Bath-induced decay of Stark many-body localization

We investigate the relaxation dynamics of an interacting Stark-localized system coupled to a dephasing bath, and compare its behavior to the conventional disorder-induced many body localized system. Specifically, we study the dynamics of population imbalance between even and odd sites, and the growth of the von Neumann entropy. For a large potential gradient, the imbalance is found to decay on a time scale that grows quadratically with the Wannier-Stark tilt. For the non-interacting system, it shows an exponential decay, which becomes a stretched exponential decay in the presence of finite interactions. This is different from a system with disorder-induced localization, where the imbalance exhibits a stretched exponential decay also for vanishing interactions. As another clear qualitative difference, we do not find a logarithmically slow growth of the von-Neumann entropy as it is found for the disordered system. Our findings can immediately be tested experimentally with ultracold atoms in optical lattices

Prethermal memory loss in interacting quantum systems coupled to thermal baths

We study the relaxation dynamics of an extended Fermi-Hubbard chain with a strong Wannier-Stark potential tilt coupled to a bath. When the system is subjected to dephasing noise, starting from a pure initial state the system's total von Neumann entropy is found to grow monotonously. The scenario becomes rather different when the system is coupled to a thermal bath of finite temperature. Here, for sufficiently large field gradients and initial energies, the entropy peaks in time and almost reaches its largest possible value (corresponding to the maximally mixed state), long before the system relaxes to thermal equilibrium. This entropy peak signals a prethermal memory loss and, relative to the time where it occurs, the system is found to exhibit a simple scaling behavior in space and time. By comparing the system's dynamics to that of a simplified model, the underlying mechanism is found to be related to the localization property of the Wannier-Stark system, which favors dissipative coupling between eigenstates that are close in energy

Heat transport in an optical lattice via Markovian feedback control

Ultracold atoms offer a unique opportunity to study many-body physics in a clean and well-controlled environment. However, the isolated nature of quantum gases makes it difficult to study transport properties of the system, which are among the key observables in condensed matter physics. In this work, we employ Markovian feedback control to synthesize two effective thermal baths that couple to the boundaries of a one-dimensional Bose-Hubbard chain. This allows for the realization of a heat-current-carrying state. We investigate the steady-state heat current, including its scaling with system size and its response to disorder. In order to study large systems, we use semi-classical Monte-Carlo simulation and kinetic theory. The numerical results from both approaches show, as expected, that for non- and weakly interacting systems with and without disorder one finds the same scaling of the heat current with respect to the system size as it is found for systems coupled to thermal baths. Finally, we propose and test a scheme for measuring the energy flow. Thus, we provide a route for the quantum simulation of heat-current-carrying steady states of matter in atomic quantum gases

Characterization of Hydrolytic Degradation of U-f Joints Through Apparent Diffusivity

The hydrolytic aging of an adhesive joint (wood-urea/formaldehyde resin) is characterized by measurements of the apparent diffusivity of two inert gases within the bond. This kind of measurement is of some interest, because it includes both chemical and geometrical changes in joint structure.Apparent diffusivities are determined in a diffusion cell after various degradation times in a cold water bath. Our results show that diffusivity increases with aging time with an asymptotic trend. Nevertheless, when the joint undergoes cyclic aging (immersion/drying), chemical degradation occurs mainly during the first cycle, while mechanical degradation observed during the drying steps also appears during the following cycles. The values of apparent diffusivity show that the solute transport is a real diffusional transport phenomenon and that resin joints are not porous

COPD and cardiovascular disease

COPD is one of the major public health problems in people aged 40 years or above. It is currently the 4th leading cause of death in the world and projected to be the 3rd leading cause of death by 2020. COPD and cardiac comorbidities are frequently associated. They share common risk factors, pathophysiological processes, signs and symptoms, and act synergistically as negative prognostic factors. Cardiac disease includes a broad spectrum of entities with distinct pathophysiology, treatment and prognosis. From an epidemiological point of view, patients with COPD are particularly vulnerable to cardiac disease. Indeed, mortality due to cardiac disease in patients with moderate COPD is higher than mortality related to respiratory failure. Guidelines reinforce that the control of comorbidities in COPD has a clear benefit over the potential risk associated with the majority of the drugs utilized. On the other hand, the true survival benefits of aggressive treatment of cardiac disease and COPD in patients with both conditions have still not been clarified. Given their relevance in terms of prevalence and prognosis, we will focus in this paper on the management of COPD patients with ischemic coronary disease, heart failure and dysrhythmia.Novartis Portugal Novartisinfo:eu-repo/semantics/publishedVersio

Describing many-body localized systems in thermal environments

In this work we formulate an efficient method for the description of many-body localized systems in weak contact with thermal environments at temperature $T$. For this purpose we exploit the representation of the system in terms of quasi-local integrals of motion ($l$-bits) to derive a quantum master equation using Born-Markov approximations. We show how this equation can be treated by using quantum-jump Monte-Carlo techniques as well as by deriving approximate kinetic equations of motion. As an example, we consider the one-dimensional Anderson model for spinless fermions including also nearest-neighbor interactions, which we diagonalize approximately by employing a recently proposed method valid in the limit of strong disorder and weak interactions. Coupling the system to a global thermal bath, we study the transport between two leads with different chemical potentials at both of its ends. We find that the temperature-dependent current is captured by an interaction-dependent version of Mott's law for variable range hopping, where transport is enhanced/lowered depending on whether the interactions are attractive or repulsive, respectively. We interpret these results in terms of spatio-energetic correlations between the $l$-bits

Indication of critical scaling in time during the relaxation of an open quantum system

Phase transitions correspond to the singular behavior of physical systems in response to continuous control parameters like temperature or external fields. Near continuous phase transitions, associated with the divergence of a correlation length, universal power-law scaling behavior with critical exponents independent of microscopic system details is found. Recently, dynamical quantum phase transitions and universal scaling have been predicted and also observed in the non-equilibrium dynamics of isolated quantum systems after a quench, with time playing the role of the control parameter. However, signatures of such critical phenomena in time in open systems, whose dynamics is driven by the dissipative contact to an environment, were so far elusive. Here, we present results indicating that critical scaling with respect to time can also occur during the relaxation dynamics of an open quantum system described by mixed states. We experimentally measure the relaxation dynamics of the large atomic spin of individual Caesium atoms induced by the dissipative coupling via spin-exchange processes to an ultracold Bose gas of Rubidium atoms. For initial states far from equilibrium, the entropy of the spin state is found to peak in time, transiently approaching its maximum possible value, before eventually relaxing to its lower equilibrium value. Moreover, a finite-size scaling analysis based on numerical simulations shows that it corresponds to a critical point with respect to time of the dissipative system in the limit of large system sizes. It is signalled by the divergence of a characteristic length at a critical time, characterized by critical exponents that are found to be independent of system details

CD8 T cell-mediated depletion of HBV surface-antigen-expressing, bilineal-differentiated liver carcinoma cells generates highly aggressive escape variants

The expression of viral antigens in chronic hepatitis B virus (HBV) infection drives continuous liver inflammation, one of the main risk factors to develop liver cancer. HBV developed immune-suppressive functions to escape from the host immune system, but their link to liver tumor development is not well understood. Here, we analyzed if and how HBV surface antigen (HBs) expression in combined hepatocellular-cholangiocarcinoma (cHCC/iCCA) cells influences their antigenicity for CD8 T cells. We randomly isolated liver tumor tissues from AlfpCre+-Trp53fl/fl/Alb-HBs+ tg mice and established primary carcinoma cell lines (pCCL) that showed a bilineal (CK7+/HNF4α+) cHCC/iCCA phenotype. These pCCL uniformly expressed HBs (HBshi), and low levels of MHC-I (MHC-Ilo), and were transiently convertible to a high antigenicity (MHC-Ihi) phenotype by IFN-γ treatment. HBshi/pCCL induced HBs/(Kb/S190–197)-specific CD8 T cells and developed slow-growing tumors in subcutaneously transplanted C57Bl/6J (B6) mice. Interestingly, pCCL-ex cells, established from HBshi/pCCL-induced and re-explanted tumors in B6 but not those in immune-deficient Rag1−/− mice showed major alterations, like an MHC-Ihi phenotype, a prominent growth-biased gene expression signature, a significantly decreased HBs expression (HBslo) and a switch to fast-growing tumors in re-transplanted B6 or PD-1−/− hosts with an unlocked PD-1/PD-L1 control system. CD8 T cell-mediated elimination of HBshi/pCCL, together with the attenuation of the negative restraints of HBs in the tumor cells, like ER-stress, reveals a novel mechanism to unleash highly aggressive HBslo/pCCL-ex immune-escape variants. Under certain conditions, HBs-specific CD8 T-cell responses thus potentiate tumor growth, an aspect that should be considered for therapeutic vaccination strategies against chronic HBV infection and liver tumors.</p