1,340 research outputs found
Dissetenes Jornades de Dret CatalĂ a Tossa: qĂĽestions actuals del dret catalĂ de la persona i de la famĂlia
CaracterizaciĂłn in vitro de nanopartĂculas dirigidas a marcadores de Cancer Stem Cells en lĂneas celulares de cáncer microcĂtico de pulmĂłn
El cáncer de pulmón es la principal causa de muerte por cáncer en todo el
mundo. A pesar de las diferentes terapias comúnmente utilizadas para tratar el cáncer de pulmón, el pronóstico de los pacientes sigue siendo pobre. Diversos trabajos han propuesto que muchos tipos de cáncer, incluyendo el cáncer de pulmón, pueden ser promovidos por las células madre del cáncer (CSC, del inglés Cancer Stem Cell). Las CSCs son un subconjunto de células
indiferenciadas con la capacidad de iniciar la formación de tumores, proliferar y diferenciarse ampliamente. Se piensa que el crecimiento y / o la recurrencia del cáncer puede estar impulsado por este grupo de células. También están
involucradas en las resistencias a la radioterapia y la quimioterapia.
Los sistemas de liberaciĂłn de fármacos a nanoescala están evolucionando rápidamente y pueden ofrecer un enfoque innovador para superar la resistencia de las CSCs a los fármacos asĂ como reducir la frecuencia de recidivas. Recientemente, las estrategias basadas en nanopartĂculas han demostrado un aumento de la eficacia terapĂ©utica y la reducciĂłn de los efectos secundarios adversos, en comparaciĂłn con los mĂ©todos terapĂ©uticos clásicos. Varios estudios han respaldado a la bomba ABCG2, al receptor CXCR4 y al CD44 como posibles marcadores de CSC en el cáncer microcĂtico de pulmĂłn.
Los objetivos directos de este trabajo son determinar la presencia de estos marcadores en la superficie de las distintas lĂneas celulares pulmonares,
estudiar la capacidad y especificidad de uniĂłn de las nanopartĂculas a las
diferentes dianas y caracterizar la internalizaciĂłn de dichas nanopartĂculas, con el fin de desarrollar un sistema de direccionamiento de fármacos que eliminarĂa selectivamente las CSCs.Lung cancer is the leading cause of cancer death worldwide. Although
many therapies are commonly used to treat lung cancer, the prognosis remains poor. Several studies have suggested that many types of cancer, including lung cancer, can be promoted by cancer stem cells (CSC). CSCs are a subset of undifferentiated with the ability to initiate the tumor, proliferation and differentiation. It is thought that growth and / or recurrence of cancer may be driven by this group of cells. They are also involved in drug resistance.
The nanoscale drug delivery systems are evolving rapidly and can offer an
innovative approach to overcome drug resistance of the CSC and reduce the
frequency of recurrences. Recently, nanoparticles based strategies have
demonstrated increased therapeutic efficacy and reduced adverse side effects, compared with those of traditional therapeutic methods. Several studies have supported the ABCG2 pump, the CXCR4 receptor and CD44 as potential markers of CSCs in small cell lung cancer.
The objectives of this study are to determine the presence of these
markers on the surface of different lung cell lines, and to study binding
specificity of nanoparticles to different targets and characterizing their
internalization, in order to develop a drug targeting system which selectively
eliminate CSCs.Universidad de Sevilla. Máster en InvestigaciĂłn MĂ©dica: clĂnica y experimenta
El mito de la princesa: Blancanieves y la Bella Durmiente segĂşn Elfriede Jelinek
Reescribir y reinterpretar cuentos tradicionales forma parte ya de una tradiciĂłn literaria a la que no pocos autores se han sumado. El presente artĂculo ofrecerá un análisis de uno de estos intentos, llevado a cabo por la escritora austriaca Elfriede Jelinek. La autora ganadora del Premio Nobel de Literatura en 2004 publicĂł un año antes Dramas de princesas. La muerte y la doncella I-V, un conjunto de cinco obras concebidas como entreactos de otros espectáculos teatrales. De entre los modelos que la autora toma como referencia, los cuentos de hadas suponen el punto de partida para dos de los dramas, La muerte y la doncella I (Blancanieves) y La Muerte y la doncella II (La Bella Durmiente). El objetivo del artĂculo será desarrollar un análisis comparado de estos dramas y de los dos textos escritos por los hermanos Grimm en el siglo xix. Para ello, analizarĂ© cĂłmo los dramas de Jelinek “leen” los textos predecesores, y se convierten de esta forma en metatextos, con unos personajes que se comentan a sĂ mismos y, fundamentalmente, a los estereotipos —los mitos— que de ellos han quedado. En definitiva, se trata de constatar las estrategias discursivas de los dramas de Jelinek para cuestionar el orden simbĂłlico dominante, sustentado y cultivado, entre otros factores, por los mitos cotidianos. En este sentido, tomarĂ© como modelo teĂłrico el estudio MitologĂas, de Roland Barthes, que tanto influenciĂł a la autora
Susana Navas Navarro (dir.), Sandra Camacho Clavijo i Alejandra de Lama Aymà (coord.), Iguales y diferentes ante el derecho privado, València, Tirant lo Blach i Universitat Autònoma de Barcelona, 2012, 937 p.
Col·legi de Registradors (coord.), Antonio Cumella Gaminde i Mercedes Tormo Santonja (dir.), Comentaris de dret patrimonial català , Barcelona, Bosch, 2005., 1045 p.
El llegat de cosa aliena (comentari a la sentència del tribunal superior de justĂcia de Catalunya de 23 d'abril de 2001)
Intercultural mediation with the roma community in health-care contexts
La mediación intercultural esencialmente es una cuestión de percepciones. Desde una posición humana y cultural debemos comprender al «otro» partiendo del principio que nuestras vidas están orientadas por normas y principios que están impregnados de valores y tradiciones culturales. Aplicar «nuestra lógica» buscando las causas y las consecuencias del comportamiento y de las actitudes de aquellos que no comparten nuestra cultura es un intento vano que no nos lleva a ningún lado. Sólo cambiando nuestro enfoque podemos lograr el entendimiento fluido y la comprensión que deseamos. En suma, debemos enfrentarnos a las dificultades de comunicación cuestionándonos por qué la realidad es percibida de esta manera. Esta aproximación aumenta nuestra capacidad de percepción, facilita actitudes de comprensión estimulando el diálogo y la comunicación.Intercultural mediation essentially deals with perceptions. Perceived reality is frequently very different and far removed from actual reality. From our human and cultural position we must endeavor to understand the «other», starting from the principle that our lives are guided by certain norms and principles that are impregnated with cultural values and traditions. Any attempt to find logical reasons for this perception, in other words, the causes and consequences of the behavior and attitudes of those who do not share our culture, will be in vain and take us nowhere. Only by changing our approach can we achieve the fluency of understanding and comprehension that we all strive for. In sum, we must face up to the difficulties of communication by questioning why reality is perceived in this way. This approach activates our perceptive capacity, facilitates attitudes of comprehension, and stimulates the dialogue and communication on which interculturality is grounded
Earnings and Wealth Inequality and Income Taxation: Quantifying the Trade-Offs of Switching to a Proportional Income Tax in the U.S. Ohio
This papaer quantifies the steady-state aggregate, distributinal and mobility effects of switching the U.S. to a proportional income tax system. As a perriquisite to the analysi, we propose a theory of earnings and wealth inequality capable of accounting quantitatively for the key aggregate and inequality facts of the U. S. economy. This theory is based on saving to smooth uninsured household-specific risk, for dynastic households that also have some life-cycle characteristics. A suitable calibration of our model economy replicates the U.S. growth facts, earnings and wealth distributions, the progressivity of the tax system and the size of the U.S. government. We also solve a similar model economy in which the government livies a proportional income tax to finance the same flow of government expenditures and public transfers. Our finding show that in this class of model worlds a switch from the U.S. tax system to a proporcional tax system implies the following trade-offs, i.) it increases efficiency as measured by aggregate output by 4,4%, ii. ) it increases inequality as measured by the Gini index of the wealth distribution by 10.4%, and iv.) it changes by little the mobility between the different earnings and wealth groups
Unemployment spells and income distribution dynamics
In the U.S., during the 1948-86 period, an approximation to the Gini Index based on the quintiles and on the top 5% of the income distribution yielded a value of 0.351. Further, during this same period, the income share earned by the first quintile was procyclical and 7% more volatile than aggregate yearly output. In this paper we quantify the role played by unemployment spells in determining these and other related issues. To this purpose, we use an extension of the general equilibrium stochastic growth model that includes an endogenous distribution of households indexed by wealth and employment status. Our main findings are the following: i) in a model economy where all households have the same endowments of skills and are subject to the same employment processes, uninsured unemployment spells alone account for a very small share of the concentration of income observed in the U.S., and of the income distribution dynamics -the approximated Gini Index in this model economy is 18% of the one observed in the U.S., and the income share earned by the first quintile is 58% more volatile, ii) this result is robust to including a technology that allows for cyclically moving factor shares, and iii) in a model economy where households are partitioned into different skills groups that are subject to different employment processes in accordance to U.S. data, unemployment spells account for a significantly greater share of the U.S. statistics -the approximated Gini Index in this model economy is 70% of the one observed in the U.S., and the income share earned by the first quintile is 10% more volatile
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