Parametric resonance of magnetization excited by electric field

Manipulation of magnetization by electric field is a central goal of spintronics because it enables energy-efficient operation of spin-based devices. Spin wave devices are promising candidates for low-power information processing but a method for energy-efficient excitation of short-wavelength spin waves has been lacking. Here we show that spin waves in nanoscale magnetic tunnel junctions can be generated via parametric resonance induced by electric field. Parametric excitation of magnetization is a versatile method of short-wavelength spin wave generation, and thus our results pave the way towards energy-efficient nanomagnonic devices

Late Pleistocene insects from the Dubrovino site at Ob River (West Siberia, Russia) and their paleoenvironmental significance

A blue-grey clay loam lens with plant and insect remains was found in an expo-sure of the Ob River, 2 km upper Dubrovino village in Novosibirskaya Oblast of Russia.Conventional radiocarbon dating of the Dubrovino deposit is ca 19,444±159 14C BP(23,234±338 cal yr BP) and coincides with Sartan glaciation period (MIS 2). Ninety-twoColeoptera species, dominated by fragments of Curculionidae and Carabidae are rep-resented in the Dubrovino deposit. Species of the tundra-steppe fauna are dominant,followed by meadow-dwelling taxa and coniferous forest taxa. A comparison of theDubrovino assemblage with the previously studied late Pleistocene Kalistratikha andBunkovo fossil assemblages showed that tundra-steppe landscapes with coniferousgroves and sparse meadow vegetation were typical for this area from the end of Kargininterglacial (MIS 3) through the end of the Sartan glaciation (MIS 2)

Correction of Phase Errors in a Spin-Wave Transmission Line by Nonadiabatic Parametric Pumping

Spin waves propagating in nanoscale ferromagnetic waveguides are considered promising for a new generation of digital and analog magnonic signal-processing devices, where the signal is encoded in a spin wave's amplitude or phase, or both. Stable, error-free operation of spin-wave devices requires well-defined spin-wave phase, which can be disrupted by technological imperfections or thermal noise, leading to the accumulation of phase errors in a magnonic circuit. The authors demonstrate that such phase errors can be corrected by the application of parametric pumping, via voltage-controlled magnetic anisotropy, to local gates placed in the spin wave's path

Generation of mouse lines with conditionally or constitutively inactivated Snca gene and Rosa26-stop-lacZ reporter located in cis on the mouse chromosome 6

α-Synuclein is involved in many important molecular processes in neuronal cells and their synapses, and its malfunction has been linked to the development of Parkinson’s and certain other neurodegenerative diseases. Animal models allowing tightly monitored conditional inactivation of the encoding gene, Snca, are indispensible for studies aimed at understanding normal function of α-synuclein in various neuronal populations and its role in pathogenesis of neurodegenerative diseases. We have recently reported the production of several novel mouse lines for manipulating expression of the endogenous Snca gene, including a line for Cre-recombinase-driven conditional inactivation of the gene (mice with floxed Snca) and a new line with a constitutive knockout of α-synuclein. Rosa26-stop-lacZ reporter cassette is commonly used for monitoring efficiency of Cre-recombination but in mouse genome Snca and Rosa26 loci are located on the same chromosome. Here we describe production of lines with a modified Snca locus, either floxed or constitutively inactivated and the Rosa26-stop-lacZ reporter cassette located in cis on the mouse chromosome 6. These new mouse lines are invaluable for fast identification of cells with inactivation of Snca by Cre-recombination and represent useful tools for in vivo studies of α-synuclein function and dysfunctio

A STUDY OF EXTREMISM AS A COMPLEX INTER-BRANCH CONCEPT

Purpose: The aim of the study is to investigate extremism as a complex inter-branch concept which complicates law enforcement practice. Methodology: This is an analytic-dialectical research whose data are obtained through the analysis of historical, legal and sociological texts and data. Main Findings: When defining extremism in the basic law of anti-extremist legislation, it is necessary to proceed from the fact that the phenomenon, the concept of which should be formulated, is manifested in different spheres of social and political life. In conclusion, extremism creates an ideological basis for terrorism, but the acts of terrorism go beyond the concept of extremism. Applications: This article can be used by regional schools, cultural organizations and universities. Novelty/Originality: In this study, correlation between the phenomena of terrorism and extremism has been studied on the basis of definition for terrorist act given in part 1 of article 205 of the criminal code of the Russian Federation

Комплексы жесткокрылых из четвертичных отложений р. Кизиха - самые южные позднеплейстоценовые насекомые Западно-Сибирской равнины

Two sites with insect remains were found in an exposure on the bank of Kizikha river, in the Rubtsovskii District of the Altaiskii Krai of Russia, Kizikha-1 with radiocarbon age 13455±150 14C BP (SPb-1347), and Kizikha-2 with the age 26094±400 14C BP (SPb-1418). This period is coincides with Sartan stadial and Kargin interstadial (MIS 2 and MIS 3). This is the southernmost late Pleistocene insect bearing deposit found in West Siberia. The fragments in both sites are represented mainly by Coleoptera. Beetle fauna from the site Kizikha-1 is represented by 34 species from 9 families. The majority of fragments belong to weevils and ground beetles. 28 species from 8 families are found in Kizikha-2 site, the majority of fragments belong to Carabidae. 7 species found in the sites, Dyschiriodes rufimanus, Cymindis cf. rostowtzowi (Carabidae), Cidnopus cf. parallelus, Pristilophus punctatissimus (Elateridae), Hemitrichapion alexsandri (Brentidae), Paophilus albilaterus and Otiorhynchus sushkini (Curculionidae), are recorded in Pleistocene deposits for the first time. Sub-fossil insect assemblages of the two sites coincides with the late Pleistocene “Otiorhynchus-type” sub-fossil insect fauna from southeastern part of West-Siberian Plain (Zinovyev, 2011; Legalov et al., 2016) with characteristics as follows: dominance of steppe species, presence of halophile species, lack of forest species. Most of these species are absent in the contemporary regional fauna. The complex of eastern species and presence of endemics of Altai-Sayan Mountain system is also characteristic to the both studied sites. Specifics of the deposit assemblages in comparison with the other late Pleistocene fauna of West Siberian Plain is in high share of meadow species that could be explained by taphonomic condition of sedimentation or microclimatic conditions caused by close location to Altai mountains. Analysis of sub-fossil insect fragments showed that open landscapes with zonal steppe and sparse meadow vegetation near rivers and in depressions were typical for this area. In comparison to contemporary conditions climate was dry and cold, but Kizikha-2 (end of MIS 3) was formed in more mild climate conditions than Kizikha-1 (end of MIS 2). Results gained from Kizikha-1 and Kizikha-2 sites are complementing data on latitudinal-zonal distribution of beetles found in late Pleistocene deposits in West Siberian Plain

Alterations in the nigrostriatal system following conditional inactivation of α-synuclein in neurons of adult and aging mice

The aetiology and pathogenesis of Parkinson’s disease (PD) are tightly linked to he gain-offunction of α-synuclein. However, gradual accumulation of α-synuclein aggregates in dopaminergic neurons of substantia nigra pars compacta (SNpc) leads to the depletion of the functional pool of soluble α-synuclein and therefore, creates a loss-of-function conditions, particularly in presynaptic terminals of these neurons. Studies of if and how this late-onset depletion of a protein involved in many important steps of neurotransmission contributes to PD progression and particularly, to worsening the nigrostriatal pathology at late stages of the disease are limited and obtained data are controversial. Recently we produced a mouse line for conditional knockout of the gene encoding α-synuclein and here we used its tamoxifen-inducible pan-neuronal inactivation to study consequences of the adult-onset (from the age of 6 months) and late-onset (from the age of 12 months) α-synuclein depletion to the nigrostriatal system. No significant changes of animal balance/coordination, the number of dopaminergic neurons in the SNpc and the content of dopamine and its metabolites in the striatum were observed after adult-onset α synuclein depletion but in ageing (18-month old) late-onset depleted mice we found significant reduction of major dopamine metabolites without changes to the content of dopamine itself. Our data suggest that this might be caused, at least partially, by reduced expression of aldehyde dehydrogenase ALDH1a1 and could lead to accumulation of toxic intermediates of dopamine catabolism. By extrapolating our findings to a potential clinical situation, we suggest that therapeutic downregulation of α-synuclein expression in PD patients is a generally safe option as it should not cause adverse side effects on the functionality of their nigrostriatal system. However, if started in aged patients, this type of therapy might trigger slight functional changes of the nigrostriatal system with potentially unwanted additive effect to already existing pathology

Zinc induces temperature-dependent reversible self-assembly of Tau

Tau is an intrinsically disordered microtubule-associated protein that is implicated in several neurodegenerative disorders called tauopathies. In these diseases, Tau is found in the form of intracellular inclusions that consist of aggregated paired helical filaments (PHFs) in neurons. Given the importance of this irreversible PHF formation in neurodegenerative disease, Tau aggregation has been extensively studied. Several different factors, such as mutations or post translational modifications, have been shown to influence the formation of late-stage non-reversible Tau aggregates. It was recently shown that zinc ions accelerated heparin-induced oligomerization of Tau constructs. Indeed, in vitro studies of PHFs have usually been performed in the presence of additional co-factors, such as heparin, in order to accelerate their formation. Using turbidimetry, we investigated the impact of zinc ions on Tau in the absence of heparin and found that zinc is able to induce a temperature-dependent reversible oligomerization of Tau. The obtained oligomers were not amyloid-like and dissociated instantly following zinc chelation or a temperature decrease. Finally, a combination of isothermal titration calorimetry and dynamic light scattering experiments showed zinc binding to a high-affinity binding site and three low-affinity sites on Tau, accompanied by a change in Tau folding. Altogether, our findings stress the importance of zinc in Tau oligomerization. This newly identified Zn-induced oligomerization mechanism may be a part of a pathway different of and concurrent to Tau aggregation cascade leading to PHF formation

Magnetic phenomena in co-containing layered double hydroxides

Magnetic behavior of CoII(n)AlIII layered double hydroxides (LDHs) (n=Co/Al=2 and 3) intercalated with nitrate was studied as a function of temperature. Both LDH compounds are paramagnetic above about 8K. A rapid increase of their magnetic moments occurs below this temperature until the moments reach the maximum values at Tmax of 4.0K and 3.2K for Co(2)Al-NO3 and Co(3)Al-NO3, respectively. Below Tmax, the zero-field-cooled and the field-cooled static magnetization curves are strongly different. Along with this low-temperature phenomena, Co(2)Al-NO3 and Co(3)Al-NO3 demonstrate anomalous behavior of their temperature dependence magnetic susceptibility in a highertemperature range: between 75 and 175K, both the paramagnetic Curie temperature and the effective magnetic moment change in a non-monotonous way. Possible structural reasons of the observed magnetic behavior of the CoII(n)AlIII LDHs are discussed.publishe