826 research outputs found
Ununfoldable Polyhedra with Convex Faces
Unfolding a convex polyhedron into a simple planar polygon is a well-studied
problem. In this paper, we study the limits of unfoldability by studying
nonconvex polyhedra with the same combinatorial structure as convex polyhedra.
In particular, we give two examples of polyhedra, one with 24 convex faces and
one with 36 triangular faces, that cannot be unfolded by cutting along edges.
We further show that such a polyhedron can indeed be unfolded if cuts are
allowed to cross faces. Finally, we prove that ``open'' polyhedra with
triangular faces may not be unfoldable no matter how they are cut.Comment: 14 pages, 9 figures, LaTeX 2e. To appear in Computational Geometry:
Theory and Applications. Major revision with two new authors, solving the
open problem about triangular face
Cabazitaxel in platinum pre-treated patients with locally advanced or metastatic transitional cell carcinoma who developed disease progression after platinum based chemotherapy : results of the phase II CAB-B1 trial
There is a paucity of chemotherapy options for patients with urothelial cancers who have relapsed following platinum based chemotherapy (CT).
CAB-B1 was a single centre phase II randomised controlled trial of Cabazitaxel (CAB; 25mg/m2 q3 week for 6 cycles) versus
best supportive care (BSC) in patients with histologically proven transitional cell carcinoma (TCC), locally advanced or
metastatic, who had recurred after receiving platinum based treatment. Primary outcome was overall response rate (ORR)
using RESIST. Secondary outcomes included Progression Free Survival (PFS) and Overall Survival (OS).
Between January 2013 and October 2016, 20 patients were randomised (10 on each arm). BSC included paclitaxel CT for 9
patients and radiotherapy for 1 patient. 8 patients completed 6 cycles of CT (3 on CAB; 5 on BSC). 2 patients had an ORR
on CAB and 1 patient on BSC. Median OS was 5.8 months (95% confidence interval (CI) 0.7-14.6) for CAB patients and
7.5 months (95% CI 1.0-10.8) for BSC patients. Median PFS was 4.8 months (95% CI 0.7-8.3) for CAB patients and 3.7
months (95% CI 1.0-7.0) for BSC patients.
CAB-B1 successfully reached the efficacy target for 1st stage, showing that there could be a role for CAB in these patients
Criminal Justice in the Supreme Courts: An Analysis of United States Supreme Court Criminal and Habeas Corpus Decisions (October 2, 2000 - September 30, 2001)
Criminal Justice in the Supreme Court: A Review of United States Supreme Court Criminal and Habeas Corpus Decisions (October 4, 1999 - October 1, 2000)
Criminal Justice in the Supreme Court: A Review of United States Supreme Court Criminal and Habeas Corpus Decisions (October 4, 1999 - October 1, 2000)
Targeting Specific PDZ Domains of PSD-95 Structural Basis for Enhanced Affinity and Enzymatic Stability of a Cyclic Peptide
AbstractA cyclic peptide, Tyr-Lys-c[-Lys-Thr-Glu(βAla)-]-Val, incorporating a β-Ala lactam side chain linker and designed to target the PDZ domains of the postsynaptic density protein 95 (PSD-95), has been synthesized and structurally characterized by NMR while free and bound to the PDZ1 domain of PSD-95. While bound, the lactam linker of the peptide makes a number of unique contacts outside the canonical PDZ binding motif, providing a novel target for PDZ-domain specificity as well as producing a 10-fold enhancement in binding affinity. Additionally, the cyclization greatly enhances the enzymatic stability, increasing the duration that the peptide inhibits the association between PSD-95 and glutamate receptors, effectively inhibiting the clustering of kainate receptors for over 14 hr after application. Highly specific regulation of kainate receptor action may provide a novel route for treatment of drug addiction and epilepsy
Effect of Three Initial Implant Programs with a Common Terminal Revalor®- 200 on Feedlot Performance and Carcass Traits of Weaned Steers
A commercial feedlot study utilizing 1,350 calf- fed steers (initial BW = 623 lb; ±23 lb) compared three initial implant strategies: Revalor®- IS (day 1), Revalor®- IS (day 1) and Revalor®- 200 (day 67), or Revalor®- XS (day 1). Each initial implant strategy was followed by a terminal Revalor®- 200 implant (day 133) to determine effects on performance and carcass traits. No differences in final body weight, intake, gain, or feed conversion were observed on either a live, or carcass adjusted basis. Th ere were also no differences in hot carcass weight, USDA quality grade, or USDA yield grade. Results from this study suggest initial implant strategy has minimal impact on feedlot and carcass performance when following with a terminal Revalor®- 200 implant
Near-Infrared Studies of V1280 Sco (Nova Scorpii 2007)
We present spectroscopic and photometric results of Nova V1280 Sco which was
discovered in outburst in early 2007 February. The large number of spectra
obtained of the object leads to one of the most extensive, near-infrared
spectral studies of a classical nova. The spectra evolve from a P-Cygni phase
to an emission-line phase and at a later stage is dominated by emission from
the dust that formed in this nova. A detailed model is computed to identify and
study characteristics of the spectral lines. Inferences from the model address
the vexing question of which novae have the ability to form dust. It is
demonstrated, and strikingly corroborated with observations, that the presence
of lines in the early spectra of low-ionization species like Na and Mg -
indicative of low temperature conditions - appear to be reliable indicators
that dust will form in the ejecta. It is theoretically expected that mass loss
during a nova outburst is a sustained process. Spectroscopic evidence for such
a sustained mass loss, obtained by tracing the evolution of a P-Cygni feature
in the Brackett gamma line, is presented here allowing a lower limit of 25-27
days to be set for the mass-loss duration. Photometric data recording the
nova's extended 12 day climb to peak brightness after discovery is used to
establish an early fireball expansion and also show that the ejection began
well before maximum brightness. The JHK light curves indicate the nova had a
fairly strong second outburst around 100 days after the first.Comment: Accepted in MNRAS. The paper contains 8 figures and 4 tables. Few
typographical errors were correcte
Ruling out Stellar Companions and Resolving the Innermost Regions of Transitional Disks with the Keck Interferometer
With the Keck Interferometer, we have studied at 2 um the innermost regions
of several nearby, young, dust depleted "transitional" disks. Our observations
target five of the six clearest cases of transitional disks in the
Taurus/Auriga star-forming region (DM Tau, GM Aur, LkCa 15, UX Tau A, and RY
Tau) to explore the possibility that the depletion of optically thick dust from
the inner disks is caused by stellar companions rather than the more typical
planet-formation hypothesis. At the 99.7% confidence level, the observed
visibilities exclude binaries with flux ratios of at least 0.05 and separations
ranging from 2.5 to 30 mas (0.35 - 4 AU) over >= 94% of the area covered by our
measurements. All targets but DM Tau show near-infrared excess in their SED
higher than our companion flux ratio detection limits. While a companion has
previously been detected in the candidate transitional disk system CoKu Tau/4,
we can exclude similar mass companions as the typical origin for the clearing
of inner dust in transitional disks and of the near-infrared excess emission.
Unlike CoKu Tau/4, all our targets show some evidence of accretion. We find
that all but one of the targets are clearly spatially resolved, and UX Tau A is
marginally resolved. Our data is consistent with hot material on small scales
(0.1 AU) inside of and separated from the cooler outer disk, consistent with
the recent SED modeling. These observations support the notion that some
transitional disks have radial gaps in their optically thick material, which
could be an indication for planet formation in the habitable zone (~ a few AU)
of a protoplanetary disk.Comment: 36 pages, 7 figures. Accepted for publication in Ap
Atmospheric phase correction using CARMA-PACS: high angular resolution observations of the FU Orionis star PP 13S*
We present 0".15 resolution observations of the 227 GHz continuum emission from the circumstellar disk around
the FU Orionis star PP 13S*. The data were obtained with the Combined Array for Research in Millimeter-wave
Astronomy (CARMA) Paired Antenna Calibration System (C-PACS), which measures and corrects the atmospheric
delay fluctuations on the longest baselines of the array in order to improve the sensitivity and angular resolution of
the observations. A description of the C-PACS technique and the data reduction procedures are presented. C-PACS
was applied to CARMA observations of PP 13S*, which led to a factor of 1.6 increase in the observed peak flux
of the source, a 36% reduction in the noise of the image, and a 52% decrease in the measured size of the source
major axis. The calibrated complex visibilities were fitted with a theoretical disk model to constrain the disk surface
density. The total disk mass from the best-fit model corresponds to 0.06 M_⊙, which is larger than the median mass of a disk around a classical T Tauri star. The disk is optically thick at a wavelength of 1.3 mm for orbital radii less than 48 AU. At larger radii, the inferred surface density of the PP 13S* disk is an order of magnitude lower than that needed to develop a gravitational instability
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