Nanoscale dispensing of single ultrasmall droplets

Nanoscale dispensing (NADIS) is a novel technique to deposit material at micrometric and submicrometric dimensions. It has great flexibility in feature shape and choice of deposited material. Due to its expected low cost and short turn-around time, it has the potential to be an interesting tool complementary to standard lithographic processes. Furthermore, NADIS has a great potential in the creation of high-density microarrays used in proteomics or genomics. The key feature of NADIS is the deposition of a liquid through an aperture created in a scanning force microscopy probe tip. The liquid is loaded into the hollow back of the pyramidal probe tip. Upon contact, liquid is transferred from the tip to the substrate surface. The transfer of liquid occurs without any external pressure. The control of the NADIS probe displacement is achieved using a standard atomic force microscope. Two different approaches to fabricate tips with apertures were investigated. The first approach relies on opening the tip during the microfabrication of the probe, whereas the second approach implies a modification of commercially available probes by focused ion beam milling. Both kinds of probes have shown their ability to perform successfully the dispensing of droplets. Nanoscale dispensing has been demonstrated for deposition of ultrasmall single droplets with volumes down toattoliters in a controlled way and with high lateral accuracy. The smallest droplet spacing that has been achieved was less than 500 nm. The size of the droplets and the possible droplet density are largely dependent on the aperture diameter and on the surface wettability. Nanoparticles and fluorescent molecules were also dispensed. In such cases, the liquid is used as a transport medium for the substances to be deposited. By moving the NADIS probe during contact on the substrate, it was possible to write features such as lines with sizes that can be as small as 400 nm. Some theoretical aspects are discussed, in particularly the capillary forces associated with axisymmetric liquid menisci. Experimentally measured capillary forces during the dispensing are compared with theoretically determined values

A cost effective AFM setup, combining interferometry and FPGA

International audienceAtomic force microscopes (AFM) provide high resolution images of surfaces. In this paper, we focus on an interferometry method for estimation of deflections in arrays of cantilever in quasi-static regime. We propose a novel complete solution with a least square based algorithm to determine interference fringe phases and its optimized FPGA implementation. Simulations and real tests show very good results and open perspectives for real-time estimation and control of cantilever arrays in the dynamic regime

Mit Schüler*innen über Anspruchsdimensionen eines inklusiven Sportunterrichts reflektieren - Entwicklung eines anforderungssituationsbezogenen Kompetenzprofils für Sportlehrkräfte

Im Rahmen eines inklusiven Sportunterrichts, an den die Ansprüche der Teilhabe, Anerkennung und individuellen Förderung aller Schüler*innen gestellt werden, werden Sportlehrkräfte mit verschiedenen Anforderungssituationen konfrontiert. Dazu zählt u.a. mit den Schüler*innen über die Ansprüche und Situationen, in denen diese verletzt werden, zu reflektieren (Greve, 2016). Jedoch ist bislang unklar, welche Kompetenzen Lehrkräfte benötigen, um diese Anforderungssituationen zu bewältigen. Einem Ansatz folgend, der Kompetenzen als Kontinuum zwischen Performanz, situationsspezifischen Fähigkeiten und Dispositionen betrachtet (Blömeke, Gustafsson & Shavelson, 2015), nimmt sich der Beitrag diesem Desiderat an. Unter der Verwendung eines integrativen Verfahrens, das sowohl kontextualisiert-performanzorientierte also auch dekontextualisiert-dispositionsorientierte Zugänge zur Modellierung miteinander verknüpft, wird ein Kompetenzprofil zur Anforderungssituation „Mit Schüler*innen über Anspruchsdimensionen eines inklusiven Sportunterrichts reflektieren“ (Erhorn & Langer, 2022, S. 108) entwickelt. Abstract In the context of inclusive physical education, which demands participation, recognition and individual support of all students, physical education teachers have to face different requirement situations. This includes reflecting with students on situations in which these demands are violated (Greve, 2016). However, it is not yet clear what competencies teachers need to meet these requirement situations. Following an approach that views competencies as a continuum between performance, situation-specific skills, and dispositions (Blömeke et al., 2015), this paper addresses this desideratum. Using an integrative procedure that combines both contextualized-performance-oriented and decontextualized-disposition-oriented approaches of modeling, a competency profile for the requirement situation "Reflecting with students on demands of inclusive physical education" (Erhorn & Langer, 2022, S. 108) is developed

Reflecting with students on demands dimensions of inclusive physical education - Development of a requirement situation-related competence profile for physical education teachers

Im Rahmen eines inklusiven Sportunterrichts, an den die Ansprüche der Teilhabe, Anerkennung und individuellen Förderung aller Schüler*innen gestellt werden, werden Sportlehrkräfte mit verschiedenen Anforderungssituationen konfrontiert. Dazu zählt u.a. mit den Schüler*innen über die Ansprüche und Situationen, in denen diese verletzt werden, zu reflektieren (Greve, 2016). Jedoch ist bislang unklar, welche Kompetenzen Lehrkräfte benötigen, um diese Anforderungssituationen zu bewältigen. Einem Ansatz folgend, der Kompetenzen als Kontinuum zwischen Performanz, situationsspezifischen Fähigkeiten und Dispositionen betrachtet (Blömeke, Gustafsson & Shavelson, 2015), nimmt sich der Beitrag diesem Desiderat an. Unter der Verwendung eines integrativen Verfahrens, das sowohl kontextualisiert-performanzorientierte also auch dekontextualisiert-dispositionsorientierte Zugänge zur Modellierung miteinander verknüpft, wird ein Kompetenzprofil zur Anforderungssituation "Mit Schüler*innen über Anspruchsdimensionen eines inklusiven Sportunterrichts reflektieren" (Erhorn & Langer, 2022, S. 108) entwickelt. (DIPF/Orig.)In the context of inclusive physical education, which demands participation, recognition and individual support of all students, physical education teachers have to face different requirement situations. This includes reflecting with students on situations in which these demands are violated (Greve, 2016). However, it is not yet clear what competencies teachers need to meet these requirement situations. Following an approach that views competencies as a continuum between performance, situation-specific skills, and dispositions (Blömeke et al., 2015), this paper addresses this desideratum. Using an integrative procedure that combines both contextualized-performance-oriented and decontextualized-disposition-oriented approaches of modeling, a competency profile for the requirement situation "Reflecting with students on demands of inclusive physical education" (Erhorn & Langer, 2022, S. 108) is developed. (DIPF/Orig.

Linking Data Sovereignty and Data Economy: Arising Areas of Tension

In the emerging information economy, data evolves as an essential asset and personal data in particular is used for data-driven business models. However, companies frequently leverage personal data without considering individuals’ data sovereignty. Therefore, we strive to strengthen individuals’ position in data ecosystems by combining concepts of data sovereignty and data economy. Our research design comprises an approach to design thinking iteratively generating, validating, and refining such concepts. As a result, we identified ten areas of tension that arise when linking data sovereignty and data economy. Subsequently, we propose initial solutions to resolve these tensions and thus contribute to knowledge about the development of fair data ecosystems benefiting both individuals’ sovereignty and companies’ access to data

Perfil e fatores associados ao câncer de próstata em Criciúma – Santa Catarina, Brasil

Background: Prostate cancer is the second most incident of the male population in Brazil. The aim of this study is to analyze the frequency of risk factors associated to the evolution of the prostate cancer and the impact of conducting examinations in the age range (55-69 years old), in assisting health professionals to manage and prevent the disease. Methods: A case-control study was performed on patients from 2011 to 2016 in Criciúma – SC, Brazil. The sample was divided into two groups, one with biopsy for prostate adenocarcinoma (case; n = 124) and the other with a negative biopsy (control; n = 251). The following variables were compared between the two groups: age, family history of prostate cancer, prostate specific antigen, and altered digital rectal examination. Results: In the case group, ranging between 55-69 years old, there was a significant higher of altered digital rectal examination (p < 0.001, odds ratio 15.5 and positive predictive value 91.3%), prostate-specific antigen ≥ 4 ng/mL (p < 0.001, odds ratio 7.02 and positive predictive value 56.2%) and when both exams were altered (p < 0.001, odds ratio was 19.63 and the positive predictive value was 90.5%). Conclusion: This findings show that, mainly between 55-69 years old, there is a significant correlation between positive biopsy, altered digital rectal examination, and PSA ≥ 4 ng/mL.Objetivo: O câncer de próstata é o segundo mais incidente na população masculina no Brasil. O objetivo do estudo é analisar a frequência dos fatores de risco associados ao desenvolvimento do câncer de próstata e o impacto da realização de exames na faixa etária de rastreamento (55-69 anos), auxiliando os profissionais de saúde no manejo e prevenção da doença. Método: Foi realizado um estudo caso-controle no período de 2011 a 2016 em Criciúma – SC, Brasil. A amostra foi dividida em dois grupos, um com biópsia de adenocarcinoma de próstata (casos; n = 124) e outro com biópsia negativa (controles; n = 251). Entre ambos os grupos, foram comparadas as variáveis: idade, história familiar de câncer de próstata, antígeno prostático específico e toque retal alterado. Resultados: No grupo dos casos, na faixa etária entre 55-69 anos, ocorreu maior significância de toque retal alterado (p < 0,001; odds ratio 15.5 e valor preditivo positivo 91,3%), antígeno prostático específico ≥ 4 ng/mL (p < 0,001; odds ratio 7.02 e valor preditivo positivo 56,2%) e quando os dois exames estavam alterados (p < 0,001; odds ratio 19.63 e valor preditivo positivo 90,5%). Conclusão: Há evidências, principalmente entre 55-69 anos, de maior correlação de biópsia positiva, toque retal alterado e PSA ≥ 4 ng/mL

Modeling, Filtering and Optimization for AFM Arrays

We will present new tools and results developed for Arrays of Microsystems and especially for AFM array design.For modeling,we developed a two-scale model of cantilever arrays in elastodynamics.A robust optimization toolbox is interfaced to aid for design before fabrication.Two real-time computation methods for filtering and control of the coupled cantilevers are studied.One is based on functions of operators and the Cauchy integral formula.It may be realized with PNR.The second one relies to diffusive realization to be implemented in a FPGA.Displacement measurement is done by interferometry