Baffin Island Fjord Macrobenthos: Bottom Communities and Environmental Significance

Cluster analysis of the benthos from ten Baffin Island fjords defines six faunal associations. The macrotidal Sunneshine Fiord has a shallow kelp-related Isopod Association. Cambridge Fiord supports a shallow Onuphid Association controlled by gravel from dropstones. A widespread Portlandia Association typified the shallow zones of more recently glaciated fjords where sedimentation rates are high. An Ophiuroid-Anemone Association was defined from current-affected submarine channel environments. A Maldanid Association covered the greatest area in all fjords and passed into an Elasipod Association in the deepest water in Cambridge Fiord. Fjord-head faunas are used to model ecological changes accompanying glacier retreat, from monospecific Portlandia, through mature Portlandia Association to Onuphid Association accompanied by diverse filter feeders and herbivores. Chlamys islandica was found living in Cambridge Fiord, which substantially increases its northern limit.Key words: macrobenthos, Arctic, cluster analysis, bivalve, Quaternary, sedimentMots clés: macrobenthos, Arctique, analyse d’ensemble, bivalve, quaternaire, sédiment

The Eastern Canadian Arctic at ca. 6 ka BP: A Time of Transition

The middle Holocene was a time of definite environmental transition in the Eastern Canadian Arctic. Based on several proxy indicators (pollen, diatoms, foraminifera, molluscs and nearshore sedimentation rates), it appears that a thermal maximum occurred around middle Holocene (6-4 ka), several thousand years after the insolation maximum — a lag caused by the thermal inertia of the earlier massive ice sheet. Terrestrial records indicate that a warming began around 6 ka, both in the subarctic (Labrador - Ungava) and on Baffin Island. Marine records, on the other hand, suggested major water structure changes around 6 ka both in the Northeastern Canadian Arctic and also along the East Greenland coast with evidence of a marine surface water temperature maximum at 8 ka. We hypothesize that the marine circulation changes, both along the Baffin Island and along the East Greenland coasts, were primarily driven by glacio-isostatic uplift of the Arctic Channels. With the cessation of water flow of Atlantic (warmer) origin, and decrease in water volume from the deeper parts of the Arctic Ocean through the Arctic Channels, the export through the Fram and Denmark straits increased and the water column changed. Changes in the concentration and duration of sea ice along the eastern Canadian coast would have had important repercussions on the biota of the coastal marine and terrestrial ecosystems.L'Holocène moyen a été une période de transition bien déterminée dans l'est de l'Arctique canadien. Selon de nombreux indicateurs (pollen, diatomées, foraminifères, mollusques et taux de sédimentation côtiers), il semble qu'un maximum thermique ait été atteint vers le milieu de l'Holocène (6-4 ka), plusieurs milliers d'années après le maximum d'insolation — un retard dû à l'inertie thermique causée par la présence de l'immense inlandsis. Les données terrestres démontrent qu'un réchauffement s'est amorcé vers 6 ka, à la fois dans le subarctique (Labrador, Ungava) et dans l'île de Baffin. Les données marines, d'autre part, indiquent qu'il y a eu des changements de structure de l'eau vers 6 ka à la fois dans le nord-est de l'Arctique canadien et le long de la côte du Groenland avec des indices de températures maximales marines de surface à 8 ka. Nous posons l'hypothèse selon laquelle les changements de circulation marine, à la fois le long de l'île de Baffin et le long de la côte est du Groenland ont été provoqués par le relèvement isostatique des chenaux arctiques. Avec l'arrêt de l'écoulement (plus chaud) en provenance de l'Atlantique et la diminution du cubage d'eau provenant des grandes profondeurs de l'océan Arctique dans les chenaux arctiques, l'évacuation par les détroits de Fram et du Danemark s'est accrue et la colonne d'eau s'est modifiée. Les changements de concentration et de durée de la glace marine le long de la côte est du Canada auraient eu d'importantes répercussions sur les écosystèmes marins côtiers et terrestres.Das mittlere Holozân war eine eindeutige Umwelt-Ùbergangszeit in der ostkanadischen Arktis. Gestùtzt auf zahlreiche Indikatoren (Pollen, Kieselalgen, Foraminiferen, Mollusken und die Sedimentationsrate am Ufer) scheint es, dap ein thermales Maximum um die Mitte des Holozàns erreicht wurde (6-4 ka), mehrere tausend Jahre nach dem Sonneneinstrahlungsmaximum - eine Verzôgerung, welche durch die thermale Trâgheit der frùheren massiven Eisdecke bewirkt wurde. Belege zu Land zeigen, daB eine Erwârmung um 6 ka begann, sowohl in der Subarktis (Labrador-Ungava) wie auch auf der Baffin-lnsel. Meeresbelege andererseits weisen auf bedeutende Wasserstruktur-Ànderungen um 6 ka, sowohl in der nordôstlichen kanadischen Arktis wie auch entlang der Kùste von Ost-Grônland, mit Anhaltspunkten fur maximale Wassertemperaturen an der Meeresober-flâche um 8 ka. Wir stellen die Hypothèse auf, daB die Wechsel der marinen Zirkulation, sowohl entlang der Baffin-lnsel wie auch der Kùsten von Ost-Grônland, in erster Linie durch die glazial-isostatische Anhebung der arktischen Kanâle hervorgerufen wurden. Mit der Beendigung des (wàrmeren) Wasserflusses vom Atlantik und der Abnahme des Wasservolumes von den tieferen Teilen des arktischen Ozeans durch die arktischen Kanâle nahm die Ausfuhr durch die Meeregen von Fram und Danemark zu, und die Wassersàule ânderte sich. Die Wechsel in der Konzentration und Dauer des Meereises entlang der ostkanadischen Kùste sollen bedeutende Auswirkungen auf Ôkosysteme an der Meereskùste und zu Land gehabt haben

Dimeric FcγR ectodomains detect pathogenic anti-platelet factor 4-heparin antibodies in heparin-induced thromobocytopenia

Background Heparin‐induced thrombocytopenia (HIT) is a major and potentially fatal consequence of antibodies produced against platelet factor 4 (PF4)–heparin complexes following heparin exposure. Not all anti‐PF4–heparin antibodies are pathogenic, so overdiagnosis can occur, with resulting inappropriate use of alternative anticoagulation therapies that have associated risks of bleeding. However, definitive platelet functional assays are not widely available for routine analysis. Objectives To assess the utility of dimeric recombinant soluble FcγRIIa (rsFcγRIIa) ectodomains for detecting HIT antibodies. Patients/Methods Plasma from 27 suspected HIT patients were tested for pathogenic anti‐PF4–heparin antibodies by binding of a novel dimeric FcγRIIa ectodomain probe. Plasmas were also tested by the use of PF4–heparin IgG ELISA, the HemosIL AcuStar HIT IgG‐specific assay, and a serotonin release assay (SRA). Results The dimeric rsFcγRIIa test produced no false positives and excluded four samples that were positive by IgG ELISA. In this small patient cohort, the novel assay correctly assigned 93% of the suspected HIT patients, with two of the HIT patients being scored as false negatives. The improved discrimination of the novel assay over the IgG ELISA, which scored four false positives, supports the mechanistic interpretation that binding of dimeric rsFcγRIIa detects pairs of closely spaced IgG antibodies in PF4–heparin immune complexes. Conclusions This study found the cell‐free, function‐based dimeric rsFcγRIIa assay to be convenient, simple, and potentially predictive of HIT. The assay had improved specificity over the IgG ELISA, and correlated strongly with the AcuStar HIT IgG‐specific assay, warranting further evaluation of its potential to identify HIT in larger patient cohorts

Response to Guttman & Levy's article ‘on the definition and varieties of attitude and wellbeing’

Guttman and Levy have prepared an extravagant critique focused mainly on the 1980 Andrews-McKennell article in this journal. The clearly stated purpose of that article was to report a “series of explorations into the affective and cognitive components of some of the more widely used measures of perceived well-being”. Guttman and Levy ignore this. They proceed on the mistaken impression that we were (or perhaps should have been) embarking upon a definitional exercise to relate the concepts of attitude and wellbeing. Yet the reason we did not cite their article on that topic was precisely because it did not address in a direct or focused way the topic that concerned us. Their critique consists of an entirely irrelevant reanalysis of some attitudinal data by Ostrom, together with a tissue of recondite definitional and methodological issues of little consequence either for the objectives or the conclusions of our research. Their dismissal of our work as ‘scientific retrogression’ rests on an a priori definition of science that fits their own methodological style but excludes that of many other prominent researchers. Their comments reflect an attempt at methodological imperialism. We defend our independence — and that of other investigators — to use promising new methodologies other than the particular approach advocated by Guttman and Levy. (Their denunciation of the new methods of structural equation modeling is not shared even by the authoritative reviewer they themselves quote.) In addition to Guttman and Levy's specific criticisms, our Response addresses general methodological issues such as the status of structural modeling and the testing of structural models. In a concluding section we identify areas that merit further research.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/43680/1/11205_2004_Article_BF00302509.pd

Noncolliding Squared Bessel Processes

We consider a particle system of the squared Bessel processes with index $\nu > -1$ conditioned never to collide with each other, in which if $-1 < \nu < 0$ the origin is assumed to be reflecting. When the number of particles is finite, we prove for any fixed initial configuration that this noncolliding diffusion process is determinantal in the sense that any multitime correlation function is given by a determinant with a continuous kernel called the correlation kernel. When the number of particles is infinite, we give sufficient conditions for initial configurations so that the system is well defined. There the process with an infinite number of particles is determinantal and the correlation kernel is expressed using an entire function represented by the Weierstrass canonical product, whose zeros on the positive part of the real axis are given by the particle-positions in the initial configuration. From the class of infinite-particle initial configurations satisfying our conditions, we report one example in detail, which is a fixed configuration such that every point of the square of positive zero of the Bessel function $J_{\nu}$ is occupied by one particle. The process starting from this initial configuration shows a relaxation phenomenon converging to the stationary process, which is determinantal with the extended Bessel kernel, in the long-term limit.Comment: v3: LaTeX2e, 26 pages, no figure, corrections made for publication in J. Stat. Phy

Disparate MgII Absorption Statistics towards Quasars and Gamma-Ray Bursts : A Possible Explanation

We examine the recent report by Prochter et al. (2006) that gamma-ray burst (GRB) sight lines have a much higher incidence of strong MgII absorption than quasar sight lines. We propose that the discrepancy is due to the different beam sizes of GRBs and quasars, and that the intervening MgII systems are clumpy with the dense part of each cloudlet of a similar size as the quasars, i.e. < 10^16 cm, but bigger than GRBs. We also discuss observational predictions of our proposed model. Most notably, in some cases the intervening MgII absorbers in GRB spectra should be seen varying, and quasars with smaller sizes should show an increased rate of strong MgII absorbers. In fact, our prediction of variable MgII lines in the GRB spectra has been now confirmed by Hao et al. (2007), who observed intervening FeII and MgII lines at z=1.48 to be strongly variable in the multi-epoch spectra of z=4.05 GRB060206.Comment: 12 pages, 2 figures; substantially revised model calculation; accepted for publication in Astrophysics & Space Science as a Lette

Stepped fans and facies-equivalent phyllosilicates in Coprates Catena, Mars

Stepped fan deposits and phyllosilicate mineralogies are relatively common features on Mars but have not previously been found in association with each other. Both of these features are widely accepted to be the result of aqueous processes, but the assumed role and nature of any water varies. In this study we have investigated two stepped fan deposits in Coprates Catena, Mars, which have a genetic link to light-toned material that is rich in Fe–Mg phyllosilicate phases. Although of different sizes and in separate, but adjacent, trough-like depressions, we identify similar features at these stepped fans and phyllosilicates that are indicative of similar formation conditions and processes. Our observations of the overall geomorphology, mineralogy and chronology of these features are consistent with a two stage formation process, whereby deposition in the troughs first occurs into shallow standing water or playas, forming fluvial or alluvial fans that terminate in delta deposits and interfinger with interpreted lacustrine facies, with a later period of deposition under sub-aerial conditions, forming alluvial fan deposits. We suggest that the distinctive stepped appearance of these fans is the result of aeolian erosion, and is not a primary depositional feature. This combined formation framework for stepped fans and phyllosilicates can also explain other similar features on Mars, and adds to the growing evidence of fluvial activity in the equatorial region of Mars during the Hesperian and Amazonian

Ozone induces glucose intolerance and systemic metabolic effects in young and aged brown Norway rats

Air pollutants have been associated with increased diabetes in humans. We hypothesized that ozone would impair glucose homeostasis by altering insulin signaling and/or endoplasmic reticular (ER) stress in young and aged rats. One, 4, 12, and 24 month old Brown Norway (BN) rats were exposed to air or ozone, 0.25 or 1.0 ppm, 6 h/day for 2 days (acute) or 2 d/week for 13 weeks (subchronic). Additionally, 4 month old rats were exposed to air or 1.0 ppm ozone, 6 h/day for 1 or 2 days (time-course). Glucose tolerance tests (GTT) were performed immediately after exposure. Serum and tissue biomarkers were analyzed 18 h after final ozone for acute and subchronic studies, and immediately after each day of exposure in the time-course study. Age-related glucose intolerance and increases in metabolic biomarkers were apparent at baseline. Acute ozone caused hyperglycemia and glucose intolerance in rats of all ages. Ozone-induced glucose intolerance was reduced in rats exposed for 13 weeks. Acute, but not subchronic ozone increased α2-macroglobulin, adiponectin and osteopontin. Time-course analysis indicated glucose intolerance at days 1 and 2 (2> 1), and a recovery 18 h post ozone. Leptin increased day 1 and epinephrine at all times after ozone. Ozone tended to decrease phosphorylated insulin receptor substrate-1 in liver and adipose tissues. ER stress appeared to be the consequence of ozone induced acute metabolic impairment since transcriptional markers of ER stress increased only after 2 days of ozone. In conclusion, acute ozone exposure induces marked systemic metabolic impairments in BN rats of all ages, likely through sympathetic stimulation