48 research outputs found
Sharing voxelwise neuroimaging results from rhesus monkeys and other species with Neurovault
© 2020 The Authors Animal neuroimaging studies can provide unique insights into brain structure and function, and can be leveraged to bridge the gap between animal and human neuroscience. In part, this power comes from the ability to combine mechanistic interventions with brain-wide neuroimaging. Due to their phylogenetic proximity to humans, nonhuman primate neuroimaging holds particular promise. Because nonhuman primate neuroimaging studies are often underpowered, there is a great need to share data amongst translational researchers. Data sharing efforts have been limited, however, by the lack of standardized tools and repositories through which nonhuman neuroimaging data can easily be archived and accessed. Here, we provide an extension of the Neurovault framework to enable sharing of statistical maps and related voxelwise neuroimaging data from other species and template-spaces. Neurovault, which was previously limited to human neuroimaging data, now allows researchers to easily upload and share nonhuman primate neuroimaging results. This promises to facilitate open, integrative, cross-species science while affording researchers the increased statistical power provided by data aggregation. In addition, the Neurovault code-base now enables the addition of other species and template-spaces. Together, these advances promise to bring neuroimaging data sharing to research in other species, for supplemental data, location-based atlases, and data that would otherwise be relegated to a file-drawer . As increasing numbers of researchers share their nonhuman neuroimaging data on Neurovault, this resource will enable novel, large-scale, cross-species comparisons that were previously impossible
Author correction : a global database for metacommunity ecology, integrating species, traits, environment and space
Correction to: Scientific Data https://doi.org/10.1038/s41597-019-0344-7, published online 08 January 202
Author correction : a global database for metacommunity ecology, integrating species, traits, environment and space
Correction to: Scientific Data https://doi.org/10.1038/s41597-019-0344-7, published online 08 January 202
The pediatric rheumatology quality of life scale: validation of the English version in a US cohort of juvenile idiopathic arthritis
Sensitisation of Eu(III)- and Tb(III)- based luminescence by Ir(III) units in Ir/lanthanide dyads: evidence for parallel energy-transfer and electron-transfer based mechanisms
A series of blue-luminescent Ir(III) complexes with a pendant binding site for lanthanide(III) ions has been
synthesized and used to prepare Ir(III)/Ln(III) dyads (Ln = Eu, Tb, Gd). Photophysical studies were used to
establish mechanisms of Ir→Ln (Ln = Tb, Eu) energy-transfer. In the Ir/Gd dyads, where direct Ir→Gd
energy-transfer is not possible, significant quenching of Ir-based luminescence nonetheless occurred;
this can be ascribed to photoinduced electron-transfer from the photo-excited Ir unit (*Ir, 3MLCT/3LC
excited state) to the pendant pyrazolyl-pyridine site which becomes a good electron-acceptor when coordinated
to an electropositive Gd(III) centre. This electron transfer quenches the Ir-based luminescence,
leading to formation of a charge-separated {Ir4+}•—(pyrazolyl-pyridine)•− state, which is short-lived possibly
due to fast back electron-transfer (<20 ns). In the Ir/Tb and Ir/Eu dyads this electron-transfer pathway
is again operative and leads to sensitisation of Eu-based and Tb-based emission using the energy liberated
from the back electron-transfer process. In addition direct Dexter-type Ir→Ln (Ln = Tb, Eu) energytransfer
occurs on a similar timescale, meaning that there are two parallel mechanisms by which excitation
energy can be transferred from *Ir to the Eu/Tb centre. Time-resolved luminescence measurements
on the sensitised Eu-based emission showed both fast and slow rise-time components, associated
with the PET-based and Dexter-based energy-transfer mechanisms respectively. In the Ir/Tb dyads, the
Ir→Tb energy-transfer is only just thermodynamically favourable, leading to rapid Tb→Ir thermally-activated
back energy-transfer and non-radiative deactivation to an extent that depends on the precise
energy gap between the *Ir and Tb-based 5D4 states. Thus, the sensitised Tb(III)-based emission is weak
and unusually short-lived due to back energy transfer, but nonetheless represents rare examples of Tb(III)
sensitisation by a energy donor that could be excited using visible light as opposed to the usually required
UV excitation