Melkersson-rosenthal syndrome associated with hemifacial spasm

Melkersson-Rosenthal Syndrome, with findings of repeating facial paralysis, orofacial edema, and fissured tongue, is rarely seen clinically.  We present the case of a 49-year-old female patient diagnosed with Melkersson-Rosenthal Syndrome, with the association of hemifacial spasm. The case diagnosed as Melkersson-Rosenthal Syndrome by the symptoms of the recurrent episodes of facial paralysis, labial edema, and lingual fissure, accompanied by hemifacial spasm is the first to be reported in the literature

Fire retardant coatings

Diplomski rad sastoji se od teorijskog i eksperimentalnog dijela. U teoretskom dijelu rada pobliže je objašnjen sastav premaza, njegovo djelovanje na površinu i vrste premaza. Također, prikazan je pregled metoda zaštite od korozije, te su detaljnije prikazani neposredni troškovi uzrokovani korozijom. Detaljnije je opisan protupožarni premaz za zaštitu čeličnih konstrukcija te je obrađen sustav zaštite protupožarnim premazom. Primjerom zaštite pasivnim protupožarnim sustavom na školskoj dvorani dan je realni prikaz izračuna faktora profila i debljine suhog filma protupožarnog premaza za klase otpornosti R30 i R60. U eksperimentalnom dijelu rada provedena su ispitivanja debljine premaza, ispitivanja u slanoj komori, ispitivanja u vlažnoj komori, ispitivanja prionjivosti, ispitivanja vatrootpornosti te ispitivanja prema normi ISO 4628. Cilj ispitivanja bio je utvrditi otpornost protupožarnog premaza na otvoreni plamen nakon izlaganja korozivnim uvjetima ovisno u sustavu antikorozivne zaštite koja se primjenjivala u sustavu sa protupožarnim premazom. Svaki uzorak je premazan temeljnim premazom, vatrootpornim premazom i završnim premazom. Ispitane su dvije skupine uzoraka, jedna klase otpornosti R30 i jedna klase otpornosti R60.This graduate thesis consists of two parts: theoretical and experimental. In theoretical part of the thesis, the definition of coatings and its effects on the surface is explained more precisely. Also, an overview of the corrosion protection and costs caused by corrosion is given. A fire protection coatings are explained more detailed and one example of fire protection on steel construction is given. Example of passive fire protection on school hall gives a realistic view of the profile factors and the thicnesses of dry film of the fire resistance coatings for R30 and R60. In experimental part of the thesis, dry film coating thickness are measured. Tests in the salt spray and humidity chamber are concluded. Adhession test with Pull-off method, fire protection test were carried out and examinations according to the ISO 4628. Each sample is coated with a primer, fireproof coating and finish coat. Two groups of samples are tested, one with the fireproof resistance class of R30 and with the fireproof resistance class R60

Isolation and Characterization of Hydroxyproline-rich Glycoproteins from Callus Cultures of Susceptible and Resistant Cultivars of Cotton Plants

Extensin is one member of a class of hydroxyproline-rich glycoproteins present in a wide variety of plants and algae [1]. Cell walls of higher plants usually contain small quantities of extensins. Their usually low level is strikingly increased in response to wounding [2,3,4], infection [5,6, 7], elicitor treatment [8,9], and under tissue culture conditions [1 0]. A number of reports,cited in [1 ], have suggested that this accumulation of the glycoprotein may act as a defense mechanism of the plant to disease. Isolation of extensins is a prerequisite to clearly understanding their roles. This step, however, is particularly difficult due to the high insolubility of the glycoprotein. Recent progress in the isolation has been accomplished either by direct elution of a precursor from carrot root and tomato cell walls with a salt solution [11 ,4] or by solubilizing intact extensins from a homogenate of potato tubers and tobacco callus at very acidic pH [12, 13]. In addition to hydroxyproline-rich glycoprotein (HRGP)-extensin precursors, these procedures have led to the solubilization of hydroxyproline-rich arabinogalactan proteins. The objectives of this research were as follows: 1) To isolate extensins from callus cultures of susceptible and resistant cultivars of Gossypium hirsutum (cotton). 2) To determine several biochemical parameters such as amino acid content, hydroxyproline content and carbohydrate content. 3) To relate the differences in the biochemical parameters such as amino acid content and hydroxyproline content to the resistance of the plant to the bacterial pathogen, Xanthomonas campestris pv . malvacearum.Biochemistr

A case of cerebral amyloid angiopathy associated with cerebral venous thrombosis

Cerebral amyloid angiopathy is a clinical picture which is commonly seen in elderly and progressing with the deposition of amyloid in the cerebral arteries without systemic amyloidosis. We report the first case in the literature, a 71 year-old patient having an association of cerebral vein thrombosis and cerebral amyloid angiopathy presenting with recurrent cerebral hemorrhages. The cause-and-result relationship of this association of cerebral vein thrombosis and cerebral amyloid angiopathy should be investigated

The efficacy of alpha-lipoic acid and/or gabapentin on the oxidant-antioxidant system in patients with diabetic polyneuropathy

Background: Diabetic peripheral sensorimotor polyneuropathy is the most common complication seen in patients with diabetes mellitus (DM). Oxidant system plays a crucial role in its physiopathology. We investigated the changes in the serum levels of total antioxidant status (TAS), total oxidant status (TOS), paraoxonase-1 (PON1) and oxidative stress index (OSI) to evaluate the antioxidant efficacy of alpha lipoic acid (ALA) and/or gabapentin in patients with diabetic polyneuropathy (DPN).Methods: Sixty-three type 2 DM patients with diabetic polyneuropathy (DPN) were enrolled in the study. Patients with DPN were divided into four groups in terms of their treatment: Group 1 consisted of treatment-naive patients; patients treated with ALA, gabapentin or combination of ALA and gabapentin comprised groups 2, 3, and 4, respectively. The patients received the medications for at least six weeks.  Serum levels of TAS, TOS, PON1 and OSI were analyzed.Results: No significant difference was observed between the groups according to the oxidative stress parameters studied.Conclusions: The use of ALA and/or gabapentin in patients with DPN did not significantly affect the oxidative stress parameters, including TAS, TOS, PON1, and OSI

Analytical Comparison of Grid File and K-d-b-tree Structures

Computing and Information Scienc

Cognitive functions in neurofibromatosis type 1 patients and unaffected siblings

Attention, learning, and perceptual problems have been reported at various degrees and rates in neurofibromatosis type 1 (NF1). We aimed to define the cognitive profiles frequently associated with NF1. Children and adolescents with NF1 (n=58) were tested using Wechsler Intelligence Scales for Children- Revised (WISC-R), Judgment of Line Orientation, and Bender Visual-Motor Gestalt tests. Comparison groups were unaffected siblings of NF1 patients (n=20), children with attention deficit and hyperactivity disorder (ADHD, n=40), and normal children (n=40). No difference was found between familial or sporadic NF1 cases. Seventeen/58 (29%) of NF1 cases had a full scale IQ 80 (n=27) scored lower in WISC-R subtests measuring visual perception when compared to a healthy control group of similar intelligence, and lower in arithmetic but better in Bender-Gestalt and Judgment of Line Orientation tests when compared to an ADHD group of similar intelligence. These results indicate a high prevalence of mental retardation in a clinical NF1 series. NF1 patients who have normal intelligence may have impaired visual perception, but their visual perceptual problems are less than in ADHD. The tendency of unaffected siblings of NF1 patients to have mildly but consistently low test scores compared to healthy controls needs to be studied further for underlying genetic or environmental factors

Cognitive functions in neurofibromatosis type 1 patients and unaffected siblings

Attention, learning, and perceptual problems have been reported at various degrees and rates in neurofibromatosis type 1 (NF1). We aimed to define the cognitive profiles frequently associated with NF1. Children and adolescents with NF1 (n=58) were tested using Wechsler Intelligence Scales for Children-Revised (WISC-R), Judgment of Line Orientation, and Bender Visual-Motor Gestalt tests. Comparison groups were unaffected siblings of NF1 patients (n=20), children with attention deficit and hyperactivity disorder (ADHD, n=40), and normal children (n=40). No difference was found between familial or sporadic NF1 cases. Seventeen/58 (29%) of NF1 cases had a full scale IQ 80 (n=27) scored lower in WISC-R subtests measuring visual perception when compared to a healthy control group of similar intelligence, and lower in arithmetic but better in Bender-Gestalt and Judgment of Line Orientation tests when compared to an ADHD group of similar intelligence. These results indicate a high prevalence of mental retardation in a clinical NF1 series. NF1 patients who have normal intelligence may have impaired visual perception, but their visual perceptual problems are less than in ADHD. The tendency of unaffected siblings of NF1 patients to have mildly but consistently low test scores compared to healthy controls needs to be studied further for underlying genetic or environmental factors

Effect of flow-induced shear stress in nanomaterial uptake by cells: Focus on targeted anti-cancer therapy

© 2020 by the authors. Licensee MDPI, Basel, Switzerland. Recently, nanomedicines have gained a great deal of attention in diverse biomedical applications, including anti-cancer therapy. Being different from normal tissue, the biophysical microenvironment of tumor cells and cancer cell mechanics should be considered for the development of nanostructures as anti-cancer agents. Throughout the last decades, many efforts devoted to investigating the distinct cancer environment and understanding the interactions between tumor cells and have been applied bio-nanomaterials. This review highlights the microenvironment of cancer cells and how it is different from that of healthy tissue. We gave special emphasis to the physiological shear stresses existing in the cancerous surroundings, since these stresses have a profound effect on cancer cell/nanoparticle interaction. Finally, this study reviews relevant examples of investigations aimed at clarifying the cellular nanoparticle uptake behavior under both static and dynamic conditions

Options in the Treatment of Subacute Sclerosing Panencephalitis: Implications for Low Resource Areas

Purpose of the review Subacute sclerosing panencephalitis (SSPE) is a rare, slowly progressive, and frequently fatal neurodegenerative disorder caused by measles virus. The risk of SSPE remains signifcant globally, with fuctuating incidence noted in in tandem with measles vaccine uptake. This review aims to explore the current global status of SSPE, its treatment, and preventive measures. Recent findings An increase in measles cases have been reported in various parts of the world for different reasons related to the regional context of the outbreak. With reduction in measles vaccine doses since the onset of the COVID-19 pandemic, the future risk of SSPE can only accelerate. In recent years, subsequent cases of SSPE have been reported in the period following documented measles outbreaks in different settings. Concomitantly, there have been efforts to evaluate the effcacy of immunomodulatory, antiviral, and antiseizure therapies that could ameliorate the devastating effects of this disease. This review elucidates on these approaches and their limitations, reasons for poor vaccine coverage in low- and middle-income countries, as well as the possible solutions to the prevention of measles and eventual avoidance of SSPE. Summary Prevention of measles virus infection with the resultant sequelae would be the most effective strategy for the management of SSPE. This approach would be particularly important in low resource setting that currently bears the double burden of widespread communicable diseases and malnutrition