Survival processing versus self-reference : a memory advantage following descriptive self-referential encoding

Previous research has shown that rating words for their relevance to a survival scenario leads to better retention of the words than rating them for self-reference. Past studies have, however, relied exclusively on an autobiographical self-reference task in which participants rate how easily a common noun brings to mind a personal experience. We report five experiments comparing survival processing to a descriptive self-reference task in which participants rated how well trait words described them. Rating trait adjectives for survival value led to higher levels of recall and recognition than rating them for their relevance to a moving home scenario. Rating the adjectives for self-reference, however, led to higher levels of recall (Experiments 1 and 3) and recollection (Experiment 2) than survival rating. Experiment 4 replaced trait adjectives with trait nouns and found that self-reference led to greater recognition accuracy than survival processing. Experiment 5 used trait nouns followed by tests of free recall and found a memory advantage following self-reference that was not influenced by the imageability of the stimuli. The findings are discussed in terms of theories of the survival processing and self-reference effects and the relationship between them

Differential Regulation of Growth-Promoting Signalling Pathways by E-Cadherin

Background: Despite the well-documented association between loss of E-cadherin and carcinogenesis, as well as the link between restoration of its expression and suppression of proliferation in carcinoma cells, the ability of E-cadherin to modulate growth-promoting cell signalling in normal epithelial cells is less well understood and frequently contradictory. The potential for E-cadherin to co-ordinate different proliferation-associated signalling pathways has yet to be fully explored. Methodology/Principal Findings: Using a normal human urothelial (NHU) cell culture system and following a calcium-switch approach, we demonstrate that the stability of NHU cell-cell contacts differentially regulates the Epidermal Growth Factor Receptor (EGFR)/Extracellular Signal-Regulated Kinase (ERK) and Phosphatidylinositol 3-Kinase (PI3-K)/AKT pathways. We show that stable cell contacts down-modulate the EGFR/ERK pathway, whilst inducing PI3-K/AKT activity, which transiently enhances cell growth at low density. Functional inactivation of E-cadherin interferes with the capacity of NHU cells to form stable calcium-mediated contacts, attenuates E-cadherin-mediated PI3-K/AKT induction and enhances NHU cell proliferation by allowing de-repression of the EGFR/ERK pathway and constitutive activation of beta-catenin-TCF signalling. Conclusions/Significance: Our findings provide evidence that E-cadherin can differentially and concurrently regulate specific growth-related signalling pathways in a context-specific fashion, with direct, functional consequences for cell proliferation and population growth. Our observations not only reveal a novel, complex role for E-cadherin in normal epithelial cell homeostasis and tissue regeneration, but also provide the basis for a more complete understanding of the consequences of E-cadherin loss on malignant transformation

Compassion Fatigue: An Application of the Concept to Informal Caregivers of Family Members with Dementia

Introduction. Compassion fatigue is a concept used with increasing frequency in the nursing literature. The objective of this paper is to identify common themes across the literature and to apply these themes, and an existing model of compassion fatigue, to informal caregivers for family members with dementia. Findings. Caregivers for family members with dementia may be at risk for developing compassion fatigue. The model of compassion fatigue provides an informative framework for understanding compassion fatigue in the informal caregiver population. Limitations of the model when applied to this population were identified as traumatic memories and the emotional relationship between parent and child, suggesting areas for future research. Conclusions. Research is needed to better understand the impact of compassion fatigue on informal caregivers through qualitative interviews, to identify informal caregivers at risk for compassion fatigue, and to provide an empirical basis for developing nursing interventions for caregivers experiencing compassion fatigue

Editor\u27s Introduction and Acknowledgments

The article offers information related to papers that were published in the publication Research in Outdoor Education Volume 9, as well as acknowledging the efforts of all who contributed to the publication

Legislative Smoking Bans for Reducing Exposure to Secondhand Smoke and Smoking Prevalence: Opportunities for Georgians

Background: Secondhand smoke, which is also referred to as environmental tobacco smoke and passive smoke, is a known human carcinogen. Secondhand smoke also causes disease and premature death in nonsmoking adults and children. Methods: We summarize studies of secondhand smoke in public places before and after smoking bans, as well as studies of cardiovascular and respiratory disease before and after such bans. Results: To protect the public from the harmful effects of secondhand smoke, smoke-free legislation is an effective public health measure. Smoking bans in public places, which have been implemented in many jurisdictions across the U.S. and in other countries, have the potential to influence social norms and reduce smoking behavior. Conclusions: Through legislative smoking bans for reducing secondhand smoke exposure and smoking prevalence, opportunities exist to protect the health of Georgians and other Americans and to reduce health care costs. These opportunities include increasing the comprehensiveness of smoking bans in public places and ensuring adequate funding to quit line services

Parental Chronic Illness: Current Limitations and Considerations for Future Research

For the past fifty years, researchers investigating the impact of parental chronic illness or disability on the family have consistently noted the limited work in this area. Citations spanning several decades are included here to deliberately underscore this fact. The purpose of this article is to highlight this ongoing limitation, as well as a number of ongoing points of disagreement. To this end, issues of insufficient research, contested methodologies, assumptions of pathology, and the divided nature of existing research will be presented. Concerning the latter, for years, studies have appeared in two contradictory perspectives: those which view the families and children of chronically ill parents as at risk, and those who find these families and children developing normally despite profound, atypical stressors. These points seem mutually exclusive, but with current research it is difficult to determine how or where these distinctions occur

The HIV Crisis in African Americans

Human Immunodeficiency Virus infection (HIV) has reached alarming proportions in the African American or black population. According to the Centers for Disease Control and Prevention (CDC), HIV has affected African American men, women, and children at a much higher rate than any other racial or ethnic population and continues to be a serious public health threat (Fact Sheet: HIV/AIDS Among African Americans, 2009). The combinations of factors contributing to this health disparity are complex. Social determinants such as poverty, unemployment and underemployment, and lack of access to health care and treatment all contribute to the problem. Problems unique to minorities, especially African Americans, include historical and current racism and discrimination, high rates of illicit drug use, incarceration, the dynamics of sexual networks, and stigma related to HIV diagnoses. In order to address this problem, public health leaders will need to collaborate with leaders in African American communities to design HIV prevention initiatives that involve strategies which are culturally acceptable and effective for this population. The interventions need to go beyond individual level interventions, and will need to address the societal and structural factors that exacerbate this disease.Master of Public Healt

Relationship between cardiovascular risk and lipid testing in one health care system: a retrospective cohort study.

BackgroundThe US Preventive Services Taskforce (USPSTF) recommends routine lipid screening beginning age 35 for men [1]. For women age 20 and older, as well as men age 20-34, screening is recommended if cardiovascular risk factors are present. Prior research has focused on underutilization but not overuse of lipid testing. The objective is to document over- and under-use of lipid testing in an insured population of persons at low, moderate and high cardiovascular disease (CVD) risk for persons not already on statins.MethodsThe study is a retrospective cohort study that included all adults without prior CVD who were continuously enrolled in a large integrated healthcare system from 2005 to 2010. Measures included lipid test frequency extracted from administrative data and Framingham cardiovascular risk equations applied using electronic medical record data. Five year lipid testing patterns were examined by age, sex and CVD risk. Generalized linear models were used to estimate the relative risk for over testing associated with patient characteristics.ResultsAmong males and females for whom testing is not recommended, 35.8 % and 61.5 % received at least one lipid test in the prior 5 years and 8.4 % and 24.4 % had two or more. Over-testing was associated with age, race, comorbidity, primary care use and neighborhood income. Among individuals at moderate and high-risk (not already treated with statins) and for whom screening is recommended, between 21.4 % and 25.1 % of individuals received no screening in the prior 5 years.ConclusionsBased on USPSTF lipid screening recommendations, this study documents substantial over-testing among individuals with low CVD risk and under-testing among individuals with moderate to high-risk not already on statins. Opportunity exists to better focus lipid screening efforts appropriate to CVD risk

Relationship Between Foveal Cone Specialization and Pit Morphology in Albinism

Purpose.Albinism is associated with disrupted foveal development, though intersubject variability is becoming appreciated. We sought to quantify this variability, and examine the relationship between foveal cone specialization and pit morphology in patients with a clinical diagnosis of albinism. Methods. We recruited 32 subjects with a clinical diagnosis of albinism. DNA was obtained from 25 subjects, and known albinism genes were analyzed for mutations. Relative inner and outer segment (IS and OS) lengthening (fovea-to-perifovea ratio) was determined from manually segmented spectral domain-optical coherence tomography (SD-OCT) B-scans. Foveal pit morphology was quantified for eight subjects from macular SD-OCT volumes. Ten subjects underwent imaging with adaptive optics scanning light ophthalmoscopy (AOSLO), and cone density was measured. Results. We found mutations in 22 of 25 subjects, including five novel mutations. All subjects lacked complete excavation of inner retinal layers at the fovea, though four subjects had foveal pits with normal diameter and/or volume. Peak cone density and OS lengthening were variable and overlapped with that observed in normal controls. A fifth hyper-reflective band was observed in the outer retina on SD-OCT in the majority of the subjects with albinism. Conclusions. Foveal cone specialization and pit morphology vary greatly in albinism. Normal cone packing was observed in the absence of a foveal pit, suggesting a pit is not required for packing to occur. The degree to which retinal anatomy correlates with genotype or visual function remains unclear, and future examination of larger patient groups will provide important insight on this issue