Epidemiological and molecular characteristics of Infectious bursal disease virus naturally infected in the broiler flocks in the Mekong Delta of Vietnam during 2015 and 2018

Infectious bursal disease is a highly contagious and economically devastating disease in the poultry industry worldwide caused by Infectious bursal disease virus (IBDV). However, the data on epidemiological and molecular characteristics of the IBDV outbreak in broiler flocks in the Mekong Delta of Vietnam is unclear. Herein, the epidemiological data of IBDV–positive flocks over a period of 2015–2018 were recorded and the hypervariable region of the VP2 gene of IBDV was amplified to analyze the local phylogeny. The current investigation showed that the overall morbidity and mortality rates of IBDV–positive flocks were 45% and 4.81%, respectively. The IBDV–positive birds occurred clinical signs and macroscopic findings involved with the very virulent (vv) IBDV outbreak. Epidemiological results revealed that IBDV was frequently infected in broiler flocks at 12–42 days, and birds belonging to Tau Vang and Binh Dinh breeds were more sensitive to IBDV. Also, the morbidity rate of IBDV was dramatically decreased in the open farming system. Flocks with complete vaccination significantly dropped morbidity in comparison with other groups. Regarding phylogenetic analysis, all identified IBDV sequences clustered in the same branch of vv phenotype and closely homology with prior strains circulated in Vietnam and other countries. These findings first indicated the epidemiological characteristics of the IBDV–positive broiler flocks in the Mekong Delta and highlighted the IBDV strain circulating in this region

Reliability and validity of the Vietnamese version of the Hamilton D-17 scale

BackgroundWhile depression is a common mental disorder, the diagnosis of this condition is still challenging. Thus, there is a need to have a validated tool to help evaluate symptoms of depression. This study aimed to evaluate the reliability and validity of the Vietnamese version of the Hamilton D-17 scale.MethodsA cross-sectional, descriptive, and validation study was conducted on 183 patients including 139 depressed and 44 non-depressed patients at the University Medical Center of Medicine and Pharmacy University at Ho Chi Minh City. Internal reliability and inter-rater reliability was measured using Cronbach's alpha and intraclass correlation coefficients (ICC). Confirmatory factor analysis (CFA) was used to evaluate construct validity. The Patient Health Questionnaire (PHQ9) was used to measure concurrent validity of the Hamilton D-17. Area under the ROC curve was used to measure criterion validity.ResultsBoth Cronbach alpha coefficient and ICC were at good level at alpha = 0.83 and ICC = 0.83. CFA with a second-order model consisting of four factors fitted the data at good to excellent level. The SRMR (Standardized Root Mean Squared Residual) was 0.066, RMSEA (Root Mean Square Error of Approximation) (90% CI) was 0.053 (0.036–0.069), CFI (comparative fit index) was 0.93, TLI (Tucker Lewis index) was 0.92. The Hamilton D-17 and the PHQ-9 had a correlation coefficient of r = 0.77 (p < 0.001). The Hamilton D-17 had a very high level of criterion validity with AUC of 0.93 (0.88–0.98).ConclusionThe Vietnamese version of the Hamilton D-17 scale has a high level of validity and reliability. The scale should be used to assess symptoms of depression among Vietnamese patients

Spatiotemporal evolution of SARS-CoV-2 Alpha and Delta variants during large nationwide outbreak of COVID-19, Vietnam, 2021

We analyzed 1,303 SARS-CoV-2 whole-genome sequences from Vietnam, and found the Alpha and Delta variants were responsible for a large nationwide outbreak of COVID-19 in 2021. The Delta variant was confined to the AY.57 lineage and caused >1.7 million infections and >32,000 deaths. Viral transmission was strongly affected by nonpharmaceutical interventions

Safety and efficacy of fluoxetine on functional outcome after acute stroke (AFFINITY): a randomised, double-blind, placebo-controlled trial

Background Trials of fluoxetine for recovery after stroke report conflicting results. The Assessment oF FluoxetINe In sTroke recoverY (AFFINITY) trial aimed to show if daily oral fluoxetine for 6 months after stroke improves functional outcome in an ethnically diverse population. Methods AFFINITY was a randomised, parallel-group, double-blind, placebo-controlled trial done in 43 hospital stroke units in Australia (n=29), New Zealand (four), and Vietnam (ten). Eligible patients were adults (aged ≥18 years) with a clinical diagnosis of acute stroke in the previous 2–15 days, brain imaging consistent with ischaemic or haemorrhagic stroke, and a persisting neurological deficit that produced a modified Rankin Scale (mRS) score of 1 or more. Patients were randomly assigned 1:1 via a web-based system using a minimisation algorithm to once daily, oral fluoxetine 20 mg capsules or matching placebo for 6 months. Patients, carers, investigators, and outcome assessors were masked to the treatment allocation. The primary outcome was functional status, measured by the mRS, at 6 months. The primary analysis was an ordinal logistic regression of the mRS at 6 months, adjusted for minimisation variables. Primary and safety analyses were done according to the patient's treatment allocation. The trial is registered with the Australian New Zealand Clinical Trials Registry, ACTRN12611000774921. Findings Between Jan 11, 2013, and June 30, 2019, 1280 patients were recruited in Australia (n=532), New Zealand (n=42), and Vietnam (n=706), of whom 642 were randomly assigned to fluoxetine and 638 were randomly assigned to placebo. Mean duration of trial treatment was 167 days (SD 48·1). At 6 months, mRS data were available in 624 (97%) patients in the fluoxetine group and 632 (99%) in the placebo group. The distribution of mRS categories was similar in the fluoxetine and placebo groups (adjusted common odds ratio 0·94, 95% CI 0·76–1·15; p=0·53). Compared with patients in the placebo group, patients in the fluoxetine group had more falls (20 [3%] vs seven [1%]; p=0·018), bone fractures (19 [3%] vs six [1%]; p=0·014), and epileptic seizures (ten [2%] vs two [<1%]; p=0·038) at 6 months. Interpretation Oral fluoxetine 20 mg daily for 6 months after acute stroke did not improve functional outcome and increased the risk of falls, bone fractures, and epileptic seizures. These results do not support the use of fluoxetine to improve functional outcome after stroke

Analysis of disease pattern and drug formulary at Da Nang Hospital for Lung Diseases before the time of the COVID-19 pandemic

Introduction: Since the COVID-19 outbreak, there have been studies showing the impact of the disease on other respiratory diseases, leading to an impact on prevention and treatment. Therefore, it is necessary to analyze data on disease patterns and hospital drug lists in order to have data as a basis for adjustment for the periods during and after the epidemic, and to meet the treatment needs that may change. Methods: In this study, we collected information from the drug supply, treatment activities, drug used and value. Drug categories and ABC analysis were used for drug formulary. ICD-10 (International Classification of Diseases 10th Revision) classification was used to analyze disease pattern. Other supporting data on drug supply activities were also used, contributing to the findings. Results and discussion: The disease pattern represents the intensive professional activities of the respiratory hospital. The disease with the highest proportion is pulmonary tuberculosis. Another respiratory disease accounted for a large proportion is COPD (Chronic obstructive pulmonary disease). The results of drug formulary analysis indicated that the hospital has developed a reasonable drug list, consistent with the disease pattern before the time of the COVID-19 pandemic. Low inventory value indicated that drug planning is close to reality. These data also suggested that further research on supportive regimens for COPD treatment in case of pulmonary disease occurrence, such as COVID-19 is required. Conclusion: This study provides pre-pandemic data to serve as the basis for future comparative studies and to identify further research directions in response to the periods during and after COVID-19. Research data also suggested the potential risks of stockpiling, inventory, as well as increasing the use of domestic drugs may be more proactive in drug supply

Oral health problems among adult patients at commune health centres in central Vietnam: prevalence and care seeking behaviour

Introduction: The burden of oral disease is an excessive issue of Vietnamese population while the accessibility of oral health services are restricted. This study were to identify the prevalence of dental caries and the oral health seeking behavior in response to oral health symptoms among adults presenting at commune health centers

Operation of Different Reverse Osmosis (RO) Membrane Modules for the Treatment of High-Strength Wastewater to Enhance the Recovery of Clean Water&mdash;A Case Study in Bac Ninh, Vietnam

In this study, a wastewater treatment plant (WWTP) in Vietnam receiving high-strength wastewater with COD of about 30,000 mg/L and various heavy metals from industries was treated by different RO membrane modules in order to meet the stringent national discharge standard and recover wastewater for reuse. The Fenton and coagulation pre-treatments were employed based on optimal conditions, which were experimentally pre-determined. For the RO membrane system, the two-stage treatment employed a plate frame RO (PFRO) followed by spiral wound RO (SPRO) to obtain high-quality permeate, while the high-pressure PFRO (HP PFRO) module was employed for the recovery of concentrated streams from the PFRO unit. As a result, a significant COD removal efficiency of 99.62% was achieved in the SPRO module. The heavy metal concentrations (i.e., Cu, Fe, Zn, Mn, Cr) measured in the output mostly met the standards for discharge levels. A significant decrease in electrical conductivity (EC) to below 250 &micro;S/cm was achieved. In addition, high rates of water recovery were achieved from the RO modules (i.e., PFRO 63%, HP PFRO 9&ndash;12%, SPRO &gt; 80&ndash;90%). The high-quality treated wastewater was thus suitable for reuse purposes. This study highlights the feasibility of RO membranes for practical treatment of high-strength wastewater and provides valuable data for the WWTP operator

Operation of Different Reverse Osmosis (RO) Membrane Modules for the Treatment of High-Strength Wastewater to Enhance the Recovery of Clean Water—A Case Study in Bac Ninh, Vietnam

In this study, a wastewater treatment plant (WWTP) in Vietnam receiving high-strength wastewater with COD of about 30,000 mg/L and various heavy metals from industries was treated by different RO membrane modules in order to meet the stringent national discharge standard and recover wastewater for reuse. The Fenton and coagulation pre-treatments were employed based on optimal conditions, which were experimentally pre-determined. For the RO membrane system, the two-stage treatment employed a plate frame RO (PFRO) followed by spiral wound RO (SPRO) to obtain high-quality permeate, while the high-pressure PFRO (HP PFRO) module was employed for the recovery of concentrated streams from the PFRO unit. As a result, a significant COD removal efficiency of 99.62% was achieved in the SPRO module. The heavy metal concentrations (i.e., Cu, Fe, Zn, Mn, Cr) measured in the output mostly met the standards for discharge levels. A significant decrease in electrical conductivity (EC) to below 250 µS/cm was achieved. In addition, high rates of water recovery were achieved from the RO modules (i.e., PFRO 63%, HP PFRO 9–12%, SPRO > 80–90%). The high-quality treated wastewater was thus suitable for reuse purposes. This study highlights the feasibility of RO membranes for practical treatment of high-strength wastewater and provides valuable data for the WWTP operator

From drainage to resource: a practice approach to reuse greywater for household irrigation purposes

The United Nations indicates that available freshwater resources will decrease significantly due to pollution growth and urbanization; two-thirds of the world's population may face water shortages by 2030. Extended use of greywater is an alternative option for reducing potable water consumption in urban areas. Recently, the reuse of treated greywater for home gardens, peri-urban agriculture, and landscaping has become a widespread concern in many developing countries. This paper presents a study on a low-cost system that can perform greywater treatment for household use. This treatment system employed physical filtration by ceramic filters, quartz gravel, hollow fiber membrane, and UV disinfection. Three greywater samples collected from the kitchen, washing basins, and bathroom were investigated. The operation process determines the system's effectiveness by considering turbidity, coliform, Biochemical Oxygen Demand (BOD5), and Chemical Oxygen Demand (COD) concentration of the inlet and outlet water. As a result, high removal efficiency (i.e., >60%) could be obtained for each investigated parameter. Results also showed that grey water generated from washing basins has the highest potential for reuse since the water quality after treatment satisfies the water reuse standards for household irrigation. The findings encourage further exploration and implementation of greywater reuse practices. HIGHLIGHTS A greywater treatment system with six filter layers and a PVDF hollow fiber membrane was investigated.; The system's performance was assessed by measuring the pH, turbidity, BOD5, COD, and coliform concentration.; UV disinfection made washing basin greywater suitable for garden irrigation, meeting international standards.; An efficient and cost-effective system for greywater reuse in Southeast Asian households.