Naturalness Reach of the Large Hadron Collider in Minimal Supergravity

We re-analyse the prospects of discovering supersymmetry at the LHC, in order to re-express coverage in terms of a fine-tuning parameter and to extend the analysis to scalar masses (m_0) above 2 TeV. We use minimal supergravity (mSUGRA) unification assumptions for the SUSY breaking parameters. Such high values of m_0 have recently been found to have a focus point, leading to relatively low fine-tuning. In addition, improvements in the simulations since the last study mean that this region no longer lacks radiative electroweak symmetry breaking. The best fine tuning reach is found in a mono-leptonic channel, where for mu>0, A_0=0 and tan beta=10 (corresponding to the focus point), all points in mSUGRA with m_0 < 4000 GeV, with a fine tuning measure up to 300 (570) are covered by the search, where the definition of fine-tuning excludes (includes) the contribution from the top Yukawa coupling. Even for arbitrarily high m_0, mSUGRA does not evade detection provided the gaugino mass parameter M_{1/2} < 460 GeV

Chewing gum and context-dependent memory: The independent roles of chewing gum and mint flavour

Two experiments independently investigated the basis of the chewing-gum induced context-dependent memory effect (Baker et al, 2004). At learning and/or recall participants either chewed flavourless gum (Experiment 1) or received mint-flavoured strips (Experiment 2). No context dependent memory effect was found with either flavourless gum or mint-flavoured strips, indicating that independently the contexts were insufficiently salient to induce the effect. This is found despite participants’ subjective ratings indicating a perceived change in state following administration of flavourless gum or mint-flavoured strips. Additionally, some preliminary evidence for a non-additive facilitative effect of receiving gum or flavour at either learning and/or recall is reported. The findings raise further concerns regarding the robustness of the previously reported context-dependent memory effect with chewing gum

Constitutional Purpose and Inter-clause Conflict: The Constraints Imposed on Congress by the Copyright Clause

The argument that the preamble of the Copyright Clause provides a strict constraint on congressional intellectual property legislation has met with broad support among legal academics, but it is viewed with some skepticism by the judiciary. The Supreme Court did acknowledge in Eldred that intellectual property legislation must, in at least some sense, promote the progress of science, but stressed that it is for Congress, not the courts, to decide what does and does not promote progress. The Court specifically rejected a stringent form of rational basis review for Copyright Clause enactments proposed in Justice Breyer\u27s dissent, noting that the Court will defer substantially to congressional findings that a particular measure will promote progress. This Article examines the wisdom of the preambular argument, but it also addresses a more important question that has likewise been the subject of a divergence of opinion between academics and the judiciary: are all the arguments about the Copyright Clause preamble actually moot? Even in the event that the preamble of the Copyright Clause is found to sharply limit congressional action under that clause, Congress might simply enact intellectual property legislation under its commerce power. Who, after all, could deny that intellectual property rights implicate interstate commerce? The prevailing view among legal academics is reflected by William Patry\u27s argument that Congress may not ignore the restrictions on its power contained in one clause merely by legislating under another clause such as the Commerce Clause. But the Eleventh Circuit reached just the opposite conclusion in Moghadam, finding that as a general matter, the fact that legislation reaches beyond the limits of one grant of legislative power has no bearing on whether it can be sustained under another. As such, the Moghadam court held that in some circumstances the Commerce Clause indeed may be used to accomplish that which may not have been permissible under the Copyright Clause In Part I, I examine the text and historical origins of the Copyright Clause itself, and consider arguments that the promote progress requirement is not really a purposive preamble at all. I argue that the opening text of the clause does constitute a purposive limitation on congressional action that courts must take seriously, whether we actually use the term preamble or not. In Part II, I examine the practical import of this limitation in light of constitutional case law and doctrine. I conclude that although a reading of the progress requirement as a purposive preamble suggests that courts ought to be less deferential to congressional assurances of compliance than would normally be required by limiting language in the Constitution, any consequent scrutiny would be meaningless if, as the Moghadam court held, Congress may simply bypass the constraints of the Copyright Clause by legislating under the Commerce Clause. In Part III, I consider four different ways to assess whether action under one constitutional clause impermissibly conflicts with the limitations imposed by a different clause and, if a conflict is found, determine which should take precedence. I argue that one must consider the relationship between the constitutional purposes of the respective clauses in order to successfully analyze such conflicts. Finally, in Part IV, I use the purposive analysis just described to examine potential conflicts between the Copyright Clause and intellectual property legislation passed under the auspices of the Commerce Clause. I suggest that although there is no necessary conflict between the two, legislation could nonetheless run afoul of the Copyright Clause preamble while passing muster under the commerce power. In those cases, I argue, judicial weighing of the rival purposive goals involved will be aided by employing the anti-monopolistic and pro-free expression goals of the copyright preamble. Thus, courts should not only ensure that Commerce Clause intellectual property legislation has the purpose of promoting the progress of science and the useful arts, but also should employ exacting scrutiny when reviewing congressional assertions that this is the case

Do divorcing couples become happier by breaking up?

Divorce is a leap in the dark. The paper investigates whether people who split up actually become happier. Using the British Household Panel Survey, we can observe an individual's level of psychological well-being in the years before and after divorce. Our results show that divorcing couples reap psychological gains from the dissolution of their marriages. Men and women benefit equally. The paper also studies the effects of bereavement, of having dependant children and of remarriage. We measure well-being by using general health questionnaire and life satisfaction scores

Kuiper Belt Occultation Predictions

Here we present observations of seven large Kuiper Belt objects. From these observations, we extract a point source catalog with ∼0.01″ precision, and astrometry of our target Kuiper Belt objects with 0.04–0.08″ precision within that catalog. We have developed a new technique to predict the future occurrence of stellar occultations by Kuiper Belt objects. The technique makes use of a maximum likelihood approach which determines the best-fit adjustment to cataloged orbital elements of an object. Using simulations of a theoretical object, we discuss the merits and weaknesses of this technique compared to the commonly adopted ephemeris offset approach. We demonstrate that both methods suffer from separate weaknesses, and thus together provide a fair assessment of the true uncertainty in a particular prediction. We present occultation predictions made by both methods for the seven tracked objects, with dates as late as 2015. Finally, we discuss observations of three separate close passages of Quaoar to field stars, which reveal the accuracy of the element adjustment approach, and which also demonstrate the necessity of considering the uncertainty in stellar position when assessing potential occultations

Challenge clusters facing LCA in environmental decision-making—what we can learn from biofuels

Purpose Bioenergy is increasingly used to help meet greenhouse gas (GHG) and renewable energy targets. However, bioenergy’s sustainability has been questioned, resulting in increasing use of life cycle assessment (LCA). Bioenergy systems are global and complex, and market forces can result in significant changes, relevant to LCA and policy. The goal of this paper is to illustrate the complexities associated with LCA, with particular focus on bioenergy and associated policy development, so that its use can more effectively inform policymakers. Methods The review is based on the results from a series of workshops focused on bioenergy life cycle assessment. Expert submissions were compiled and categorized within the first two workshops. Over 100 issues emerged. Accounting for redundancies and close similarities in the list, this reduced to around 60 challenges, many of which are deeply interrelated. Some of these issues were then explored further at a policyfacing workshop in London, UK. The authors applied a rigorous approach to categorize the challenges identified to be at the intersection of biofuels/bioenergy LCA and policy. Results and discussion The credibility of LCA is core to its use in policy. Even LCAs that comply with ISO standards and policy and regulatory instruments leave a great deal of scope for interpretation and flexibility. Within the bioenergy sector, this has led to frustration and at times a lack of obvious direction. This paper identifies the main challenge clusters: overarching issues, application and practice and value and ethical judgments. Many of these are reflective of the transition from application of LCA to assess individual products or systems to the wider approach that is becoming more common. Uncertainty in impact assessment strongly influences planning and compliance due to challenges in assigning accountability, and communicating the inherent complexity and uncertainty within bioenergy is becoming of greater importance. Conclusions The emergence of LCA in bioenergy governance is particularly significant because other sectors are likely to transition to similar governance models. LCA is being stretched to accommodate complex and broad policy-relevant questions, seeking to incorporate externalities that have major implications for long-term sustainability. As policy increasingly relies on LCA, the strains placed on the methodology are becoming both clearer and impedimentary. The implications for energy policy, and in particular bioenergy, are large

Multiple novel prostate cancer susceptibility signals identified by fine-mapping of known risk loci among Europeans

Genome-wide association studies (GWAS) have identified numerous common prostate cancer (PrCa) susceptibility loci. We have fine-mapped 64 GWAS regions known at the conclusion of the iCOGS study using large-scale genotyping and imputation in 25 723 PrCa cases and 26 274 controls of European ancestry. We detected evidence for multiple independent signals at 16 regions, 12 of which contained additional newly identified significant associations. A single signal comprising a spectrum of correlated variation was observed at 39 regions; 35 of which are now described by a novel more significantly associated lead SNP, while the originally reported variant remained as the lead SNP only in 4 regions. We also confirmed two association signals in Europeans that had been previously reported only in East-Asian GWAS. Based on statistical evidence and linkage disequilibrium (LD) structure, we have curated and narrowed down the list of the most likely candidate causal variants for each region. Functional annotation using data from ENCODE filtered for PrCa cell lines and eQTL analysis demonstrated significant enrichment for overlap with bio-features within this set. By incorporating the novel risk variants identified here alongside the refined data for existing association signals, we estimate that these loci now explain ∼38.9% of the familial relative risk of PrCa, an 8.9% improvement over the previously reported GWAS tag SNPs. This suggests that a significant fraction of the heritability of PrCa may have been hidden during the discovery phase of GWAS, in particular due to the presence of multiple independent signals within the same regio

Impact of impurities in shielding material on simulations of instrument background in space

A major source of background for x-ray focal plane detectors in space instrumentation aboard missions, such as Extended Roentgen Survey with an Imaging Telescope Array and Athena Wide Field Imager, is the space radiation environment. High-energy radiations from the environment interact with the spacecraft structure leading to large productions of secondary particles with energies that are detectable in the science region of interest for instrumentation. Reducing the background from these events is vital for the success of many missions. Graded-Z shielding is a common solution to help reduce the instrument background. Layers of materials with decreasing atomic numbers near detectors help reduce the background. Much of the design is determined through iterative simulations to find an optimal solution that meets the requirements for the scientific operation of the instrument. Recent results have indicated an underestimate in the instrument background from the simulations. One hypothesis has been that the simulations do not typically include the impurities in the shielding materials. The work presented investigates the association of impurities in the graded-Z materials and the instrument background spectra. Typically, impurities are not included in material definitions as they can significantly increase computational time. The impurities, percentage loading, and distribution have all been explored and evaluated for an Al-Mo-Be graded-Z shield

Effect of a Virtual Patient Navigation Program on Behavioral Health Admissions in the Emergency Department: A Randomized Clinical Trial

This randomized clinical trial assesses whether the availability of a 45-day behavioral health-virtual patient navigation program decreases hospitalization among adult patients presenting to the emergency department with a behavioral health crisis or need. Importance The number of patients presenting to emergency departments (EDs) for psychiatric care continues to increase. Psychiatrists often make a conservative recommendation to admit patients because robust outpatient services for close follow-up are lacking. Objective To assess whether the availability of a 45-day behavioral health-virtual patient navigation program decreases hospitalization among patients presenting to the ED with a behavioral health crisis or need. Design, Setting, and Participants This randomized clinical trial enrolled 637 patients who presented to 6 EDs spanning urban and suburban locations within a large integrated health care system in North Carolina from June 12, 2017, through February 14, 2018; patients were followed up for up to 45 days. Eligible patients were aged 18 years or older, with a behavioral health crisis and a completed telepsychiatric ED consultation. The availability of the behavioral health-virtual patient navigation intervention was randomly allocated to specific days (Monday through Friday from 7 am to 7 pm) so that, in a 2-week block, there were 5 intervention days and 5 usual care days; 323 patients presented on days when the program was offered, and 314 presented on usual care days. Data analysis was performed from March 7 through June 13, 2018, using an intention-to-treat approach. Interventions The behavioral health-virtual patient navigation program included video contact with a patient while in the ED and telephonic outreach 24 to 72 hours after discharge and then at least weekly for up to 45 days. Main Outcomes and Measures The primary outcome was the conversion of an ED encounter to hospital admission. Secondary outcomes included 45-day follow-up encounters with a self-harm diagnosis and postdischarge acute care use. Results Among 637 participants, 358 (56.2%) were men, and the mean (SD) age was 39.7 (16.6) years. The conversion rates were 55.1% (178 of 323) in the intervention group vs 63.1% (198 of 314) in the usual care group (odds ratio, 0.74; 95% CI, 0.54-1.02; P = .06). The percentage of patient encounters with follow-up encounters having a self-harm diagnosis was significantly lower in the intervention group compared with the usual care group (36.8% [119 of 323] vs 45.5% [143 of 314]; P = .03). Conclusions and Relevance Although the primary result did not reach statistical significance, there is a strong signal of potential positive benefit in an area that lacks evidence, suggesting that there should be additional investment and inquiry into virtual behavioral health programs. Question Does offering virtual patient navigation reduce admission rates for patients presenting to the emergency department with a behavioral health crisis? Findings In this randomized clinical trial, there were fewer admissions on days when the navigation program was available (55.1%) vs on days with usual care (63.1%), although the difference was not statistically significant. Significantly fewer patients who used the navigation program had a follow-up encounter involving a self-harm diagnosis within 45 days compared with patients who received usual care (36.8% vs 45.5%). Meaning Although the primary result did not reach statistical significance, there is a strong signal of potential positive benefit in an area that lacks evidence, suggesting that there should be additional investment and inquiry into this area.Open access journalThis item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at [email protected]