More than Grants: How Funders Can Use Their Influence for Good

Trusts and foundations are increasingly looking to become agents of social change themselves as well as funders of it—asking themselves whether providing more than direct services might make more of a difference. Two common ways that funders do this are through providing support to help organisations develop their capacity, and by using a funder's influence to advocate for change. Here we focus on the latter, looking at influencing practices of funders from around the world—exploring the methods that these take, the evidence for whether it works and how funders can approach impact measurement

The official autobiography of Hilary Laura Boles (Original writing, Novel).

Abstract Not Available. Source: Masters Abstracts International, Volume: 39-02, page: 0356. Adviser: Alistair MacLeod. Thesis (M.A.)--University of Windsor (Canada), 2000

Fallow deer (Dama dama dama) management in Roman South-East Britain

This paper presents new carbon, nitrogen and sulphur isotope data for European fallow deer (Dama dama dama) in Roman Britain and discusses results in light of evidence from classical texts, landscape archaeology, zooarchaeology and the limited available samples of metric data. The new isotope data presented here are from Fishbourne Roman Palace (Sussex), two sites on the Isle of Thanet (Kent) and a further two sites in London. In spite of small sample sizes the data make an important contribution to the very limited corpus of scientific research on the species and provide new resolution to the nature of fallow deer movement and management in Roman Britain

Farming and feasting during the Bronze Age–Iron Age transition in Britain (ca. 900–500 bce): multi-isotope evidence for societal change

The Late Bronze Age saw the rise of a new site type in southern Britain, commonly termed a midden. These vast monumental mounds, some comprising tens of thousands of artefacts/ecofacts dominated by animal bone and ceramics, signal a societal refocus towards agricultural intensification and communal feasting on a grand scale. These sites point to agricultural produce being the mainstay of the economy, with bronze having a reduced social and economic importance. This likely created new regimes of managing landscapes and livestock and new networks and agricultural catchments anchored on the sites. Major questions remain surrounding the strategies employed to enhance agricultural productivity, how landscapes and livestock were managed, and how different sites and regions met these challenges at a time of climatic deterioration. This article employs multi-isotope analyses on domestic and wild fauna to address these questions. It presents carbon, nitrogen, and sulfur (δ13C, δ15N, and δ34S, respectively) isotope analyses on 235 animals from 6 midden sites in 2 major regions of midden accumulation: the Vale of Pewsey in Wiltshire and the Thames Valley. The results demonstrate distinct differences in approaches to maximising agricultural productivity, with varied strategies apparent at a site, species, and regional level. Some sites, such as Potterne and Runnymede, clearly drew domestic fauna from a wide catchment where wide-ranging management and foddering regimes were employed. Other sites, such as East Chisenbury, had a more restricted catchment but a tightly controlled, intensive management regime. These data provide new insights into regional responses to the reorganisation of the economy, landscape use, and developing agricultural networks during the Bronze Age–Iron Age transition in Britain, revealing dynamic and evolving societal change

Bronze Age subsistence strategies in the southeastern Carpathian Bend area, Romania:Results from stable isotope analyses

Here we report the results of stable carbon and nitrogen isotope analyses of human and faunal remains from two Bronze Age (Monteoru culture) sites near Buzău in Romania, in the eastern foothills of the Carpathian Mountains. The results for 54 humans from Sărata Monteoru and 10 from Cârlomăneşti indicate diets that were dominated by C3 terrestrial resources, consistent with the archaeofaunal inventories from the sites and archaeobotanical data from the wider region. Statistically significant differences in the average δ15N values of the two skeletal populations hint at a change in economic practices between early and late phases of the Monteoru culture. Consumer diets at the two sites were quantified using multiple mixing models generated with the Bayesian statistical program FRUITS (Food Reconstruction Using Isotopic Transferred Signals). The model outputs suggest the inhabitants of the later settlement, Sărata Monteoru, were less dependent on animal-derived products and relied more on cereals and legumes for energy and protein, compared to their predecessors at Cârlomăneşti. Based on changes in the faunal record we speculate that dairying may also have increased in importance between the early and later phases of the Monteoru culture

An integrated stable isotope study of plants and animals from Kouphovouno, southern Greece: a new look at Neolithic farming

This paper presents the first study that combines the use of ancient crop and animal stable isotopes (carbon and nitrogen) and Zooarchaeology Mass Spectrometry species identification (ZooMS) for reconstructing early farming practices at Kouphovouno, a Middle–Late Neolithic village in southern Greece (c. 5950–4500 cal. BC). Debate surrounding the nature of early farming predominantly revolves around the intensity of crop cultivation: did early farmers move around the landscape while practicing temporary farming methods such as slash and burn agriculture or did they create more permanent fields by investing high labor inputs into smaller pieces of land that produced higher crop yields? The need to address these questions using a direct assessment of the intensity and scale of cultivation is apparent, and an integrated stable isotope approach provides such an opportunity. The results of this study support the model of small-scale mixed farming, where crop cultivation and animal husbandry are closely integrated. The farmers directed their intensive management towards crops grown for human consumption (free-threshing wheat), while growing fodder crop (hulled barley) more extensively. Pulses were cultivated under a high-manuring/high-watering regime, likely in garden plots in rotation with free-threshing wheat. The diets of the livestock enable us to investigate which parts of the landscape were used for browsing and grazing and indicate that animal management changed in the Late Neolithic. The sheep and goats were now kept in smaller numbers and grazed together and new pasture grasses may have been sought for the grazing of cattle. This study demonstrates that beyond its applicability for palaeodietary reconstruction, analysis of stable isotopes of archaeological crop and animal remains has important implications for understanding the relationship between humans, plants and animals in an archaeological context

Tuberous sclerosis complex tumor suppressor–mediated S6 kinase inhibition by phosphatidylinositide-3-OH kinase is mTOR independent

The evolution of mitogenic pathways has led to the parallel requirement for negative control mechanisms, which prevent aberrant growth and the development of cancer. Principally, such negative control mechanisms are represented by tumor suppressor genes, which normally act to constrain cell proliferation (Macleod, K. 2000. Curr. Opin. Genet. Dev. 10:81–93). Tuberous sclerosis complex (TSC) is an autosomal-dominant genetic disorder, characterized by mutations in either TSC1 or TSC2, whose gene products hamartin (TSC1) and tuberin (TSC2) constitute a putative tumor suppressor complex (TSC1-2; van Slegtenhorst, M., M. Nellist, B. Nagelkerken, J. Cheadle, R. Snell, A. van den Ouweland, A. Reuser, J. Sampson, D. Halley, and P. van der Sluijs. 1998. Hum. Mol. Genet. 7:1053–1057). Little is known with regard to the oncogenic target of TSC1-2, however recent genetic studies in Drosophila have shown that S6 kinase (S6K) is epistatically dominant to TSC1-2 (Tapon, N., N. Ito, B.J. Dickson, J.E. Treisman, and I.K. Hariharan. 2001. Cell. 105:345–355; Potter, C.J., H. Huang, and T. Xu. 2001. Cell. 105:357–368). Here we show that loss of TSC2 function in mammalian cells leads to constitutive S6K1 activation, whereas ectopic expression of TSC1-2 blocks this response. Although activation of wild-type S6K1 and cell proliferation in TSC2-deficient cells is dependent on the mammalian target of rapamycin (mTOR), by using an S6K1 variant (GST-ΔC-S6K1), which is uncoupled from mTOR signaling, we demonstrate that TSC1-2 does not inhibit S6K1 via mTOR. Instead, we show by using wortmannin and dominant interfering alleles of phosphatidylinositide-3-OH kinase (PI3K) that increased S6K1 activation is contingent upon the suppression of TSC2 function by PI3K in normal cells and is PI3K independent in TSC2-deficient cells

Balancing biological and economic goals in commercial and recreational fisheries:Systems modelling of sea bass fisheries

The importance of social and economic factors, in addition to biological factors, in fisheries management is being increasingly recognised. However, exploration of trade-offs between biological, social, and economic factors under different sustainable catch limits for recreational and commercial fisheries is limited, especially in Europe. The European sea bass (Dicentrarchus labrax) is valuable and important for both commercial and recreational fisheries. Stocks have rapidly declined and management measures have been implemented, but trade-offs between social, biological, and economic factors have not been explicitly considered. In this study, a system dynamics model framework capturing biological and economic elements of the European sea bass fishery was developed and refined to incorporate a catch limit reflecting sustainable fishing with adjustable partition between recreational and commercial sectors, under low, medium, or high recruitment. Model outputs were used to explore the relative impact of different catch allocations on trade-offs between biological sustainability and economic impact when recruitment was limiting or not. Recruitment had a large impact on the fish population dynamics and the viability of the sectors. At high and moderate recruitment, management contributed to stock sustainability and sector economic impact, but recruitment is important in determining the balance between sectors

Feeding the Roman army in Britain

How did the Roman Empire supply and maintain its frontier garrisons? What was the impact on populations and landscapes of conquered territories? The Feeding the Roman Army in Britain project will answer these questions by establishing how soldiers were provisioned and how frontiers operated as economic as well as militarised zones