Importance of the dietary fat on the prevention and control of metabolic disturbances and cardiovascular disease

A Organização Mundial da Saúde (OMS) reiterou recentemente que o consumo de dietas inadequadas e a inatividade física estão entre os dez principais fatores de mortalidade. Diversos ensaios aleatorizados demonstram que intervenções alimentares adequadas podem diminuir ou prevenir significativamente o aparecimento de várias doenças crônicas não transmissíveis. Neste contexto, o papel da dieta vem sendo exaustivamente avaliado em estudos clínicos e epidemiológicos. Assim, já foi bem estabelecido na literatura que a quantidade e o tipo de gordura alimentar exercem influência direta sobre fatores de risco cardiovascular, tais como a concentração de lípides e de lipoproteínas plasmáticas, bem como sua associação a processos inflamatórios. Os ácidos graxos participam de complexos sistemas de sinalização intracelular, função que vem sendo bastante explorada. Os ácidos graxos poli-insaturados não somente influenciam a composição das membranas, metabolismo celular e sinais de tradução, mas também modulam a expressão de genes, regulando a atividade e a produção de diversos fatores de transcrição. A proposta deste artigo é rever tópicos relevantes referentes ao metabolismo de lípides e os relacionar a terapias nutricionais que possam contribuir para a prevenção e o tratamento de doenças associadas.The World Health Organization (WHO) has recently reinforced the fact that inadequate diets, along with physical inactivity, are among the ten main determinant factors of mortality. Several randomized trials demonstrated that dietary interventions may lower or even prevent the occurrence of several non-communicable diseases. In this context, the role of diet has been exhaustively evaluated in several clinical and epidemiological studies. Thus, it is well established in literature that the amount and type of dietary fat have a direct influence on cardiovascular risk factors, such as lipids and plasma lipoprotein concentration, as well as their association with inflammatory processes. Fatty acids also participate in complex intracellular signaling systems, a function which has been currently investigated. Dietary polyunsaturated fatty acids (PUFA) act not only by altering membrane lipid composition, cellular metabolism and signal transduction, but also modulating gene expression by regulating the activity and/or production of different nuclear transcription factors. The aim of this article is to review important topics regarding the lipids metabolism and correlate them with nutritional therapies that may contribute to the prevention and treatment of related diseases

evidence from Portugal

In the last two decades, many European countries allowed the sale of over-the-counter (OTC) drugs outside pharmacies. This was expected to lower retail prices through increased competition. Evidence of such price reductions is scarce. We assess the impact of supermarket and outlet entry in the OTC drug market on OTC prices charged by incumbent pharmacies using a difference-in-differences strategy. We use price data on five popular OTC drugs for all retailers located in Lisbon for three distinct points in time (2006, 2010, and 2015). Our results suggest that competitive pressure in the market is mainly exerted by supermarkets, which charge, on average, 20% lower prices than pharmacies. The entry of a supermarket among the main competitors of an incumbent pharmacy is associated with an average 4% to 6% decrease in prices relative to the control group. These price reductions are long-lasting but fairly localized. We find no evidence of price reductions following OTC outlet entry. Additional results from a reduced-form entry model and a propensity score matching difference-in-differences approach support the view that these effects are causal.authorsversionpublishe

História Interdisciplinar da Loucura, Psiquiatria e Saúde mental — VII

A obra reune um conjunto de textos apresentados nas VII Jornadas Internacionais de História da Loucura, Psiquiatria e Saúde Mental realizada em Coimbra em Maio de 2016

IV Jornadas Internacionais de História da Psiquiatria e Saúde Mental

A obra reune um conjunto de textos apresentados nas IV Jornadas Internacionais de História da Loucura, Psiquiatria e Saúde Mental realizada em Coimbra em Maio de 201

Saberes e práticas em torno do adoecer da alma e do corpo

Obra coletiva que reune textos de especialistas sobre saberes e práticas em torno da saúde e da doenç

The Lean Startup approach in the implementation of a children location device

Mestrado em Gestão/MBANesta dissertação de mestrado, a metodologia Lean Startup é usada para desenvolver uma solução comercial de um dispositivo vestível capaz de rastrear crianças.In this master thesis, The Lean Startup methodology is used to develop a business solution of a wearable device that is able to track children.info:eu-repo/semantics/publishedVersio

VI Jornadas Internacionais de História da Psiquiatria e Saúde Mental

A obra reune um conjunto de textos apresentados nas VI Jornadas Internacionais de História da Loucura, Psiquiatria e Saúde Mental realizada em Coimbra em Maio de 201

V Jornadas Internacionais de História da Psiquiatria e Saúde Mental

A obra reune um conjunto de textos apresentados nas V Jornadas Internacionais de História da Loucura, Psiquiatria e Saúde Mental realizada em Coimbra em Maio de 201

L’enseignement pharmaceutique au Portugal. Etude de cas de la Faculte de Pharmacie de l’Universite de Coimbra (1902)

Les auteurs font l’historique de l’enseignement pharmaceutique au Portugal. Leur recherche se centre essentiellement sur les réformes qui ont marqué la pharmacie dans la première moitié du XXe siècle, une période de profondes modifications scientifiques, techniques et professionnelles au niveau de la pharmacie portugaise. Ils effectuent une étude de cas pour l’École/ Faculté de Pharmacie de l’Université en centrant leur attention aussi bien sur l’enseignement que sur la recherche réalisée, ayant pour rideau de fond le contexte politique, social et scientifique.Pharmaceutical teaching in Portugal - the case study of the University of Coimbra´s Faculty of Pharmacy — The authors make a record of pharmaceutical teaching in Portugal centering their investigation mainly on the reforms that marked pharmacy in the first half of the XX century, a period of scientific, technical and deep professional changes in Portuguese pharmacy. A case study was completed for the University´s School / Faculty of Pharmacy focusing its attention not only on the teaching but also the investigation accomplished, having the political, social and scientific context as a background