heating and temperature holding are increased significantly. Reliability of assumptions and developed method is confirmed by the comparison with the experimental data. The obtained experimental graph of total deformation of the composite patch allowed us to clearly determine the moment of residual stress occurrence in the structure under repair. This moment matches quite exactly (with the discrepancy not exceeding 5 min) the gel point determined analytically based on dependence of the degree of curing on the moulding mode. Consequently, the research together with the results previously obtained allows making an integrated choice of geometric parameters of the repair composite patch and temperature–time regime of its curing in order to ensure the specified level of strength and stiffness of the structure under repair

A clinical case of post-COVID-19 myoendocarditis and arrhythmic syndrome at the outpatient stage

Background: Infection with the SARS-CoV-2 virus entails the development of complications which affect the prognosis of the underlying disease. More than 40% of COVID-19 complications represent diseases of the cardiovascular system, most of which are the rhythm and conduction disturbances. In order to avoid these complications, it is necessary to detect cases of infection in a timely manner at the outpatient stage. Clinical case description: A 40-year-old patient came to the clinic with complaints of interruptions in the heart rhythm that appeared after the coronavirus infection. The laboratory examination (CBC) revealed signs of systemic inflammation (leukocytosis 12.6×109 U/l; erythrocyte sedimentation rate 18 mm/h, C-reactive protein 18 mg/l); the instrumental examination of the heart revealed the rhythm disturbances in the form of frequent ventricular ectopic activity and weakness of the SA node. The patient received propafenone (150 mg, 3 times a day) as a therapy with a positive effect. Against the background of improvement in the patient’s condition and despite the history of myocarditis and a positive result of enzyme immunoassay for antibodies to SARS-CoV-2 (IgG, 10 BAU/ml), the patient was prescribed immunization with the CoviVac vaccine. After the immunization, the condition worsening was observed in the form of an increase in the rhythm disturbances, which required an inpatient treatment. A clinical diagnosis of recurrent ventricular arrhythmia — ventricular extrasystole was established, and the therapy was corrected. The outcome was favorable. Conclusion: Myocarditis is one of the most common complications of SARS-CoV-2 and should be kept in mind at all stages of medical care. This clinical case demonstrates the importance of the correct diagnosis and treatment of post-COVID myocarditis, as well as the need to assess contraindications for SARS-CoV-2 vaccination in patients with cardiac complications

Distemper, extinction, and vaccination of the Amur tiger

Canine distemper virus (CDV) has recently emerged as an extinction threat for the endangered Amur tiger (Panthera tigris altaica). CDV is vaccine-preventable, and control strategies could require vaccination of domestic dogs and/or wildlife populations. However, vaccination of endangered wildlife remains controversial, which has led to a focus on interventions in domestic dogs, often assumed to be the source of infection. Effective decision making requires an understanding of the true reservoir dynamics, which poses substantial challenges in remote areas with diverse host communities. We carried out serological, demographic, and phylogenetic studies of dog and wildlife populations in the Russian Far East to show that a number of wildlife species are more important than dogs, both in maintaining CDV and as sources of infection for tigers. Critically, therefore, because CDV circulates among multiple wildlife sources, dog vaccination alone would not be effective at protecting tigers. We show, however, that low-coverage vaccination of tigers themselves is feasible and would produce substantive reductions in extinction risks. Vaccination of endangered wildlife provides a valuable component of conservation strategies for endangered species

Helicobacter pylori Adapts to Chronic Infection and Gastric Disease via pH-Responsive BabA-Mediated Adherence

International audienceThe BabA adhesin mediates high-affinity binding of Helicobacter pylori to the ABO blood group antigen-glycosylated gastric mucosa. Here we show that BabA is acid responsive-binding is reduced at low pH and restored by acid neutralization. Acid responsiveness differs among strains; often correlates with different intragastric regions and evolves during chronic infection and disease progression; and depends on pH sensor sequences in BabA and on pH reversible formation of high-affinity binding BabA multimers. We propose that BabA's extraordinary reversible acid responsiveness enables tight mucosal bacterial adherence while also allowing an effective escape from epithelial cells and mucus that are shed into the acidic bactericidal lumen and that bio-selection and changes in BabA binding properties through mutation and recombination with babA-related genes are selected by differences among individuals and by changes in gastric acidity over time. These processes generate diverse H. pylori subpopulations, in which BabA's adaptive evolution contributes to H. pylori persistence and overt gastric disease

The evolving SARS-CoV-2 epidemic in Africa: Insights from rapidly expanding genomic surveillance

INTRODUCTION Investment in Africa over the past year with regard to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) sequencing has led to a massive increase in the number of sequences, which, to date, exceeds 100,000 sequences generated to track the pandemic on the continent. These sequences have profoundly affected how public health officials in Africa have navigated the COVID-19 pandemic. RATIONALE We demonstrate how the first 100,000 SARS-CoV-2 sequences from Africa have helped monitor the epidemic on the continent, how genomic surveillance expanded over the course of the pandemic, and how we adapted our sequencing methods to deal with an evolving virus. Finally, we also examine how viral lineages have spread across the continent in a phylogeographic framework to gain insights into the underlying temporal and spatial transmission dynamics for several variants of concern (VOCs). RESULTS Our results indicate that the number of countries in Africa that can sequence the virus within their own borders is growing and that this is coupled with a shorter turnaround time from the time of sampling to sequence submission. Ongoing evolution necessitated the continual updating of primer sets, and, as a result, eight primer sets were designed in tandem with viral evolution and used to ensure effective sequencing of the virus. The pandemic unfolded through multiple waves of infection that were each driven by distinct genetic lineages, with B.1-like ancestral strains associated with the first pandemic wave of infections in 2020. Successive waves on the continent were fueled by different VOCs, with Alpha and Beta cocirculating in distinct spatial patterns during the second wave and Delta and Omicron affecting the whole continent during the third and fourth waves, respectively. Phylogeographic reconstruction points toward distinct differences in viral importation and exportation patterns associated with the Alpha, Beta, Delta, and Omicron variants and subvariants, when considering both Africa versus the rest of the world and viral dissemination within the continent. Our epidemiological and phylogenetic inferences therefore underscore the heterogeneous nature of the pandemic on the continent and highlight key insights and challenges, for instance, recognizing the limitations of low testing proportions. We also highlight the early warning capacity that genomic surveillance in Africa has had for the rest of the world with the detection of new lineages and variants, the most recent being the characterization of various Omicron subvariants. CONCLUSION Sustained investment for diagnostics and genomic surveillance in Africa is needed as the virus continues to evolve. This is important not only to help combat SARS-CoV-2 on the continent but also because it can be used as a platform to help address the many emerging and reemerging infectious disease threats in Africa. In particular, capacity building for local sequencing within countries or within the continent should be prioritized because this is generally associated with shorter turnaround times, providing the most benefit to local public health authorities tasked with pandemic response and mitigation and allowing for the fastest reaction to localized outbreaks. These investments are crucial for pandemic preparedness and response and will serve the health of the continent well into the 21st century

ВИХОВНИЙ ПОТЕНЦІАЛ ЖІНКИ-МАТЕРІ В СТАНОВЛЕННІ МАЙБУТНЬОЇ ОСОБИСТОСТІ

The article analyses the influence of maternal education on the formation of a child’s personality. It has been found that disharmonious system of family upbringing and broken relationship between mother and child lead to the negative consequences such as the occurrence of mental and physical abnormalities in a young person, which complicates the process of socialization. There have been determined the conditions for the effectiveness of family education as well as psychological and pedagogical features of maternal education that one needs to consider when planning forms and methods of educational work. В статье проанализировано влияние материнского воспитания на формирование личности ребенка. Установлено, что негативными последствиями дисгармоничности системы семейного воспитания и нарушения отношений между матерью и ребенком является возникновение психических, физических отклонений у маленькой личности, что затрудняет процесс ее социализации. Определены условия эффективности семейного воспитания и выделены психолого-педагогические особенности материнского воспитания, которые необходимо учитывать при планировании форм и методов воспитательной работы.У статті проаналізовано вплив материнського виховання на формування особистості дитини. Встановлено, що негативними наслідками дисгармонійності системи сімейного виховання та порушення стосунків між матір’ю та дитиною є виникнення психічних, фізичних відхилень у маленької особистості, що ускладнює процес її соціалізації. Визначено умови ефективності сімейного виховання та виокремлено психолого-педагогічні особливості материнського виховання, які необхідно враховувати при плануванні форм і методів виховної роботи