Thermoluminescence, optical absorption and ESR studies in (KCl)1-x(KBr)x mixed alkali halide crystals doped with gold

Mixed crystals of KCl–KBr of different compositions were grown with Czochralski technique. Crystals were doped with gold. Both the undoped and gold doped crystals were γ γ -irradiated using 60 Co 60 Co source. All the irradiated samples were subjected to thermoluminescence, optical absorption and ESR studies. The present study shows the composition dependence of the parameters and enhancement in the luminescence intensity as well as the absorption coefficient with gold doping. Non-linear variation of color center peak position and half band width of F-center with composition has been observed. The results of the above studies are presented in this paper

Electrical Conductivity and Dielectric Properties of KH2PO4 Crystals Modified with KBr and NaBr

Pure KH2PO4 (KDP) and KDP crystals containing KBr and NaBr with/without gold doping were grown by slow evaporation technique. All the grown crystals were γ- irradiated using 60Co source. Electrical conductivity measurements were carried out perpendicular to the unique direction before and after γ-irradiation. The present measurement shows that the conductivity of KDP crystals increases with the addition of KBr and NaBr and with gold-doping as well as temperature. Computed values of activation energies from the conductivity measurements are given. Dielectric constant is measured as a function of frequency. Study confirms the contribution of space charge polarization. © 2005 IACS

Implicating genes, pleiotropy, and sexual dimorphism at blood lipid loci through multi-ancestry meta-analysis

Funding GMP, PN, and CW are supported by NHLBI R01HL127564. GMP and PN are supported by R01HL142711. AG acknowledge support from the Wellcome Trust (201543/B/16/Z), European Union Seventh Framework Programme FP7/2007–2013 under grant agreement no. HEALTH-F2-2013–601456 (CVGenes@Target) & the TriPartite Immunometabolism Consortium [TrIC]-Novo Nordisk Foundation’s Grant number NNF15CC0018486. JMM is supported by American Diabetes Association Innovative and Clinical Translational Award 1–19-ICTS-068. SR was supported by the Academy of Finland Center of Excellence in Complex Disease Genetics (Grant No 312062), the Finnish Foundation for Cardiovascular Research, the Sigrid Juselius Foundation, and University of Helsinki HiLIFE Fellow and Grand Challenge grants. EW was supported by the Finnish innovation fund Sitra (EW) and Finska Läkaresällskapet. CNS was supported by American Heart Association Postdoctoral Fellowships 15POST24470131 and 17POST33650016. Charles N Rotimi is supported by Z01HG200362. Zhe Wang, Michael H Preuss, and Ruth JF Loos are supported by R01HL142302. NJT is a Wellcome Trust Investigator (202802/Z/16/Z), is the PI of the Avon Longitudinal Study of Parents and Children (MRC & WT 217065/Z/19/Z), is supported by the University of Bristol NIHR Biomedical Research Centre (BRC-1215–2001) and the MRC Integrative Epidemiology Unit (MC_UU_00011), and works within the CRUK Integrative Cancer Epidemiology Programme (C18281/A19169). Ruth E Mitchell is a member of the MRC Integrative Epidemiology Unit at the University of Bristol funded by the MRC (MC_UU_00011/1). Simon Haworth is supported by the UK National Institute for Health Research Academic Clinical Fellowship. Paul S. de Vries was supported by American Heart Association grant number 18CDA34110116. Julia Ramierz acknowledges support by the People Programme of the European Union’s Seventh Framework Programme grant n° 608765 and Marie Sklodowska-Curie grant n° 786833. Maria Sabater-Lleal is supported by a Miguel Servet contract from the ISCIII Spanish Health Institute (CP17/00142) and co-financed by the European Social Fund. Jian Yang is funded by the Westlake Education Foundation. Olga Giannakopoulou has received funding from the British Heart Foundation (BHF) (FS/14/66/3129). CHARGE Consortium cohorts were supported by R01HL105756. Study-specific acknowledgements are available in the Additional file 32: Supplementary Note. The views expressed in this manuscript are those of the authors and do not necessarily represent the views of the National Heart, Lung, and Blood Institute; the National Institutes of Health; or the U.S. Department of Health and Human Services.Peer reviewedPublisher PD

Implicating genes, pleiotropy, and sexual dimorphism at blood lipid loci through multi-ancestry meta-analysis

Publisher Copyright: © 2022, The Author(s).Background: Genetic variants within nearly 1000 loci are known to contribute to modulation of blood lipid levels. However, the biological pathways underlying these associations are frequently unknown, limiting understanding of these findings and hindering downstream translational efforts such as drug target discovery. Results: To expand our understanding of the underlying biological pathways and mechanisms controlling blood lipid levels, we leverage a large multi-ancestry meta-analysis (N = 1,654,960) of blood lipids to prioritize putative causal genes for 2286 lipid associations using six gene prediction approaches. Using phenome-wide association (PheWAS) scans, we identify relationships of genetically predicted lipid levels to other diseases and conditions. We confirm known pleiotropic associations with cardiovascular phenotypes and determine novel associations, notably with cholelithiasis risk. We perform sex-stratified GWAS meta-analysis of lipid levels and show that 3–5% of autosomal lipid-associated loci demonstrate sex-biased effects. Finally, we report 21 novel lipid loci identified on the X chromosome. Many of the sex-biased autosomal and X chromosome lipid loci show pleiotropic associations with sex hormones, emphasizing the role of hormone regulation in lipid metabolism. Conclusions: Taken together, our findings provide insights into the biological mechanisms through which associated variants lead to altered lipid levels and potentially cardiovascular disease risk.Peer reviewe

Implicating genes, pleiotropy, and sexual dimorphism at blood lipid loci through multi-ancestry meta-analysis

Abstract Background Genetic variants within nearly 1000 loci are known to contribute to modulation of blood lipid levels. However, the biological pathways underlying these associations are frequently unknown, limiting understanding of these findings and hindering downstream translational efforts such as drug target discovery. Results To expand our understanding of the underlying biological pathways and mechanisms controlling blood lipid levels, we leverage a large multi-ancestry meta-analysis (N = 1,654,960) of blood lipids to prioritize putative causal genes for 2286 lipid associations using six gene prediction approaches. Using phenome-wide association (PheWAS) scans, we identify relationships of genetically predicted lipid levels to other diseases and conditions. We confirm known pleiotropic associations with cardiovascular phenotypes and determine novel associations, notably with cholelithiasis risk. We perform sex-stratified GWAS meta-analysis of lipid levels and show that 3–5% of autosomal lipid-associated loci demonstrate sex-biased effects. Finally, we report 21 novel lipid loci identified on the X chromosome. Many of the sex-biased autosomal and X chromosome lipid loci show pleiotropic associations with sex hormones, emphasizing the role of hormone regulation in lipid metabolism. Conclusions Taken together, our findings provide insights into the biological mechanisms through which associated variants lead to altered lipid levels and potentially cardiovascular disease risk

Growth and characterization of NLO crystal

369-371Pure ammonium dihydrogen orthophosphate (ADP) crystals and ADP crystals doped with nitrite tri-acetic acid and ethylene diamine tetra acetic acid (EDTA) have been grown by slow evaporation technique. Grown crystals have been characterized using X-ray diffraction and energy dispersive X-ray spectroscopy (EDAX). Second harmonic generation (SHG) efficiency measurements are carried out by Kurtz method. It has been found that the ADP crystals containing nitrite tri acetic acid and EDTA have resulted appreciable increase in SHG efficiency as compared to pure ADP crystals. Dielectric constant and dielectric loss are measured as a function of frequency. Study confirms the contribution of space charge polarization

Electrical conductivity and dielectric measurements in Au⁺doped/undoped KDP crystals with KCl and NaCl as additives

123-128Pure potassium dihydrogen orthophosphate (KDP) containing KCl or NaCl with and without gold doping were grown by slow evaporation technique. All the grown crystals were -irradiated using 60Co source. Electrical conductivity measurements were carried out perpendicular to the unique direction before and after g-irradiation. The conductivity of KDP crystals increases with the addition of KCl and NaCl and with gold doping as well as temperature. Computed values of activation energies from the conductivity measurements are given. The dielectric constant and dielectric loss have been measured as a function of frequency. The study confirms the contribution of space charge polarization

Comparative Study of Erbium Doped KDP Single Crystals Grown by Different Techniques

International audienceErbium doped potassium dihydrogen Orthophosphate (KDP) single crystals were grown by different techniques-SR method, Seed Rotation and Slow Evaporation with the vision to improve the properties of the crystal. The objective of this study is to show how the dopant Erbium influences the growth, morphology and characteristics of KDP crystal. The crystal size grown by SR method on unidirectional {101} pyramidal face was around 150 mm in length and 16 mm in diameter. The Chemical composition of the grown crystals is confirmed by EDAX Analysis. The grown crystals are subjected to PXRD analysis using XrdwinPD 4-dectris computer based diffractometer with a characteristic Cu Kα (1.540598) radiations from 10 0 to 60 0 at a scan rate of 10 0 /min, confirm the crystalline nature and shifts in peak positions due to doping is observed. Using Scherer's equation crstallite size has been calculated and the crystallite size is around 44 nm. Solubility of crystals grown by slow evaporation technique is determined using water as a solvent. The solubility curve shows that that Erbium doped KDP crystals has higher solubility than the pure KDP. The SHG efficiency is determined by Kurtz powder technique. It is found that relative SHG conversion efficiency of crystal grown by SR method is greater compared to other techniques. Optical transmission spectra are recorded for the crystals in the wavelength region 200 to 1100nm using Perkin-Elmer Lambda 35 UV-Vis spectrophotometer. It is found that percentage transmission of crystals grown by SR method is more as compared to other techniques. The electronic band transitions is studied from the plot of (αhv) 2 versus photon energy (hv) and the band gap energy has been calculated. The addition of Erbium improves the quality and transparency of crystals, which shows the suitability of the ingot for optical applications. Introduction. With the advanced research approach on efficient nonlinear optical material (NLO) is intensively studied for various optical device applications. Potassium dihydrogen orthophosphate (KDP) is a best known NLO material and has been used for second harmonic generation for high pulse energy, laser frequency conversion, low repetition (<100 Hz) rate lasers, electro-optical modulation and Q-switching applications [1-3]. As a result, significant efforts have been made to find novel and efficient NLO materials