The Haematopoietic Stem Cell Niche: New Insights into the Mechanisms Regulating Haematopoietic Stem Cell Behaviour

The concept of the haematopoietic stem cell (HSC) niche was formulated by Schofield in the 1970s, as a region within the bone marrow containing functional cell types that can maintain HSC potency throughout life. Since then, ongoing research has identified numerous cell types and a plethora of signals that not only maintain HSCs, but also dictate their behaviour with respect to homeostatic requirements and exogenous stresses. It has been proposed that there are endosteal and vascular niches within the bone marrow, which are thought to regulate different HSC populations. However, recent data depicts a more complicated picture, with functional crosstalk between cells in these two regions. In this review, recent research into the endosteal/vascular cell types and signals regulating HSC behaviour are considered, together with the possibility of a single subcompartmentalised niche

Extreme asteroids in the Pan-STARRS 1 Survey

Using the first 18 months of the Pan-STARRS 1 survey we have identified 33 candidate high-amplitude objects for follow-up observations and carried out observations of 22 asteroids. 4 of the observed objects were found to have observed amplitude $A_{obs}\geq 1.0$ mag. We find that these high amplitude objects are most simply explained by single rubble pile objects with some density-dependent internal strength, allowing them to resist mass shedding even at their highly elongated shapes. 3 further objects although below the cut-off for 'high-amplitude' had a combination of elongation and rotation period which also may require internal cohesive strength, depending on the density of the body. We find that none of the 'high-amplitude asteroids' identified here require any unusual cohesive strengths to resist rotational fission. 3 asteroids were sufficiently observed to allow for shape and spin pole models to be determined through light curve inversion. 45864 was determined to have retrograde rotation with spin pole axes $\lambda=218\pm 10^{\circ}, \beta=-82\pm 5^{\circ}$ and asteroid 206167 was found to have best fit spin pole axes $\lambda= 57 \pm 5^{\circ}$, $\beta=-67 \pm 5^{\circ}$. An additional object not initially measured with $A_{obs}>1.0$ mag, 49257, was determined to have a shape model which does suggest a high-amplitude object. Its spin pole axes were best fit for values $\lambda=112\pm 6^{\circ}, \beta=6\pm 5^{\circ}$. In the course of this project to date no large super-fast rotators ($P_{rot} < 2.2$ h) have been identified.Comment: 31 pages; accepted by A

The Detection of Inside-out Disk Growth in M33

We present resolved stellar photometry of 4 fields along the major axis of the M33 disk from images taken with the Advanced Camera for Surveys aboard the Hubble Space Telescope. The photometry provides a detailed census of the red clump in all fields and reaches the ancient main sequence in the outermost field. Through detailed modeling of the color-magnitude diagrams, we find that the percentage of the stellar mass formed prior to z=1 changes from 71 +/- 9% in the innermost field to 16 +/- 6% in the outermost field. The disk shows a clear trend of increasing scale-length with time, evolving from 1.0 +/- 0.1 kpc 10 Gyr ago to 1.8 +/- 0.1 kpc at times more recent than 5 Gyr ago, in agreement with analytical predictions for disk growth. Beyond the disk truncation radius, however, the stellar density profile steepens with time and the age gradient reverses, in agreement with recent simulations. The late and slow growth of the stellar disk may be due in part to the low mass of M33.Comment: 7 pages, 4 figures, accepted for publication in ApJ Letter

Chandra Detection of a TypeII Quasar at z=3.288

We report on observations of a TypeII quasar at redshift z=3.288, identified as a hard X-ray source in a 185 ks observation with the Chandra X-ray Observatory and as a high-redshift photometric candidate from deep, multiband optical imaging. CXOJ084837.9+445352 (hereinafter CXO52) shows an unusually hard X-ray spectrum from which we infer an absorbing column density N(H) = (4.8+/-2.1)e23 / cm2 (90% confidence) and an implied unabsorbed 2-10 keV rest-frame luminosity of L(2-10) = 3.3e44 ergs/s, well within the quasar regime. Hubble Space Telescope imaging shows CXO52 to be elongated with slight morphological differences between the WFPC2 F814W and NICMOS F160W bands. Optical and near-infrared spectroscopy of CXO52 show high-ionization emission lines with velocity widths ~1000 km/s and flux ratios similar to a Seyfert2 galaxy or radio galaxy. The latter are the only class of high-redshift TypeII luminous AGN which have been extensively studied to date. Unlike radio galaxies, however, CXO52 is radio quiet, remaining undetected at radio wavelengths to fairly deep limits, f(4.8GHz) < 40 microJy. High-redshift TypeII quasars, expected from unification models of active galaxies and long-thought necessary to explain the X-ray background, are poorly constrained observationally with few such systems known. We discuss recent observations of similar TypeII quasars and detail search techniques for such systems: namely (1) X-ray selection, (2) radio selection, (3) multi-color imaging selection, and (4) narrow-band imaging selection. Such studies are likely to begin identifying luminous, high-redshift TypeII systems in large numbers. We discuss the prospects for these studies and their implications to our understanding of the X-ray background.Comment: 28 pages, 5 figures; to appear in The Astrophysical Journa

The DEEP2 Galaxy Redshift Survey: The Voronoi-Delaunay Method Catalog of Galaxy Groups

We present a public catalog of galaxy groups constructed from the spectroscopic sample of galaxies in the fourth data release from the Deep Extragalactic Evolutionary Probe 2 (DEEP2) Galaxy Redshift Survey, including the Extended Groth Strip (EGS). The catalog contains 1165 groups with two or more members in the EGS over the redshift range 0 0.6 in the rest of DEEP2. Twenty-five percent of EGS galaxies and fourteen percent of high-z DEEP2 galaxies are assigned to galaxy groups. The groups were detected using the Voronoi-Delaunay method (VDM) after it has been optimized on mock DEEP2 catalogs following similar methods to those employed in Gerke et al. In the optimization effort, we have taken particular care to ensure that the mock catalogs resemble the data as closely as possible, and we have fine-tuned our methods separately on mocks constructed for the EGS and the rest of DEEP2. We have also probed the effect of the assumed cosmology on our inferred group-finding efficiency by performing our optimization on three different mock catalogs with different background cosmologies, finding large differences in the group-finding success we can achieve for these different mocks. Using the mock catalog whose background cosmology is most consistent with current data, we estimate that the DEEP2 group catalog is 72% complete and 61% pure (74% and 67% for the EGS) and that the group finder correctly classifies 70% of galaxies that truly belong to groups, with an additional 46% of interloper galaxies contaminating the catalog (66% and 43% for the EGS). We also confirm that the VDM catalog reconstructs the abundance of galaxy groups with velocity dispersions above ~300 km s^(–1) to an accuracy better than the sample variance, and this successful reconstruction is not strongly dependent on cosmology. This makes the DEEP2 group catalog a promising probe of the growth of cosmic structure that can potentially be used for cosmological tests

Delayed Stellar Mass Assembly in the Low Surface Brightness Dwarf Galaxy KDG215

We present HI spectral line and optical broadband images of the nearby low surface brightness dwarf galaxy KDG215. The HI images, acquired with the Karl G. Jansky Very Large Array (VLA), reveal a dispersion dominated ISM with only weak signatures of coherent rotation. The HI gas reaches a peak mass surface density of 6 M$_{\odot}$ pc$^{-2}$ at the location of the peak surface brightness in the optical and the UV. Although KDG215 is gas-rich, the H$\alpha$ non-detection implies a very low current massive star formation rate. In order to investigate the recent evolution of this system, we have derived the recent and lifetime star formation histories from archival Hubble Space Telescope images. The recent star formation history shows a peak star formation rate $\sim$1 Gyr ago, followed by a decreasing star formation rate to the present day quiescent state. The cumulative star formation history indicates that a significant fraction of the stellar mass assembly in KDG215 has occurred within the last 1.25 Gyr. KDG215 is one of only a few known galaxies which demonstrates such a delayed star formation history. While the ancient stellar population (predominantly red giants) is prominent, the look-back time by which 50% of the mass of all stars ever formed had been created is among the youngest of any known galaxy.Comment: Accepted for publication in the Astrophysical Journal Letter

Selective deforestation and exposure of African wildlife to bat-borne viruses

Proposed mechanisms of zoonotic virus spillover often posit that wildlife transmission and amplification precede human outbreaks. Between 2006 and 2012, the palm Raphia farinifera, a rich source of dietary minerals for wildlife, was nearly extirpated from Budongo Forest, Uganda. Since then, chimpanzees, black-and-white colobus, and red duiker were observed feeding on bat guano, a behavior not previously observed. Here we show that guano consumption may be a response to dietary mineral scarcity and may expose wildlife to bat-borne viruses. Videos from 2017–2019 recorded 839 instances of guano consumption by the aforementioned species. Nutritional analysis of the guano revealed high concentrations of sodium, potassium, magnesium and phosphorus. Metagenomic analyses of the guano identified 27 eukaryotic viruses, including a novel betacoronavirus. Our findings illustrate how “upstream” drivers such as socioeconomics and resource extraction can initiate elaborate chains of causation, ultimately increasing virus spillover risk.Peer reviewe

Artificial Fluid Properties for Large-Eddy Simulation of Compressible Turbulent Mixing

An alternative methodology is described for Large-Eddy Simulation of flows involving shocks, turbulence and mixing. In lieu of filtering the governing equations, it is postulated that the large-scale behavior of an ''LES'' fluid, i.e., a fluid with artificial properties, will be similar to that of a real fluid, provided the artificial properties obey certain constraints. The artificial properties consist of modifications to the shear viscosity, bulk viscosity, thermal conductivity and species diffusivity of a fluid. The modified transport coefficients are designed to damp out high wavenumber modes, close to the resolution limit, without corrupting lower modes. Requisite behavior of the artificial properties is discussed and results are shown for a variety of test problems, each designed to exercise different aspects of the models. When combined with a 10th-order compact scheme, the overall method exhibits excellent resolution characteristics for turbulent mixing, while capturing shocks and material interfaces in crisp fashion