The power of like 2: how social marketing works

The Power of Like 2: How Social Marketing Works is the second research report in a series examining the ways in which brands can quantify the paid and earned effects of their social marketing programs on Facebook and optimize their efforts. The analysis leverages data and insights from the comScore Social Essentials™ and comScore AdEffx™ products. By understanding the core elements of maximizing reach on Facebook – Fan Reach, Engagement, and Amplification – brands can benchmark their performance against other brands and devise strategies to improve on these dimensions and deliver measurable social marketing ROI. The report includes original analysis demonstrating ways in which exposure to earned and paid media on Facebook drives behavioral lifts in purchase behavior. &nbsp

Understanding Music Interaction, and Why It Matters

This is the introductory chapter of a book dedicated to new research in, and emerging new understandings of, music and human-computer interaction—known for short as music interaction. Music interaction research plays a key role in innovative approaches to diverse musical activities, including performance, composition, education, analysis, production and collaborative music making. Music interaction is pivotal in new research directions in a range of activities, including audience participation, interaction between music and dancers, tools for algorithmic music, music video games, audio games, turntablism and live coding. More generally, music provides a powerful source of challenges and new ideas for human-computer interaction (HCI). This introductory chapter reviews the relationship between music and human-computer interaction and outlines research themes and issues that emerge from the collected work of researchers and practitioners in this book

Music and HCI

Music is an evolutionarily deep-rooted, abstract, real-time, complex, non-verbal, social activity. Consequently, interaction design in music can be a valuable source of challenges and new ideas for HCI. This workshop will reflect on the latest research in Music and HCI (Music Interaction for short), with the aim of strengthening the dialogue between the Music Interaction community and the wider HCI community. We will explore recent ideas from Music Interaction that may contribute new perspectives to general HCI practice, and conversely, recent HCI research in non-musical domains with implications for Music Interaction. We will also identify any concerns of Music Interaction that may require unique approaches. Contributors engaged in research in any area of Music Interaction or HCI who would like to contribute to a sustained widening of the dialogue between the distinctive concerns of the Music Interaction community and the wider HCI community will be welcome

OCTOPUS: an open cosmogenic isotope and luminescence database

We present a database of cosmogenic radionuclide and luminescence measurements in fluvial sediment. With support from the Australian National Data Service (ANDS) we have built infrastructure for hosting and maintaining the data at the University of Wollongong and making this available to the research community via an Open Geospatial Consortium (OGC)-compliant web service. The cosmogenic radionuclide (CRN) part of the database consists of 10Be and 26Al measurements in modern fluvial sediment samples from across the globe, along with ancillary geospatial vector and raster layers, including sample site, basin outline, digital elevation model, gradient raster, flow-direction and flow-accumulation rasters, atmospheric pressure raster, and CRN production scaling and topographic shielding factor rasters. Sample metadata are comprehensive and include all necessary information for the recalculation of denudation rates using CAIRN, an open-source program for calculating basin-wide denudation rates from 10Be and 26Al data. Further all data have been recalculated and harmonised using the same program. The luminescence part of the database consists of thermoluminescence (TL) and optically stimulated luminescence (OSL) measurements in fluvial sediment samples from stratigraphic sections and sediment cores from across the Australian continent and includes ancillary vector and raster geospatial data. The database can be interrogated and downloaded via a custom-built web map service. More advanced interrogation and exporting to various data formats, including the ESRI Shapefile and Google Earth\u27s KML, is also possible via the Web Feature Service (WFS) capability running on the OCTOPUS server. Use of open standards also ensures that data layers are visible to other OGC-compliant data-sharing services. OCTOPUS and its associated data curation framework provide the opportunity for researchers to reuse previously published but otherwise unusable CRN and luminescence data. This delivers the potential to harness old but valuable data that would otherwise be lost to the research community

Liver-Targeting of Interferon-Alpha with Tissue-Specific Domain Antibodies

PMCID: PMC3581439This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited

Arable soil formation and erosion: a hillslope-based cosmogenic nuclide study in the United Kingdom

Arable soils are critical resources that support multiple ecosystem services. They are frequently threatened, however, by accelerated erosion. Subsequently, policy to ensure their long-term security is an urgent societal priority. Although their long-term security relies upon a balance between the rates of soil loss and formation, there have been few investigations of the formation rates of soils supporting arable agriculture. This paper addresses this knowledge gap by presenting the first isotopically constrained soil formation rates for an arable (Nottinghamshire, UK) and coniferous woodland hillslope (Shropshire, UK). Rates ranged from 0.026 to 0.096 mm yr−1 across the two sites. These rates fall within the range of previously published rates for soils in temperate climates and on sandstone lithologies but significantly differed from those measured in the only other UK-based study. We suggest this is due to the parent material at our sites being more susceptible to weathering. Furthermore, soil formation rates were found to be greatest for aeolian-derived sandstone when compared with fluvially derived lithology raising questions about the extent to which the petrographic composition of the parent material governs rates of soil formation. On the hillslope currently supporting arable agriculture, we utilized cosmogenically derived rates of soil formation and erosion in a first-order lifespan model and found, in a worst-case scenario, that the backslope A horizon could be eroded in 138 years with bedrock exposure occurring in 212 years under the current management regime. These findings represent the first quantitative estimate of cultivated soil lifespans in the UK

Heteroepitaxial growth of ferromagnetic MnSb(0001) films on Ge/Si(111) virtual substrates

Molecular beam epitaxial growth of ferromagnetic MnSb(0001) has been achieved on high quality, fully relaxed Ge(111)/Si(111) virtual substrates grown by reduced pressure chemical vapor deposition. The epilayers were characterized using reflection high energy electron diffraction, synchrotron hard X-ray diffraction, X-ray photoemission spectroscopy, and magnetometry. The surface reconstructions, magnetic properties, crystalline quality, and strain relaxation behavior of the MnSb films are similar to those of MnSb grown on GaAs(111). In contrast to GaAs substrates, segregation of substrate atoms through the MnSb film does not occur, and alternative polymorphs of MnSb are absent

Circulating mitochondrial DNA is an early indicator of severe illness and mortality from COVID-19

BackgroundMitochondrial DNA (MT-DNA) are intrinsically inflammatory nucleic acids released by damaged solid organs. Whether circulating cell-free MT-DNA quantitation could be used to predict the risk of poor COVID-19 outcomes remains undetermined.MethodsWe measured circulating MT-DNA levels in prospectively collected, cell-free plasma samples from 97 subjects with COVID-19 at hospital presentation. Our primary outcome was mortality. Intensive care unit (ICU) admission, intubation, vasopressor, and renal replacement therapy requirements were secondary outcomes. Multivariate regression analysis determined whether MT-DNA levels were independent of other reported COVID-19 risk factors. Receiver operating characteristic and area under the curve assessments were used to compare MT-DNA levels with established and emerging inflammatory markers of COVID-19.ResultsCirculating MT-DNA levels were highly elevated in patients who eventually died or required ICU admission, intubation, vasopressor use, or renal replacement therapy. Multivariate regression revealed that high circulating MT-DNA was an independent risk factor for these outcomes after adjusting for age, sex, and comorbidities. We also found that circulating MT-DNA levels had a similar or superior area under the curve when compared against clinically established measures of inflammation and emerging markers currently of interest as investigational targets for COVID-19 therapy.ConclusionThese results show that high circulating MT-DNA levels are a potential early indicator for poor COVID-19 outcomes.FundingWashington University Institute of Clinical Translational Sciences COVID-19 Research Program and Washington University Institute of Clinical Translational Sciences (ICTS) NIH grant UL1TR002345

Autologous humanized PDX modeling for immuno-oncology recapitulates features of the human tumor microenvironment.

BACKGROUND: Interactions between immune and tumor cells are critical to determining cancer progression and response. In addition, preclinical prediction of immune-related drug efficacy is limited by interspecies differences between human and mouse, as well as inter-person germline and somatic variation. To address these gaps, we developed an autologous system that models the tumor microenvironment (TME) from individual patients with solid tumors. METHOD: With patient-derived bone marrow hematopoietic stem and progenitor cells (HSPCs), we engrafted a patient\u27s hematopoietic system in MISTRG6 mice, followed by transfer of patient-derived xenograft (PDX) tissue, providing a fully genetically matched model to recapitulate the individual\u27s TME. We used this system to prospectively study tumor-immune interactions in patients with solid tumor. RESULTS: Autologous PDX mice generated innate and adaptive immune populations; these cells populated the TME; and tumors from autologously engrafted mice grew larger than tumors from non-engrafted littermate controls. Single-cell transcriptomics revealed a prominent vascular endothelial growth factor A (VEGFA) signature in TME myeloid cells, and inhibition of human VEGF-A abrogated enhanced growth. CONCLUSIONS: Humanization of the interleukin 6 locus in MISTRG6 mice enhances HSPC engraftment, making it feasible to model tumor-immune interactions in an autologous manner from a bedside bone marrow aspirate. The TME from these autologous tumors display hallmarks of the human TME including innate and adaptive immune activation and provide a platform for preclinical drug testing