The Social Philosophy of Gillian Rose: Speculative Diremptions, Absolute Ethical Life

This thesis provides an original reconstruction of Gillian Rose’s work as a distinctive social philosophy within the Frankfurt School tradition that holds together the methodological, logical, descriptive, metaphysical and normative moments of social theory; provides a critical theory of modern society; and offers distinctive versions of ideology critique based on the history of jurisprudence, and mutual recognition based on a Hegelian view of appropriation. Rose’s philosophy integrates three key moments of the Frankfurt tradition: a view of the social totality as both an epistemological necessity and normative ideal; a philosophy that is its own metaphilosophy because it integrates its own logical and social preconditions within itself; and a critical analysis of modern society that is simultaneously a critique of social theory. Rose’s work is original in the way it organises these three moments around absolute ethical life as the social totality, its Hegelian basis, and its metaphysical focus on law and jurisprudence. Rose’s Hegelian philosophy includes an account of reason that is both social and logical without reducing philosophy to the sociology of knowledge, thereby steering between dogmatism and relativism. Central to this position are the historically developing nature of rationality and knowing, and an account of the nature of explanation as depending on a necessarily and necessarily imperfectly posited totality. No totality is ever fully attained but is brought to view through the Hegelian-speculative exposition of history, dirempted experience, and the tensions immanent to social theories. Rose explored one main social totality within her social philosophy – absolute ethical life – as the implied unity of law and ethics, and of finite and infinite. This enables a critique simultaneously and immanently of society and social philosophy in three ways. First, of both the social form of bourgeois property law and social contract theories reflective of it. Second, of social theorising that insufficiently appreciates its jurisprudential determinations and/or attempts to eliminate metaphysics. Third, the broken middle shows the state-civil society and the law-ethics diremptions as two fundamental features of modern society and as frequently unacknowledged influences on social theorising

High-throughput chromatin accessibility profiling at single-cell resolution.

Here we develop a high-throughput single-cell ATAC-seq (assay for transposition of accessible chromatin) method to measure physical access to DNA in whole cells. Our approach integrates fluorescence imaging and addressable reagent deposition across a massively parallel (5184) nano-well array, yielding a nearly 20-fold improvement in throughput (up to ~1800 cells/chip, 4-5 h on-chip processing time) and library preparation cost (~81¢ per cell) compared to prior microfluidic implementations. We apply this method to measure regulatory variation in peripheral blood mononuclear cells (PBMCs) and show robust, de novo clustering of single cells by hematopoietic cell type

Multiscale Monte Carlo equilibration: Pure Yang-Mills theory

We present a multiscale thermalization algorithm for lattice gauge theory, which enables efficient parallel generation of uncorrelated gauge field configurations. The algorithm combines standard Monte Carlo techniques with ideas drawn from real space renormalization group and multigrid methods. We demonstrate the viability of the algorithm for pure Yang-Mills gauge theory for both heat bath and hybrid Monte Carlo evolution, and show that it ameliorates the problem of topological freezing up to controllable lattice spacing artifacts

The Oxford Common File Layout: A common approach to digital preservation

The Oxford Common File Layout describes a shared approach to filesystem layouts for institutional and preservation repositories, providing recommendations for how digital repository systems should structure and store files on disk or in object stores. The authors represent institutions where digital preservation practices have been established and proven over time or where significant work has been done to flesh out digital preservation practices. A community of practitioners is surfacing and is assessing successful preservation approaches designed to address a spectrum of use cases. With this context as a background, the Oxford Common File Layout (OCFL) will be described as the culmination of over two decades of experience with existing standards and practices

Radial Lattice Quantization of 3D ϕ4\phi^4 Field Theory

The quantum extension of classical finite elements, referred to as quantum finite elements ({\bf QFE})~\cite{Brower:2018szu,Brower:2016vsl}, is applied to the radial quantization of 3d $\phi^4$ theory on a simplicial lattice for the $\mathbb R \times \mathbb S^2$ manifold. Explicit counter terms to cancel the one- and two-loop ultraviolet defects are implemented to reach the quantum continuum theory. Using the Brower-Tamayo~\cite{Brower:1989mt} cluster Monte Carlo algorithm, numerical results support the QFE ansatz that the critical conformal field theory (CFT) is reached in the continuum with the full isometries of $\mathbb R \times \mathbb S^2$ restored. The Ricci curvature term, while technically irrelevant in the quantum theory, is shown to dramatically improve the convergence opening, the way for high precision Monte Carlo simulation to determine the CFT data: operator dimensions, trilinear OPE couplings and the central charge.Comment: 8 pages, 7 figure

Near-conformal dynamics in a chirally broken system

Composite Higgs models must exhibit very different dynamics from quantum chromodynamics (QCD) regardless whether they describe the Higgs boson as a dilatonlike state or a pseudo-Nambu-Goldstone boson. Large separation of scales and large anomalous dimensions are frequently desired by phenom- enological models. Mass-split systems are well-suited for composite Higgs models because they are governed by a conformal fixed point in the ultraviolet but are chirally broken in the infrared. In this work we use lattice field theory calculations with domain wall fermions to investigate a system with four light and six heavy flavors. We demonstrate how a nearby conformal fixed point affects the properties of the four light flavors that exhibit chiral symmetry breaking in the infrared. Specifically we describe hyperscaling of dimensionful physical quantities and determine the corresponding anomalous mass dimension. We obtain ym = 1 + γ* = 1.47(5) suggesting that Nf = 10 lies inside the conformal window. Comparing the low energy spectrum to predictions of dilaton chiral perturbation theory, we observe excellent agreement which supports the expectation that the 4+6 mass-split system exhibits near-conformal dynamics with a relatively light 0þþ isosinglet scalar