Sintomatologia de depressão e suporte familiar em adolescentes: um estudo de correlação

A adolescência é marcada por diversas mudanças físicas/hormonais, sociais e psicológicas, podendo favorecer o desenvolvimento de diversos transtornos e sintomas mentais, como, por exemplo, a sintomatologia depressiva, sendo que a família pode influenciar o desencadeamento/ manutenção de tais sintomas. O objetivo da pesquisa foi avaliar a correlação existente entre sintomatologia depressiva e a percepção de suporte familiar em estudantes do ensino médio. Foram participantes da pesquisa 154 adolescentes de uma escola pública. Os materiais utilizados foram um questionário de caracterização (contendo diversos fatores de risco para a depressão).O Inventário de Depressão Infantil (CDI)) e o Parental Bonding Instrument (PBI), aplicados coletivamente em sala de aula. Os principais resultados demonstraram que quanto maior a simtomatologia depressiva no adolescente mais inadequado é a percepção do suporte familiar e quanto maior a freqüencia dos fatores de risco, maior é a simtomatologia depressiva no adolescente, estando o suporte familiar correlacionado negativamente com a simtomatologia depressiva nesta amostra.In adolescence, there are many changes such as: physical, hormonal and psychological that could have a bearing on the development of an assortment of disorders and mental symptoms, for example depression symptomology, which the family can have an influence over by starting and maintaining the development of these symptoms. The objective of the research is to evaluate the correlation that exists between the depression symptomology and the perception of family support in high school students. One hundred and fifty-four (154) students from a public high school participated in the research. The materiais used were an identification questionnaire (with several risk factors in depression), the Children’s Depression Inventory (CDI) Scale, and the Parental Bonding Instrument (PBI). The questionnaires were given collectively in the classroom. The main results showed that the more an adolescent exhibited a depressive symptomology, the more inadequate the adolescent’s family support is, and thus a greater risk factor. In this sample of adolescents, the research can conclude that family support is negatively related to depressive symptomology

Obtaining microalgae biomass tolerant to herbicides for production of bio-fertilizers: a review based on methodi ordinatio methodology

The objective of this work was to use a systematic review of the literature on the cultivation of microalgae resistant to herbicide using the Method Methodi Ordinatio, which assists the search, selection, collection and classification of scientific articles. Initially, research was done on the databases Scopus, Science Direct and Web of Science, using the keywords “microalgae” and “herbicide”. The results were imported to the Mendeley bibliographic reference manager. Subsequently, the index In Ordinatio index was applied, which works with the three most important factors in a scientific article: The impact factor, the year of publication and the number of citations of the research. This index turns it is possible to classify the most important articles in the area of herbicide-tolerant microalgae and note the importance of this method, which made it possible to find current studies and demonstrate the relevance of this research theme. In order to show the dynamics of the methodology, a research with the theme is presented, comprising works from years 2008 to 2018. The results indicate that the methodology is effective in relation to the objectives proposed, and the most relevant work on the cultivation of herbicide resistant microalgae are used to construct the scenario in this theme.info:eu-repo/semantics/publishedVersio

On the investigation of state space reconstruction of nonlinear aeroelastic response time series,

Abstract. Stall-induced aeroelastic motion may present severe non-linear behavior. Mathematical models for predicting such phenomena are still not available for practical applications and they are not enough reliable to capture physical effects. Experimental data can provide suitable information to help the understanding of typical non-linear aeroelastic phenomena. Dynamic systems techniques based on time series analysis can be adequately applied to non-linear aeroelasticity. When experimental data are available, the methods of state space reconstruction have been widely considered. This paper presents the state space reconstruction approach for the characterization of the stall-induced aeroelastic non-linear behavior. A wind tunnel scaled wing model has been tested. The wing model is subjected to different airspeeds and dynamic incidence angle variations. The method of delays is used to identify an embedded attractor in the state space from experimentally acquired aeroelastic response time series. To obtain an estimate of the time delay used in the state space reconstruction from time series, the autocorrelation function analyis is used. For the calculation of the embedding dimension the correlation integral approach is considered. The reconstructed attractors can reveal typical non-linear structures associated, for instance, to chaos or limit cycles

Primary metabolism components of seeds from Brazilian Amazon tree species

The contents of the main components of the primary metabolism (soluble sugars, starch, proteins, oils, fatty acids) and minerals (P, Ca, Mg, K, Fe, Zn, Mn, Cu) were characterized in seeds of five Brazilian Amazon tree species (Andira parviflora, Bertholletia excelsa, Helicostylis tomentosa, Hymenaea parviflora, and Parkia pendula). Soluble sugar contents were high in P. pendula seeds (14%), whereas starch predominated in A. parviflora seeds (58.7%). A. parviflora and H. parviflora seeds were rich in proteins (35.1% and 32.4%, respectively). The oil contents ranged from 1.4% in A. parviflora to 70.7% in B. excelsa. Only B. excelsa and P. pendula seeds may be considered oilseeds, with 70.7% and 28.4% oil, respectively. The fatty acid compositions showed high proportions of unsaturated fatty acids, mainly oleic and linoleic acids, regardless of the species. B. excelsa and P. pendula also showed high amounts of P, Mg, K and Zn

Angiotensin II type 1/adenosine A2A receptor oligomers: a novel target for tardive dyskinesia

Tardive dyskinesia (TD) is a serious motor side effect that may appear after long-term treatment with neuroleptics and mostly mediated by dopamine D2 receptors (D2Rs). Striatal D2R functioning may be finely regulated by either adenosine A2A receptor (A2AR) or angiotensin receptor type 1 (AT1R) through putative receptor heteromers. Here, we examined whether A2AR and AT1R may oligomerize in the striatum to synergistically modulate dopaminergic transmission. First, by using bioluminescence resonance energy transfer, we demonstrated a physical AT1R-A2AR interaction in cultured cells. Interestingly, by protein-protein docking and molecular dynamics simulations, we described that a stable heterotetrameric interaction may exist between AT1R and A2AR bound to antagonists (i.e. losartan and istradefylline, respectively). Accordingly, we subsequently ascertained the existence of AT1R/A2AR heteromers in the striatum by proximity ligation in situ assay. Finally, we took advantage of a TD animal model, namely the reserpine-induced vacuous chewing movement (VCM), to evaluate a novel multimodal pharmacological TD treatment approach based on targeting the AT1R/A2AR complex. Thus, reserpinized mice were co-treated with sub-effective losartan and istradefylline doses, which prompted a synergistic reduction in VCM. Overall, our results demonstrated the existence of striatal AT1R/A2AR oligomers with potential usefulness for the therapeutic management of TD

Visceral Manipulation Decreases Pain, Increases Cervical Mobility and Electromyographic Activity of the Upper Trapezius Muscle in Non-Specific Neck Pain Subjects with Functional Dyspepsia: Two Case Reports

Background and Purpose: The lack of clear knowledge about the etiology of nonspecific neck pain (NS-NP) strengthens the need for other mech-anisms, still poorly described in the literature, to be investigated. Therefore, a quantitative analysis of two cases of NS-NP in subjects with functiona dyspepsia was conducted in order to verify the immediate and seven-day postintervention effects of visceral manipulation (VM) to the stomach and liver on neck pain, cervical range of motion (ROM), and electromyographic (EMG) activity of the upper trapezius muscle. Case Description: Case A was an 18-year-old female with a complaint of nonspecific neck pain for one year, with reported pain on waking, momentary intermittent pain, and occasional symptoms of paresthesia in the upper limbs. Case B was a 25-year-old female with a complaint of cervical pain for one year, accompanied by pain in the unilateral temporomandibular joint, and medial thoracic region. Both cases presented functional dyspepsia.Outcomes: The results demonstrated (sub-jects A and B, respectively) a general increase in cervical ROM (range: 12.5% to 44.44%) and amplitude of the EMG signal (immediately postintervention: 57.62 and 20.78; post seven days: 53.54% and 18.83%), and an increase in muscle fiber conduction velocity immediately postintervention (4.44% and 7.44%) and a de-crease seven days postintervention (25.25% and 21.18%). For pain, a decrease was observed immediately postintervention (23.07% and 76.92%) and seven days postintervention (100% for both subjects). Discussion: A single VM provided important clinical improvement in neck pain, cervical spine range of motion, and EMG activity of the upper trapezius muscle, immediately and seven days postintervention in two NS-NP subjects with func-tional dyspepsia

Tinnitus emerging in the context of a COVID-19 infection seems not to differ in its characteristics from tinnitus unrelated to COVID-19

Background and aim: COVID-19 is a respiratory disease caused by the new coronavirus SARS-CoV-2, for which the first cases were reported in China, by December 2019. The spectrum of clinical presentations is wide, ranging from asymptomatic cases to a severe acute respiratory syndrome, sometimes with multiple systems involvement. Viral infections, including those related to respiratory virus, may cause hearing loss and, by extent, considering its pathophysiology, tinnitus. A systematic review on inner ear related symptoms in patients with COVID-19 reported 4.5% occurrence rate of tinnitus, with high variance of prevalence between the studies. Our aim is to further explore the relationship between COVID-19 and tinnitus. For this purpose we analyzed a sample of people who had suffered from a COVID-19 infection in the city of Volta Redonda, Brazil. In detail, we compared those with new onset tinnitus during or after the COVID-19 infection with those without tinnitus and those with tinnitus onset before the COVID-19 infection. Methods: Fifty-seven patients over 18 years old and previously diagnosed with COVID-19 confirmed by a RT-PCR test were included. Patients were subdivided in three groups: no tinnitus (NT), tinnitus that already existed before COVID-19 (chronic tinnitus, CT) and tinnitus that arose during or after COVID-19 (post-COVID-19 tinnitus, PCT). Data concerning COVID-19 symptoms, drugs prescribed for COVID-19, tinnitus characteristics, comorbidities and other otological symptoms were collected. For all the patients, tonal audiometry and otoacoustic emissions were performed. Tinnitus patients fulfilled the Tinnitus Handicap Inventory (THI) and visual-analog scales (VAS) for loudness and distress. Patients with CT answered a simple question about the worsening of their tinnitus after COVID-19. Results: PCT was reported by 19.3% of the patients, while 22.8% reported CT. No statistical difference was found between CT and PCT concerning hearing function, tinnitus characteristics and tinnitus distress. There was also no statistically significant difference between PCT and NT with respect to COVID-19 symptoms and pharmacological COVID-19 treatment. Patients with CT reported worsening of their tinnitus after COVID-19. Conclusion: As with other viral infections, inner ear symptoms may be associated with COVID-19. In our sample patients with tinnitus onset before COVID-19 and those with tinnitus onset during or after COVID-19 did not differ significantly in their clinical characteristics and their hearing function, suggesting that tinnitus occurring in the context of a COVID-19 infection is not related to a unique pathophysiological mechanism. The comparison of COVID-19 patients, who developed tinnitus with those who did not develop tinnitus did not reveal any differences in COVID-19 symptoms or COVID-19 treatment. Thus, there was no hint, that a specific expression of COVID-19 is closely related to post COVID-19 tinnitus onset. Although some drugs used to treat tinnitus are known to damage the inner ear cells (especially hydroxychloroquine), we did not see any relationship between the intake of these drugs and tinnitus onset, eventually due to the short prescription time and low doses. Among those patients who had tinnitus before COVID-19 30,8% reported worsening after COVID-19. Overall, tinnitus emerging in the context of a COVID-19 infection seems not to differ from tinnitus unrelated to COVID-19. For further exploring the relationship of tinnitus and COVID-19, large population based studies are warranted