241 research outputs found
Large mass boundary condensation patterns in the stationary Keller-Segel system
We consider the boundary value problem in
with Neumann boundary condition, where is a bounded smooth
domain in , This problem is equivalent to the
stationary Keller-Segel system from chemotaxis. We establish the existence of a
solution which exhibits a sharp boundary layer along the entire
boundary as . These solutions have large mass in
the sense that $ \int_\Omega \lambda e^{u_\lambda} \sim |\log\lambda|.
Multi-bubble nodal solutions for slightly subcritical elliptic problems in domains with symmetries
We study the existence of sign-changing solutions with multiple bubbles to
the slightly subcritical problem -\Delta u=|u|^{2^*-2-\e}u \hbox{in}\Omega,
\quad u=0 \hbox{on}\partial \Omega, where is a smooth bounded domain
in , , and \e>0 is a small parameter. In
particular we prove that if is convex and satisfies a certain
symmetry, then a nodal four-bubble solution exists with two positive and two
negative bubbles
Torus action on S^n and sign changing solutions for conformally invariant equations
International audienc
Boundary clustered layers near the higher critical exponents
We consider the supercritical problem {equation*} -\Delta u=|u|
^{p-2}u\text{\in}\Omega,\quad u=0\text{\on}\partial\Omega, {equation*} where
is a bounded smooth domain in and smaller than
the critical exponent for the Sobolev
embedding of in , We show that in some suitable domains there are positive
and sign changing solutions with positive and negative layers which concentrate
along one or several -dimensional submanifolds of as
approaches from below.
Key words:Nonlinear elliptic boundary value problem; critical and
supercritical exponents; existence of positive and sign changing solutions
Platelets promote human macrophages-mediated macropinocytosis of Clostridioides difficile
Clostridioides difficile is the main causative agent of hospital-acquired diarrhea and the potentially lethal disease, C. difficile infection. The cornerstone of the current therapy is the use of antibiotics, which is not fully effective. The molecular mechanisms, inflammatory conditions and host-immune responses that could benefit the persistence or elimination of C. difficile remain unclear. Macrophages perform different ways of endocytosis as part of their immune surveillance functions and platelets, classically known for their coagulatory role, are also important modulators of the immune system. The aim of this study was to evaluate the endocytosis of vegetative C. difficile by human macrophages and the involvement of platelets in this process. Our results showed that both macrophages and platelets interact with live and heat-killed C. difficile. Furthermore, platelets form complexes with human monocytes in healthy donor´s fresh blood and the presence of C. difficile increased these cell-cell interactions. Using flow cytometry and confocal microscopy, we show that macrophages can internalize C. difficile and that platelets improve this uptake. By using inhibitors of different endocytic pathways, we demonstrate that macropinocytosis is the route of entry of C. difficile into the cell. Taken together, our findings are the first evidence for the internalization of vegetative non-toxigenic and hypervirulent C. difficile by human macrophages and highlight the role of platelets in innate immunity during C. difficile infection. Deciphering the crosstalk of C. difficile with immune cells could provide new tools for understanding the pathogenesis of C. difficile infection and for the development of hostdirected therapies.Fil: Barbero, Angela Maria. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro de Investigaciones y Transferencia del Noroeste de la Provincia de Buenos Aires. Universidad Nacional del Noroeste de la Provincia de Buenos Aires. Centro de Investigaciones y Transferencia del Noroeste de la Provincia de Buenos Aires; ArgentinaFil: Hernández del Pino, Rodrigo Emanuel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro de Investigaciones y Transferencia del Noroeste de la Provincia de Buenos Aires. Universidad Nacional del Noroeste de la Provincia de Buenos Aires. Centro de Investigaciones y Transferencia del Noroeste de la Provincia de Buenos Aires; ArgentinaFil: Fuentes, Federico. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; ArgentinaFil: Barrionuevo, Paula. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; ArgentinaFil: Pasquinelli, Virginia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro de Investigaciones y Transferencia del Noroeste de la Provincia de Buenos Aires. Universidad Nacional del Noroeste de la Provincia de Buenos Aires. Centro de Investigaciones y Transferencia del Noroeste de la Provincia de Buenos Aires; Argentin
Estudio de factibilidad para la comercialización de zapatillas y mochilas eco-amigables en la ciudad del Cusco, año 2018.
Esta investigación analiza y evalúa la posibilidad de distribuir dos tipos de productos textiles
eco-amigables: unas zapatillas y una mochila/maletín, las cuales están hechas de materiales
naturales y su producción contribuyen al comercio justo, dirigido a personas que buscan una
alternativa sustentable a los convencionales.
Se establece un mercado objetivo, en este caso son los jóvenes de 21 a 29 años
pertenecientes a los sectores socioeconómicos A, B y C de la provincia de Cusco, se
determinó el precio de las zapatillas y de la mochila/maletín mediante la encuesta realizada
y analizando el precio de la competencia, los precios hallados fueron de 300 soles las
zapatillas y 180 la mochila/ maletín.
Se determinó la localización del local comercial mediante la herramienta de promedios
ponderados, será en el distrito de Cusco, plaza San Francisco.
Se determinan los equipos y muebles necesarios para distribución, para la correcta
determinación del área del local comercial se utiliza el cálculo de superficie de Guerchet
resultando un total de 26.2 m², pero existe un local comercial en alquiler en la zona de La
plaza San Francisco con un área de 43.6 m², se utilizará este local.
Se determinan los costos de mercadería, administración y venta, alquiler del local, entre otros
gastos.
Para llevar a cabo el proyecto, se necesita una inversión de S/. 341 725.63, el 29.26%
representa el préstamo mediante una entidad bancaria.This research analyzes and evaluates the possibility of distributing two types of ecological
textile products: a pair of sneakers and a backpack / briefcase, which are made of natural
materials and support fair trade, aimed at people looking for a sustainable alternative to
conventional ones.
A target market is established, in this case young people between the ages of 21 and 29
belonging to the socioeconomic sectors A, B and C of the province of Cusco, determined the
price of the shoes and the backpack / briefcase through the survey and analyzing the price of
the competition, the prices found were 300 soles for the shoes and 180 for the backpack /
briefcase.
The location of the commercial premises was determined through the tool of weighted
averages, it will be in the district of Cusco, Plaza San Francisco.
The necessary equipment and furniture are determined for distribution, for the correct
determination of the commercial premises area the Guerchet surface calculation is used,
resulting in a total of 26.2 m², but there is a commercial space for rent in the San Francisco
Plaza area. An area of 43.6 m², this place will be used.
The costs of merchandise, administration and sale, rental of the premises, among other
expenses, are determined.
To carry out the project, an investment of S/.341 725.63, el 29.26% represents the loan through a bank.Tesi
One-step preparation of nitrogen doped titanium oxide/Au/reduced graphene oxide composite thin films for photocatalytic applications
© The Royal Society of Chemistry 2015. Titanium dioxide (TiO2) and TiO2/Au/reduced graphene oxide (rGO) nanocomposite thin films were grown by ultraviolet matrix assisted pulsed laser evaporation (UV-MAPLE) in controlled O2 or N2 atmospheres. An UV KrF∗ excimer laser (λ = 248 nm, τFWHM ∼ 25 ns, ν = 10 Hz) was used for the irradiation of the MAPLE targets consisting of TiO2 nanoparticles (NPs) or mixtures of TiO2 NPs, Au NPs, and graphene oxide (GO) platelets in aqueous solutions. The effect of Au and GO addition as well as nitrogen doping on the photocatalytic activity of the TiO2 thin films was investigated. The evaluation of the photocatalytic activity was performed by photodegradation of the organic methylene blue model dye pollutant under UV-visible light, >simulated sun> irradiation conditions. Our results show that the photocatalytic properties of TiO2 were significantly improved by the addition of Au NPs and rGO platelets. Nitrogen inclusion into the rGO structure further contributes to the enhancement of the TiO2/Au/rGO nanocomposites photocatalytic activity.The authors thank the financial support of the Executive Unit for Financing Higher Education, Research, Development, and Innovation of the Romanian Ministry of Education and Scientific Research under the contract PN-IIPT-PCCA-2011-3.2-1235 and the Spanish Ministry of Economy and Competitiveness under the contract ENE2014-56109-C3-3-R.Peer reviewedPeer Reviewe
Análisis y propuesta de construcción de marca en una empresa social de Lima: caso de estudio: HOSEG
La presente investigación plantea la necesidad de conocer cómo construir una marca fuerte
para una empresa social basándose en el modelo de Kevin Keller, incluyendo el planteamiento de la
propuesta de valor, la definición del posicionamiento de la marca y determinando qué actividades
de marketing construyen Valor Capital de Marca para el cliente.
La aproximación de la investigación se realiza mediante el estudio de caso de una empresa
social peruana la cual ofrece al mercado productos outdoor, con la peculiaridad que por cada casaca
que logran vender donan otra a niños de escasos recursos de los andes peruanos. La empresa tiene
como objetivo de corto plazo ingresar a un nuevo segmento del mercado; por tal motivo, la
investigación presenta como uno de sus objetivos específicos identificar y definir el target al cual la
marca puede dirigirse y plantear la propuesta de construcción de marca enfocada en este nuevo
target.
Para lograrlo se comenzó con realización de un análisis interno y externo a la empresa para
crear una visión general y comprender los factores que influyen en ella. Posteriormente, a través de
entrevistas a los clientes actuales y al gerente de marca de la empresa, se identifica la propuesta de
valor actual y se define el posicionamiento de marca basados en el modelo de Keller. Luego, se
realizaron focus groups, cuyos participantes formaban parte del nuevo target propuesto, para
identificar insights que puedan agregar valor a la propuesta de la marca.
La propuesta de valor potenciada con los insights recabados en los focus groups fue validada
a través de encuestas realizadas a personas del target propuesto. Luego, con la información obtenida
en los focus groups y en las encuestas se propusieron actividades de marketing que contribuyeran a
la construcción de una marca fuerte. Finalmente, se compara el valor económico generado para la
empresa en ambos escenarios: con actividades de marketing y sin actividades de marketing.Tesi
Sign-changing tower of bubbles for a sinh-Poisson equation with asymmetric exponents
Motivated by the statistical mechanics description of stationary
2D-turbulence, for a sinh-Poisson type equation with asymmetric nonlinearity,
we construct a concentrating solution sequence in the form of a tower of
singular Liouville bubbles, each of which has a different degeneracy exponent.
The asymmetry parameter corresponds to the ratio between the
intensity of the negatively rotating vortices and the intensity of the
positively rotating vortices. Our solutions correspond to a superposition of
highly concentrated vortex configurations of alternating orientation; they
extend in a nontrivial way some known results for . Thus, by
analyzing the case we emphasize specific properties of the
physically relevant parameter in the vortex concentration phenomena
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